FI85706C - Foerfarande foer framstaellning av nytt terapeutiskt anvaendbart 1-(4-aminofenyl)-4-metyl -7,8-metylendioxi-3,4-dihydro-5h-2,3-bensodiazepin och syraadditionssalter daerav. - Google Patents
Foerfarande foer framstaellning av nytt terapeutiskt anvaendbart 1-(4-aminofenyl)-4-metyl -7,8-metylendioxi-3,4-dihydro-5h-2,3-bensodiazepin och syraadditionssalter daerav. Download PDFInfo
- Publication number
- FI85706C FI85706C FI873525A FI873525A FI85706C FI 85706 C FI85706 C FI 85706C FI 873525 A FI873525 A FI 873525A FI 873525 A FI873525 A FI 873525A FI 85706 C FI85706 C FI 85706C
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- FI
- Finland
- Prior art keywords
- hydride
- benzodiazepine
- methylenedioxy
- aminophenyl
- methyl
- Prior art date
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Psychiatry (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU359486 | 1986-08-15 | ||
| HU863594A HU198494B (en) | 1986-08-15 | 1986-08-15 | Process for producing new 3,4-dihydro-5h-2,3-benzodiazepine derivative and acid addition salts thereof, as well as pharmaceutical compositions comprising same |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| FI873525A0 FI873525A0 (fi) | 1987-08-14 |
| FI873525A7 FI873525A7 (fi) | 1988-02-16 |
| FI85706B FI85706B (fi) | 1992-02-14 |
| FI85706C true FI85706C (fi) | 1992-05-25 |
Family
ID=10964707
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI873525A FI85706C (fi) | 1986-08-15 | 1987-08-14 | Foerfarande foer framstaellning av nytt terapeutiskt anvaendbart 1-(4-aminofenyl)-4-metyl -7,8-metylendioxi-3,4-dihydro-5h-2,3-bensodiazepin och syraadditionssalter daerav. |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US4835152A (en, 2012) |
| JP (1) | JPS6399073A (en, 2012) |
| AT (1) | ATA202187A (en, 2012) |
| AU (1) | AU596206B2 (en, 2012) |
| BE (1) | BE1002415A4 (en, 2012) |
| CA (1) | CA1284322C (en, 2012) |
| CH (1) | CH673652A5 (en, 2012) |
| CS (1) | CS264150B2 (en, 2012) |
| DD (1) | DD265627A5 (en, 2012) |
| DE (1) | DE3727226A1 (en, 2012) |
| DK (1) | DK164555C (en, 2012) |
| ES (1) | ES2004985A6 (en, 2012) |
| FI (1) | FI85706C (en, 2012) |
| FR (1) | FR2602773B1 (en, 2012) |
| GB (1) | GB2194236B (en, 2012) |
| HU (1) | HU198494B (en, 2012) |
| IT (1) | IT1222508B (en, 2012) |
| NL (1) | NL8701909A (en, 2012) |
| NO (1) | NO164656C (en, 2012) |
| PL (1) | PL148535B1 (en, 2012) |
| RU (1) | RU1779251C (en, 2012) |
| SE (1) | SE467357B (en, 2012) |
| YU (1) | YU46223B (en, 2012) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU219778B (hu) * | 1990-12-21 | 2001-07-30 | Gyógyszerkutató Intézet Közös Vállalat | Eljárás N-acil-2,3-benzodiazepin-származékok, savaddíciós sóik és az ezeket tartalmazó gyógyászati készítmények előállítására, valamint a vegyületek egy csoportja, és az ezeket tartalmazó gyógyászati készítmények |
| HU206719B (en) * | 1990-12-21 | 1992-12-28 | Gyogyszerkutato Intezet | Process for producing 1-/4-acylamino-phenyl/-7,8-methylenedioxy-5h-2,3-benzodiazepine derivatives, acid addicional salts and pharmaceutical compositions containing them |
| US5639751A (en) * | 1990-12-21 | 1997-06-17 | Cyogyszerkutato Intezet Kft | N-acyl-2,3-benzodiazepine derivatives for treating acute and chronic neurodegenerative disorders |
| US6288057B1 (en) * | 1994-08-31 | 2001-09-11 | Eli Lilly And Company | Physical form of dihydro-2,3-benzodiazepine derivative |
| TR199501071A2 (tr) * | 1994-08-31 | 1996-06-21 | Lilly Co Eli | Dihidro-2,3-benzodiazepin türevlerinin üretilmesi icin stereoselektif islem. |
| PL181112B1 (pl) * | 1995-03-28 | 2001-05-31 | Eli Lilly & Co | Nowa fizyczna postać (R)-7-acetylo-5-(4-aminofenylo)-8,9-dihydro-8-metylo-7H-1,3-dioksolo[4,5-h] [2,3]-benzodiazepiny, sposób jej otrzymywania oraz kompozycja farmaceutyczna |
| US5891871A (en) * | 1996-03-21 | 1999-04-06 | Cocensys, Inc. | Substituted 2,3-benzodiazepin-4-ones and the use thereof |
| UA67749C2 (uk) * | 1997-08-12 | 2004-07-15 | Егіш Дьйодьсердьяр Рт. | Похідна 8-заміщеного-9н-1,3-діоксол/4,5-h//2,3/бензодіазепіну з властивостями амра/каїнатного антагоніста, спосіб одержання похідних, фармацевтична композиція (варіанти), спосіб її одержання та спосіб лікування |
| US6649607B2 (en) * | 2001-05-18 | 2003-11-18 | Vela Pharmaceuticals, Inc. | Compositions and methods for treating or preventing convulsions or seizures |
| EP1575521A4 (en) * | 2002-12-03 | 2008-04-30 | Vela Acquisition Corp | PHARMACEUTICAL COMPOSITION OF 1- (3-HYDROXY-4-METHOXYPHENYL) -4-METHYL-5-ETHYL-7,8-DIMETHOXY-5H-2,3-BENZODIAZEPINE AND ITS USE |
| US7022700B2 (en) * | 2002-12-03 | 2006-04-04 | Vela Pharmaceuticals, Inc. | Method of increasing neutrophil production using optically-pure (R)-2,3-benzodiazepines |
| CA2508542A1 (en) * | 2002-12-03 | 2004-06-17 | Vela Pharmaceuticals, Inc. | Pharmaceutical composition of 1-(3,4-dimethoxyphenyl)-4-methyl-5-ethyl-7-methoxy-8-hydroxy-5h-2,3-benzodiazepine and uses thereof |
| US6864251B2 (en) * | 2002-12-03 | 2005-03-08 | Vela Pharmaceuticals, Inc. | Treatment of LTB4-mediated inflammatory disorders with optically-pure (R)-2,3-benzodiazepines |
| US6638928B1 (en) | 2002-12-03 | 2003-10-28 | Vela Pharmaceuticals, Inc. | Treatment of irritable bowel syndrome and nonulcer dyspepsia with substituted 2,3-benzodiazepines |
| US20040162284A1 (en) * | 2003-02-19 | 2004-08-19 | Harris Herbert W. | Method of lowering body temperature with (S) tofisopam |
| US20040224943A1 (en) * | 2003-02-19 | 2004-11-11 | Leventer Steven M. | Method of lowering body temperature with (R) - 2,3-benzodiazepines |
| CA2525273C (en) * | 2003-05-16 | 2012-04-17 | Vela Pharmaceuticals, Inc. | Treatment of gastrointestinal dysfunction and related stress with an enantiomerically-pure (r) 2,3-benzodiazepine |
| US20070021412A1 (en) * | 2003-05-16 | 2007-01-25 | Vela Pharmaceuticals, Inc. | Treatment of gastrointestinal dysfunction and related stress with an enantiomerically-pure (S) 2,3-benzodiazepine |
| US20040254173A1 (en) * | 2003-06-13 | 2004-12-16 | Leventer Steven M. | Modulation of dopamine responses with substituted (S)-2,3-benzodiazepines |
| US20050096464A1 (en) * | 2003-10-30 | 2005-05-05 | Heikki Heikkila | Separation process |
| EP4197536A1 (en) * | 2021-12-20 | 2023-06-21 | Universitat de València | Haloperidol for use in the treatment of spinal muscular atrophy |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU186760B (en) * | 1981-03-12 | 1985-09-30 | Gyogyszerkutato Intezet | Process for preparing 3,4-dihydro-5h-2,3-aenzodiazepine derivatives |
| DE3319491A1 (de) * | 1982-06-19 | 1983-10-13 | Alps Electric Co., Ltd., Tokyo | Papierfuehrungsmechanismus fuer schreibgeraete |
| HU191698B (en) * | 1984-07-27 | 1987-03-30 | Gyogyszerkutato Intezet | Process for producing new 1-aryl-5h-2beta-benzodiazepines |
-
1986
- 1986-08-15 HU HU863594A patent/HU198494B/hu not_active IP Right Cessation
-
1987
- 1987-08-11 AT AT0202187A patent/ATA202187A/de not_active Application Discontinuation
- 1987-08-12 CH CH3115/87A patent/CH673652A5/de not_active IP Right Cessation
- 1987-08-13 YU YU151487A patent/YU46223B/sh unknown
- 1987-08-14 DK DK424887A patent/DK164555C/da not_active IP Right Cessation
- 1987-08-14 GB GB8719265A patent/GB2194236B/en not_active Expired - Lifetime
- 1987-08-14 JP JP62201967A patent/JPS6399073A/ja active Pending
- 1987-08-14 BE BE8700909A patent/BE1002415A4/fr not_active IP Right Cessation
- 1987-08-14 NO NO873426A patent/NO164656C/no unknown
- 1987-08-14 ES ES8702415A patent/ES2004985A6/es not_active Expired
- 1987-08-14 FR FR878711578A patent/FR2602773B1/fr not_active Expired - Lifetime
- 1987-08-14 CA CA000544626A patent/CA1284322C/en not_active Expired - Lifetime
- 1987-08-14 RU SU874203196A patent/RU1779251C/ru active
- 1987-08-14 DD DD87306060A patent/DD265627A5/de not_active IP Right Cessation
- 1987-08-14 AU AU76880/87A patent/AU596206B2/en not_active Ceased
- 1987-08-14 SE SE8703169A patent/SE467357B/sv not_active IP Right Cessation
- 1987-08-14 IT IT21667/87A patent/IT1222508B/it active
- 1987-08-14 PL PL1987267326A patent/PL148535B1/pl unknown
- 1987-08-14 DE DE19873727226 patent/DE3727226A1/de not_active Withdrawn
- 1987-08-14 CS CS876007A patent/CS264150B2/cs unknown
- 1987-08-14 FI FI873525A patent/FI85706C/fi not_active IP Right Cessation
- 1987-08-14 NL NL8701909A patent/NL8701909A/nl not_active Application Discontinuation
- 1987-08-20 US US07/087,341 patent/US4835152A/en not_active Expired - Fee Related
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM | Patent lapsed | ||
| MM | Patent lapsed |
Owner name: BIOGAL GYOGYSZERGYAR RT. |