FI834650L - Foerfarande foer renande av antracyklinoniska glykosider medelst selektiv adsorption vid hartser. - Google Patents

Foerfarande foer renande av antracyklinoniska glykosider medelst selektiv adsorption vid hartser. Download PDF

Info

Publication number
FI834650L
FI834650L FI834650A FI834650A FI834650L FI 834650 L FI834650 L FI 834650L FI 834650 A FI834650 A FI 834650A FI 834650 A FI834650 A FI 834650A FI 834650 L FI834650 L FI 834650L
Authority
FI
Finland
Prior art keywords
renande
hartser
glycosider
anthracyclinoniska
medelst
Prior art date
Application number
FI834650A
Other languages
English (en)
Finnish (fi)
Other versions
FI834650A7 (fi
FI834650A0 (fi
Inventor
Ernesto Oppici
Carlo Varesio
Onorino Giacoma Rosa
Original Assignee
Erba Farmitalia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Erba Farmitalia filed Critical Erba Farmitalia
Publication of FI834650A0 publication Critical patent/FI834650A0/fi
Publication of FI834650A7 publication Critical patent/FI834650A7/fi
Publication of FI834650L publication Critical patent/FI834650L/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
FI834650A 1982-12-23 1983-12-16 Foerfarande foer renande av antracyklinoniska glykosider medelst selektiv adsorption vid hartser. FI834650L (fi)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT24939/82A IT1155446B (it) 1982-12-23 1982-12-23 Procedimento per la purificazione di glucosidi antraciclinonici mediante adsobimento selettivo su resine

Publications (3)

Publication Number Publication Date
FI834650A0 FI834650A0 (fi) 1983-12-16
FI834650A7 FI834650A7 (fi) 1984-06-24
FI834650L true FI834650L (fi) 1984-06-24

Family

ID=11215200

Family Applications (1)

Application Number Title Priority Date Filing Date
FI834650A FI834650L (fi) 1982-12-23 1983-12-16 Foerfarande foer renande av antracyklinoniska glykosider medelst selektiv adsorption vid hartser.

Country Status (30)

Country Link
US (1) US4861870A (en:Method)
JP (2) JPS59118797A (en:Method)
KR (1) KR900008743B1 (en:Method)
AT (1) AT383601B (en:Method)
AU (1) AU570935B2 (en:Method)
BE (1) BE898506A (en:Method)
CA (1) CA1204738A (en:Method)
CH (1) CH657623A5 (en:Method)
CS (1) CS258114B2 (en:Method)
DE (1) DE3345445C2 (en:Method)
DK (1) DK594083A (en:Method)
ES (1) ES528226A0 (en:Method)
FI (1) FI834650L (en:Method)
FR (1) FR2538394B1 (en:Method)
GB (1) GB2133005B (en:Method)
GR (1) GR79135B (en:Method)
HK (1) HK74887A (en:Method)
HU (1) HU197917B (en:Method)
IE (1) IE56678B1 (en:Method)
IL (1) IL70500A (en:Method)
IT (1) IT1155446B (en:Method)
NL (1) NL193108C (en:Method)
NO (1) NO834765L (en:Method)
NZ (1) NZ206605A (en:Method)
PT (1) PT77883B (en:Method)
SE (1) SE8307134L (en:Method)
SG (1) SG34587G (en:Method)
SU (6) SU1440350A3 (en:Method)
YU (1) YU247183A (en:Method)
ZA (1) ZA839564B (en:Method)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5124317A (en) * 1985-08-02 1992-06-23 Farmitalia Carlo Erba S.P.A. Injectable ready-to-use solutions containing an antitumor anthracycline glycoside
US5977082A (en) * 1985-08-02 1999-11-02 Pharmacia & Upjohn Company Injectable ready-to-use solutions containing an antitumor anthracycline glycoside
DK356087A (da) * 1987-07-09 1989-01-10 Biogal Gyogyszergyar Fremgangsmaade til isolering af et antibiotikum
US5188945A (en) * 1991-09-09 1993-02-23 American Cyanamid Company Recovery process for antibiotics ll-e19020 alpha and beta
US5437861A (en) * 1993-03-16 1995-08-01 Applied Immune Sciences, Inc. Removal of selected factors from whole blood or its components; and prevention and treatment of septic shock syndrome
DE19521419C2 (de) * 1995-06-14 1997-11-27 Plasma Applikation Mbh Ges Verdampfereinheit zur Verdampfung von Materialien im elektrischen Vakuumbogen
AU8750698A (en) 1997-08-28 1999-03-22 Mercian Corporation Method of purifying daunomycin
JP3900243B2 (ja) 1997-12-05 2007-04-04 メルシャン株式会社 結晶質アントラサイクリン抗生物質およびその製造方法
KR100274787B1 (ko) * 1998-05-08 2003-10-22 보령제약 주식회사 독소루비신및이의염산염의제조정제방법
DE69922681T2 (de) 1998-10-16 2005-05-25 Mercian Corp. Kristallisation von doxorubicin-hydrochlorid
KR100351718B1 (ko) * 1999-11-02 2002-09-11 보령제약 주식회사 4'-에피-독소루비신의 정제방법
US20090099346A1 (en) * 2003-07-02 2009-04-16 Victor Matvienko Thermally stable crystalline epirubicin hydrochloride
CN100412084C (zh) * 2003-07-02 2008-08-20 獀洛克斯股份有限公司 热稳定的结晶盐酸表柔比星及其制造方法
TW200510719A (en) * 2003-08-06 2005-03-16 Pharmacia Italia Spa Method for detecting contaminants in pharmaceutical products
US7388083B2 (en) * 2005-03-07 2008-06-17 Solux Corporation Epimerization of 4′-C bond and modification of 14-CH3-(CO)-fragment in anthracyclin antibiotics
RU2450013C2 (ru) * 2005-12-13 2012-05-10 Солюкс Корпорейшен Способ получения 4-деметилдаунорубицина
US8802830B2 (en) * 2005-12-20 2014-08-12 Solux Corporation Synthesis of epirubicin from 13-dihydrodaunorubicine
US8357785B2 (en) * 2008-01-08 2013-01-22 Solux Corporation Method of aralkylation of 4′-hydroxyl group of anthracylins
US8173621B2 (en) 2008-06-11 2012-05-08 Gilead Pharmasset Llc Nucleoside cyclicphosphates
KR20110099138A (ko) 2008-12-23 2011-09-06 파마셋 인코포레이티드 뉴클레오시드 포스포르아미데이트
US8716263B2 (en) 2008-12-23 2014-05-06 Gilead Pharmasset Llc Synthesis of purine nucleosides
TW201026716A (en) 2008-12-23 2010-07-16 Pharmasset Inc Nucleoside analogs
EP2301943B1 (en) 2009-09-08 2014-01-08 Heraeus Precious Metals GmbH & Co. KG Crystallization of epidaunorubicin x HCI
EP2752422B1 (en) 2010-03-31 2017-08-16 Gilead Pharmasset LLC Stereoselective synthesis of phosphorus containing actives
CN102120750B (zh) * 2011-01-30 2013-04-03 山东新时代药业有限公司 一种盐酸表柔比星的纯化方法
DE102011103751A1 (de) 2011-05-31 2012-12-06 Heraeus Precious Metals Gmbh & Co. Kg Kristallisierung von Epirubicinhydrochlorid
CN103087124B (zh) * 2012-11-21 2016-01-13 浙江海正药业股份有限公司 一种制备阿霉素的方法
EP2778171A1 (en) 2013-03-15 2014-09-17 Synbias Pharma Ltd. Crystalline monohydrate of epirubicin hydrochloride
WO2017075994A1 (zh) * 2015-11-05 2017-05-11 浙江海正药业股份有限公司 一种表柔比星或其盐酸盐的分离纯化方法

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE639897A (en:Method) *
US2960437A (en) * 1954-09-03 1960-11-15 Pfizer & Co C Ion exchange purification of basic antibiotics
US2827417A (en) * 1954-09-03 1958-03-18 Pfizer & Co C Ion exchange purification of basic antibiotics
US2793978A (en) * 1955-06-27 1957-05-28 Olin Mathieson Ion exchange purification of neomycin
US3221008A (en) * 1962-01-30 1965-11-30 Merck & Co Inc Ion exchange process for the recovery of ionic organic substances
FR1533151A (fr) * 1962-05-18 1968-07-19 Rhone Poulenc Sa Nouvel antibiotique et sa préparation
FR1527892A (fr) * 1967-03-15 1968-06-07 Rhone Poulenc Sa Nouveau procédé de préparation de l'antibiotique 13057 r.p.
FR1593235A (en:Method) * 1968-11-18 1970-05-25
JPS4944347A (en:Method) * 1972-09-01 1974-04-26
US3882195A (en) * 1973-05-16 1975-05-06 Air Prod & Chem Pre-emulsification-delayed initiation suspension pearl polymerization process
JPS5134915B2 (en:Method) * 1974-07-27 1976-09-29
AU519670B2 (en) * 1975-01-22 1981-12-17 Farmitalia Carlo Erba S.R.L. Optically active daunosaminyl derivatives of anthracyclin- /nes
NL7602342A (nl) * 1975-03-13 1976-09-15 Rhone Poulenc Ind Naftaceenderivaat met antibiotische activiteit.
US4029548A (en) * 1976-05-07 1977-06-14 The Upjohn Company Process for producing antibiotics U-50,147 and U-51,738
IT1098212B (it) * 1978-05-09 1985-09-07 Farmaceutici Italia Antracioline antitumorali sostituite
JPS5543012A (en) * 1978-09-20 1980-03-26 Sanraku Inc Novel anthracycline derivatine and its preparation
JPS6023679B2 (ja) * 1979-07-13 1985-06-08 メルシャン株式会社 ロドマイシン群抗生物質とその製造法
JPS5750994A (en) * 1980-09-12 1982-03-25 Microbial Chem Res Found Novel antibiotic mf266 substance and its preparation
JPS57159496A (en) * 1981-03-28 1982-10-01 Sanraku Inc Preparation of adriamycin
IT1210476B (it) * 1981-05-28 1989-09-14 Erba Farmitalia Antracicline.

Also Published As

Publication number Publication date
IE833060L (en) 1984-06-23
AU570935B2 (en) 1988-03-31
FI834650A7 (fi) 1984-06-24
SU1575943A3 (ru) 1990-06-30
ZA839564B (en) 1984-08-29
DE3345445A1 (de) 1984-06-28
NO834765L (no) 1984-06-25
IT1155446B (it) 1987-01-28
GR79135B (en:Method) 1984-10-02
AU2245583A (en) 1984-06-28
KR900008743B1 (ko) 1990-11-29
JP2749272B2 (ja) 1998-05-13
JPS59118797A (ja) 1984-07-09
PT77883A (en) 1984-01-01
FR2538394A1 (fr) 1984-06-29
FR2538394B1 (fr) 1986-03-28
GB2133005B (en) 1986-04-30
SE8307134D0 (sv) 1983-12-22
NL193108C (nl) 1998-11-03
IL70500A0 (en) 1984-03-30
CS980283A2 (en) 1987-12-17
YU247183A (en) 1985-10-31
JPH0439476B2 (en:Method) 1992-06-29
SU1447287A3 (ru) 1988-12-23
SU1450748A3 (ru) 1989-01-07
DK594083A (da) 1984-06-24
IT8224939A0 (it) 1982-12-23
HK74887A (en) 1987-10-23
HUT35270A (en) 1985-06-28
SE8307134L (sv) 1984-06-24
NZ206605A (en) 1987-02-20
IE56678B1 (en) 1991-11-06
DK594083D0 (da) 1983-12-22
GB2133005A (en) 1984-07-18
KR840007438A (ko) 1984-12-07
SU1440350A3 (ru) 1988-11-23
NL193108B (nl) 1998-07-01
CA1204738A (en) 1986-05-20
DE3345445C2 (de) 1995-09-21
SU1450747A3 (ru) 1989-01-07
SG34587G (en) 1988-03-04
SU1470197A3 (ru) 1989-03-30
AT383601B (de) 1987-07-27
NL8304327A (nl) 1984-07-16
ES8504758A1 (es) 1985-05-01
HU197917B (en) 1989-06-28
ATA440083A (de) 1986-12-15
CH657623A5 (it) 1986-09-15
FI834650A0 (fi) 1983-12-16
US4861870A (en) 1989-08-29
PT77883B (en) 1986-04-09
CS258114B2 (en) 1988-07-15
GB8333511D0 (en) 1984-01-25
ES528226A0 (es) 1985-05-01
JPH07252291A (ja) 1995-10-03
BE898506A (fr) 1984-04-16
IL70500A (en) 1990-07-12

Similar Documents

Publication Publication Date Title
FI834650L (fi) Foerfarande foer renande av antracyklinoniska glykosider medelst selektiv adsorption vid hartser.
FI834495L (fi) Foerfarande vid bearbetning av stockar.
FI833185L (fi) Foerfarande vid framstaellning av vaeteperoxid
FI833931A0 (fi) Foerbaettringar vid foerfaranden foer framstaellning av 3-aryl-5-pyrazol-derivat
FI834857L (fi) Separering av arabinos genom selektiv adsorption i zeolitmolekylsaoll.
FI832607L (fi) Anvaendande av glukos vid aoterfoerande av oanvaenda bestaondsdelar
FI834257L (fi) Anordning vid foervaringsstaell.
FI831449L (fi) Saett vid framstaellning av sulfatmassa
FI842169A0 (fi) Foerbaettringar vid vinschar.
FI841468A0 (fi) Identifiering av tryck vid styva segel.
FI842205L (fi) Foerfarande foer anordnande av expansionsfogar vid gjutning av en betongbaedd.
FI834669A7 (fi) Anordning vid hydrocyklonrenare.
FI65375B (fi) Saett vid aoterkompressionsindustning av en loesning
FI821186L (fi) Sugskaop vid en flaekt
FI834362L (fi) Vid behandling av hoegt blodtryck anvaendbara foereningar.
FI840690L (fi) Foerfarande foer selektiv framstaellning av dihydrobenzen.
FI840942A7 (fi) Foerfarande foer taeckande av kemikaliefoerlusterna vid massaframstaellning.
FI841712L (fi) Anordning vid foerpackningskartong.
FI842619A0 (fi) Anordning vid vaerme/kylsystem foer floedesinjustering.
FI834602L (fi) Anordning vid fiskodlingskasse.
FI833812A0 (fi) Anordning vid innerpanel foer eliminering av en kallstraolande vaegg-, tak- eller golvyta
FI834366A7 (fi) Braennarsystem vid vaermeaggregat.
FI842654A0 (fi) Anordning vid vaegg.
FI834802A7 (fi) Anordning vid tippbar gjutform.
FI872302A0 (fi) Foerfarande foer anvaendning av en vaetskepumps pumphjul vid en borstloes vaexelstroemsmotor.

Legal Events

Date Code Title Description
FC Application refused

Owner name: FARMITALIA CARLO ERBA S.P.A