FI68398C - Foerfarande foer framstaellning av nya terapeutiskt anvaendbara tetrazolylalkoxikarbostyrilderivat - Google Patents

Foerfarande foer framstaellning av nya terapeutiskt anvaendbara tetrazolylalkoxikarbostyrilderivat Download PDF

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Publication number
FI68398C
FI68398C FI792699A FI792699A FI68398C FI 68398 C FI68398 C FI 68398C FI 792699 A FI792699 A FI 792699A FI 792699 A FI792699 A FI 792699A FI 68398 C FI68398 C FI 68398C
Authority
FI
Finland
Prior art keywords
group
carbostyril
formula
colorless
reaction
Prior art date
Application number
FI792699A
Other languages
English (en)
Finnish (fi)
Other versions
FI792699A (fi
FI68398B (fi
Inventor
Takao Nishi
Kazuyuki Nakagawa
Original Assignee
Otsuka Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=14470137&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FI68398(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Otsuka Pharma Co Ltd filed Critical Otsuka Pharma Co Ltd
Publication of FI792699A publication Critical patent/FI792699A/fi
Application granted granted Critical
Publication of FI68398B publication Critical patent/FI68398B/fi
Publication of FI68398C publication Critical patent/FI68398C/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
FI792699A 1978-09-01 1979-08-30 Foerfarande foer framstaellning av nya terapeutiskt anvaendbara tetrazolylalkoxikarbostyrilderivat FI68398C (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP10786978A JPS5535019A (en) 1978-09-01 1978-09-01 Carbostyryl derivative
JP10786978 1978-09-01

Publications (3)

Publication Number Publication Date
FI792699A FI792699A (fi) 1980-03-02
FI68398B FI68398B (fi) 1985-05-31
FI68398C true FI68398C (fi) 1985-09-10

Family

ID=14470137

Family Applications (1)

Application Number Title Priority Date Filing Date
FI792699A FI68398C (fi) 1978-09-01 1979-08-30 Foerfarande foer framstaellning av nya terapeutiskt anvaendbara tetrazolylalkoxikarbostyrilderivat

Country Status (23)

Country Link
US (1) US4277479A (hu)
JP (1) JPS5535019A (hu)
AR (1) AR229342A1 (hu)
AT (1) AT364363B (hu)
AU (1) AU538410B2 (hu)
BE (1) BE878548A (hu)
CA (1) CA1139761A (hu)
CH (1) CH641799A5 (hu)
DE (1) DE2934747A1 (hu)
DK (1) DK158788C (hu)
ES (1) ES483792A1 (hu)
FI (1) FI68398C (hu)
FR (1) FR2434809A1 (hu)
GB (1) GB2033893B (hu)
IT (1) IT1119929B (hu)
MX (1) MX6749E (hu)
NL (1) NL183888C (hu)
NO (1) NO153177C (hu)
PH (1) PH18452A (hu)
PT (1) PT70136A (hu)
SE (1) SE432252B (hu)
SU (1) SU1064868A3 (hu)
ZA (1) ZA794627B (hu)

Families Citing this family (68)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57156469A (en) * 1981-03-19 1982-09-27 Otsuka Pharmaceut Co Ltd Preparation of tetrazole derivative
JPS57183761A (en) * 1981-04-30 1982-11-12 Otsuka Pharmaceut Co Ltd Carbostyril derivative
JPS5859980A (ja) * 1981-10-05 1983-04-09 Otsuka Pharmaceut Co Ltd カルボスチリル誘導体
JPS5877880A (ja) * 1981-11-05 1983-05-11 Otsuka Pharmaceut Co Ltd テトラゾ−ル誘導体
DE3225169A1 (de) * 1982-07-06 1984-01-12 Basf Ag, 6700 Ludwigshafen Chinolinderivate, verfahren zu ihrer herstellung, diese enthaltende mikrobizide und ihre verwendung zur bekaempfung von pilzen
US4803162A (en) * 1984-05-15 1989-02-07 Fluorodiagnostic Limited Partners Composition, article and process for detecting a microorganism
NZ212209A (en) * 1984-05-29 1988-08-30 Pfizer Quinolone derivatives and pharmaceutical compositions
GB8529362D0 (en) * 1985-11-28 1986-01-02 Pfizer Ltd Quinolone cardiac stimulants
DK167187A (da) 1986-04-02 1987-10-03 Otsuka Pharma Co Ltd Carbostyrilderivater og salte deraf, fremgangsmaade til fremstilling af saadanne forbindelser og laegemiddel indeholdende disse
JPH0681727B2 (ja) * 1986-04-02 1994-10-19 大塚製薬株式会社 血小板粘着抑制剤
KR940000785B1 (ko) * 1986-04-02 1994-01-31 오오쓰까세이야꾸 가부시끼가이샤 카르보스티릴 유도체 및 그의 염의 제조 방법
JPH0681752B2 (ja) * 1986-04-02 1994-10-19 大塚製薬株式会社 カルボスチリル誘導体
JP2753622B2 (ja) 1988-05-02 1998-05-20 大塚製薬株式会社 カルボスチリル誘導体
US5064837A (en) * 1989-11-13 1991-11-12 Schering Corporation 3-substituted-1-aryl-2(h)-quinolones and their pharmaceutical compositions
DE69014867T2 (de) * 1990-01-08 1995-07-06 Otsuka Pharma Co Ltd Zusammensetzung eines haartonikums sowie eines haarpflegemittels.
TW201305B (hu) * 1991-04-03 1993-03-01 Otsuka Pharma Co Ltd
AU653060B2 (en) * 1991-08-23 1994-09-15 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivative and platelet agglutination inhibitor
JPH0776521A (ja) * 1993-09-07 1995-03-20 Otsuka Pharmaceut Co Ltd 気道炎症抑制剤
US6187790B1 (en) 1999-03-04 2001-02-13 Neal R. Cutler Use of cilostazol for treatment of sexual dysfunction
JP4060523B2 (ja) * 1999-11-24 2008-03-12 大塚製薬株式会社 カルボスチリル誘導体の製造法
US20030045547A1 (en) 2001-05-02 2003-03-06 Shinji Aki Process for producing carbostyril derivatives
US6515128B2 (en) 2000-03-20 2003-02-04 Teva Pharmaceutical Industries Ltd. Processes for preparing cilostazol
IL151838A0 (en) 2000-03-20 2003-04-10 Teva Pharma Processes for preparing 6-hydroxy-3,4-dihydroquinolinone, cilostazol and n- (4-methoxyphenyl)-3-chloropropionamide
US6825214B2 (en) * 2000-08-14 2004-11-30 Teva Pharmaceutical Industries, Ltd. Substantially pure cilostazol and processes for making same
PL365672A1 (en) * 2000-08-14 2005-01-10 Teva Pharmaceutical Industries Ltd. Processes for preparing cilostazol
US6451813B1 (en) 2001-01-26 2002-09-17 R. T. Alamo Ventures I, Llc Treatment of gastroparesis in certain patient groups
US6458804B1 (en) 2001-01-26 2002-10-01 R.T. Alamo Venturesi, Llc Methods for the treatment of central nervous system disorders in certain patient groups
US7399864B2 (en) * 2001-05-02 2008-07-15 Otsuka Pharmaceutical Co., Ltd. Process for producing carbostyril derivatives
US20050101631A1 (en) * 2002-08-01 2005-05-12 Otsuka Pharmaceuticals Company Process for producing carbostyril derivatives
JP2003063965A (ja) * 2001-06-13 2003-03-05 Otsuka Pharmaceut Factory Inc 注射用シロスタゾール水性製剤
US6531603B1 (en) * 2001-06-29 2003-03-11 Grayson Walker Stowell Polymorphic forms of 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone
US6573382B2 (en) * 2001-06-29 2003-06-03 Grayson Walker Stowell Polymorphic forms of 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone
WO2003002121A1 (en) * 2001-06-29 2003-01-09 Aaipharma, Inc. Polymorphic forms of 6-[4-(1-cyclohexyl-1h-tetrazol-5-yl)butoxy]-3, 4-dihydro-2(1h)-quinolinone
US6388080B1 (en) 2001-06-29 2002-05-14 Grayson Walker Stowell Polymorphic forms of 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone
US6657061B2 (en) * 2001-06-29 2003-12-02 Grayson Walker Stowell Polymorphic forms of 6-[4-1(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone
US6596871B2 (en) * 2001-06-29 2003-07-22 Grayson Walker Stowell Polymorphic forms of 6-[4-(1-cyclohexyl-1h-tetraol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone
AU2002322456A1 (en) * 2001-06-29 2003-03-03 Aaipharma, Inc. Polymorphic forms of 6-(4-(1-cyclohexyl-1h-tetrazol-5-yl)butoxy)-3, 4-dihydro-2(1h)-quinolinone
US6660864B2 (en) * 2001-06-29 2003-12-09 Grayson Walker Stowell Polymorphic forms of 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone
SI1489080T1 (sl) * 2002-09-10 2011-05-31 Otsuka Pharma Co Ltd Postopek za pridobivanje cilostazola
US6743806B2 (en) * 2002-10-23 2004-06-01 Otsuka Pharmaceutical Company, Limited Active oxygen scavenger
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
TWI323660B (en) * 2003-02-25 2010-04-21 Otsuka Pharma Co Ltd Pten inhibitor or maxi-k channels opener
ITMI20031670A1 (it) * 2003-08-26 2005-02-27 Dinamite Dipharma S P A In Forma A Bbreviata Diph Processo per la preparazione di cilostazolo e di suoi intermedi.
US7524960B2 (en) * 2004-03-16 2009-04-28 Chemagis Ltd. Highly pure cilostazol and an improved process for obtaining same
US20050255155A1 (en) * 2004-05-11 2005-11-17 Glenmark Pharmaceuticals Limited Modified release cilostazol compositions
EP1802304A1 (en) * 2004-09-17 2007-07-04 Ranbaxy Laboratories Limited Cilostazol-containing pharmaceutical composition based on particles of less than 50 micrometers
CN100462360C (zh) * 2005-08-15 2009-02-18 上海立科药物化学有限公司 N-环己基-5-(4-氯丁基)-1h-四氮唑的合成方法
KR101299320B1 (ko) 2005-09-15 2013-09-03 오츠카 세이야쿠 가부시키가이샤 초과산화물 억제제 효과를 갖는 프로부콜 및테트라졸릴알콕시-디히드로카르보스티릴 유도체를 함유하는조합 약물
US20070105898A1 (en) * 2005-11-09 2007-05-10 Apotex Pharmachem Inc. Process for the production of cilostazol
AR065588A1 (es) 2007-03-09 2009-06-17 Otsuka Pharma Co Ltd Un medicamento para tratar enfermedad pulmonar obstructiva cronica
TW200848041A (en) 2007-03-30 2008-12-16 Otsuka Pharma Co Ltd A medicament for treating schizophrenia comprising cilostazol
EP2152689B1 (en) * 2007-04-25 2013-01-02 Concert Pharmaceuticals Inc. Analogues of cilostazol
US8349817B2 (en) * 2007-04-25 2013-01-08 Concert Pharmaceuticals, Inc. Analogues of cilostazol
WO2008143361A1 (en) 2007-05-22 2008-11-27 Otsuka Pharmaceutical Co., Ltd. A medicament comprising a carbostyril derivative and donepezil for treating alzheimer's disease
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
DK2170930T3 (da) 2007-06-04 2012-11-05 Synergy Pharmaceuticals Inc Agonister af guanylatcyclase, anvendelige til behandlingen af gastrointestinale sygdomme, inflammation, cancer og andre sygdomme
JP2011522828A (ja) 2008-06-04 2011-08-04 シナジー ファーマシューティカルズ インコーポレイテッド 胃腸障害、炎症、癌、およびその他の障害の治療のために有用なグアニル酸シクラーゼのアゴニスト
ES2624828T3 (es) 2008-07-16 2017-07-17 Synergy Pharmaceuticals Inc. Agonistas de la guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros
EP2194048A1 (en) 2008-12-02 2010-06-09 Dirk Sartor Nitrate esters for the treatment of vascular and metabolic diseases
CN102933205B (zh) 2010-04-28 2014-08-13 诺弗米克斯有限公司 西洛他唑共晶和组合物
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
ES2664873T3 (es) 2011-03-01 2018-04-23 Synergy Pharmaceuticals Inc. Proceso de preparación de agonistas de guanilato ciclasa C
EP2958577A2 (en) 2013-02-25 2015-12-30 Synergy Pharmaceuticals Inc. Guanylate cyclase receptor agonists for use in colonic cleansing
US9708367B2 (en) 2013-03-15 2017-07-18 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase and their uses
AU2014235209B2 (en) 2013-03-15 2018-06-14 Bausch Health Ireland Limited Guanylate cyclase receptor agonists combined with other drugs
KR102272746B1 (ko) 2013-06-05 2021-07-08 보슈 헬스 아일랜드 리미티드 구아닐레이트 사이클라제 c의 초순수 작용제, 및 이의 제조 및 사용 방법
KR20220147691A (ko) 2013-08-09 2022-11-03 알데릭스, 인코포레이티드 인산염 수송을 억제하기 위한 화합물 및 방법
JP2022533251A (ja) 2019-05-21 2022-07-21 アルデリックス， インコーポレイテッド 患者において血清リン酸塩を低下させるための組み合わせ

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2470084A (en) * 1945-09-25 1949-05-17 Bilhuber Inc E Substituted alpha-halogen alkyl tetrazoles and process for obtaining the same
US2470085A (en) * 1947-03-07 1949-05-17 Bilhuber Inc E Substituted amino alkyl tetrazoles
AR207554A1 (es) * 1972-12-02 1976-10-15 Otsuka Pharma Co Ltd Procedimiento para producir derivados de 3-alquil-5-((3,4-dihidro-5-carbostiril)oximetil)-oxazolidinona-(2)
JPS5310986B2 (hu) * 1974-02-05 1978-04-18
JPS5310989B2 (hu) * 1974-04-25 1978-04-18
US4070470A (en) * 1974-06-24 1978-01-24 Otsuka Pharmaceutical Co., Ltd. Platelet aggregation inhibiting carbostyrils, their compositions and method of use
FI58329C (fi) * 1974-11-08 1981-01-12 Otsuka Pharma Co Ltd Foerfarande foer framstaellning av i 8-staellning substituerade 5-(3'-alkylamino-2'-hydroxi)propoxi-3,4-dihydrokarbostyrilderivat
US4129565A (en) * 1975-07-11 1978-12-12 Nisshin Flour Milling Co., Ltd. Isocarbostyril derivatives
US4210753A (en) * 1976-03-17 1980-07-01 Otsuka Pharmaceutical Co., Ltd. Carbostyril compounds
JPS52116482A (en) * 1976-03-24 1977-09-29 Otsuka Pharmaceut Co Ltd Carbostyril derivatives and its preparation
JPS5430183A (en) * 1977-08-10 1979-03-06 Otsuka Pharmaceut Co Ltd 3,4-dihydrocarbostyril derivative

Also Published As

Publication number Publication date
MX6749E (es) 1986-06-25
NO153177B (no) 1985-10-21
NL183888C (nl) 1989-02-16
ZA794627B (en) 1980-08-27
IT7968748A0 (it) 1979-08-31
SU1064868A3 (ru) 1983-12-30
US4277479A (en) 1981-07-07
DK363179A (da) 1980-03-02
CA1139761A (en) 1983-01-18
GB2033893B (en) 1982-12-01
DK158788B (da) 1990-07-16
ATA584579A (de) 1981-03-15
IT1119929B (it) 1986-03-19
PH18452A (en) 1985-07-18
FI792699A (fi) 1980-03-02
GB2033893A (en) 1980-05-29
NO792829L (no) 1980-03-04
AU538410B2 (en) 1984-08-16
AT364363B (de) 1981-10-12
FR2434809B1 (hu) 1982-09-17
SE7907236L (sv) 1980-03-02
NL7906523A (nl) 1980-03-04
FR2434809A1 (fr) 1980-03-28
CH641799A5 (de) 1984-03-15
JPS5535019A (en) 1980-03-11
BE878548A (fr) 1979-12-17
JPS6155514B2 (hu) 1986-11-28
NO153177C (no) 1986-01-29
DE2934747A1 (de) 1980-03-13
SE432252B (sv) 1984-03-26
ES483792A1 (es) 1980-09-01
AU5039779A (en) 1980-03-06
DK158788C (da) 1990-12-10
AR229342A1 (es) 1983-07-29
PT70136A (en) 1979-09-01
DE2934747C2 (hu) 1988-01-28
FI68398B (fi) 1985-05-31

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MA Patent expired

Owner name: OTSUKA PHARMACEUTICAL CO., LTD.