JPS57183761A - Carbostyril derivative - Google Patents
Carbostyril derivativeInfo
- Publication number
- JPS57183761A JPS57183761A JP56066730A JP6673081A JPS57183761A JP S57183761 A JPS57183761 A JP S57183761A JP 56066730 A JP56066730 A JP 56066730A JP 6673081 A JP6673081 A JP 6673081A JP S57183761 A JPS57183761 A JP S57183761A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- carbostyril
- cerebral
- formulai
- cycloalkylalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
NEW MATERIAL:A carbostyril derivative shown by the formulaI[R1 is carboxy, lower alkoxycarbonyl, group shown by the formula II (R2 and R3 are alkyl, alkanoyloxyalkyl, cycloalkyl, cycloalkylalkyl, or phenylalkyl), or group by the formula III (R4 is alkyl, cycloalkyl, cycloalkylalkyl, or phenyl); A is alkylene].
EXAMPLE: 3-[4-(1-Cyclohexyltetrazole-5-yl) butoxy]carbostyril.
USE: A preventive and remedy for thrombosis such as cerebral apoplexy, cerebral infarct, myocardial infarction, etc. An improver for cerebral circulation, antiphlgistic, antasthmatic, cardiac, hypotensive, and phosphodiesterase inhibitor.
PROCESS: For example, a 3-hydroxycarbostyril derivative shown by the formula IV and a compound shown by the formula X-A-R1(X is halogen) are subjected to dehydrohalogenation, to give a compound shown by the formulaI.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP56066730A JPS57183761A (en) | 1981-04-30 | 1981-04-30 | Carbostyril derivative |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP56066730A JPS57183761A (en) | 1981-04-30 | 1981-04-30 | Carbostyril derivative |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS57183761A true JPS57183761A (en) | 1982-11-12 |
JPH0114911B2 JPH0114911B2 (en) | 1989-03-14 |
Family
ID=13324293
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP56066730A Granted JPS57183761A (en) | 1981-04-30 | 1981-04-30 | Carbostyril derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS57183761A (en) |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS62135423A (en) * | 1985-12-09 | 1987-06-18 | Otsuka Pharmaceut Co Ltd | Improver for hypoxia |
JPS6345220A (en) * | 1986-04-02 | 1988-02-26 | Otsuka Pharmaceut Co Ltd | Platelet adhesion suppresser |
JPS646271A (en) * | 1986-04-02 | 1989-01-10 | Otsuka Pharma Co Ltd | Carbostyril derivative |
WO1989010919A1 (en) | 1988-05-02 | 1989-11-16 | Otsuka Pharmaceutical Co., Ltd. | Carbostyril derivatives |
US5597922A (en) * | 1994-07-29 | 1997-01-28 | State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon | Glycine receptor antagonist pharmacophore |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS52125163A (en) * | 1976-04-14 | 1977-10-20 | Otsuka Pharmaceut Co Ltd | Novel benzcyclamide derivatives |
JPS5430179A (en) * | 1977-08-10 | 1979-03-06 | Otsuka Pharmaceut Co Ltd | Carbostyril derivative |
JPS54115383A (en) * | 1978-02-28 | 1979-09-07 | Otsuka Pharmaceut Co Ltd | Carbostyril derivative |
JPS54163825A (en) * | 1978-06-15 | 1979-12-26 | Otsuka Pharma Co Ltd | Phosphoesterase inhibitor |
JPS5535019A (en) * | 1978-09-01 | 1980-03-11 | Otsuka Pharmaceut Co Ltd | Carbostyryl derivative |
JPS5579370A (en) * | 1978-12-08 | 1980-06-14 | Otsuka Pharmaceut Co Ltd | Carbostyril derivative |
-
1981
- 1981-04-30 JP JP56066730A patent/JPS57183761A/en active Granted
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS52125163A (en) * | 1976-04-14 | 1977-10-20 | Otsuka Pharmaceut Co Ltd | Novel benzcyclamide derivatives |
JPS5430179A (en) * | 1977-08-10 | 1979-03-06 | Otsuka Pharmaceut Co Ltd | Carbostyril derivative |
JPS54115383A (en) * | 1978-02-28 | 1979-09-07 | Otsuka Pharmaceut Co Ltd | Carbostyril derivative |
JPS54163825A (en) * | 1978-06-15 | 1979-12-26 | Otsuka Pharma Co Ltd | Phosphoesterase inhibitor |
JPS5535019A (en) * | 1978-09-01 | 1980-03-11 | Otsuka Pharmaceut Co Ltd | Carbostyryl derivative |
JPS5579370A (en) * | 1978-12-08 | 1980-06-14 | Otsuka Pharmaceut Co Ltd | Carbostyril derivative |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS62135423A (en) * | 1985-12-09 | 1987-06-18 | Otsuka Pharmaceut Co Ltd | Improver for hypoxia |
JPS6345220A (en) * | 1986-04-02 | 1988-02-26 | Otsuka Pharmaceut Co Ltd | Platelet adhesion suppresser |
JPS646271A (en) * | 1986-04-02 | 1989-01-10 | Otsuka Pharma Co Ltd | Carbostyril derivative |
WO1989010919A1 (en) | 1988-05-02 | 1989-11-16 | Otsuka Pharmaceutical Co., Ltd. | Carbostyril derivatives |
US5597922A (en) * | 1994-07-29 | 1997-01-28 | State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon | Glycine receptor antagonist pharmacophore |
Also Published As
Publication number | Publication date |
---|---|
JPH0114911B2 (en) | 1989-03-14 |
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