JPS57183761A - Carbostyril derivative - Google Patents

Carbostyril derivative

Info

Publication number
JPS57183761A
JPS57183761A JP56066730A JP6673081A JPS57183761A JP S57183761 A JPS57183761 A JP S57183761A JP 56066730 A JP56066730 A JP 56066730A JP 6673081 A JP6673081 A JP 6673081A JP S57183761 A JPS57183761 A JP S57183761A
Authority
JP
Japan
Prior art keywords
formula
carbostyril
cerebral
formulai
cycloalkylalkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP56066730A
Other languages
Japanese (ja)
Other versions
JPH0114911B2 (en
Inventor
Takao Nishi
Fujio Tafusa
Tatsuyoshi Tanaka
Kazuyuki Nakagawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Otsuka Pharmaceutical Co Ltd
Original Assignee
Otsuka Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharmaceutical Co Ltd filed Critical Otsuka Pharmaceutical Co Ltd
Priority to JP56066730A priority Critical patent/JPS57183761A/en
Publication of JPS57183761A publication Critical patent/JPS57183761A/en
Publication of JPH0114911B2 publication Critical patent/JPH0114911B2/ja
Granted legal-status Critical Current

Links

Abstract

NEW MATERIAL:A carbostyril derivative shown by the formulaI[R1 is carboxy, lower alkoxycarbonyl, group shown by the formula II (R2 and R3 are alkyl, alkanoyloxyalkyl, cycloalkyl, cycloalkylalkyl, or phenylalkyl), or group by the formula III (R4 is alkyl, cycloalkyl, cycloalkylalkyl, or phenyl); A is alkylene].
EXAMPLE: 3-[4-(1-Cyclohexyltetrazole-5-yl) butoxy]carbostyril.
USE: A preventive and remedy for thrombosis such as cerebral apoplexy, cerebral infarct, myocardial infarction, etc. An improver for cerebral circulation, antiphlgistic, antasthmatic, cardiac, hypotensive, and phosphodiesterase inhibitor.
PROCESS: For example, a 3-hydroxycarbostyril derivative shown by the formula IV and a compound shown by the formula X-A-R1(X is halogen) are subjected to dehydrohalogenation, to give a compound shown by the formulaI.
COPYRIGHT: (C)1982,JPO&Japio
JP56066730A 1981-04-30 1981-04-30 Carbostyril derivative Granted JPS57183761A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP56066730A JPS57183761A (en) 1981-04-30 1981-04-30 Carbostyril derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP56066730A JPS57183761A (en) 1981-04-30 1981-04-30 Carbostyril derivative

Publications (2)

Publication Number Publication Date
JPS57183761A true JPS57183761A (en) 1982-11-12
JPH0114911B2 JPH0114911B2 (en) 1989-03-14

Family

ID=13324293

Family Applications (1)

Application Number Title Priority Date Filing Date
JP56066730A Granted JPS57183761A (en) 1981-04-30 1981-04-30 Carbostyril derivative

Country Status (1)

Country Link
JP (1) JPS57183761A (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62135423A (en) * 1985-12-09 1987-06-18 Otsuka Pharmaceut Co Ltd Improver for hypoxia
JPS6345220A (en) * 1986-04-02 1988-02-26 Otsuka Pharmaceut Co Ltd Platelet adhesion suppresser
JPS646271A (en) * 1986-04-02 1989-01-10 Otsuka Pharma Co Ltd Carbostyril derivative
WO1989010919A1 (en) 1988-05-02 1989-11-16 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivatives
US5597922A (en) * 1994-07-29 1997-01-28 State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon Glycine receptor antagonist pharmacophore

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS52125163A (en) * 1976-04-14 1977-10-20 Otsuka Pharmaceut Co Ltd Novel benzcyclamide derivatives
JPS5430179A (en) * 1977-08-10 1979-03-06 Otsuka Pharmaceut Co Ltd Carbostyril derivative
JPS54115383A (en) * 1978-02-28 1979-09-07 Otsuka Pharmaceut Co Ltd Carbostyril derivative
JPS54163825A (en) * 1978-06-15 1979-12-26 Otsuka Pharma Co Ltd Phosphoesterase inhibitor
JPS5535019A (en) * 1978-09-01 1980-03-11 Otsuka Pharmaceut Co Ltd Carbostyryl derivative
JPS5579370A (en) * 1978-12-08 1980-06-14 Otsuka Pharmaceut Co Ltd Carbostyril derivative

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS52125163A (en) * 1976-04-14 1977-10-20 Otsuka Pharmaceut Co Ltd Novel benzcyclamide derivatives
JPS5430179A (en) * 1977-08-10 1979-03-06 Otsuka Pharmaceut Co Ltd Carbostyril derivative
JPS54115383A (en) * 1978-02-28 1979-09-07 Otsuka Pharmaceut Co Ltd Carbostyril derivative
JPS54163825A (en) * 1978-06-15 1979-12-26 Otsuka Pharma Co Ltd Phosphoesterase inhibitor
JPS5535019A (en) * 1978-09-01 1980-03-11 Otsuka Pharmaceut Co Ltd Carbostyryl derivative
JPS5579370A (en) * 1978-12-08 1980-06-14 Otsuka Pharmaceut Co Ltd Carbostyril derivative

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62135423A (en) * 1985-12-09 1987-06-18 Otsuka Pharmaceut Co Ltd Improver for hypoxia
JPS6345220A (en) * 1986-04-02 1988-02-26 Otsuka Pharmaceut Co Ltd Platelet adhesion suppresser
JPS646271A (en) * 1986-04-02 1989-01-10 Otsuka Pharma Co Ltd Carbostyril derivative
WO1989010919A1 (en) 1988-05-02 1989-11-16 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivatives
US5597922A (en) * 1994-07-29 1997-01-28 State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon Glycine receptor antagonist pharmacophore

Also Published As

Publication number Publication date
JPH0114911B2 (en) 1989-03-14

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