ATA584579A - Verfahren zum herstellen neuer tetrazolyl- alkoxycarbostyrilderivate - Google Patents
Verfahren zum herstellen neuer tetrazolyl- alkoxycarbostyrilderivateInfo
- Publication number
- ATA584579A ATA584579A AT584579A AT584579A ATA584579A AT A584579 A ATA584579 A AT A584579A AT 584579 A AT584579 A AT 584579A AT 584579 A AT584579 A AT 584579A AT A584579 A ATA584579 A AT A584579A
- Authority
- AT
- Austria
- Prior art keywords
- alkoxycarbostyrile
- tetrazolyl
- derivatives
- producing new
- producing
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D257/04—Five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Hospice & Palliative Care (AREA)
- Cardiology (AREA)
- Psychiatry (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP10786978A JPS5535019A (en) | 1978-09-01 | 1978-09-01 | Carbostyryl derivative |
Publications (2)
Publication Number | Publication Date |
---|---|
ATA584579A true ATA584579A (de) | 1981-03-15 |
AT364363B AT364363B (de) | 1981-10-12 |
Family
ID=14470137
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT0584579A AT364363B (de) | 1978-09-01 | 1979-09-03 | Verfahren zum herstellen neuer tetrazolylalkoxycarbostyrilderivate |
Country Status (23)
Country | Link |
---|---|
US (1) | US4277479A (de) |
JP (1) | JPS5535019A (de) |
AR (1) | AR229342A1 (de) |
AT (1) | AT364363B (de) |
AU (1) | AU538410B2 (de) |
BE (1) | BE878548A (de) |
CA (1) | CA1139761A (de) |
CH (1) | CH641799A5 (de) |
DE (1) | DE2934747A1 (de) |
DK (1) | DK158788C (de) |
ES (1) | ES483792A1 (de) |
FI (1) | FI68398C (de) |
FR (1) | FR2434809A1 (de) |
GB (1) | GB2033893B (de) |
IT (1) | IT1119929B (de) |
MX (1) | MX6749E (de) |
NL (1) | NL183888C (de) |
NO (1) | NO153177C (de) |
PH (1) | PH18452A (de) |
PT (1) | PT70136A (de) |
SE (1) | SE432252B (de) |
SU (1) | SU1064868A3 (de) |
ZA (1) | ZA794627B (de) |
Families Citing this family (68)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS57156469A (en) * | 1981-03-19 | 1982-09-27 | Otsuka Pharmaceut Co Ltd | Preparation of tetrazole derivative |
JPS57183761A (en) * | 1981-04-30 | 1982-11-12 | Otsuka Pharmaceut Co Ltd | Carbostyril derivative |
JPS5859980A (ja) * | 1981-10-05 | 1983-04-09 | Otsuka Pharmaceut Co Ltd | カルボスチリル誘導体 |
JPS5877880A (ja) * | 1981-11-05 | 1983-05-11 | Otsuka Pharmaceut Co Ltd | テトラゾ−ル誘導体 |
DE3225169A1 (de) * | 1982-07-06 | 1984-01-12 | Basf Ag, 6700 Ludwigshafen | Chinolinderivate, verfahren zu ihrer herstellung, diese enthaltende mikrobizide und ihre verwendung zur bekaempfung von pilzen |
US4803162A (en) * | 1984-05-15 | 1989-02-07 | Fluorodiagnostic Limited Partners | Composition, article and process for detecting a microorganism |
GR851296B (de) * | 1984-05-29 | 1985-11-25 | Pfizer | |
GB8529362D0 (en) * | 1985-11-28 | 1986-01-02 | Pfizer Ltd | Quinolone cardiac stimulants |
KR940000785B1 (ko) * | 1986-04-02 | 1994-01-31 | 오오쓰까세이야꾸 가부시끼가이샤 | 카르보스티릴 유도체 및 그의 염의 제조 방법 |
JPH0681752B2 (ja) * | 1986-04-02 | 1994-10-19 | 大塚製薬株式会社 | カルボスチリル誘導体 |
DK167187A (da) | 1986-04-02 | 1987-10-03 | Otsuka Pharma Co Ltd | Carbostyrilderivater og salte deraf, fremgangsmaade til fremstilling af saadanne forbindelser og laegemiddel indeholdende disse |
JPH0681727B2 (ja) * | 1986-04-02 | 1994-10-19 | 大塚製薬株式会社 | 血小板粘着抑制剤 |
JP2753622B2 (ja) | 1988-05-02 | 1998-05-20 | 大塚製薬株式会社 | カルボスチリル誘導体 |
US5064837A (en) * | 1989-11-13 | 1991-11-12 | Schering Corporation | 3-substituted-1-aryl-2(h)-quinolones and their pharmaceutical compositions |
JPH07100648B1 (de) * | 1990-01-08 | 1995-11-01 | ||
TW201305B (de) * | 1991-04-03 | 1993-03-01 | Otsuka Pharma Co Ltd | |
KR930702307A (ko) * | 1991-08-23 | 1993-09-08 | 오오쓰까 아끼히꼬 | 카르보스티릴 유도체 및 혈소판 응집 억제제 |
JPH0776521A (ja) * | 1993-09-07 | 1995-03-20 | Otsuka Pharmaceut Co Ltd | 気道炎症抑制剤 |
US6187790B1 (en) | 1999-03-04 | 2001-02-13 | Neal R. Cutler | Use of cilostazol for treatment of sexual dysfunction |
JP4060523B2 (ja) * | 1999-11-24 | 2008-03-12 | 大塚製薬株式会社 | カルボスチリル誘導体の製造法 |
US20030045547A1 (en) | 2001-05-02 | 2003-03-06 | Shinji Aki | Process for producing carbostyril derivatives |
US6515128B2 (en) | 2000-03-20 | 2003-02-04 | Teva Pharmaceutical Industries Ltd. | Processes for preparing cilostazol |
WO2001070697A1 (en) | 2000-03-20 | 2001-09-27 | Teva Pharmaceutical Industries Ltd. | Processes for preparing 6-hydroxy-3,4-dihydroquinolinone, cilostazol and n-(4-methoxyphenyl)-3-chloropropionamide |
US6825214B2 (en) * | 2000-08-14 | 2004-11-30 | Teva Pharmaceutical Industries, Ltd. | Substantially pure cilostazol and processes for making same |
CA2419181A1 (en) * | 2000-08-14 | 2002-02-21 | Teva Pharmaceutical Industries Ltd. | Processes for preparing cilostazol |
US6451813B1 (en) | 2001-01-26 | 2002-09-17 | R. T. Alamo Ventures I, Llc | Treatment of gastroparesis in certain patient groups |
US6458804B1 (en) | 2001-01-26 | 2002-10-01 | R.T. Alamo Venturesi, Llc | Methods for the treatment of central nervous system disorders in certain patient groups |
US20050101631A1 (en) * | 2002-08-01 | 2005-05-12 | Otsuka Pharmaceuticals Company | Process for producing carbostyril derivatives |
US7399864B2 (en) * | 2001-05-02 | 2008-07-15 | Otsuka Pharmaceutical Co., Ltd. | Process for producing carbostyril derivatives |
JP2003063965A (ja) * | 2001-06-13 | 2003-03-05 | Otsuka Pharmaceut Factory Inc | 注射用シロスタゾール水性製剤 |
US6573382B2 (en) * | 2001-06-29 | 2003-06-03 | Grayson Walker Stowell | Polymorphic forms of 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone |
US6531603B1 (en) * | 2001-06-29 | 2003-03-11 | Grayson Walker Stowell | Polymorphic forms of 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone |
US6596871B2 (en) * | 2001-06-29 | 2003-07-22 | Grayson Walker Stowell | Polymorphic forms of 6-[4-(1-cyclohexyl-1h-tetraol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone |
WO2003002529A2 (en) * | 2001-06-29 | 2003-01-09 | Aaipharma, Inc. | Polymorphic forms of 6-[4-(1-cyclohexyl-1h-tetrazol-5-yl)butoxy]-3, 4-dihydro-2(1h)-quinolinone |
US6657061B2 (en) * | 2001-06-29 | 2003-12-02 | Grayson Walker Stowell | Polymorphic forms of 6-[4-1(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone |
WO2003002121A1 (en) * | 2001-06-29 | 2003-01-09 | Aaipharma, Inc. | Polymorphic forms of 6-[4-(1-cyclohexyl-1h-tetrazol-5-yl)butoxy]-3, 4-dihydro-2(1h)-quinolinone |
US6660864B2 (en) * | 2001-06-29 | 2003-12-09 | Grayson Walker Stowell | Polymorphic forms of 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone |
US6388080B1 (en) | 2001-06-29 | 2002-05-14 | Grayson Walker Stowell | Polymorphic forms of 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone |
ES2358324T3 (es) * | 2002-09-10 | 2011-05-09 | Otsuka Pharmaceutical Co., Ltd. | Procedimiento para la producción de cilostazol. |
US6743806B2 (en) * | 2002-10-23 | 2004-06-01 | Otsuka Pharmaceutical Company, Limited | Active oxygen scavenger |
US7772188B2 (en) | 2003-01-28 | 2010-08-10 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
TWI323660B (en) | 2003-02-25 | 2010-04-21 | Otsuka Pharma Co Ltd | Pten inhibitor or maxi-k channels opener |
ITMI20031670A1 (it) * | 2003-08-26 | 2005-02-27 | Dinamite Dipharma S P A In Forma A Bbreviata Diph | Processo per la preparazione di cilostazolo e di suoi intermedi. |
IL167483A (en) * | 2004-03-16 | 2011-04-28 | Chemagis Ltd | Process for obtaining highly pure cilostazol |
US20050255155A1 (en) * | 2004-05-11 | 2005-11-17 | Glenmark Pharmaceuticals Limited | Modified release cilostazol compositions |
US20080206348A1 (en) * | 2004-09-17 | 2008-08-28 | Deepak Murpani | Cilostazol-Containing Pharmaceutical Composition Based On Particles Of Less Than 50 Micrometers |
CN100462360C (zh) * | 2005-08-15 | 2009-02-18 | 上海立科药物化学有限公司 | N-环己基-5-(4-氯丁基)-1h-四氮唑的合成方法 |
ES2378896T3 (es) * | 2005-09-15 | 2012-04-18 | Otsuka Pharmaceutical Co., Ltd. | Combinación de fármacos que contiene Probucol y un derivado de tetrazolilalcoxi-dihidrocarbostirilo con efectos inhibidores del superóxido |
US20070105898A1 (en) * | 2005-11-09 | 2007-05-10 | Apotex Pharmachem Inc. | Process for the production of cilostazol |
AR065588A1 (es) | 2007-03-09 | 2009-06-17 | Otsuka Pharma Co Ltd | Un medicamento para tratar enfermedad pulmonar obstructiva cronica |
TW200848041A (en) | 2007-03-30 | 2008-12-16 | Otsuka Pharma Co Ltd | A medicament for treating schizophrenia comprising cilostazol |
EP2527336A1 (de) | 2007-04-25 | 2012-11-28 | Concert Pharmaceuticals Inc. | Deuterium Analoga von Cilostazol |
US8349817B2 (en) * | 2007-04-25 | 2013-01-08 | Concert Pharmaceuticals, Inc. | Analogues of cilostazol |
PL2157973T3 (pl) | 2007-05-22 | 2015-12-31 | Otsuka Pharma Co Ltd | Lek zawierający pochodną karbostyrylu i donepezil do leczenia choroby Alzheimera |
ES2393885T7 (es) | 2007-06-04 | 2014-01-30 | Synergy Pharmaceuticals Inc. | Agonistas de la guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos |
US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
ES2522968T3 (es) | 2008-06-04 | 2014-11-19 | Synergy Pharmaceuticals Inc. | Agonistas de guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos |
AU2009270833B2 (en) | 2008-07-16 | 2015-02-19 | Bausch Health Ireland Limited | Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders |
EP2194048A1 (de) * | 2008-12-02 | 2010-06-09 | Dirk Sartor | Nitratester zur Behandlung von vaskularen und metabolischen Krankheiten |
US8779146B2 (en) | 2010-04-28 | 2014-07-15 | Nuformix Limited | Cilostazol cocrystals and compositions |
US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
JP6251038B2 (ja) | 2011-03-01 | 2017-12-20 | シナジー ファーマシューティカルズ インコーポレイテッド | グアニル酸シクラーゼcアゴニストの調製方法 |
AU2014218599C1 (en) | 2013-02-25 | 2018-09-06 | Bausch Health Ireland Limited | Guanylate cyclase receptor agonists for use in colonic cleansing |
CA2905435A1 (en) | 2013-03-15 | 2014-09-25 | Synergy Pharmaceuticals Inc. | Compositions useful for the treatment of gastrointestinal disorders |
JP2016514671A (ja) | 2013-03-15 | 2016-05-23 | シナジー ファーマシューティカルズ インコーポレイテッド | グアニル酸シクラーゼのアゴニストおよびその使用 |
US10011637B2 (en) | 2013-06-05 | 2018-07-03 | Synergy Pharmaceuticals, Inc. | Ultra-pure agonists of guanylate cyclase C, method of making and using same |
JP6694385B2 (ja) | 2013-08-09 | 2020-05-13 | アーデリクス,インコーポレーテッド | リン酸塩輸送阻害のための化合物及び方法 |
JP2022533251A (ja) | 2019-05-21 | 2022-07-21 | アルデリックス, インコーポレイテッド | 患者において血清リン酸塩を低下させるための組み合わせ |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2470084A (en) * | 1945-09-25 | 1949-05-17 | Bilhuber Inc E | Substituted alpha-halogen alkyl tetrazoles and process for obtaining the same |
US2470085A (en) * | 1947-03-07 | 1949-05-17 | Bilhuber Inc E | Substituted amino alkyl tetrazoles |
AR207554A1 (es) * | 1972-12-02 | 1976-10-15 | Otsuka Pharma Co Ltd | Procedimiento para producir derivados de 3-alquil-5-((3,4-dihidro-5-carbostiril)oximetil)-oxazolidinona-(2) |
JPS5310986B2 (de) * | 1974-02-05 | 1978-04-18 | ||
JPS5310989B2 (de) * | 1974-04-25 | 1978-04-18 | ||
FI59246C (fi) * | 1974-06-24 | 1981-07-10 | Otsuka Pharma Co Ltd | Foerfarande foer framstaellning av benscykloamidderivat anvaendbara vid trombos- och emboliterapin |
FI58329C (fi) * | 1974-11-08 | 1981-01-12 | Otsuka Pharma Co Ltd | Foerfarande foer framstaellning av i 8-staellning substituerade 5-(3'-alkylamino-2'-hydroxi)propoxi-3,4-dihydrokarbostyrilderivat |
US4129565A (en) * | 1975-07-11 | 1978-12-12 | Nisshin Flour Milling Co., Ltd. | Isocarbostyril derivatives |
US4210753A (en) * | 1976-03-17 | 1980-07-01 | Otsuka Pharmaceutical Co., Ltd. | Carbostyril compounds |
JPS52116482A (en) * | 1976-03-24 | 1977-09-29 | Otsuka Pharmaceut Co Ltd | Carbostyril derivatives and its preparation |
JPS5430183A (en) * | 1977-08-10 | 1979-03-06 | Otsuka Pharmaceut Co Ltd | 3,4-dihydrocarbostyril derivative |
-
1978
- 1978-09-01 JP JP10786978A patent/JPS5535019A/ja active Granted
-
1979
- 1979-08-22 CA CA000334272A patent/CA1139761A/en not_active Expired
- 1979-08-28 DE DE19792934747 patent/DE2934747A1/de active Granted
- 1979-08-29 US US06/070,710 patent/US4277479A/en not_active Expired - Lifetime
- 1979-08-29 AR AR277883A patent/AR229342A1/es active
- 1979-08-29 AU AU50397/79A patent/AU538410B2/en not_active Expired
- 1979-08-29 PH PH22976A patent/PH18452A/en unknown
- 1979-08-30 DK DK363179A patent/DK158788C/da active
- 1979-08-30 NL NLAANVRAGE7906523,A patent/NL183888C/xx not_active IP Right Cessation
- 1979-08-30 SU SU792804457A patent/SU1064868A3/ru active
- 1979-08-30 FI FI792699A patent/FI68398C/fi not_active IP Right Cessation
- 1979-08-31 MX MX798357U patent/MX6749E/es unknown
- 1979-08-31 ES ES483792A patent/ES483792A1/es not_active Expired
- 1979-08-31 CH CH792079A patent/CH641799A5/de not_active IP Right Cessation
- 1979-08-31 NO NO792829A patent/NO153177C/no unknown
- 1979-08-31 BE BE0/196976A patent/BE878548A/xx not_active IP Right Cessation
- 1979-08-31 ZA ZA00794627A patent/ZA794627B/xx unknown
- 1979-08-31 FR FR7921869A patent/FR2434809A1/fr active Granted
- 1979-08-31 IT IT68748/79A patent/IT1119929B/it active
- 1979-08-31 SE SE7907236A patent/SE432252B/sv not_active IP Right Cessation
- 1979-08-31 PT PT70136A patent/PT70136A/pt unknown
- 1979-09-03 AT AT0584579A patent/AT364363B/de not_active IP Right Cessation
- 1979-09-03 GB GB7930520A patent/GB2033893B/en not_active Expired
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
ELJ | Ceased due to non-payment of the annual fee |