AT356108B - Verfahren zum herstellen von neuen spiro- piperidinverbindungen - Google Patents
Verfahren zum herstellen von neuen spiro- piperidinverbindungenInfo
- Publication number
- AT356108B AT356108B AT388878A AT388878A AT356108B AT 356108 B AT356108 B AT 356108B AT 388878 A AT388878 A AT 388878A AT 388878 A AT388878 A AT 388878A AT 356108 B AT356108 B AT 356108B
- Authority
- AT
- Austria
- Prior art keywords
- producing new
- spiropiperidine compounds
- spiropiperidine
- compounds
- producing
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1577878A JPS54109983A (en) | 1978-02-13 | 1978-02-13 | Novel spiroamine derivative and its preparation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ATA388878A ATA388878A (de) | 1979-09-15 |
| AT356108B true AT356108B (de) | 1980-04-10 |
Family
ID=11898262
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT388878A AT356108B (de) | 1978-02-13 | 1978-05-29 | Verfahren zum herstellen von neuen spiro- piperidinverbindungen |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US4233307A (de) |
| JP (1) | JPS54109983A (de) |
| AT (1) | AT356108B (de) |
| AU (1) | AU511735B2 (de) |
| BE (1) | BE867517A (de) |
| CA (1) | CA1092106A (de) |
| CH (1) | CH635841A5 (de) |
| DE (1) | DE2822227A1 (de) |
| ES (1) | ES470155A1 (de) |
| FR (1) | FR2442845A1 (de) |
| IT (1) | IT7849577A0 (de) |
| NL (1) | NL7805814A (de) |
| SE (1) | SE7805949L (de) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4337260A (en) * | 1981-09-10 | 1982-06-29 | Yoshitomi Pharmaceutical Industries, Ltd. | Imidazopyridine-spiro-piperidine compounds |
| IL96507A0 (en) * | 1989-12-08 | 1991-08-16 | Merck & Co Inc | Nitrogen-containing spirocycles and pharmaceutical compositions containing them |
| AU680020B2 (en) * | 1993-06-07 | 1997-07-17 | Merck & Co., Inc. | Spiro-substituted azacycles as neurokinin antagonists |
| US5763471A (en) * | 1994-04-07 | 1998-06-09 | Cemaf | Melatoninergic agonist spiro indolepyrrolidine! derivatives, process for their preparation and their use as medicinal products |
| FR2724170B1 (fr) * | 1994-09-02 | 1997-05-30 | Cemaf | Nouveaux derives de spiro(indole-pyrrolidine) agonistes de la melatonine, leur procede de preparation et leur utilisation a titre de medicament |
| US5607936A (en) * | 1994-09-30 | 1997-03-04 | Merck & Co., Inc. | Substituted aryl piperazines as neurokinin antagonists |
| US5962462A (en) * | 1996-12-13 | 1999-10-05 | Merck & Co., Inc. | Spiro-substituted azacycles as modulators of chemokine receptor activity |
| US6013652A (en) * | 1997-12-04 | 2000-01-11 | Merck & Co., Inc. | Spiro-substituted azacycles as neurokinin antagonists |
| TR200200118T2 (tr) * | 1999-07-21 | 2002-12-23 | Astrazeneca Ab | Yeni bileşimler |
| GB0213715D0 (en) * | 2002-06-14 | 2002-07-24 | Syngenta Ltd | Chemical compounds |
| AU2003268512A1 (en) * | 2002-09-09 | 2004-03-29 | Janssen Pharmaceutica N.V. | Hydroxy alkyl substituted 1,3,8-triazaspiro[4.5]decan-4-one derivatives useful for the treatment of ORL-1 receptor mediated disorders |
| US7786141B2 (en) * | 2004-08-19 | 2010-08-31 | Vertex Pharmaceuticals Incorporated | Dihydrospiroindene modulators of muscarinic receptors |
| KR20070046929A (ko) * | 2004-08-19 | 2007-05-03 | 버텍스 파마슈티칼스 인코포레이티드 | 무스카린 수용체 조절제 |
| RU2007124373A (ru) * | 2004-11-29 | 2009-01-10 | Вертекс Фармасьютикалз Инкорпорейтед (Us) | Модуляторы мускариновых рецептеров |
| JP2008542375A (ja) * | 2005-06-02 | 2008-11-27 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | Ｏｒｌ−１受容体モジュレーターとして有用な新規３−スピロ環式インドリル誘導体 |
| US8193208B2 (en) * | 2005-09-09 | 2012-06-05 | Purdue Pharma L.P. | Fused and spirocycle compounds and the use thereof |
| JP2009521483A (ja) * | 2005-12-22 | 2009-06-04 | バーテックス ファーマシューティカルズ インコーポレイテッド | ムスカリン受容体のモジュレーター |
| EP1987034B1 (de) * | 2006-02-22 | 2011-07-20 | Vertex Pharmceuticals Incorporated | Kondensierte spiropiperidine als modulatoren muskarinartiger rezeptoren |
| AU2007221214A1 (en) * | 2006-02-22 | 2007-09-07 | Vertex Pharmaceuticals Incorporated | Modulators of muscarinic receptors |
| CN101500565A (zh) * | 2006-06-29 | 2009-08-05 | 弗特克斯药品有限公司 | 毒蕈碱性受体的调节剂 |
| AU2007284548A1 (en) * | 2006-08-15 | 2008-02-21 | Vertex Pharmaceuticals Incorporated | Modulators of muscarinic receptors |
| EP2051715A2 (de) * | 2006-08-18 | 2009-04-29 | Vertex Pharmceuticals Incorporated | Modulatoren muskarinischer rezeptoren |
| CN101622254B (zh) * | 2006-11-28 | 2013-05-29 | 詹森药业有限公司 | 3-(3-氨基-2-(r)-羟基-丙基)-1-(4-氟-苯基)-8-(8-甲基-萘-1-基甲基)-1,3,8-三氮杂-螺[4.5]癸烷-4-酮的盐 |
| MX2009011006A (es) * | 2007-04-09 | 2009-11-02 | Janssen Pharmaceutica Nv | Derivados de 1,3,8-trisustituido-1,3,8-triaza-espiro[4.5]decano-4- ona como ligandos del receptor de orl-1 para el tratamiento de ansiedad y depresion. |
| JP5224543B2 (ja) * | 2007-05-18 | 2013-07-03 | 興和株式会社 | 新規なスピロオキシインドール化合物及びこれを含有する医薬 |
| US7973162B2 (en) | 2007-10-03 | 2011-07-05 | Vertex Pharmaceuticals Incorporated | Modulators of muscarinic receptors |
| KR20240149461A (ko) * | 2022-01-18 | 2024-10-14 | 메이즈 테라퓨틱스, 인코퍼레이티드 | Apol1 저해제 및 사용 방법 |
| WO2025019479A1 (en) * | 2023-07-17 | 2025-01-23 | Maze Therapeutics, Inc. | Apol1 inhibitors and methods of use |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3299075A (en) * | 1964-03-12 | 1967-01-17 | Smith Kline French Lab | Spiro [3h-indole-3, 3'-pyrrolidine and piperidine] derivatives |
-
1978
- 1978-02-13 JP JP1577878A patent/JPS54109983A/ja active Pending
- 1978-05-16 AU AU36169/78A patent/AU511735B2/en not_active Expired
- 1978-05-22 DE DE19782822227 patent/DE2822227A1/de not_active Withdrawn
- 1978-05-24 ES ES470155A patent/ES470155A1/es not_active Expired
- 1978-05-24 SE SE7805949A patent/SE7805949L/xx not_active Application Discontinuation
- 1978-05-24 CH CH566278A patent/CH635841A5/de not_active IP Right Cessation
- 1978-05-25 FR FR7815606A patent/FR2442845A1/fr active Granted
- 1978-05-26 IT IT7849577A patent/IT7849577A0/it unknown
- 1978-05-26 BE BE188062A patent/BE867517A/xx not_active IP Right Cessation
- 1978-05-29 CA CA304,287A patent/CA1092106A/en not_active Expired
- 1978-05-29 AT AT388878A patent/AT356108B/de not_active IP Right Cessation
- 1978-05-29 NL NL7805814A patent/NL7805814A/xx not_active Application Discontinuation
- 1978-05-30 US US05/910,537 patent/US4233307A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| JPS54109983A (en) | 1979-08-29 |
| SE7805949L (sv) | 1979-08-14 |
| BE867517A (fr) | 1978-09-18 |
| ES470155A1 (es) | 1979-01-01 |
| AU511735B2 (en) | 1980-09-04 |
| ATA388878A (de) | 1979-09-15 |
| CA1092106A (en) | 1980-12-23 |
| CH635841A5 (de) | 1983-04-29 |
| DE2822227A1 (de) | 1979-08-16 |
| FR2442845B1 (de) | 1981-07-24 |
| FR2442845A1 (fr) | 1980-06-27 |
| NL7805814A (nl) | 1979-08-15 |
| US4233307A (en) | 1980-11-11 |
| AU3616978A (en) | 1979-11-22 |
| IT7849577A0 (it) | 1978-05-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ELJ | Ceased due to non-payment of the annual fee | ||
| ELJ | Ceased due to non-payment of the annual fee |