JPS57156469A - Preparation of tetrazole derivative - Google Patents
Preparation of tetrazole derivativeInfo
- Publication number
- JPS57156469A JPS57156469A JP4106981A JP4106981A JPS57156469A JP S57156469 A JPS57156469 A JP S57156469A JP 4106981 A JP4106981 A JP 4106981A JP 4106981 A JP4106981 A JP 4106981A JP S57156469 A JPS57156469 A JP S57156469A
- Authority
- JP
- Japan
- Prior art keywords
- azide
- reacting
- compound
- formula
- derivative
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
PURPOSE: To obtain the titled compound which is a synthetic intermediate for medicines, by reacting a hydroxyamide derivative easily available from an inexpensive lactone, etc. as a starting material with a halogenating agent, and reacting the resultant product with hydrazoic acid or a metallic azide thereof.
CONSTITUTION: A hydroxyamide derivative of formulaI(R' is alkyl cycloalkyl, cycloalkylalkyl, phenol or phenylalkyl; A is alkylene), e.g. N-cyclohexyl-5-hydroxyvaleramide, is reacted with a halogenating agent, e.g. phosphorus oxychloride or phosphorus pentachloride, and the resultant product is then reacted with hydrazoic acid or a metallic azide, e.g. sodium azide or aluminum azide, to afford a tetrazole derivative of formula II (X is halogen), e.g. 1-cyclohexyl-5-(4-chlorobutyl)tetrazole. The compound of formulaIis obtained by reacting a lactone of formula III with a compound of the formula R'NH2.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP4106981A JPS57156469A (en) | 1981-03-19 | 1981-03-19 | Preparation of tetrazole derivative |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP4106981A JPS57156469A (en) | 1981-03-19 | 1981-03-19 | Preparation of tetrazole derivative |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS57156469A true JPS57156469A (en) | 1982-09-27 |
JPH0227346B2 JPH0227346B2 (en) | 1990-06-15 |
Family
ID=12598148
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP4106981A Granted JPS57156469A (en) | 1981-03-19 | 1981-03-19 | Preparation of tetrazole derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS57156469A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100935893B1 (en) | 2007-09-11 | 2010-01-07 | 국방과학연구소 | Process for production of 1,1'-dimethyl-5,5'-bitetrazole |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5535019A (en) * | 1978-09-01 | 1980-03-11 | Otsuka Pharmaceut Co Ltd | Carbostyryl derivative |
-
1981
- 1981-03-19 JP JP4106981A patent/JPS57156469A/en active Granted
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5535019A (en) * | 1978-09-01 | 1980-03-11 | Otsuka Pharmaceut Co Ltd | Carbostyryl derivative |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100935893B1 (en) | 2007-09-11 | 2010-01-07 | 국방과학연구소 | Process for production of 1,1'-dimethyl-5,5'-bitetrazole |
Also Published As
Publication number | Publication date |
---|---|
JPH0227346B2 (en) | 1990-06-15 |
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