JPS5616487A - Preparation of rifamycin derivative - Google Patents
Preparation of rifamycin derivativeInfo
- Publication number
- JPS5616487A JPS5616487A JP9178079A JP9178079A JPS5616487A JP S5616487 A JPS5616487 A JP S5616487A JP 9178079 A JP9178079 A JP 9178079A JP 9178079 A JP9178079 A JP 9178079A JP S5616487 A JPS5616487 A JP S5616487A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- primary amine
- amount
- formaldehyde
- reducing agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
PURPOSE: To obtain the titled substance useful as an antibiotic readily, by reacting 3-formylrifamycin S with a condensation product prepared from a primary amine and a specific amount of formaldehyde, etc., and then with a reducing agent.
CONSTITUTION: 3-Formylrifamycin S of formula I is reacted with a condensation product prepared from a primary amine of the formula R-NH2 (R is alkyl, aryl, aralkyl or cycloalkyl group) and formaldehyde in an amount of at least equimolar with the primary amine. The reaction product is then reduced with a mild reducing agent, e.g. ascorbic acid, to give a compound of formula II. Alternatively, the compound of formula I is reacted with a condensation product obtained from a primary amine of the formula R-NH2 and formaldehyde in a molar, amount of twice that of the the primary amine and an alcohol of the formula R'-OH (R' is lower alkyl group) in an amount of twice that of the primary amine, and then reduced with the mild reducing agent.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP9178079A JPS5616487A (en) | 1979-07-18 | 1979-07-18 | Preparation of rifamycin derivative |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP9178079A JPS5616487A (en) | 1979-07-18 | 1979-07-18 | Preparation of rifamycin derivative |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS5616487A true JPS5616487A (en) | 1981-02-17 |
Family
ID=14036097
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP9178079A Pending JPS5616487A (en) | 1979-07-18 | 1979-07-18 | Preparation of rifamycin derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5616487A (en) |
-
1979
- 1979-07-18 JP JP9178079A patent/JPS5616487A/en active Pending
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