JPS57183757A - 5-oxopyrrolidine derivative, antiulcer comprising it as active ingredient, and its preparation - Google Patents

5-oxopyrrolidine derivative, antiulcer comprising it as active ingredient, and its preparation

Info

Publication number
JPS57183757A
JPS57183757A JP6621681A JP6621681A JPS57183757A JP S57183757 A JPS57183757 A JP S57183757A JP 6621681 A JP6621681 A JP 6621681A JP 6621681 A JP6621681 A JP 6621681A JP S57183757 A JPS57183757 A JP S57183757A
Authority
JP
Japan
Prior art keywords
formula
antiulcer
compound shown
alkyl
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP6621681A
Other languages
Japanese (ja)
Inventor
Takeshi Tomiyama
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kotobuki Seiyaku Co Ltd
Original Assignee
Kotobuki Seiyaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kotobuki Seiyaku Co Ltd filed Critical Kotobuki Seiyaku Co Ltd
Priority to JP6621681A priority Critical patent/JPS57183757A/en
Publication of JPS57183757A publication Critical patent/JPS57183757A/en
Pending legal-status Critical Current

Links

Abstract

NEW MATERIAL:A 5-oxo-pyrrolidine derivative shown by the formulaI[R1 is phenetyl which may have substituent group, farnesyl, geranyl, or cyclohexyl which may have substitutent group; R2 is OH, -NHR3(R3 is H, lower alkyl, cyclohexyl which may have substituent group, prenyl, geranyl, or farnesyl)..
EXAMPLE: 1-m-Methyl-benzyl-5-oxo-8-pyrrolidinecarboxylic acid.
USE: An antiulcer. Capable of being medicated perorally or parenterally.
PROCESS: For example, an itaconic acid shown by the formula II (R is H or alkyl) or its alkyl ester is reacted with an amine shown by the formula III, to give a compound shown by the formula IV. The compound shown by the formula IV where R is alkyl is reacted with a compound shown by the formula NH2R3, to give a compound shown by the formulaI.
COPYRIGHT: (C)1982,JPO&Japio
JP6621681A 1981-04-30 1981-04-30 5-oxopyrrolidine derivative, antiulcer comprising it as active ingredient, and its preparation Pending JPS57183757A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP6621681A JPS57183757A (en) 1981-04-30 1981-04-30 5-oxopyrrolidine derivative, antiulcer comprising it as active ingredient, and its preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP6621681A JPS57183757A (en) 1981-04-30 1981-04-30 5-oxopyrrolidine derivative, antiulcer comprising it as active ingredient, and its preparation

Publications (1)

Publication Number Publication Date
JPS57183757A true JPS57183757A (en) 1982-11-12

Family

ID=13309405

Family Applications (1)

Application Number Title Priority Date Filing Date
JP6621681A Pending JPS57183757A (en) 1981-04-30 1981-04-30 5-oxopyrrolidine derivative, antiulcer comprising it as active ingredient, and its preparation

Country Status (1)

Country Link
JP (1) JPS57183757A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0194901A2 (en) * 1985-03-15 1986-09-17 Shionogi & Co., Ltd. Isoprenoidamine derivatives, compositions containing them, their preparation, and their use
JP2009533354A (en) * 2006-04-07 2009-09-17 アボット・ラボラトリーズ Inhibitor of 11β-hydroxysteroid dehydrogenase type 1 enzyme

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
CHIM THER *
J.MED CHEM *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0194901A2 (en) * 1985-03-15 1986-09-17 Shionogi & Co., Ltd. Isoprenoidamine derivatives, compositions containing them, their preparation, and their use
US4900749A (en) * 1985-03-15 1990-02-13 Shionogi & Co., Ltd. Isoprenoidamine compounds useful as antiulcer agents
US4977170A (en) * 1985-03-15 1990-12-11 Shionogi & Co., Ltd. Isoprenoidamine compounds which are useful antiulcer agents
JP2009533354A (en) * 2006-04-07 2009-09-17 アボット・ラボラトリーズ Inhibitor of 11β-hydroxysteroid dehydrogenase type 1 enzyme

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