JPS57183757A - 5-oxopyrrolidine derivative, antiulcer comprising it as active ingredient, and its preparation - Google Patents
5-oxopyrrolidine derivative, antiulcer comprising it as active ingredient, and its preparationInfo
- Publication number
- JPS57183757A JPS57183757A JP6621681A JP6621681A JPS57183757A JP S57183757 A JPS57183757 A JP S57183757A JP 6621681 A JP6621681 A JP 6621681A JP 6621681 A JP6621681 A JP 6621681A JP S57183757 A JPS57183757 A JP S57183757A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- antiulcer
- compound shown
- alkyl
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
NEW MATERIAL:A 5-oxo-pyrrolidine derivative shown by the formulaI[R1 is phenetyl which may have substituent group, farnesyl, geranyl, or cyclohexyl which may have substitutent group; R2 is OH, -NHR3(R3 is H, lower alkyl, cyclohexyl which may have substituent group, prenyl, geranyl, or farnesyl)..
EXAMPLE: 1-m-Methyl-benzyl-5-oxo-8-pyrrolidinecarboxylic acid.
USE: An antiulcer. Capable of being medicated perorally or parenterally.
PROCESS: For example, an itaconic acid shown by the formula II (R is H or alkyl) or its alkyl ester is reacted with an amine shown by the formula III, to give a compound shown by the formula IV. The compound shown by the formula IV where R is alkyl is reacted with a compound shown by the formula NH2R3, to give a compound shown by the formulaI.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP6621681A JPS57183757A (en) | 1981-04-30 | 1981-04-30 | 5-oxopyrrolidine derivative, antiulcer comprising it as active ingredient, and its preparation |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP6621681A JPS57183757A (en) | 1981-04-30 | 1981-04-30 | 5-oxopyrrolidine derivative, antiulcer comprising it as active ingredient, and its preparation |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS57183757A true JPS57183757A (en) | 1982-11-12 |
Family
ID=13309405
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP6621681A Pending JPS57183757A (en) | 1981-04-30 | 1981-04-30 | 5-oxopyrrolidine derivative, antiulcer comprising it as active ingredient, and its preparation |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS57183757A (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0194901A2 (en) * | 1985-03-15 | 1986-09-17 | Shionogi & Co., Ltd. | Isoprenoidamine derivatives, compositions containing them, their preparation, and their use |
JP2009533354A (en) * | 2006-04-07 | 2009-09-17 | アボット・ラボラトリーズ | Inhibitor of 11β-hydroxysteroid dehydrogenase type 1 enzyme |
-
1981
- 1981-04-30 JP JP6621681A patent/JPS57183757A/en active Pending
Non-Patent Citations (2)
Title |
---|
CHIM THER * |
J.MED CHEM * |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0194901A2 (en) * | 1985-03-15 | 1986-09-17 | Shionogi & Co., Ltd. | Isoprenoidamine derivatives, compositions containing them, their preparation, and their use |
US4900749A (en) * | 1985-03-15 | 1990-02-13 | Shionogi & Co., Ltd. | Isoprenoidamine compounds useful as antiulcer agents |
US4977170A (en) * | 1985-03-15 | 1990-12-11 | Shionogi & Co., Ltd. | Isoprenoidamine compounds which are useful antiulcer agents |
JP2009533354A (en) * | 2006-04-07 | 2009-09-17 | アボット・ラボラトリーズ | Inhibitor of 11β-hydroxysteroid dehydrogenase type 1 enzyme |
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