JPS57171992A - Novel secalonic acid derivative and its preparation - Google Patents
Novel secalonic acid derivative and its preparationInfo
- Publication number
- JPS57171992A JPS57171992A JP5621981A JP5621981A JPS57171992A JP S57171992 A JPS57171992 A JP S57171992A JP 5621981 A JP5621981 A JP 5621981A JP 5621981 A JP5621981 A JP 5621981A JP S57171992 A JPS57171992 A JP S57171992A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound
- acid
- secalonic
- novel
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:A compound of formulaI[R is group of formula II (R1 and R2 are H or lower alkyl) or formula III (R3 is H, alkyl, aryl, alkoxyl, halogen, cyano, carboxylic acid, solfonic acid, etc.)].
EXAMPLE: 4,4'-Bis(maleimidomethyl)-secalonic acid A.
USE: An antitumor agnet and an intermediate for preparing medicines with lower toxicity than the secalonic acid of formula IV.
PROCESS: The secalonic acid of formula IV is reacted with a compound of formula R-CH2OH to give the compound of formulaI. The reaction is a dehydration reaction between the compound of formula III with the compound of the formula R-CH2OH, and in the presence of an inorganic acid, e.g. concentrated solfuric acid or fuming sulfuric acid, or a dehydrating agent, e.g. zinc chloride or phosphorus pentoxide, or a catalyst. The amount of the compound of the formula R-CH2OH is in the range of 1W10mol, preferably 2W4mol, based on one mole compound of formula IV.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP5621981A JPS57171992A (en) | 1981-04-16 | 1981-04-16 | Novel secalonic acid derivative and its preparation |
US06/366,333 US4418061A (en) | 1981-04-16 | 1982-04-07 | Secalonic acid derivatives and method for preparing thereof |
EP82103231A EP0064199B1 (en) | 1981-04-16 | 1982-04-16 | Novel secalonic acid derivatives and method for preparing thereof |
DE8282103231T DE3265553D1 (en) | 1981-04-16 | 1982-04-16 | Novel secalonic acid derivatives and method for preparing thereof |
US06/529,635 US4556651A (en) | 1981-04-16 | 1983-09-06 | Secalonic acid derivatives as antitumor agents |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP5621981A JPS57171992A (en) | 1981-04-16 | 1981-04-16 | Novel secalonic acid derivative and its preparation |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS57171992A true JPS57171992A (en) | 1982-10-22 |
JPS644519B2 JPS644519B2 (en) | 1989-01-25 |
Family
ID=13020988
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP5621981A Granted JPS57171992A (en) | 1981-04-16 | 1981-04-16 | Novel secalonic acid derivative and its preparation |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS57171992A (en) |
-
1981
- 1981-04-16 JP JP5621981A patent/JPS57171992A/en active Granted
Also Published As
Publication number | Publication date |
---|---|
JPS644519B2 (en) | 1989-01-25 |
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