JPS57171992A - Novel secalonic acid derivative and its preparation - Google Patents

Novel secalonic acid derivative and its preparation

Info

Publication number
JPS57171992A
JPS57171992A JP5621981A JP5621981A JPS57171992A JP S57171992 A JPS57171992 A JP S57171992A JP 5621981 A JP5621981 A JP 5621981A JP 5621981 A JP5621981 A JP 5621981A JP S57171992 A JPS57171992 A JP S57171992A
Authority
JP
Japan
Prior art keywords
formula
compound
acid
secalonic
novel
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP5621981A
Other languages
Japanese (ja)
Other versions
JPS644519B2 (en
Inventor
Kazuyuki Shibuya
Kunihiko Ishii
Mitsuru Shibukawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Asahi Kasei Corp
Asahi Chemical Industry Co Ltd
Original Assignee
Asahi Chemical Industry Co Ltd
Asahi Kasei Kogyo KK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Asahi Chemical Industry Co Ltd, Asahi Kasei Kogyo KK filed Critical Asahi Chemical Industry Co Ltd
Priority to JP5621981A priority Critical patent/JPS57171992A/en
Priority to US06/366,333 priority patent/US4418061A/en
Priority to EP82103231A priority patent/EP0064199B1/en
Priority to DE8282103231T priority patent/DE3265553D1/en
Publication of JPS57171992A publication Critical patent/JPS57171992A/en
Priority to US06/529,635 priority patent/US4556651A/en
Publication of JPS644519B2 publication Critical patent/JPS644519B2/ja
Granted legal-status Critical Current

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  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:A compound of formulaI[R is group of formula II (R1 and R2 are H or lower alkyl) or formula III (R3 is H, alkyl, aryl, alkoxyl, halogen, cyano, carboxylic acid, solfonic acid, etc.)].
EXAMPLE: 4,4'-Bis(maleimidomethyl)-secalonic acid A.
USE: An antitumor agnet and an intermediate for preparing medicines with lower toxicity than the secalonic acid of formula IV.
PROCESS: The secalonic acid of formula IV is reacted with a compound of formula R-CH2OH to give the compound of formulaI. The reaction is a dehydration reaction between the compound of formula III with the compound of the formula R-CH2OH, and in the presence of an inorganic acid, e.g. concentrated solfuric acid or fuming sulfuric acid, or a dehydrating agent, e.g. zinc chloride or phosphorus pentoxide, or a catalyst. The amount of the compound of the formula R-CH2OH is in the range of 1W10mol, preferably 2W4mol, based on one mole compound of formula IV.
COPYRIGHT: (C)1982,JPO&Japio
JP5621981A 1981-04-16 1981-04-16 Novel secalonic acid derivative and its preparation Granted JPS57171992A (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
JP5621981A JPS57171992A (en) 1981-04-16 1981-04-16 Novel secalonic acid derivative and its preparation
US06/366,333 US4418061A (en) 1981-04-16 1982-04-07 Secalonic acid derivatives and method for preparing thereof
EP82103231A EP0064199B1 (en) 1981-04-16 1982-04-16 Novel secalonic acid derivatives and method for preparing thereof
DE8282103231T DE3265553D1 (en) 1981-04-16 1982-04-16 Novel secalonic acid derivatives and method for preparing thereof
US06/529,635 US4556651A (en) 1981-04-16 1983-09-06 Secalonic acid derivatives as antitumor agents

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP5621981A JPS57171992A (en) 1981-04-16 1981-04-16 Novel secalonic acid derivative and its preparation

Publications (2)

Publication Number Publication Date
JPS57171992A true JPS57171992A (en) 1982-10-22
JPS644519B2 JPS644519B2 (en) 1989-01-25

Family

ID=13020988

Family Applications (1)

Application Number Title Priority Date Filing Date
JP5621981A Granted JPS57171992A (en) 1981-04-16 1981-04-16 Novel secalonic acid derivative and its preparation

Country Status (1)

Country Link
JP (1) JPS57171992A (en)

Also Published As

Publication number Publication date
JPS644519B2 (en) 1989-01-25

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