JPS5788163A - Preparation of o-aminomethylphenylacetyl lactam - Google Patents
Preparation of o-aminomethylphenylacetyl lactamInfo
- Publication number
- JPS5788163A JPS5788163A JP16265680A JP16265680A JPS5788163A JP S5788163 A JPS5788163 A JP S5788163A JP 16265680 A JP16265680 A JP 16265680A JP 16265680 A JP16265680 A JP 16265680A JP S5788163 A JPS5788163 A JP S5788163A
- Authority
- JP
- Japan
- Prior art keywords
- acid
- polyphosphoric acid
- methylphenylacetamide
- dehydration
- polyphosphoric
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
PURPOSE: To obtain the titled compound useful as a raw material for preparing o-aminomethylphenylacetic acid in high yield, by reacting methylphenylacetamide with paraformaldehyde through dehydration in the presence of polyphosphoric acid as a dehydrating agent.
CONSTITUTION: Methylphenylacetamide of formulaIis reacted with paraformaldehyede in the presence of polyphosphoric acid at 110W160°C for 1W20hr through dehydration to give the aimed compound of formula II. The polyphosphoric acid is a viscous sirupy substance obtained by dehydrating and concentrating orthophosphoric acid under heating, and consists of orthophosphoric acid, pyrophosphric acid, tetrapolyphosphoric acid, etc. The P2O5 content of 77W86wt% may be preferred. The amount of the polyphosphoric acid used is preferably 200W800g based on one mole compound of formulaI.
USE: A raw material for preparing o-aminomethylphenylacetic acid which is an intermediate for cephalosporin antibiotics.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP16265680A JPS5788163A (en) | 1980-11-20 | 1980-11-20 | Preparation of o-aminomethylphenylacetyl lactam |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP16265680A JPS5788163A (en) | 1980-11-20 | 1980-11-20 | Preparation of o-aminomethylphenylacetyl lactam |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS5788163A true JPS5788163A (en) | 1982-06-01 |
Family
ID=15758767
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP16265680A Pending JPS5788163A (en) | 1980-11-20 | 1980-11-20 | Preparation of o-aminomethylphenylacetyl lactam |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5788163A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH03124531U (en) * | 1990-03-30 | 1991-12-17 |
-
1980
- 1980-11-20 JP JP16265680A patent/JPS5788163A/en active Pending
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH03124531U (en) * | 1990-03-30 | 1991-12-17 |
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