JPS57149271A - Preparation of o-aminomethylphenylacetic lactam - Google Patents

Preparation of o-aminomethylphenylacetic lactam

Info

Publication number
JPS57149271A
JPS57149271A JP3316881A JP3316881A JPS57149271A JP S57149271 A JPS57149271 A JP S57149271A JP 3316881 A JP3316881 A JP 3316881A JP 3316881 A JP3316881 A JP 3316881A JP S57149271 A JPS57149271 A JP S57149271A
Authority
JP
Japan
Prior art keywords
phenylacetamide
reacted
polyphosphoric acid
alkylbenzene
paraformaldehyde
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP3316881A
Other languages
Japanese (ja)
Inventor
Mamoru Nakai
Takuji Enomiya
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ube Corp
Original Assignee
Ube Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ube Industries Ltd filed Critical Ube Industries Ltd
Priority to JP3316881A priority Critical patent/JPS57149271A/en
Publication of JPS57149271A publication Critical patent/JPS57149271A/en
Pending legal-status Critical Current

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Abstract

PURPOSE: To obtain the titled compound useful as an intermediae for cephalosporin antibiotic substances in high yield, by reacting phenylacetamide with paraformaldehyde in the presence of relatively reduced amounts of polyphosphoric acid and an alkylbenzene.
CONSTITUTION: Phenylacetamide is reacted with paraformaldehyde or the phenylacetamide is previously reacted with a formaldehyde to form an N-hydroxymethylphenylacetamide of formula II, which is then reacted in the presence of polyphosphoric acid and an alkylbenzene, e.g. toluene, ethylbenzene or mixed xylene, at 95W150°C for 1W40hr and dehydrated to give the aimed compound of formula III. The polyphosphoric acid to be used is a viscous syrupy substance obtained by dehydrating and concentrating orthophosphoric acid under heating, and preferably contains 77W86wt% P2O5. The amount thereof to be used is 150W270g based on one mole compund of formulaIor II.
COPYRIGHT: (C)1982,JPO&Japio
JP3316881A 1981-03-10 1981-03-10 Preparation of o-aminomethylphenylacetic lactam Pending JPS57149271A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP3316881A JPS57149271A (en) 1981-03-10 1981-03-10 Preparation of o-aminomethylphenylacetic lactam

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP3316881A JPS57149271A (en) 1981-03-10 1981-03-10 Preparation of o-aminomethylphenylacetic lactam

Publications (1)

Publication Number Publication Date
JPS57149271A true JPS57149271A (en) 1982-09-14

Family

ID=12379001

Family Applications (1)

Application Number Title Priority Date Filing Date
JP3316881A Pending JPS57149271A (en) 1981-03-10 1981-03-10 Preparation of o-aminomethylphenylacetic lactam

Country Status (1)

Country Link
JP (1) JPS57149271A (en)

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