IT7968748A0 - Derivati del tetrazolil alcossi carbostirile e procedimento per laloro fabbricazione - Google Patents

Derivati del tetrazolil alcossi carbostirile e procedimento per laloro fabbricazione

Info

Publication number
IT7968748A0
IT7968748A0 IT7968748A IT6874879A IT7968748A0 IT 7968748 A0 IT7968748 A0 IT 7968748A0 IT 7968748 A IT7968748 A IT 7968748A IT 6874879 A IT6874879 A IT 6874879A IT 7968748 A0 IT7968748 A0 IT 7968748A0
Authority
IT
Italy
Prior art keywords
carbostyryl
derivatives
procedure
manufacturing
tetrazolyl
Prior art date
Application number
IT7968748A
Other languages
English (en)
Other versions
IT1119929B (it
Inventor
Takao Nishi
Kazuyuki Nakagawa
Original Assignee
Otsuka Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=14470137&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IT7968748(A0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Otsuka Pharma Co Ltd filed Critical Otsuka Pharma Co Ltd
Publication of IT7968748A0 publication Critical patent/IT7968748A0/it
Application granted granted Critical
Publication of IT1119929B publication Critical patent/IT1119929B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Psychiatry (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
IT68748/79A 1978-09-01 1979-08-31 Derivati del tetrazolil alcossi carbostirile e procedimento per la loro fabbricazione IT1119929B (it)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP10786978A JPS5535019A (en) 1978-09-01 1978-09-01 Carbostyryl derivative

Publications (2)

Publication Number Publication Date
IT7968748A0 true IT7968748A0 (it) 1979-08-31
IT1119929B IT1119929B (it) 1986-03-19

Family

ID=14470137

Family Applications (1)

Application Number Title Priority Date Filing Date
IT68748/79A IT1119929B (it) 1978-09-01 1979-08-31 Derivati del tetrazolil alcossi carbostirile e procedimento per la loro fabbricazione

Country Status (23)

Country Link
US (1) US4277479A (it)
JP (1) JPS5535019A (it)
AR (1) AR229342A1 (it)
AT (1) AT364363B (it)
AU (1) AU538410B2 (it)
BE (1) BE878548A (it)
CA (1) CA1139761A (it)
CH (1) CH641799A5 (it)
DE (1) DE2934747A1 (it)
DK (1) DK158788C (it)
ES (1) ES483792A1 (it)
FI (1) FI68398C (it)
FR (1) FR2434809A1 (it)
GB (1) GB2033893B (it)
IT (1) IT1119929B (it)
MX (1) MX6749E (it)
NL (1) NL183888C (it)
NO (1) NO153177C (it)
PH (1) PH18452A (it)
PT (1) PT70136A (it)
SE (1) SE432252B (it)
SU (1) SU1064868A3 (it)
ZA (1) ZA794627B (it)

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US4803162A (en) * 1984-05-15 1989-02-07 Fluorodiagnostic Limited Partners Composition, article and process for detecting a microorganism
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GB8529362D0 (en) * 1985-11-28 1986-01-02 Pfizer Ltd Quinolone cardiac stimulants
JPH0681727B2 (ja) * 1986-04-02 1994-10-19 大塚製薬株式会社 血小板粘着抑制剤
KR940000785B1 (ko) * 1986-04-02 1994-01-31 오오쓰까세이야꾸 가부시끼가이샤 카르보스티릴 유도체 및 그의 염의 제조 방법
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JP2753622B2 (ja) 1988-05-02 1998-05-20 大塚製薬株式会社 カルボスチリル誘導体
US5064837A (en) * 1989-11-13 1991-11-12 Schering Corporation 3-substituted-1-aryl-2(h)-quinolones and their pharmaceutical compositions
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TW201305B (it) * 1991-04-03 1993-03-01 Otsuka Pharma Co Ltd
US5506239A (en) * 1991-08-23 1996-04-09 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivative and platelets aggregation inhibitory agent
JPH0776521A (ja) * 1993-09-07 1995-03-20 Otsuka Pharmaceut Co Ltd 気道炎症抑制剤
US6187790B1 (en) 1999-03-04 2001-02-13 Neal R. Cutler Use of cilostazol for treatment of sexual dysfunction
JP4060523B2 (ja) * 1999-11-24 2008-03-12 大塚製薬株式会社 カルボスチリル誘導体の製造法
US20030045547A1 (en) * 2001-05-02 2003-03-06 Shinji Aki Process for producing carbostyril derivatives
WO2001070697A1 (en) 2000-03-20 2001-09-27 Teva Pharmaceutical Industries Ltd. Processes for preparing 6-hydroxy-3,4-dihydroquinolinone, cilostazol and n-(4-methoxyphenyl)-3-chloropropionamide
US6515128B2 (en) 2000-03-20 2003-02-04 Teva Pharmaceutical Industries Ltd. Processes for preparing cilostazol
US6825214B2 (en) * 2000-08-14 2004-11-30 Teva Pharmaceutical Industries, Ltd. Substantially pure cilostazol and processes for making same
SK2992003A3 (en) * 2000-08-14 2003-10-07 Teva Pharma Processes for preparing cilostazol
US6458804B1 (en) 2001-01-26 2002-10-01 R.T. Alamo Venturesi, Llc Methods for the treatment of central nervous system disorders in certain patient groups
US6451813B1 (en) 2001-01-26 2002-09-17 R. T. Alamo Ventures I, Llc Treatment of gastroparesis in certain patient groups
US20050101631A1 (en) * 2002-08-01 2005-05-12 Otsuka Pharmaceuticals Company Process for producing carbostyril derivatives
US7399864B2 (en) * 2001-05-02 2008-07-15 Otsuka Pharmaceutical Co., Ltd. Process for producing carbostyril derivatives
JP2003063965A (ja) * 2001-06-13 2003-03-05 Otsuka Pharmaceut Factory Inc 注射用シロスタゾール水性製剤
US6660864B2 (en) * 2001-06-29 2003-12-09 Grayson Walker Stowell Polymorphic forms of 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone
WO2003002529A2 (en) * 2001-06-29 2003-01-09 Aaipharma, Inc. Polymorphic forms of 6-[4-(1-cyclohexyl-1h-tetrazol-5-yl)butoxy]-3, 4-dihydro-2(1h)-quinolinone
US6388080B1 (en) 2001-06-29 2002-05-14 Grayson Walker Stowell Polymorphic forms of 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone
US6657061B2 (en) * 2001-06-29 2003-12-02 Grayson Walker Stowell Polymorphic forms of 6-[4-1(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone
WO2003002121A1 (en) * 2001-06-29 2003-01-09 Aaipharma, Inc. Polymorphic forms of 6-[4-(1-cyclohexyl-1h-tetrazol-5-yl)butoxy]-3, 4-dihydro-2(1h)-quinolinone
US6531603B1 (en) * 2001-06-29 2003-03-11 Grayson Walker Stowell Polymorphic forms of 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone
US6573382B2 (en) * 2001-06-29 2003-06-03 Grayson Walker Stowell Polymorphic forms of 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone
US6596871B2 (en) * 2001-06-29 2003-07-22 Grayson Walker Stowell Polymorphic forms of 6-[4-(1-cyclohexyl-1h-tetraol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone
KR100551926B1 (ko) * 2002-09-10 2006-02-17 오쓰까 세이야꾸 가부시키가이샤 시로스타졸의 제조 방법
US6743806B2 (en) * 2002-10-23 2004-06-01 Otsuka Pharmaceutical Company, Limited Active oxygen scavenger
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
TWI323660B (en) 2003-02-25 2010-04-21 Otsuka Pharma Co Ltd Pten inhibitor or maxi-k channels opener
ITMI20031670A1 (it) * 2003-08-26 2005-02-27 Dinamite Dipharma S P A In Forma A Bbreviata Diph Processo per la preparazione di cilostazolo e di suoi intermedi.
IL167483A (en) * 2004-03-16 2011-04-28 Chemagis Ltd Process for obtaining highly pure cilostazol
US20050255155A1 (en) * 2004-05-11 2005-11-17 Glenmark Pharmaceuticals Limited Modified release cilostazol compositions
US20080206348A1 (en) * 2004-09-17 2008-08-28 Deepak Murpani Cilostazol-Containing Pharmaceutical Composition Based On Particles Of Less Than 50 Micrometers
CN100462360C (zh) * 2005-08-15 2009-02-18 上海立科药物化学有限公司 N-环己基-5-(4-氯丁基)-1h-四氮唑的合成方法
CA2620296C (en) 2005-09-15 2013-10-22 Otsuka Pharmaceutical Co., Ltd. Combination drug containing probucol and a tetrazolylalkoxy-dihydrocarbostyril derivative with superoxide supressant effects
US20070105898A1 (en) * 2005-11-09 2007-05-10 Apotex Pharmachem Inc. Process for the production of cilostazol
AR065588A1 (es) 2007-03-09 2009-06-17 Otsuka Pharma Co Ltd Un medicamento para tratar enfermedad pulmonar obstructiva cronica
TW200848041A (en) 2007-03-30 2008-12-16 Otsuka Pharma Co Ltd A medicament for treating schizophrenia comprising cilostazol
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US20160184387A1 (en) 2013-08-09 2016-06-30 Dominique Charmot Compounds and methods for inhibiting phosphate transport
CN114340631A (zh) 2019-05-21 2022-04-12 阿德利克斯股份有限公司 用于降低患者的血清磷酸盐的组合

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Also Published As

Publication number Publication date
GB2033893A (en) 1980-05-29
SE432252B (sv) 1984-03-26
FI68398C (fi) 1985-09-10
AT364363B (de) 1981-10-12
ZA794627B (en) 1980-08-27
DE2934747C2 (it) 1988-01-28
JPS6155514B2 (it) 1986-11-28
CA1139761A (en) 1983-01-18
NO153177C (no) 1986-01-29
BE878548A (fr) 1979-12-17
FI68398B (fi) 1985-05-31
FR2434809B1 (it) 1982-09-17
MX6749E (es) 1986-06-25
NO153177B (no) 1985-10-21
SU1064868A3 (ru) 1983-12-30
CH641799A5 (de) 1984-03-15
SE7907236L (sv) 1980-03-02
DE2934747A1 (de) 1980-03-13
NO792829L (no) 1980-03-04
FR2434809A1 (fr) 1980-03-28
GB2033893B (en) 1982-12-01
AU538410B2 (en) 1984-08-16
FI792699A (fi) 1980-03-02
JPS5535019A (en) 1980-03-11
NL7906523A (nl) 1980-03-04
ES483792A1 (es) 1980-09-01
DK363179A (da) 1980-03-02
AU5039779A (en) 1980-03-06
DK158788C (da) 1990-12-10
DK158788B (da) 1990-07-16
PT70136A (en) 1979-09-01
ATA584579A (de) 1981-03-15
IT1119929B (it) 1986-03-19
NL183888C (nl) 1989-02-16
PH18452A (en) 1985-07-18
US4277479A (en) 1981-07-07
AR229342A1 (es) 1983-07-29

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Legal Events

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TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19950831