FI67704C - Foerfarande foer framstaellning av ett nytt terapeutiskt anvaendbart kristallint monohydrat av 7-(d-alfa-amino-alfa-(p-hydroxifenyl)acetamido)-3-metyl-3-cefem-4-karboxylsyra - Google Patents

Foerfarande foer framstaellning av ett nytt terapeutiskt anvaendbart kristallint monohydrat av 7-(d-alfa-amino-alfa-(p-hydroxifenyl)acetamido)-3-metyl-3-cefem-4-karboxylsyra Download PDF

Info

Publication number
FI67704C
FI67704C FI771339A FI771339A FI67704C FI 67704 C FI67704 C FI 67704C FI 771339 A FI771339 A FI 771339A FI 771339 A FI771339 A FI 771339A FI 67704 C FI67704 C FI 67704C
Authority
FI
Finland
Prior art keywords
cefadroxil
water
monohydrate
hydroxyphenyl
acetonitrile
Prior art date
Application number
FI771339A
Other languages
English (en)
Finnish (fi)
Other versions
FI771339A (de
FI67704B (fi
Inventor
Daniel Bouzard
Abraham Weber
Jaques Stemer
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10087928&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FI67704(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of FI771339A publication Critical patent/FI771339A/fi
Publication of FI67704B publication Critical patent/FI67704B/fi
Application granted granted Critical
Publication of FI67704C publication Critical patent/FI67704C/fi

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FI771339A 1976-04-27 1977-04-27 Foerfarande foer framstaellning av ett nytt terapeutiskt anvaendbart kristallint monohydrat av 7-(d-alfa-amino-alfa-(p-hydroxifenyl)acetamido)-3-metyl-3-cefem-4-karboxylsyra FI67704C (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB17028/76A GB1532682A (en) 1976-04-27 1976-04-27 Process for the preparation of cephadroxil
GB1702876 1976-04-27

Publications (3)

Publication Number Publication Date
FI771339A FI771339A (de) 1977-10-28
FI67704B FI67704B (fi) 1985-01-31
FI67704C true FI67704C (fi) 1985-05-10

Family

ID=10087928

Family Applications (1)

Application Number Title Priority Date Filing Date
FI771339A FI67704C (fi) 1976-04-27 1977-04-27 Foerfarande foer framstaellning av ett nytt terapeutiskt anvaendbart kristallint monohydrat av 7-(d-alfa-amino-alfa-(p-hydroxifenyl)acetamido)-3-metyl-3-cefem-4-karboxylsyra

Country Status (26)

Country Link
US (3) US4234721A (de)
JP (2) JPS6022717B2 (de)
AT (1) AT350183B (de)
AU (1) AU510338B2 (de)
BE (1) BE853974A (de)
CA (1) CA1115268A (de)
CH (1) CH632270A5 (de)
CY (1) CY1066A (de)
DE (1) DE2718741C2 (de)
DK (1) DK157026C (de)
ES (1) ES458241A1 (de)
FI (1) FI67704C (de)
FR (2) FR2349589A1 (de)
GB (1) GB1532682A (de)
GR (1) GR72788B (de)
HK (1) HK39780A (de)
IE (1) IE44872B1 (de)
IT (1) IT8049917A0 (de)
KE (1) KE3064A (de)
LU (1) LU77202A1 (de)
MY (1) MY8100135A (de)
NL (1) NL7704618A (de)
PH (2) PH16581A (de)
SE (1) SE437521B (de)
YU (2) YU39801B (de)
ZA (1) ZA772485B (de)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR820001564B1 (ko) * 1981-05-09 1982-09-02 동신제약 주식회사 새로운 실릴화제를 이용한 세팔로스포린 유도체의 제조방법
FR2555989B1 (fr) * 1983-12-06 1987-02-20 Bristol Myers Sa Monohydrate de chlorocephadroxyle
JPS60169486A (ja) * 1984-02-10 1985-09-02 Yamanouchi Pharmaceut Co Ltd ７−アミノ−３−置換メチル−３−セフエム−４−カルボン酸およびその低級アルキルシリル誘導体の製造法
GB8714180D0 (en) * 1987-06-17 1987-07-22 Rifar Srl Anhydrous crystalline cefadroxil
US4904776A (en) * 1987-04-24 1990-02-27 Rifar S.R.L. Method for producing crystalline cefadroxil hemihydrate
US4962195A (en) * 1987-04-24 1990-10-09 Rifar S.R.L. Solvate of cefadroxyl
US5023331A (en) * 1987-04-24 1991-06-11 Rifar S.R.L. Cefadroxil solvates
US4898938A (en) * 1987-08-03 1990-02-06 Rifar S.R.L. Method for preparing crystalline cefadroxil monohydrate
IT1233863B (it) * 1988-02-24 1992-04-21 Opos Biochimica Srl Procedimento per la preparazione dell'acido 7-(d(-)-alfa-amino-alfa- (p-idrossifenil)acetamido)-3-metil-3-cefem-4-carbossilico monoidrato
US5034522A (en) * 1988-08-02 1991-07-23 Biocraft Laboratories, Inc. Method for the production of 3-methyl cephem derivatives
WO1991000865A1 (en) * 1989-07-10 1991-01-24 Gema S.A. A novel stable form of cephradine, process for its production and intermediates used therein
US5142043A (en) * 1990-05-10 1992-08-25 Biocraft Laboratories, Inc. Process for preparing cephalexin monohydrate
US6248881B1 (en) 1991-03-08 2001-06-19 Biochemie Gmbh Intermediates and process for the production of 3-vinyl cephalosporins
DE69231815T2 (de) 1991-03-08 2001-09-27 Biochemie Ges.M.B.H., Kundl Verfahren zur Herstellung von Cephalosporinen und Zwischenprodukte in diesem Verfahren
AT396106B (de) * 1991-03-08 1993-06-25 Biochemie Gmbh Neues verfahren zur herstellung von 3-vinylcephalosporinverbindungen
SK283674B6 (sk) * 1993-03-12 2003-11-04 Pharmacia & Upjohn Company Kryštalická voľná kyselina ceftiofuru a spôsob jej prípravy a farmaceutická kompozícia, ktorá ju obsahuje
US5604222A (en) * 1993-12-27 1997-02-18 Lupin Laboratories, Ltd. Method for the preparation of 2-chloro sulfinyl azetidinones
DE69523447T2 (de) 1994-04-15 2002-05-16 Pharmacia & Upjohn Co., Kalamazoo Kristallformen von 1-[5-methansulfonamidoindolyl-2-carbonyl]-4-[3-[1-methylethylamino]-2-pyridinyl] piperazin
US5578721A (en) * 1994-07-11 1996-11-26 Lupin Laboratories Limited Process for preparation of 3-exomethylene cepham sulfoxide esters
US5574154A (en) * 1994-09-29 1996-11-12 Alnejma Bulk Pharmaceutical Co. A.B.P.C. Process for the preparation of cephalosporanic compounds
GB9423459D0 (en) * 1994-11-21 1995-01-11 Biochemie Gmbh Silylation process
IT1289955B1 (it) * 1997-02-21 1998-10-19 Solchem Italiana Spa Acyclovir sale sodico biidrato e sua preparazione
US6080427A (en) * 1997-04-17 2000-06-27 Bristol-Myers Squibb Company Cefadroxil monohydrate tablet formulation
IN190389B (de) 1999-07-14 2003-07-26 Ranbaxy Lab Ltd
AU5418300A (en) * 1999-07-14 2001-01-30 Ranbaxy Laboratories Limited Process for preparing crystalline cefadroxil hemihydrate from cefadroxil dimethylformamide solvate
US20060173064A1 (en) * 2001-08-24 2006-08-03 Lippa Arnold S (-)-1-(3,4-Dichlorophenyl)-3-azabi cyclo[3.1.0]hexane, compositions thereof, and uses for treating alcohol-related disorders
US6569887B2 (en) * 2001-08-24 2003-05-27 Dov Pharmaceuticals Inc. (−)-1-(3,4-Dichlorophenyl)-3-azabicyclo[3.1.0]hexane, compositions thereof, and uses as a dopamine-reuptake
US7235655B2 (en) * 2002-03-22 2007-06-26 Pharmacia & Upjohn Company Processes to prepare eplerenone
US20080081834A1 (en) 2002-07-31 2008-04-03 Lippa Arnold S Methods and compositions employing bicifadine for treating disability or functional impairment associated with acute pain, chronic pain, or neuropathic disorders
US20040077849A1 (en) * 2002-10-16 2004-04-22 Orchid Chemicals & Pharmaceuticals Limited Process for the preparation of cefadroxil
RU2005117630A (ru) * 2002-11-08 2006-01-20 Дов Фармасьютикал, Инк. (Us) Полиморфы гидрохлорида бицифадина
US7842791B2 (en) * 2002-12-19 2010-11-30 Nancy Jean Britten Dispersible pharmaceutical compositions
US7230097B2 (en) 2003-03-10 2007-06-12 Lupin Ltd. Process for preparation of 7-[α-Amino (4-hydroxyphenyl) acetamido]-3-substituted-3-cephem-4-carboxylic acid
US20070072945A1 (en) * 2004-03-31 2007-03-29 Pohoreski Anton Sulphur-containing oils for controlling plant pathogens and stimulating nutrient uptake
US20070043100A1 (en) * 2005-08-16 2007-02-22 Hagen Eric J Novel polymorphs of azabicyclohexane
US20060100263A1 (en) * 2004-11-05 2006-05-11 Anthony Basile Antipyretic compositions and methods
RU2008107336A (ru) * 2005-07-27 2009-09-10 Дов Фармасьютикал, Инк. (Us) Новые 1-арил-з-азабицикло{3.1.0.} гексаны: получение и применение для лечения психоневрологических расстройств
US20080045725A1 (en) 2006-04-28 2008-02-21 Murry Jerry A Process For The Synthesis of (+) And (-)-1-(3,4-Dichlorophenyl)-3-Azabicyclo[3.1.0]Hexane
KR101420451B1 (ko) * 2006-05-19 2014-07-16 디에스엠 시노켐 파마슈티칼스 네덜란드 비.브이. 세파드록실의 결정화 방법
US8138377B2 (en) * 2006-11-07 2012-03-20 Dov Pharmaceutical, Inc. Arylbicyclo[3.1.0]hexylamines and methods and compositions for their preparation and use
US20080269348A1 (en) * 2006-11-07 2008-10-30 Phil Skolnick Novel Arylbicyclo[3.1.0]Hexylamines And Methods And Compositions For Their Preparation And Use
DK2118074T3 (en) 2007-02-01 2014-03-10 Resverlogix Corp Compounds for the prevention and treatment of cardiovascular diseases
US9133159B2 (en) 2007-06-06 2015-09-15 Neurovance, Inc. 1-heteroaryl-3-azabicyclo[3.1.0]hexanes, methods for their preparation and their use as medicaments
WO2008153937A2 (en) * 2007-06-06 2008-12-18 Dov Pharmaceutical, Inc. Novel 1- heteroaryl-3-azabicyclo[3.1.0]hexanes, methods for their preparation and their use as medicaments
CA2992231C (en) 2009-03-18 2022-03-29 Resverlogix Corp. Phenyl-quinazolin-4(3h)-one and phenyl-pyrido[2,3-d]pyrimidin-4(3h)-one derivatives and compositions thereof useful as anti-inflammatory agents
CN102408438B (zh) * 2010-09-26 2015-01-07 石药集团中奇制药技术（石家庄）有限公司 一种头孢丙烯一水合物的制备方法
CN102134250B (zh) * 2011-01-19 2013-03-13 天津大学 一种头孢羟氨苄单水合物的结晶方法及结晶
US20140206740A1 (en) 2011-07-30 2014-07-24 Neurovance, Inc. Use Of (1R,5S)-(+)-(Napthalen-2-yl)-3-Azabicyclo[3.1.0]Hexane In The Treatment Of Conditions Affected By Monoamine Neurotransmitters

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US29164A (en) * 1860-07-17 Improvement in fish-oils
US3489750A (en) * 1967-09-05 1970-01-13 Bristol Myers Co 7-amino-cephalosporanic and decephalosporanic acid derivatives
USRE29164E (en) 1967-09-05 1977-03-29 Bristol-Myers Company 7-Amino-cephalosporanic and decephalosporanic acid derivatives
US3655656A (en) * 1970-06-04 1972-04-11 Lilly Co Eli Crystalline cephalexin monohydrate
US3694437A (en) * 1970-08-19 1972-09-26 Lilly Co Eli Process for preparing cephalosporin compounds
US3781282A (en) * 1971-01-20 1973-12-25 W Garbrecht Cephalosporin process and product
JPS5318515B2 (de) 1971-12-17 1978-06-15
DE2163514A1 (de) * 1971-12-21 1973-07-05 Toyama Chemical Co Ltd Verfahren zur herstellung von cephalosporinen
FR2166316A1 (en) * 1972-01-07 1973-08-17 Toyama Chemical Co Ltd 7-acylcephalosporins - prepd via a silylated inter
US3985741A (en) * 1972-09-15 1976-10-12 Bristol-Myers Company Production of p-hydroxycephalexin
BE806868A (fr) 1972-11-02 1974-02-15 Lorenzini Sas Inst Biochim Procede de preparation de l'acide 7-(d-alpha-aminophenylacetamido) -3-desacetoxycephalosporanique
GB1472746A (en) * 1973-07-05 1977-05-04 Glaxo Lab Ltd Cephalosporin compounds
US4091215A (en) * 1974-06-05 1978-05-23 Bristol-Myers Company 7-D-α-Amino-.alpha.-(p-acetoxyphenyl)acetamido-3-methyl-3-cephem-4-carboxylic acid
GB1476981A (en) 1974-06-05 1977-06-16 Bristol Myers Co Substituted penicillanic acids
AU2550077A (en) * 1976-06-14 1978-11-30 Merck Patent Gmbh Penicillins and cephalosporins
US4160863A (en) * 1977-04-07 1979-07-10 Bristol-Myers Company Process for the preparation of the crystalline monohydrate of 7-[D-α-aα-(p-hydroxyphenyl)acetamido]-3-methyl-3-cephem-4-carboxylic acid
NL162387C (nl) * 1977-09-06 1980-05-16 Gist Brocades Nv Werkwijze voor het bereiden van 6-(d-alpha-amino-p- -hydroxyfenylacetamido)penicillanzuur.
IT1126544B (it) * 1979-12-07 1986-05-21 Dobfar Spa Procedimento per la preparazione di derivati dell'acido 7-amino-desacetossi cefalosporanico

Also Published As

Publication number Publication date
USRE31730E (en) 1984-11-13
JPS52142091A (en) 1977-11-26
FR2365570B1 (de) 1980-06-06
YU137982A (en) 1983-04-30
DE2718741C2 (de) 1985-03-21
YU43081B (en) 1989-02-28
IE44872B1 (en) 1982-04-21
IE44872L (en) 1977-10-27
US4504657A (en) 1985-03-12
LU77202A1 (de) 1977-11-22
GB1532682A (en) 1978-11-22
JPH0246009B2 (de) 1990-10-12
ZA772485B (en) 1978-03-29
PH16581A (en) 1983-11-22
FR2365570A1 (fr) 1978-04-21
FI771339A (de) 1977-10-28
US4234721A (en) 1980-11-18
KE3064A (en) 1980-07-25
AU2460777A (en) 1978-11-02
PH17254A (en) 1984-07-03
NL7704618A (nl) 1977-10-31
JPS60185718A (ja) 1985-09-21
AT350183B (de) 1979-05-10
HK39780A (en) 1980-08-08
YU108677A (en) 1982-10-31
DK157026C (da) 1990-04-02
DK183277A (da) 1977-10-28
FI67704B (fi) 1985-01-31
JPS6022717B2 (ja) 1985-06-03
CA1115268A (en) 1981-12-29
ES458241A1 (es) 1978-11-01
IT8049917A0 (it) 1980-10-16
SE437521B (sv) 1985-03-04
GR72788B (de) 1983-12-05
FR2349589A1 (fr) 1977-11-25
ATA296277A (de) 1978-10-15
MY8100135A (en) 1981-12-31
FR2349589B1 (de) 1981-11-20
CH632270A5 (de) 1982-09-30
YU39801B (en) 1985-04-30
CY1066A (en) 1980-10-24
DK157026B (da) 1989-10-30
DE2718741A1 (de) 1977-11-17
AU510338B2 (en) 1980-06-19
SE7704739L (sv) 1977-12-01
BE853974A (fr) 1977-10-26

Similar Documents

Publication Publication Date Title
FI67704C (fi) Foerfarande foer framstaellning av ett nytt terapeutiskt anvaendbart kristallint monohydrat av 7-(d-alfa-amino-alfa-(p-hydroxifenyl)acetamido)-3-metyl-3-cefem-4-karboxylsyra
RU2118959C1 (ru) ГИДРОХЛОРИД 7β-[(Z)-2-(2-АМИНО-4-ТИАЗОЛИЛ)-2-ГИДРОКСИИМИНОАЦЕТАМИДО]-3-(1,2,3-ТРИАЗОЛ-4-ИЛ)-ТИОМЕТИЛТИО-3-ЦЕФЕМ-4-КАРБОНОВОЙ КИСЛОТЫ, ЕГО КРИСТАЛЛОГИДРАТ И СПОСОБ ИХ ПОЛУЧЕНИЯ
JPS638116B2 (de)
EA017984B1 (ru) Кристаллические безводные формы лактата n-гидрокси-3-[4-[[[2-(2-метил-1h-индол-3-ил)этил]амино]метил]фенил]-2e-2-акриламида
FR2677356A1 (fr) Derives heterocycliques d'acylamino-2 thiazoles-5 substitues, leur preparation et compositions pharmaceutiques en contenant.
JPS585186B2 (ja) シンキポリヨウドイオンセイベンゼンユウドウタイノ セイゾウホウ
US4160863A (en) Process for the preparation of the crystalline monohydrate of 7-[D-α-aα-(p-hydroxyphenyl)acetamido]-3-methyl-3-cephem-4-carboxylic acid
RU1804461C (ru) Способ получени кристаллического моногидрата цефадроксила
PT92275A (pt) Processo para a preparacao de hidratos de um antibiotico beta-lactamico
KR0158883B1 (ko) 결정성 세펨산 부가염 및 이의 제조방법
JPS59130889A (ja) 新規なセフアロスポリン中間体
JPH10511377A (ja) セフォタキシムの製造
SU1595340A3 (ru) Способ получени безводного кристаллического цефадроксила
RU2073680C1 (ru) Кристаллические кислотно-аддитивные соли чистых диастереомеров 1-(2,2-диметилпропионилокси)-этилового эфира 3-цефем-4-карбоновой кислоты и способы их получения
AU615026B2 (en) Crystalline beta-lactam solvate
JP2572563B2 (ja) セファロスポリン中間生成物の新規安定な結晶形
SU784780A3 (ru) Способ получени -изомеров производных пенициллина или их фармацевтически приемлемых солей
EP0094639A2 (de) Heptahydrat von Natrium-7-beta-(2D-2-amino-2-carboxyethylthioacetamido)-7-alpha-methoxy-3-(1-methyl-1H-tetrazol-5-yl)-thiomethyl-3-cephem-4-carboxylat, seine Herstellung und es enthaltende Präparate
FI72123C (fi) 7-/d(-)- -(4-etyl-2,3-dioxo-1 -piperazinkarboxiamido)- -(4-hydroxifenyl)acetamido/-3-/5-(1-metyl -1,2,3,4-tetrazolyl)tiometyl/- 3-cefem-4-karboxylsyrans n,n-dimetylacetamidaddukt och foerfarande foer framstaellning av denna.
KR830000341B1 (ko) 세팔로스포린 유도체의 제법
IE48581B1 (en) Benzolylureido-phenyl acetamido cephalosporins
KR810001937B1 (ko) 세파드록실 모노하이드레이트의 제조방법
CA1146543A (en) Cefadroxil salts with amino acids
JPH0118916B2 (de)
KR830000340B1 (ko) 세팔로스포린 유도체의 제법

Legal Events

Date Code Title Description
MA Patent expired
MA Patent expired

Owner name: BRISTOL-MYERS CO