FI65247C - Foerfarande foer framstaellning av nya terapeutiskt anvaendbara trans-4,4a,5,6,7,8,8a,9-1h(och 2h)-oktahydropyrazolo(3,4-g)kinoliner - Google Patents

Foerfarande foer framstaellning av nya terapeutiskt anvaendbara trans-4,4a,5,6,7,8,8a,9-1h(och 2h)-oktahydropyrazolo(3,4-g)kinoliner Download PDF

Info

Publication number
FI65247C
FI65247C FI792046A FI792046A FI65247C FI 65247 C FI65247 C FI 65247C FI 792046 A FI792046 A FI 792046A FI 792046 A FI792046 A FI 792046A FI 65247 C FI65247 C FI 65247C
Authority
FI
Finland
Prior art keywords
trans
mixture
allyl
therapeutic
methyl
Prior art date
Application number
FI792046A
Other languages
English (en)
Finnish (fi)
Other versions
FI792046A (fi
FI65247B (fi
Inventor
Edmund Carl Kornfeld
Nicholas James Bach
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of FI792046A publication Critical patent/FI792046A/fi
Priority to FI830705A priority Critical patent/FI68052C/fi
Priority to FI830706A priority patent/FI830706A0/fi
Priority to FI830707A priority patent/FI74459C/fi
Application granted granted Critical
Publication of FI65247B publication Critical patent/FI65247B/fi
Publication of FI65247C publication Critical patent/FI65247C/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Pyridine Compounds (AREA)
FI792046A 1979-01-22 1979-06-28 Foerfarande foer framstaellning av nya terapeutiskt anvaendbara trans-4,4a,5,6,7,8,8a,9-1h(och 2h)-oktahydropyrazolo(3,4-g)kinoliner FI65247C (fi)

Priority Applications (3)

Application Number Priority Date Filing Date Title
FI830705A FI68052C (fi) 1979-01-22 1983-03-02 Foerfarande foer framstaellning av nya terapeutiskt anvaendbara trans-4,4a,5,6,7,8,8a,9-oktahydro-1h(och 2h)-pyrazolo(3,4--g)kinoliner
FI830706A FI830706A0 (fi) 1979-01-22 1983-03-02 Foerfarande foer framstaellning av nya terapeutiskt anvaendbara trans-4,4a,5,6,7,8,8a,9-oktahydro-1h(och 2h) pyrazolo/3,4-g/kinoliner
FI830707A FI74459C (fi) 1979-01-22 1983-03-02 6-oxodekahydrokinolinderivat anvaendbart som mellanprodukt vid framstaellning av tricykliska dopamin-agonister.

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US506179A 1979-01-22 1979-01-22
US506179 1979-01-22
US06/031,641 US4198415A (en) 1979-01-22 1979-04-19 Prolactin inhibiting octahydro pyrazolo[3,4-g]quinolines
US3164179 1979-04-19

Publications (3)

Publication Number Publication Date
FI792046A FI792046A (fi) 1980-07-23
FI65247B FI65247B (fi) 1983-12-30
FI65247C true FI65247C (fi) 1984-04-10

Family

ID=26673868

Family Applications (1)

Application Number Title Priority Date Filing Date
FI792046A FI65247C (fi) 1979-01-22 1979-06-28 Foerfarande foer framstaellning av nya terapeutiskt anvaendbara trans-4,4a,5,6,7,8,8a,9-1h(och 2h)-oktahydropyrazolo(3,4-g)kinoliner

Country Status (25)

Country Link
US (1) US4198415A (da)
EP (2) EP0050881B1 (da)
AT (1) AT371819B (da)
AU (1) AU528076B2 (da)
CA (1) CA1136140A (da)
CH (3) CH644377A5 (da)
DD (5) DD148340A5 (da)
DE (2) DE2966945D1 (da)
DK (1) DK268879A (da)
EG (1) EG14696A (da)
ES (4) ES482087A1 (da)
FI (1) FI65247C (da)
FR (5) FR2446832A1 (da)
GB (4) GB2092581A (da)
GR (1) GR72516B (da)
IE (1) IE48394B1 (da)
IL (1) IL57668A (da)
LU (1) LU81439A1 (da)
MY (1) MY8500683A (da)
NZ (2) NZ190835A (da)
PH (3) PH14909A (da)
PL (4) PL119715B1 (da)
PT (1) PT69829A (da)
RO (2) RO82159A (da)
ZA (1) ZA793243B (da)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL65269A0 (en) * 1981-03-24 1982-05-31 Lilly Co Eli 6-substituted hexahydroindazolo or hexahydroisoindolo isoquinolines
US4540787A (en) * 1982-06-03 1985-09-10 Eli Lilly And Company Method of preparing trans-D1-1-alkyl-6-oxodecahydroquinolines
US4468401A (en) * 1982-11-03 1984-08-28 Eli Lilly And Company Method of blocking peripheral norepinephrine release
US4647667A (en) * 1982-11-03 1987-03-03 Eli Lilly And Company Octa- and deca-hydroquinoline intermediates
US4567266A (en) * 1982-11-03 1986-01-28 Eli Lilly And Company Method of preparing octahydro-1H(and 2H)-pyrazolo[3,4-g]quinolines
US4471121A (en) * 1982-11-03 1984-09-11 Eli Lilly And Company Method of resolving trans-d alpha-1-n-propyl-6-oxodecahydroquinoline and di-p-toluoyltartaric acid salts thereof
ES524452A0 (es) * 1982-11-03 1985-04-16 Lilly Co Eli Un procedimiento para la preparacion de derivados de pirazolo-quinolinas.
EP0127708B1 (en) * 1983-06-03 1987-09-09 Eli Lilly And Company Trans-dl-1-alkyl-6-alkoxyoctahydroquinolines
US4626591A (en) * 1983-08-10 1986-12-02 Eli Lilly And Company Trans-dl-1-alkyl-6-alkoxy-1,2,3,4,4a,5,8,8a octa-hydroquinolines
US4521421A (en) * 1983-09-26 1985-06-04 Eli Lilly And Company Treatment of sexual dysfunction
US4528290A (en) * 1984-01-30 1985-07-09 Eli Lilly And Company Stimulating dopamine D-1 receptors
US4501890A (en) * 1983-09-26 1985-02-26 Eli Lilly And Company Trans-(±)-2,4,6-substituted-5,5a,6,7,8,9,9a,10-octahydro-pyrimido[4,5-g]quinolines
IL72730A (en) * 1983-09-26 1987-10-30 Lilly Co Eli Octahydro-2-pyrimido(4,5-g)quinolinamines,their preparation and pharmaceutical compositions containing them
US4507478A (en) * 1983-09-26 1985-03-26 Eli Lilly And Company 2-Mercaptopyrimidohexahydroquinolines and related compounds
IL73001A0 (en) * 1983-09-26 1984-12-31 Lilly Co Eli Improvements in and relating to 6-oxodecahydroquinolines
CA1270488A (en) * 1983-09-26 1990-06-19 John M. Schaus Pyrazole-ring alkylated pyrazoloquinolines and intermediates
US4689415A (en) * 1984-04-18 1987-08-25 Eli Lilly And Company Trans octahydroquinoline intermediate
US4587351A (en) * 1984-04-18 1986-05-06 Eli Lilly And Company Synthesis of ketones with calcium hypochlorite
US4537893A (en) * 1984-04-27 1985-08-27 Eli Lilly And Company Octahydrothiazolo[4,5-g]quinolines and use as prolactin secretion inhibitors
PH22541A (en) * 1984-08-02 1988-10-17 Lilly Co Eli Octahydro-oxazolo(4,5-g)quinolines
US4600777A (en) * 1984-08-02 1986-07-15 Eli Lilly And Company Method of preparing 1-alkyl-7-oxodecahydroquinolines, and cis(±) and tran(±)isomers so prepared
US4537964A (en) * 1984-08-03 1985-08-27 Eli Lilly And Company Method of preparing permissibly-substituted 1H(and 2H)pyrazolo[3,4-g]quinolines; pyrimido[4,5,g]quinolines; thiazolo[4,5,g]quinolines and intermediates therefore
US4537965A (en) * 1984-08-03 1985-08-27 Eli Lilly And Company Method of preparing 4aR,8aR-5-permissibly substituted-6-oxo-octahydro-1H(and 2H)-pyrazolo[3,4-g]quinolines, useful as intermediates
NZ212947A (en) * 1984-08-03 1988-07-28 Lilly Co Eli Preparation of tricyclic quinoline derivatives
US4552956A (en) * 1984-08-15 1985-11-12 Eli Lilly And Company Partially hydrogenated pyrazolo, pyrimido and thiazolo[1,4]benzoxazines
US4587336A (en) * 1984-08-15 1986-05-06 Eli Lilly And Company Partially hydrogenated intermediate pyrazolo, pyrimido and thiazolo[1,4]benzoxazines
FR2578254B1 (fr) * 1985-03-01 1987-03-06 Roussel Uclaf Nouveaux derives de la pyrazolobenzoxazine, leurs sels, procede de preparation, application a titre de medicaments, compositions les renfermant, et des intermediaires
US4595754A (en) * 1985-03-04 1986-06-17 Eli Lilly And Company Process for preparing cis N-alkylperhydroquinolines
US4927828A (en) * 1985-03-08 1990-05-22 The Trustees Of Princeton University Diastereoisomeric tetrahydropyrido-(2,3,d) pyrimidine derivatives
US4622398A (en) * 1985-06-24 1986-11-11 Eli Lilly And Company Dialkylaminotetrahydroquinazoline
US4977160A (en) * 1986-06-16 1990-12-11 Eli Lilly And Company BCD tricyclic ergoline part-structure analogues
US4826986A (en) * 1986-06-16 1989-05-02 Eli Lilly And Company 6-Oxo-trans-octa- and decahydroquinolines
US5134143A (en) * 1986-06-16 1992-07-28 Eli Lilly And Company BCD tricyclic ergoline part-structure analogues
US4762843A (en) * 1986-09-15 1988-08-09 Warner-Lambert Company Hetero [f] fused carbocyclic pyridines as dopaminergic agents
US4977149A (en) * 1989-07-24 1990-12-11 Eli Lilly And Company Pyridoquinoline dopamine agonists, compositions and use
US5057515A (en) * 1989-07-24 1991-10-15 Eli Lilly And Company Method for agonizing a dopamine receptor
US5006525A (en) * 1989-07-24 1991-04-09 Eli Lilly And Company Dopamine agonists method
US4939259A (en) * 1989-07-24 1990-07-03 Eli Lilly And Company 2-oxo-pyrido[2,3-g]quinoline derivatives
JPH0772175B2 (ja) * 1990-09-28 1995-08-02 フアイザー・インコーポレイテツド 窒素含有非芳香族複素環の縮合環類似体
US5416090A (en) * 1991-01-31 1995-05-16 Eli Lilly And Company Method of treating inflammation
US20030212085A1 (en) * 2001-04-17 2003-11-13 Mccall Robert B. Treatment of fibromyalgia and chronic fatigue syndrome
MY148644A (en) * 2005-07-18 2013-05-15 Orion Corp New pharmaceutical compounds

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3084165A (en) * 1959-05-21 1963-04-02 Bayer Ag Quinone derivatives and processes for producing the same
US3600393A (en) * 1969-03-03 1971-08-17 Aldrich Chem Co Inc Dialkylamino alkylamino pyrazolo (3,4b) quinolines
US3859291A (en) * 1973-10-01 1975-01-07 Morton Norwich Products Inc 9-(p-anisidino)-7-methyl-(1h)-pyrazolo(3,4-f)quinoline
US4028381A (en) * 1975-05-05 1977-06-07 Ciba-Geigy Corporation Pyrazolobenzazepines

Also Published As

Publication number Publication date
FR2446832B1 (da) 1983-08-05
DE2966951D1 (en) 1984-06-07
DD148517A5 (de) 1981-05-27
GB2092581A (en) 1982-08-18
NZ201279A (en) 1984-07-06
IL57668A (en) 1983-06-15
FI792046A (fi) 1980-07-23
PL120037B1 (en) 1982-02-27
GB2040915A (en) 1980-09-03
ATA452479A (de) 1982-12-15
FI65247B (fi) 1983-12-30
EP0050881B1 (en) 1984-04-25
MY8500683A (en) 1985-12-31
PH14908A (en) 1982-01-29
CA1136140A (en) 1982-11-23
GB2092580B (en) 1983-08-03
EG14696A (en) 1986-09-30
FR2446834A1 (fr) 1980-08-14
PL119715B1 (en) 1982-01-30
FR2446834B1 (da) 1982-03-05
ES482089A1 (es) 1980-08-01
GB2092580A (en) 1982-08-18
NZ190835A (en) 1984-07-06
FR2446821A1 (fr) 1980-08-14
CH644607A5 (fr) 1984-08-15
DD148339A5 (de) 1981-05-20
DD144670A5 (de) 1980-10-29
RO82159B (ro) 1983-06-30
EP0013787B1 (en) 1984-05-02
ES482091A1 (es) 1980-04-01
GR72516B (da) 1983-11-16
FR2446822A1 (fr) 1980-08-14
CH644365A5 (fr) 1984-07-31
PH14909A (en) 1982-01-29
PL119785B1 (en) 1982-01-30
AT371819B (de) 1983-08-10
DD148518A5 (de) 1981-05-27
LU81439A1 (fr) 1979-09-12
EP0050881A1 (en) 1982-05-05
EP0013787A1 (en) 1980-08-06
GB2092579A (en) 1982-08-18
RO77563A (ro) 1981-11-04
US4198415A (en) 1980-04-15
IE48394B1 (en) 1985-01-09
FR2446832A1 (fr) 1980-08-14
FR2446822B1 (da) 1981-10-02
PL122153B1 (en) 1982-06-30
RO82159A (ro) 1983-07-07
ZA793243B (en) 1981-02-25
PL216719A1 (da) 1980-06-16
PT69829A (en) 1979-07-01
AU528076B2 (en) 1983-04-14
AU4844579A (en) 1980-07-31
FR2446820A1 (fr) 1980-08-14
GB2040915B (en) 1983-05-11
IE791209L (en) 1980-07-22
ES482087A1 (es) 1980-04-01
DD148340A5 (de) 1981-05-20
CH644377A5 (fr) 1984-07-31
DK268879A (da) 1980-07-23
PH14991A (en) 1982-03-12
DE2966945D1 (de) 1984-05-30
ES482090A1 (es) 1980-04-01
IL57668A0 (en) 1979-10-31

Similar Documents

Publication Publication Date Title
FI65247C (fi) Foerfarande foer framstaellning av nya terapeutiskt anvaendbara trans-4,4a,5,6,7,8,8a,9-1h(och 2h)-oktahydropyrazolo(3,4-g)kinoliner
US5614530A (en) Substituted N-arylmethyl and heterocyclmethyl-1H-pyrazolo[3,4-b]quinolin-4-amines and compositions and methods of use thereof
US5061795A (en) Hexa-cyclic compound
DE69831236T2 (de) Trizyklische pyrol- oder pyrazolderivate
WO1994004533A1 (en) Condensed indole derivatives as 5ht2c and 5ht2b antagonists
KR870001072B1 (ko) 옥타하이드로티아졸로[4,5-g] 퀴놀린의 제조방법
FI71936B (fi) Foerfarande foer framstaellning av neuroleptiskt aktiva 2-substituerade-8-fluor-5-(4-fluorfenyl)-2,3,4,4a 5,9b-hexahydro-4a 9b-trans-1h-pyrido/4,3-b/indolderivat
US5512590A (en) 5,6-dihydro-4h-imidazo 2',1':2,3!imidazo- 4,5,1-ij!quinoline and 4,5-dihydroimidazo- 1,2-a!pyrolo 1,2,3-cd!benzimidazole derivatives, their preparation and application in therapeutics
FI65248C (fi) Foerfarande foer framstaellning av terapeutiskt anvaendbara trns-dl-5-alkyl-4,4a,5,6,7,8,8a,9-oktahydro-2h-pyrrolo(3,4- g)inoliner
JPH09501954A (ja) イミダゾ［５，１−ｃ］［１，４］ベンゾキサジン−１−オンのイミダゾリルアルキル誘導体およびそれらの製造法
KR880001430B1 (ko) 옥타하이드로-옥사졸로[4,5-g]퀴놀린 유도체
FI89801C (fi) Foerfarande foer framstaellning av terapeutiskt aktiva kinolinderivat
FI68052B (fi) Foerfarande foer framstaellning av nya terapeutiskt anvaendbara trans-4,4a,5,6,7,8,8a,9-oktahydro-1h(och 2h)-pyrazolo-(3,4-g)kinoliner
FI78091C (fi) Analogifoerfarande foer framstaellning av saosom dopaminoagonister anvaendbara pyrimido/4,5-g/kinolinderivat.
US4367231A (en) Method of using octahydro pyrazolo[3,4-g]quinolines
US4515949A (en) [2-(1H-indol-1-yl)ethyl]-2-piperazine and pyrido[1,2-a]indol-9-one as intermediates for pyrazino(2,3-3,4)pyrido(1,2-a) indoles which are useful for treating hypertension in mammals
EP0277625A2 (en) Tetrahydropyrido[3',4':4,5]pyrrolo[2,3-c]quinolines, intermediates and a process for the preparation thereof and their use as hypotensive agents
US20040072856A1 (en) 4-ANILINO[2,3-b]QUINOLINE DERIVATIVES,THEIR PREPARATION PROCECC ANDPHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME
JP3354526B2 (ja) トロバフロキサシン酸塩の製造方法
FI89601B (fi) Foerfarande foer framstaellning av terapeutiskt aktiva imidazo/2,1-b/kinazolin-5(3H)-on- och imidazo/1,2-a/pyrido/2,3-d/pyrimidin-5(3H)-onderivat
CA1133487A (en) Octahydro pyrazolo (3,4-g) quinolines
EP0013789B1 (en) Amino-substituted 4,5,6,7-tetrahydro-1h (or 2h)-indazoles, their preparation and pharmaceutical compositions containing them
KR830000273B1 (ko) 옥타하이드로 피라졸로[3,4-g]퀴놀린의 제조방법
EP0014792B1 (en) Tetrahydro-2h-benzo(c)pyrroles, their preparation, pharmaceutical compositions containing them and the compounds for use as therapeuticals
KR830000326B1 (ko) 옥타하이드로 피라졸로[3,4-g] 퀴놀린의 제조방법

Legal Events

Date Code Title Description
MM Patent lapsed

Owner name: ELI LILLY AND COMPANY