ES482091A1 - Un procedimiento para la preparacion de compuestos interme- dios utiles en la preparacion de octahidropirazolo (3,4-g) quinolinas. - Google Patents

Un procedimiento para la preparacion de compuestos interme- dios utiles en la preparacion de octahidropirazolo (3,4-g) quinolinas.

Info

Publication number
ES482091A1
ES482091A1 ES482091A ES482091A ES482091A1 ES 482091 A1 ES482091 A1 ES 482091A1 ES 482091 A ES482091 A ES 482091A ES 482091 A ES482091 A ES 482091A ES 482091 A1 ES482091 A1 ES 482091A1
Authority
ES
Spain
Prior art keywords
quinolines
preparation
pharmaceutical compositions
compositions containing
octahydro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES482091A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of ES482091A1 publication Critical patent/ES482091A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems

Abstract

Un procedimiento para la preparación de compuestos intermedios útiles en la preparación de octahidropirazolo (3,4-g) quinolinas de fórmula **(Fórmula-01)** donde R es alquilo o bencilo y R1 es COOZ'', donde Z'' es alquilo C1-C2 o fenilo-alquilo C1-C2, cuyo procedimiento se caracteriza por haber reaccionar un compuesto de fórmula **(Fórmula-02)** donde R y Z'' son los definidos anteriormente y Z es alquilo C1-C3, alquenilo C2-C3, alquinilo C2- C3, cicloalquilo C5-C6, fenilo o fenilo sustituido, mediante hidrólisis para formar un ácido 6-hidroxi-3-carboxílico, seguido de reesterificación con un alcohol en presencia de un ácido.
ES482091A 1979-01-22 1979-06-29 Un procedimiento para la preparacion de compuestos interme- dios utiles en la preparacion de octahidropirazolo (3,4-g) quinolinas. Expired ES482091A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US506179A 1979-01-22 1979-01-22
US06/031,641 US4198415A (en) 1979-01-22 1979-04-19 Prolactin inhibiting octahydro pyrazolo[3,4-g]quinolines

Publications (1)

Publication Number Publication Date
ES482091A1 true ES482091A1 (es) 1980-04-01

Family

ID=26673868

Family Applications (4)

Application Number Title Priority Date Filing Date
ES482089A Expired ES482089A1 (es) 1979-01-22 1979-06-29 Un procedimiento para la preparacion de octahidro pirazolo- (3,4-g) aminolinas.
ES482091A Expired ES482091A1 (es) 1979-01-22 1979-06-29 Un procedimiento para la preparacion de compuestos interme- dios utiles en la preparacion de octahidropirazolo (3,4-g) quinolinas.
ES482090A Expired ES482090A1 (es) 1979-01-22 1979-06-29 Un procedimiento para la preparacion de compuestos interme- dios utiles en la preparacion de octahidropirazolo (3,4-g) quinolinas.
ES482087A Expired ES482087A1 (es) 1979-01-22 1979-06-29 Un procedimiento para la preparacion de un compuesto.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES482089A Expired ES482089A1 (es) 1979-01-22 1979-06-29 Un procedimiento para la preparacion de octahidro pirazolo- (3,4-g) aminolinas.

Family Applications After (2)

Application Number Title Priority Date Filing Date
ES482090A Expired ES482090A1 (es) 1979-01-22 1979-06-29 Un procedimiento para la preparacion de compuestos interme- dios utiles en la preparacion de octahidropirazolo (3,4-g) quinolinas.
ES482087A Expired ES482087A1 (es) 1979-01-22 1979-06-29 Un procedimiento para la preparacion de un compuesto.

Country Status (25)

Country Link
US (1) US4198415A (es)
EP (2) EP0013787B1 (es)
AT (1) AT371819B (es)
AU (1) AU528076B2 (es)
CA (1) CA1136140A (es)
CH (3) CH644377A5 (es)
DD (5) DD148340A5 (es)
DE (2) DE2966951D1 (es)
DK (1) DK268879A (es)
EG (1) EG14696A (es)
ES (4) ES482089A1 (es)
FI (1) FI65247C (es)
FR (5) FR2446832A1 (es)
GB (4) GB2040915B (es)
GR (1) GR72516B (es)
IE (1) IE48394B1 (es)
IL (1) IL57668A (es)
LU (1) LU81439A1 (es)
MY (1) MY8500683A (es)
NZ (2) NZ201279A (es)
PH (3) PH14909A (es)
PL (4) PL120037B1 (es)
PT (1) PT69829A (es)
RO (2) RO82159A (es)
ZA (1) ZA793243B (es)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL65269A0 (en) * 1981-03-24 1982-05-31 Lilly Co Eli 6-substituted hexahydroindazolo or hexahydroisoindolo isoquinolines
US4540787A (en) * 1982-06-03 1985-09-10 Eli Lilly And Company Method of preparing trans-D1-1-alkyl-6-oxodecahydroquinolines
US4468401A (en) * 1982-11-03 1984-08-28 Eli Lilly And Company Method of blocking peripheral norepinephrine release
US4471121A (en) * 1982-11-03 1984-09-11 Eli Lilly And Company Method of resolving trans-d alpha-1-n-propyl-6-oxodecahydroquinoline and di-p-toluoyltartaric acid salts thereof
ES524452A0 (es) * 1982-11-03 1985-04-16 Lilly Co Eli Un procedimiento para la preparacion de derivados de pirazolo-quinolinas.
US4567266A (en) * 1982-11-03 1986-01-28 Eli Lilly And Company Method of preparing octahydro-1H(and 2H)-pyrazolo[3,4-g]quinolines
US4647667A (en) * 1982-11-03 1987-03-03 Eli Lilly And Company Octa- and deca-hydroquinoline intermediates
EP0127708B1 (en) * 1983-06-03 1987-09-09 Eli Lilly And Company Trans-dl-1-alkyl-6-alkoxyoctahydroquinolines
US4626591A (en) * 1983-08-10 1986-12-02 Eli Lilly And Company Trans-dl-1-alkyl-6-alkoxy-1,2,3,4,4a,5,8,8a octa-hydroquinolines
US4528290A (en) * 1984-01-30 1985-07-09 Eli Lilly And Company Stimulating dopamine D-1 receptors
US4521421A (en) * 1983-09-26 1985-06-04 Eli Lilly And Company Treatment of sexual dysfunction
RO89126A (ro) * 1983-09-26 1986-04-30 Eli Lilly And Co,Us Procedeu de preparare a unor derivati de chinolina
US4507478A (en) * 1983-09-26 1985-03-26 Eli Lilly And Company 2-Mercaptopyrimidohexahydroquinolines and related compounds
IL73001A0 (en) * 1983-09-26 1984-12-31 Lilly Co Eli Improvements in and relating to 6-oxodecahydroquinolines
US4501890A (en) * 1983-09-26 1985-02-26 Eli Lilly And Company Trans-(±)-2,4,6-substituted-5,5a,6,7,8,9,9a,10-octahydro-pyrimido[4,5-g]quinolines
CA1270488A (en) * 1983-09-26 1990-06-19 John M. Schaus Pyrazole-ring alkylated pyrazoloquinolines and intermediates
US4587351A (en) * 1984-04-18 1986-05-06 Eli Lilly And Company Synthesis of ketones with calcium hypochlorite
US4689415A (en) * 1984-04-18 1987-08-25 Eli Lilly And Company Trans octahydroquinoline intermediate
US4537893A (en) * 1984-04-27 1985-08-27 Eli Lilly And Company Octahydrothiazolo[4,5-g]quinolines and use as prolactin secretion inhibitors
DK349185A (da) * 1984-08-02 1986-02-03 Lilly Co Eli Octahydro-oxazolo(4,5-g) quinolin-forbindelser og fremgangsmaade til fremstilling heraf
US4600777A (en) * 1984-08-02 1986-07-15 Eli Lilly And Company Method of preparing 1-alkyl-7-oxodecahydroquinolines, and cis(±) and tran(±)isomers so prepared
HUT40656A (en) * 1984-08-03 1987-01-28 Lilly Co Eli Process for producing tricyclic quinoline derivatives
US4537964A (en) * 1984-08-03 1985-08-27 Eli Lilly And Company Method of preparing permissibly-substituted 1H(and 2H)pyrazolo[3,4-g]quinolines; pyrimido[4,5,g]quinolines; thiazolo[4,5,g]quinolines and intermediates therefore
US4537965A (en) * 1984-08-03 1985-08-27 Eli Lilly And Company Method of preparing 4aR,8aR-5-permissibly substituted-6-oxo-octahydro-1H(and 2H)-pyrazolo[3,4-g]quinolines, useful as intermediates
US4552956A (en) * 1984-08-15 1985-11-12 Eli Lilly And Company Partially hydrogenated pyrazolo, pyrimido and thiazolo[1,4]benzoxazines
US4587336A (en) * 1984-08-15 1986-05-06 Eli Lilly And Company Partially hydrogenated intermediate pyrazolo, pyrimido and thiazolo[1,4]benzoxazines
FR2578254B1 (fr) * 1985-03-01 1987-03-06 Roussel Uclaf Nouveaux derives de la pyrazolobenzoxazine, leurs sels, procede de preparation, application a titre de medicaments, compositions les renfermant, et des intermediaires
US4595754A (en) * 1985-03-04 1986-06-17 Eli Lilly And Company Process for preparing cis N-alkylperhydroquinolines
US4927828A (en) * 1985-03-08 1990-05-22 The Trustees Of Princeton University Diastereoisomeric tetrahydropyrido-(2,3,d) pyrimidine derivatives
US4622398A (en) * 1985-06-24 1986-11-11 Eli Lilly And Company Dialkylaminotetrahydroquinazoline
US4826986A (en) * 1986-06-16 1989-05-02 Eli Lilly And Company 6-Oxo-trans-octa- and decahydroquinolines
US5134143A (en) * 1986-06-16 1992-07-28 Eli Lilly And Company BCD tricyclic ergoline part-structure analogues
US4977160A (en) * 1986-06-16 1990-12-11 Eli Lilly And Company BCD tricyclic ergoline part-structure analogues
US4762843A (en) * 1986-09-15 1988-08-09 Warner-Lambert Company Hetero [f] fused carbocyclic pyridines as dopaminergic agents
US5057515A (en) * 1989-07-24 1991-10-15 Eli Lilly And Company Method for agonizing a dopamine receptor
US5006525A (en) * 1989-07-24 1991-04-09 Eli Lilly And Company Dopamine agonists method
US4977149A (en) * 1989-07-24 1990-12-11 Eli Lilly And Company Pyridoquinoline dopamine agonists, compositions and use
US4939259A (en) * 1989-07-24 1990-07-03 Eli Lilly And Company 2-oxo-pyrido[2,3-g]quinoline derivatives
DK0550635T3 (da) * 1990-09-28 1995-09-04 Pfizer Cykliske forbindelser med kondeserede ringe, som er analoger til nitrogenholdige ikke-aromatiske het erocykliske forbindelser
US5416090A (en) * 1991-01-31 1995-05-16 Eli Lilly And Company Method of treating inflammation
US20030212085A1 (en) * 2001-04-17 2003-11-13 Mccall Robert B. Treatment of fibromyalgia and chronic fatigue syndrome
MY148644A (en) * 2005-07-18 2013-05-15 Orion Corp New pharmaceutical compounds

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3084165A (en) * 1959-05-21 1963-04-02 Bayer Ag Quinone derivatives and processes for producing the same
US3600393A (en) * 1969-03-03 1971-08-17 Aldrich Chem Co Inc Dialkylamino alkylamino pyrazolo (3,4b) quinolines
US3859291A (en) * 1973-10-01 1975-01-07 Morton Norwich Products Inc 9-(p-anisidino)-7-methyl-(1h)-pyrazolo(3,4-f)quinoline
US4028381A (en) * 1975-05-05 1977-06-07 Ciba-Geigy Corporation Pyrazolobenzazepines

Also Published As

Publication number Publication date
DD144670A5 (de) 1980-10-29
DD148340A5 (de) 1981-05-20
PL119715B1 (en) 1982-01-30
CH644365A5 (fr) 1984-07-31
IL57668A0 (en) 1979-10-31
EP0050881A1 (en) 1982-05-05
IL57668A (en) 1983-06-15
LU81439A1 (fr) 1979-09-12
GB2092581A (en) 1982-08-18
CH644607A5 (fr) 1984-08-15
PH14908A (en) 1982-01-29
GB2092580A (en) 1982-08-18
AU4844579A (en) 1980-07-31
PT69829A (en) 1979-07-01
AU528076B2 (en) 1983-04-14
DK268879A (da) 1980-07-23
PH14991A (en) 1982-03-12
DE2966945D1 (de) 1984-05-30
IE791209L (en) 1980-07-22
NZ201279A (en) 1984-07-06
ES482089A1 (es) 1980-08-01
FR2446832B1 (es) 1983-08-05
PL120037B1 (en) 1982-02-27
ES482090A1 (es) 1980-04-01
PL122153B1 (en) 1982-06-30
DD148517A5 (de) 1981-05-27
FR2446822A1 (fr) 1980-08-14
PL119785B1 (en) 1982-01-30
DD148518A5 (de) 1981-05-27
PH14909A (en) 1982-01-29
FR2446821A1 (fr) 1980-08-14
ES482087A1 (es) 1980-04-01
IE48394B1 (en) 1985-01-09
FI65247B (fi) 1983-12-30
GR72516B (es) 1983-11-16
MY8500683A (en) 1985-12-31
CA1136140A (en) 1982-11-23
GB2092580B (en) 1983-08-03
DE2966951D1 (en) 1984-06-07
DD148339A5 (de) 1981-05-20
RO82159B (ro) 1983-06-30
FR2446832A1 (fr) 1980-08-14
GB2040915B (en) 1983-05-11
ATA452479A (de) 1982-12-15
FI792046A (fi) 1980-07-23
GB2040915A (en) 1980-09-03
US4198415A (en) 1980-04-15
RO82159A (ro) 1983-07-07
EG14696A (en) 1986-09-30
ZA793243B (en) 1981-02-25
FR2446820A1 (fr) 1980-08-14
FI65247C (fi) 1984-04-10
AT371819B (de) 1983-08-10
FR2446822B1 (es) 1981-10-02
CH644377A5 (fr) 1984-07-31
GB2092579A (en) 1982-08-18
RO77563A (ro) 1981-11-04
EP0050881B1 (en) 1984-04-25
NZ190835A (en) 1984-07-06
FR2446834A1 (fr) 1980-08-14
EP0013787B1 (en) 1984-05-02
EP0013787A1 (en) 1980-08-06
PL216719A1 (es) 1980-06-16
FR2446834B1 (es) 1982-03-05

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