FI111641B - Menetelmä aryylipiperatsinyyli-heterosyklisten yhdisteiden valmistamiseksi - Google Patents

Menetelmä aryylipiperatsinyyli-heterosyklisten yhdisteiden valmistamiseksi Download PDF

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Publication number
FI111641B
FI111641B FI932012A FI932012A FI111641B FI 111641 B FI111641 B FI 111641B FI 932012 A FI932012 A FI 932012A FI 932012 A FI932012 A FI 932012A FI 111641 B FI111641 B FI 111641B
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FI
Finland
Prior art keywords
formula
neutralizing agent
piperazine
water
compound
Prior art date
Application number
FI932012A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI932012A0 (fi
FI932012A (fi
Inventor
Frank R Busch
Dennis M Godek
Douglas J M Allen
Sabeto A Diroma
Paul Bowles
Original Assignee
Pfizer
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Publication date
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Application filed by Pfizer filed Critical Pfizer
Publication of FI932012A0 publication Critical patent/FI932012A0/fi
Publication of FI932012A publication Critical patent/FI932012A/fi
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Quinoline Compounds (AREA)
  • Lubricants (AREA)
  • Eye Examination Apparatus (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Management, Administration, Business Operations System, And Electronic Commerce (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Cephalosporin Compounds (AREA)
FI932012A 1992-08-26 1993-05-04 Menetelmä aryylipiperatsinyyli-heterosyklisten yhdisteiden valmistamiseksi FI111641B (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/936,179 US5206366A (en) 1992-08-26 1992-08-26 Process for preparing aryl piperazinyl-heterocyclic compounds
US93617992 1992-08-26

Publications (3)

Publication Number Publication Date
FI932012A0 FI932012A0 (fi) 1993-05-04
FI932012A FI932012A (fi) 1994-02-27
FI111641B true FI111641B (fi) 2003-08-29

Family

ID=25468285

Family Applications (1)

Application Number Title Priority Date Filing Date
FI932012A FI111641B (fi) 1992-08-26 1993-05-04 Menetelmä aryylipiperatsinyyli-heterosyklisten yhdisteiden valmistamiseksi

Country Status (27)

Country Link
US (1) US5206366A (zh)
EP (2) EP1029861B1 (zh)
JP (1) JP2742370B2 (zh)
KR (1) KR0123441B1 (zh)
CN (1) CN1033089C (zh)
AT (2) ATE273976T1 (zh)
AU (1) AU642836B1 (zh)
BR (1) BR9302065A (zh)
CZ (1) CZ281893B6 (zh)
DE (2) DE69333597T2 (zh)
DK (2) DK0584903T3 (zh)
EG (1) EG20214A (zh)
ES (2) ES2225015T3 (zh)
FI (1) FI111641B (zh)
HU (1) HU223312B1 (zh)
IL (1) IL105622A (zh)
MX (1) MX9302813A (zh)
MY (1) MY109731A (zh)
NO (1) NO300685B1 (zh)
NZ (1) NZ247539A (zh)
PL (1) PL173840B1 (zh)
PT (2) PT1029861E (zh)
RU (1) RU2061695C1 (zh)
SI (1) SI9300287A (zh)
SK (1) SK280584B6 (zh)
YU (1) YU48964B (zh)
ZA (1) ZA936225B (zh)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
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US5206366A (en) * 1992-08-26 1993-04-27 Pfizer Inc. Process for preparing aryl piperazinyl-heterocyclic compounds
US5338846A (en) * 1992-08-26 1994-08-16 Pfizer Inc. Process for preparing aryl piperazinyl-heterocyclic compounds with a piperazine salt
US5359068A (en) * 1993-06-28 1994-10-25 Pfizer Inc. Processes and intermediates for the preparation of 5-[2-(4-(benzoisothiazol-3-yl)-piperazin-1-yl)ethyl]-6-chloro-1,3-dihydro-indol-2-one
ATE199147T1 (de) * 1995-06-06 2001-02-15 Aventis Pharma Inc Benzisoxazol- und indazol- derivate als antipsychotika
ATE236902T1 (de) * 1996-05-07 2003-04-15 Pfizer Mesylat des trihydrats des 5-(2-(4-(1,2- benzothiazol-3-yl)-1-piperazinyl)ethyl)-6-chlor 1,3-dihydro-2(1h)-indol-2-ons (=ziprasidon), seine herstellung und seine anwendung als dopamin d2 antagonist
TW491847B (en) * 1996-05-07 2002-06-21 Pfizer Mesylate dihydrate salts of 5-(2-(4-(1,2-benzisothiazol-3-yl)-1-piperazinyl)-ethyl)-6-chloro-1,3-dihydro-2h-indol-2-one
US5945421A (en) * 1997-08-11 1999-08-31 Warner-Lambert Company Dopamine D4 receptor antagonists
US6040448A (en) * 1997-10-24 2000-03-21 Neurogen Corporation Certain 1-(2-naphthyl) and 1-(2-azanaphthyl)-4-(1-phenylmethyl) piperazines, dopamine receptor subtype specific ligands
IL127497A (en) * 1997-12-18 2002-07-25 Pfizer Prod Inc Medicinal products containing piperazinyl-heterocyclic compounds for the treatment of psychiatric disorders
CN100391455C (zh) * 1998-03-06 2008-06-04 阿斯特拉曾尼卡有限公司 靛红和羟吲哚衍生物的制药用途
US6150366A (en) * 1998-06-15 2000-11-21 Pfizer Inc. Ziprasidone formulations
US6660858B2 (en) 2001-03-28 2003-12-09 Lion Bioscience Ag 2-aminobenzoxazole derivatives and combinatorial libraries thereof
UY27668A1 (es) * 2002-02-20 2003-10-31 Pfizer Prod Inc Composición de ziprasidona y controles sintéticos
US20040048876A1 (en) * 2002-02-20 2004-03-11 Pfizer Inc. Ziprasidone composition and synthetic controls
WO2004026864A1 (en) * 2002-09-17 2004-04-01 Warner-Lambert Company Llc Heterocyclic substituted piperazines for the treatment of schizophrenia
BR0315516A (pt) * 2002-10-24 2005-08-23 Pfizer Prod Inc Derivados de acila de 5-(2-(4-(1,2-benzoisotiazol-3-il)-1-piperazinil)etil)-6-clo ro-1,3-dihidro-2h-indol-2-ona tendo atividade neuroléptica
CA2505397A1 (en) * 2002-11-08 2004-05-21 Warner-Lambert Company Llc Phenylalkyl and pyridylalkyl piperazine derivatives
WO2004050655A1 (en) * 2002-12-04 2004-06-17 Dr. Reddy's Laboratories Limited Polymorphic forms of ziprasidone and its hydrochloride
US7488729B2 (en) 2002-12-04 2009-02-10 Dr. Reddy's Laboratories Limited Polymorphic forms of ziprasidone and its hydrochloride salt and process for preparation thereof
CN1255105C (zh) * 2002-12-17 2006-05-10 上海医药工业研究院 齐拉西酮及其盐的水溶性包合物及其制备方法
WO2004089948A1 (en) * 2003-04-11 2004-10-21 Hetero Drugs Limited Novel crystalline forms of ziprasidone hydrochloride
US7678799B2 (en) * 2003-06-03 2010-03-16 Teva Pharmaceutical Industries Ltd. Crystalline ziprasidone HCl and processes for preparation thereof
US20050049295A1 (en) * 2003-06-12 2005-03-03 Dr. Reddy's Laboratories Limited Process for the preparation of 5-(2-(4-(1,2-benzisothiazol-3-yl)-1piperazinyl) ethyl)-6-chloro-1, 3-dihydro-2h-indol-2-one hydrochloride (ziprasidone hydrochloride) and its intermediate
US7160888B2 (en) * 2003-08-22 2007-01-09 Warner Lambert Company Llc [1,8]naphthyridin-2-ones and related compounds for the treatment of schizophrenia
WO2005040160A2 (en) 2003-10-24 2005-05-06 Teva Pharmaceutical Industries Ltd. Processes for preparation of ziprasidone
CN1934108A (zh) * 2003-12-18 2007-03-21 特瓦制药工业有限公司 齐拉西酮碱的多晶型b2
ATE451367T1 (de) * 2004-02-27 2009-12-15 Ranbaxy Lab Ltd Verfahren zur herstellung von ziprasidon
ITMI20040944A1 (it) * 2004-05-11 2004-08-11 Dinamite Dipharma S P A In For Polimorfo di ziprasidone cloridrato e procedimento per la sua preparazione
CA2467538C (en) * 2004-05-14 2010-08-24 Apotex Pharmachem Inc. New amorphous ziprasidone hydrochloride (5-[2-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]ethyl]-6-chloro-1,3-dihydro-2h-indol-2-one hydrochloride) and processes to produce the same
CA2471219A1 (en) * 2004-06-14 2005-12-14 Apotex Pharmachem Inc. Improved preparation of an anhydrate form of 5-[2-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]ethyl]-6-chloro-1,3-dihydro-2h-indol-2-one hydrochloride (ziprasidone hydrochloride)
US7728136B2 (en) 2004-06-18 2010-06-01 Lupin Limited Method for the preparation of aryl piperazinyl-heterocyclic compounds
WO2006026426A2 (en) * 2004-08-27 2006-03-09 University Of Kentucky Research Foundation Amyloid peptide inactivating enzyme to treat alzheimer’s disease peripherally
ES2250000B1 (es) * 2004-09-29 2007-06-01 Medichem, S.A. Procedimiento para la preparacion de ziprasidona.
ES2250001B1 (es) * 2004-09-29 2007-06-01 Medichem, S.A. Proceso para la purificacion de ziprasidona.
US7777037B2 (en) * 2004-10-27 2010-08-17 Dr. Reddy's Laboratories Limited Ziprasidone process
CA2593497A1 (en) * 2005-02-11 2006-08-17 Judith Aronhime Amorphous ziprasidone mesylate
CA2599391A1 (en) * 2005-03-14 2006-09-21 Teva Pharmaceutical Industries Ltd. Crystalline forms of ziprasidone mesylate
EP1858892A1 (en) * 2005-03-14 2007-11-28 Teva Pharmaceutical Industries Ltd Anhydrous ziprasidone mesylate and a process for its preparation
EA200701856A1 (ru) * 2005-04-01 2008-02-28 Уорнер-Ламберт Компани Ллс Тетрагидропиридоазепин-8-оны и родственные соединения для лечения шизофрении
HU230479B1 (hu) * 2006-05-02 2016-07-28 Richter Gedeon Nyrt. Eljárás 5-{2-[4-(1,2-benzizotiazol-3-il)-1-piperazinil]-etil}-6-klór-1,3-dihidro-2H-indol-2-on (Ziprasidon) előállítására
HUP0600868A3 (en) * 2006-11-24 2009-03-30 Richter Gedeon Nyrt 5-{2-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]ethyl}-6-chloro-1,3-dihydro-2h-indol-2-one hydrogen bromide polimorphs and process for their preparation
WO2009116085A2 (en) * 2008-03-11 2009-09-24 Alkem Laboratories Ltd. An improved process for the preparation of ziprasidone
WO2011143430A1 (en) 2010-05-12 2011-11-17 Abbott Laboratories Indazole inhibitors of kinase
PL391810A1 (pl) 2010-07-14 2012-01-16 Zakłady Farmaceutyczne POLPHARMA Spółka Akcyjna Nowe sole ziprasidonu oraz sposoby ich otrzymywania
WO2012020424A1 (en) 2010-08-12 2012-02-16 Arch Pharmalabs Limited A short process for the preparation of ziprasidone and intermediates thereof
SI23610A (sl) 2011-01-13 2012-07-31 Diagen@d@o@o Nove adicijske soli ziprasidona postopek za njihovo pripravo in njihova uporaba v terapiji

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US5206366A (en) * 1992-08-26 1993-04-27 Pfizer Inc. Process for preparing aryl piperazinyl-heterocyclic compounds
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Also Published As

Publication number Publication date
CZ87793A3 (en) 1994-04-13
HUT65750A (en) 1994-07-28
CZ281893B6 (cs) 1997-03-12
HU9301291D0 (en) 1993-07-28
CN1033089C (zh) 1996-10-23
EP0584903A1 (en) 1994-03-02
NO300685B1 (no) 1997-07-07
ATE206422T1 (de) 2001-10-15
SI9300287A (en) 1994-03-31
PL173840B1 (pl) 1998-05-29
DE69330853D1 (de) 2001-11-08
EP0584903B1 (en) 2001-10-04
US5206366A (en) 1993-04-27
JPH06184143A (ja) 1994-07-05
IL105622A0 (en) 1993-09-22
SK280584B6 (sk) 2000-04-10
KR0123441B1 (ko) 1997-11-24
RU2061695C1 (ru) 1996-06-10
DE69330853T2 (de) 2002-05-02
EP1029861B1 (en) 2004-08-18
ATE273976T1 (de) 2004-09-15
SK48593A3 (en) 1994-04-06
AU642836B1 (en) 1993-10-28
CN1083061A (zh) 1994-03-02
DK1029861T3 (da) 2004-11-15
EG20214A (en) 1997-11-30
YU56593A (sh) 1996-07-24
NZ247539A (en) 1995-09-26
ES2161703T3 (es) 2001-12-16
MX9302813A (es) 1994-02-28
PL299002A1 (en) 1994-03-21
FI932012A0 (fi) 1993-05-04
ES2225015T3 (es) 2005-03-16
DE69333597T2 (de) 2005-09-15
KR940003952A (ko) 1994-03-14
JP2742370B2 (ja) 1998-04-22
PT584903E (pt) 2002-02-28
DK0584903T3 (da) 2001-12-03
NO931656L (no) 1994-02-28
FI932012A (fi) 1994-02-27
YU48964B (sh) 2003-01-31
HU223312B1 (hu) 2004-05-28
ZA936225B (en) 1995-02-27
MY109731A (en) 1997-05-31
EP1029861A1 (en) 2000-08-23
PT1029861E (pt) 2004-11-30
DE69333597D1 (de) 2004-09-23
NO931656D0 (no) 1993-05-06
BR9302065A (pt) 1994-07-26
IL105622A (en) 1998-06-15

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