FI109793B - Menetelmä taksaanijohdannaisten valmistamiseksi, menetelmässä käytettävä lähtöaine ja välituote - Google Patents

Menetelmä taksaanijohdannaisten valmistamiseksi, menetelmässä käytettävä lähtöaine ja välituote Download PDF

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Publication number
FI109793B
FI109793B FI951595A FI951595A FI109793B FI 109793 B FI109793 B FI 109793B FI 951595 A FI951595 A FI 951595A FI 951595 A FI951595 A FI 951595A FI 109793 B FI109793 B FI 109793B
Authority
FI
Finland
Prior art keywords
carbon atoms
radical
radicals
alkyl
general formula
Prior art date
Application number
FI951595A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI951595A (fi
FI951595A0 (fi
Inventor
Jean-Manuel Mas
Viviane Massonneau
Original Assignee
Aventis Pharma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Sa filed Critical Aventis Pharma Sa
Publication of FI951595A publication Critical patent/FI951595A/fi
Publication of FI951595A0 publication Critical patent/FI951595A0/fi
Application granted granted Critical
Publication of FI109793B publication Critical patent/FI109793B/fi

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/04—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/04—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D263/06—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by oxygen atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epoxy Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
FI951595A 1992-10-05 1995-04-04 Menetelmä taksaanijohdannaisten valmistamiseksi, menetelmässä käytettävä lähtöaine ja välituote FI109793B (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
FR9211741A FR2696458B1 (fr) 1992-10-05 1992-10-05 Procédé de préparation de dérivés du taxane.
FR9211741 1992-10-05
PCT/FR1993/000967 WO1994007877A1 (fr) 1992-10-05 1993-10-04 Procede de preparation de derives du taxane
FR9300967 1993-10-04

Publications (3)

Publication Number Publication Date
FI951595A FI951595A (fi) 1995-04-04
FI951595A0 FI951595A0 (fi) 1995-04-04
FI109793B true FI109793B (fi) 2002-10-15

Family

ID=9434119

Family Applications (1)

Application Number Title Priority Date Filing Date
FI951595A FI109793B (fi) 1992-10-05 1995-04-04 Menetelmä taksaanijohdannaisten valmistamiseksi, menetelmässä käytettävä lähtöaine ja välituote

Country Status (24)

Country Link
US (3) US5616739A (hu)
EP (1) EP0663906B1 (hu)
JP (1) JP3014760B2 (hu)
KR (1) KR100311198B1 (hu)
AT (1) ATE146174T1 (hu)
AU (1) AU689080B2 (hu)
CA (1) CA2146250C (hu)
CZ (1) CZ283261B6 (hu)
DE (1) DE69306591T2 (hu)
DK (1) DK0663906T3 (hu)
ES (1) ES2095081T3 (hu)
FI (1) FI109793B (hu)
FR (1) FR2696458B1 (hu)
GR (1) GR3021997T3 (hu)
HU (1) HU226412B1 (hu)
MX (1) MX9305766A (hu)
NO (1) NO309089B1 (hu)
NZ (1) NZ256445A (hu)
PL (1) PL182284B1 (hu)
RU (1) RU2116303C1 (hu)
SK (1) SK280627B6 (hu)
TW (1) TW419472B (hu)
WO (1) WO1994007877A1 (hu)
ZA (1) ZA937318B (hu)

Families Citing this family (79)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2696464B1 (fr) * 1992-10-05 1994-11-10 Rhone Poulenc Rorer Sa Nouveau procédé d'estérification de la baccatine III et de la désacétyl-10 baccatine III.
FR2697522B1 (fr) * 1992-10-30 1994-11-25 Rhone Poulenc Rorer Sa Procédé de préparation de dérivés du taxane.
FR2698361B1 (fr) * 1992-11-20 1995-01-13 Rhone Poulenc Rorer Sa Procédé de préparation d'un acide oxazolidine-1,3 carboxylique-5.
MX9307777A (es) 1992-12-15 1994-07-29 Upjohn Co 7-HALO-Y 7ß, 8ß-METANO-TAXOLES, USO ANTINEOPLASTICO Y COMPOSICIONES FARMACEUTICAS QUE LOS CONTIENEN.
US5973160A (en) * 1992-12-23 1999-10-26 Poss; Michael A. Methods for the preparation of novel sidechain-bearing taxanes
CA2161328A1 (en) * 1993-06-11 1994-12-22 Robert C. Kelly Delta 6,7-taxols antineoplastic use and pharmaceutical compositions containing them
FR2706457B1 (fr) * 1993-06-16 1995-07-28 Rhone Poulenc Rorer Sa Procédé de préparation d'un acide oxazolidinecarboxylique utile pour préparer des taxoïdes thérapeutiquement actifs.
US6005120A (en) 1993-07-20 1999-12-21 Florida State University Tricyclic and tetracyclic taxanes
US5981537A (en) * 1993-11-12 1999-11-09 Pharmacia & Upjohn Company Pyrimidine-thioalkyl and alkylether compounds
IL127597A (en) * 1994-01-28 2003-07-31 Upjohn Co Iso-taxol analogs
US5679807A (en) * 1995-01-30 1997-10-21 Hauser, Inc. Preparation of taxol and docetaxel through primary amines
CA2170661A1 (en) * 1995-03-22 1996-09-23 John K. Thottathil Novel methods for the preparation of taxanes using oaxzolidine intermediates
GB9512471D0 (en) * 1995-06-20 1995-08-23 Pharmacia Spa Method for the preparation of taxol and its derivatives
US5688977A (en) * 1996-02-29 1997-11-18 Napro Biotherapeutics, Inc. Method for docetaxel synthesis
CZ293480B6 (cs) * 1996-05-08 2004-05-12 Pharmaciaá@Áupjohnácompany Oxazolidinové estery silylovaného baccatinu III
US7288665B1 (en) 1997-08-18 2007-10-30 Florida State University Process for selective derivatization of taxanes
PT1019347E (pt) 1997-08-21 2003-08-29 Univ Florida State Metodo para a sintese de taxanos
WO1999032109A1 (en) * 1997-12-23 1999-07-01 Bristol-Myers Squibb Company 7-deoxy-6-nitrogen substituted paclitaxels
JP4776843B2 (ja) 1999-10-01 2011-09-21 イムノゲン インコーポレーティッド 免疫複合体及び化学療法剤を用いる癌治療用組成物及び方法
MXPA03002494A (es) 2000-09-22 2004-05-24 Bristol Myers Squibb Co Metodo para reducir toxicidad de quimio terapias combinadas.
US6891050B2 (en) * 2001-08-10 2005-05-10 Dabur India Limited Process for the preparation of taxanes such as paclitaxel, docetaxel and structurally similar analogs
US6881852B2 (en) * 2002-02-05 2005-04-19 Dabur India Limited Process of purification of paclitaxel and docetaxel
US7247738B2 (en) * 2002-05-07 2007-07-24 Dabur India Limited Method of preparation of anticancer taxanes using 3-[(substituted-2-trialkylsilyl) ethoxycarbonyl]-5-oxazolidine carboxylic acids
US6900342B2 (en) * 2002-05-10 2005-05-31 Dabur India Limited Anticancer taxanes such as paclitaxel, docetaxel and their structural analogs, and a method for the preparation thereof
US7351542B2 (en) 2002-05-20 2008-04-01 The Regents Of The University Of California Methods of modulating tubulin deacetylase activity
PT1530465E (pt) 2002-06-26 2010-01-05 Medigene Ag Processo para produção de uma preparação lipossomal catiónica que compreende um composto lipofílico
CA2501805C (en) * 2002-10-09 2012-05-22 Phytogen Life Sciences, Inc. Novel taxanes and methods related to use and preparation thereof
US6838569B2 (en) 2002-12-16 2005-01-04 Dabur India Limited Process for preparation of paclitaxel trihydrate and docetaxel trihydrate
EP2390262A1 (en) 2003-05-16 2011-11-30 Intermune, Inc. Synthetic chemokine receptor ligands and methods of use thereof
WO2005040758A2 (en) * 2003-10-24 2005-05-06 Intermune, Inc. Use of pirfenidone in therapeutic regimens
US7202370B2 (en) * 2003-10-27 2007-04-10 Conor Medsystems, Inc. Semi-synthesis of taxane intermediates from 9-dihydro-13-acetylbaccatin III
MX2007001589A (es) * 2004-08-09 2007-08-02 Alios Biopharma Inc Variantes de polipeptido resistentes a proteasa, hiperglicosiladas sinteticas, formulaciones orales y metodos para utilizar las mismas.
US7597884B2 (en) * 2004-08-09 2009-10-06 Alios Biopharma, Inc. Hyperglycosylated polypeptide variants and methods of use
US7446126B2 (en) 2004-10-08 2008-11-04 Indena S.P.A. Semisynthesis process for the preparation of 10-deacetyl-N-debenzoyl-paclitaxel
EP1712552A1 (en) * 2005-04-11 2006-10-18 INDENA S.p.A. Semisynthesis process for the preparation of 10-deacetyl-n-debenzoyl-paclitaxel
EP1647552A1 (en) * 2004-10-08 2006-04-19 INDENA S.p.A. Semisynthesis process for the preparation of 10-deacetyl-n-debenzoyl-paclitaxel
US20060188508A1 (en) * 2005-02-17 2006-08-24 Cohen Stanley N Methods and compositions for modulating angiogenesis
BRPI0709075A2 (pt) 2006-03-20 2011-10-11 Medigene Ag tratamento de cáncer de mama triplo receptor negativo
AU2007226937A1 (en) * 2006-03-21 2007-09-27 Dr. Reddy's Laboratories Ltd. Docetaxel polymorphs and processes
ITMI20062479A1 (it) * 2006-12-21 2008-06-22 Indena Spa Processo per la preparazione di secotassani
WO2008146369A1 (ja) * 2007-05-30 2008-12-04 Mitsubishi Electric Corporation 電気車のブレーキ制御装置
US9198893B2 (en) 2008-05-22 2015-12-01 Galera Labs, Llc Combination antitumor therapy
KR101003822B1 (ko) 2008-06-20 2010-12-27 주식회사 셀트리온화학연구소 도세탁셀의 제조방법 및 도세탁셀의 제조를 위한 신규한중간체
WO2010005850A1 (en) 2008-07-08 2010-01-14 The J. David Gladstone Institutes Methods and compositions for modulating angiogenesis
CN101735179B (zh) * 2008-11-19 2012-09-12 上海百灵医药科技有限公司 一种多烯紫杉醇的制备方法，其中间体及制备方法
EP2358693A4 (en) * 2008-11-20 2012-04-18 Reddys Lab Ltd Dr PREPARATION OF DOCETAXEL
PL388144A1 (pl) 2009-05-29 2010-12-06 Przedsiębiorstwo Produkcyjno-Wdrożeniowe Ifotam Spółka Z Ograniczoną Odpowiedzialnością Solwaty (2R,3S)-3-tert-butoksykarbonylamino-2-hydroksy-3-fenylopropionianu 4-acetoksy-2α-benzoiloksy -5β,20-epoksy-1,7β,10β-trihydroksy-9-okso-taks-11-en-13α-ylu, sposób ich otrzymywania i zastosowanie
IN2015DN00552A (hu) 2012-07-19 2015-06-26 Redwood Bioscience Inc
CN104884056A (zh) 2012-11-12 2015-09-02 雷德伍德生物科技股份有限公司 用于制备缀合物的化合物和方法
ES2653487T3 (es) 2013-02-15 2018-02-07 The Regents Of The University Of California Receptor de antígeno quimérico y métodos de uso del mismo
KR20150135332A (ko) 2013-03-14 2015-12-02 더 보드 오브 트러스티스 오브 더 리랜드 스탠포드 쥬니어 유니버시티 미토콘드리아 알데히드 탈수소효소-2 조절인자들 및 이들의 사용 방법
WO2015081282A1 (en) 2013-11-27 2015-06-04 Redwood Bioscience, Inc. Hydrazinyl-pyrrolo compounds and methods for producing a conjugate
DK3107899T3 (da) 2014-02-19 2020-11-16 Aviv Therapeutics Inc Mitokondriel aldehyddehydrogenase 2 (aldh2)-bindende polycykliske amider og anvendelse deraf til cancerbehandling
TWI684600B (zh) 2014-03-21 2020-02-11 美商艾伯維有限公司 抗－ｅｇｆｒ抗體及抗體藥物結合物
EP3373977A4 (en) 2015-11-12 2019-07-17 The Board of Trustees of the Leland Stanford Junior University CELLULAR PENETRATION-RICH GUANIDINIC OLIGOPHOSPHOTRIESTERS FOR THE DELIVERY OF MEDICATION AND PROBE
TWI760319B (zh) 2015-12-30 2022-04-11 杏國新藥股份有限公司 乳癌治療
EP3231421A1 (en) 2016-04-11 2017-10-18 Greenaltech, S.L. Uses of a carotenoid in the treatment or prevention of stress induced conditions
KR20180135458A (ko) 2016-04-26 2018-12-20 알.피.쉐러 테크놀러지즈 엘엘씨 항체 컨쥬게이트 및 이의 제조 및 이용 방법
HUE057856T2 (hu) 2016-06-01 2022-06-28 Servier Ip Uk Ltd Polialkilén-oxid-aszparagináz készítményei és eljárás ezek elõállítására és alkalmazására
TW202304996A (zh) 2016-06-08 2023-02-01 美商艾伯維有限公司 抗-b7-h3抗體及抗體藥物結合物
CN109641962A (zh) 2016-06-08 2019-04-16 艾伯维公司 抗b7-h3抗体和抗体药物偶联物
CA3027033A1 (en) 2016-06-08 2017-12-14 Abbvie Inc. Anti-cd98 antibodies and antibody drug conjugates
EP3468993A1 (en) 2016-06-08 2019-04-17 AbbVie Inc. Anti-b7-h3 antibodies and antibody drug conjugates
WO2017214458A2 (en) 2016-06-08 2017-12-14 Abbvie Inc. Anti-cd98 antibodies and antibody drug conjugates
IL267613B1 (en) 2017-01-05 2024-07-01 Syncore Biotechnology Co Ltd Pancreatic cancer treatment
BR112019014615A2 (pt) 2017-01-18 2020-06-02 F1 Oncology, Inc. Receptores de antígeno quimérico contra axl ou ror2 e métodos de uso dos mesmos
EP3388082A1 (en) 2017-04-13 2018-10-17 Galera Labs, LLC Combination cancer immunotherapy with pentaaza macrocyclic ring complex
CN111902147A (zh) 2018-01-31 2020-11-06 加莱拉实验室有限责任公司 五氮杂大环状环配合物和基于铂的抗癌剂的组合癌症治疗
KR20210009315A (ko) 2018-04-11 2021-01-26 오하이오 스테이트 이노베이션 파운데이션 안약 전달용 서방형 마이크로 입자를 이용한 방법 및 조성물
CA3105879A1 (en) 2018-07-18 2020-01-23 Manzanita Pharmaceuticals, Inc. Conjugates for delivering an anti-cancer agent to nerve cells, methods of use and methods of making thereof
EP3946626A1 (en) 2019-04-02 2022-02-09 Kenjockety Biotechnology, Inc. Efflux pump-cancer antigen multi-specific antibodies and compositions, reagents, kits and methods related thereto
AU2021214370A1 (en) 2020-01-29 2022-08-18 Kenjockety Biotechnology, Inc. Anti-MDR1 antibodies and uses thereof
CA3182472A1 (en) 2020-06-04 2021-12-09 Kenjockety Biotechnology, Inc. Anti-abcg2 antibodies and uses thereof
AU2021283080A1 (en) 2020-06-04 2022-12-15 Kenjockety Biotechnology, Inc. ABCG2 efflux pump-cancer antigen multi-specific antibodies and compositions, reagents, kits and methods related thereto
KR20230061429A (ko) 2020-09-02 2023-05-08 켄조케티 바이오테크놀러지 인코포레이티드 항-abcc1 항체 및 이의 용도
CA3203652A1 (en) 2020-11-13 2022-05-19 William Robert ARATHOON Anti-mrp4 (encoded by abcc4 gene) antibodies and uses thereof
UY39610A (es) 2021-01-20 2022-08-31 Abbvie Inc Conjugados anticuerpo-fármaco anti-egfr
CA3238353A1 (en) 2021-12-13 2023-06-22 William Robert ARATHOON Anti-abcb1 antibodies
WO2023159220A1 (en) 2022-02-18 2023-08-24 Kenjockety Biotechnology, Inc. Anti-cd47 antibodies

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5175315A (en) * 1989-05-31 1992-12-29 Florida State University Method for preparation of taxol using β-lactam
US5136060A (en) * 1989-11-14 1992-08-04 Florida State University Method for preparation of taxol using an oxazinone
US5015744A (en) * 1989-11-14 1991-05-14 Florida State University Method for preparation of taxol using an oxazinone
MX9102128A (es) * 1990-11-23 1992-07-08 Rhone Poulenc Rorer Sa Derivados de taxano,procedimiento para su preparacion y composicion farmaceutica que los contiene
US5319112A (en) * 1992-08-18 1994-06-07 Virgnia Tech Intellectual Properties, Inc. Method for the conversion of cephalomannine to taxol and for the preparation of N-acyl analogs of taxol

Also Published As

Publication number Publication date
AU5115093A (en) 1994-04-26
JP3014760B2 (ja) 2000-02-28
EP0663906A1 (fr) 1995-07-26
WO1994007877A1 (fr) 1994-04-14
DK0663906T3 (da) 1996-12-30
TW419472B (en) 2001-01-21
DE69306591T2 (de) 1997-04-17
KR100311198B1 (ko) 2002-04-24
FR2696458B1 (fr) 1994-11-10
HU226412B1 (en) 2008-11-28
NZ256445A (en) 1997-01-29
PL308241A1 (en) 1995-07-24
RU95113717A (ru) 1996-12-27
CZ84195A3 (en) 1995-09-13
CZ283261B6 (cs) 1998-02-18
HUT72679A (en) 1996-05-28
KR950703546A (ko) 1995-09-20
FI951595A (fi) 1995-04-04
JPH08501788A (ja) 1996-02-27
CA2146250C (fr) 2003-03-11
US5677462A (en) 1997-10-14
NO951201D0 (no) 1995-03-29
NO309089B1 (no) 2000-12-11
ES2095081T3 (es) 1997-02-01
GR3021997T3 (en) 1997-03-31
HU9500971D0 (en) 1995-06-28
CA2146250A1 (fr) 1994-04-14
ZA937318B (en) 1994-04-25
FI951595A0 (fi) 1995-04-04
DE69306591D1 (de) 1997-01-23
US5616739A (en) 1997-04-01
EP0663906B1 (fr) 1996-12-11
NO951201L (no) 1995-03-29
MX9305766A (es) 1995-01-31
US5869680A (en) 1999-02-09
SK280627B6 (sk) 2000-05-16
PL182284B1 (pl) 2001-12-31
FR2696458A1 (fr) 1994-04-08
SK43695A3 (en) 1995-08-09
AU689080B2 (en) 1998-03-26
ATE146174T1 (de) 1996-12-15
RU2116303C1 (ru) 1998-07-27

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