FI105548B - Menetelmä farmaseuttisesti aktiivisten 1,3-dihydro-2H-imidatso(4,5-b)kinolin-2-onien valmistamiseksi - Google Patents

Menetelmä farmaseuttisesti aktiivisten 1,3-dihydro-2H-imidatso(4,5-b)kinolin-2-onien valmistamiseksi Download PDF

Info

Publication number
FI105548B
FI105548B FI942010A FI942010A FI105548B FI 105548 B FI105548 B FI 105548B FI 942010 A FI942010 A FI 942010A FI 942010 A FI942010 A FI 942010A FI 105548 B FI105548 B FI 105548B
Authority
FI
Finland
Prior art keywords
formula
alkyl
optionally substituted
dihydro
amino
Prior art date
Application number
FI942010A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI942010A0 (fi
FI942010A (fi
Inventor
Eddy Jean Edgard Freyne
Chaffoy De Courcelles Didie De
Alfons Herman Raeymaekers
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of FI942010A0 publication Critical patent/FI942010A0/fi
Publication of FI942010A publication Critical patent/FI942010A/fi
Application granted granted Critical
Publication of FI105548B publication Critical patent/FI105548B/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/72—Two oxygen atoms, e.g. hydantoin
    • C07D233/76—Two oxygen atoms, e.g. hydantoin with substituted hydrocarbon radicals attached to the third ring carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/96—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
FI942010A 1991-10-30 1994-04-29 Menetelmä farmaseuttisesti aktiivisten 1,3-dihydro-2H-imidatso(4,5-b)kinolin-2-onien valmistamiseksi FI105548B (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US78495591A 1991-10-30 1991-10-30
US78495591 1991-10-30
EP9202496 1992-10-27
PCT/EP1992/002496 WO1993009118A1 (en) 1991-10-30 1992-10-27 1,3-dihydro-2h-imidazo(4,5-b)quinolin-2-one derivatives as phosphodiesterase inhibitors

Publications (3)

Publication Number Publication Date
FI942010A0 FI942010A0 (fi) 1994-04-29
FI942010A FI942010A (fi) 1994-04-29
FI105548B true FI105548B (fi) 2000-09-15

Family

ID=25134048

Family Applications (1)

Application Number Title Priority Date Filing Date
FI942010A FI105548B (fi) 1991-10-30 1994-04-29 Menetelmä farmaseuttisesti aktiivisten 1,3-dihydro-2H-imidatso(4,5-b)kinolin-2-onien valmistamiseksi

Country Status (24)

Country Link
US (3) US5521187A (ja)
EP (2) EP0541153A1 (ja)
JP (1) JP3488922B2 (ja)
KR (1) KR100251895B1 (ja)
CN (1) CN1041726C (ja)
AT (1) ATE131479T1 (ja)
AU (1) AU660337B2 (ja)
CA (1) CA2121230C (ja)
DE (1) DE69206820T2 (ja)
DK (1) DK0610372T3 (ja)
ES (1) ES2083773T3 (ja)
FI (1) FI105548B (ja)
GR (1) GR3018909T3 (ja)
HU (1) HU220608B1 (ja)
IL (1) IL103570A (ja)
MX (1) MX9206258A (ja)
NO (1) NO300976B1 (ja)
NZ (1) NZ244779A (ja)
PH (1) PH31245A (ja)
PL (1) PL170749B1 (ja)
RU (1) RU2127273C1 (ja)
TW (1) TW249234B (ja)
WO (1) WO1993009118A1 (ja)
ZA (1) ZA928373B (ja)

Families Citing this family (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PH31245A (en) * 1991-10-30 1998-06-18 Janssen Pharmaceutica Nv 1,3-Dihydro-2H-imidazoÄ4,5-BÜ-quinolin-2-one derivatives.
US5502177A (en) * 1993-09-17 1996-03-26 Gilead Sciences, Inc. Pyrimidine derivatives for labeled binding partners
US5703827A (en) * 1996-02-29 1997-12-30 Monolithic System Technology, Inc. Method and structure for generating a boosted word line voltage and a back bias voltage for a memory array
US6007992A (en) * 1997-11-10 1999-12-28 Gilead Sciences, Inc. Pyrimidine derivatives for labeled binding partners
US6028183A (en) 1997-11-07 2000-02-22 Gilead Sciences, Inc. Pyrimidine derivatives and oligonucleotides containing same
AU2001293847B2 (en) * 2000-10-02 2007-05-24 Janssen Pharmaceutica N.V. Metabotropic glutamate receptor antagonists
SE0100902D0 (sv) * 2001-03-15 2001-03-15 Astrazeneca Ab Compounds
SE0100903D0 (sv) * 2001-03-15 2001-03-15 Astrazeneca Ab Compounds
JP4510383B2 (ja) 2001-05-23 2010-07-21 田辺三菱製薬株式会社 軟骨疾患修復治療用組成物
JP4510384B2 (ja) 2001-05-23 2010-07-21 田辺三菱製薬株式会社 骨折治癒促進用組成物
SE0103710D0 (sv) * 2001-11-07 2001-11-07 Astrazeneca Ab Compounds
NZ535438A (en) * 2002-03-29 2006-08-31 Janssen Pharmaceutica Nv Radiolabelled quinoline and quinolinone derivatives and their use as metabotropic glutamate receptor ligands
SE0202539D0 (sv) 2002-08-27 2002-08-27 Astrazeneca Ab Compounds
GB0221246D0 (en) * 2002-09-13 2002-10-23 Astrazeneca Ab Compounds
JP2007502293A (ja) 2003-08-12 2007-02-08 スリーエム イノベイティブ プロパティズ カンパニー ヒドロキシルアミン置換イミダゾ含有化合物
RU2006105101A (ru) 2003-08-27 2007-10-10 3М Инновейтив Пропертиз Компани (US) Арилокси и арилалкиленокси замещенные имидазохинолины
CA2537763A1 (en) 2003-09-05 2005-03-17 3M Innovative Properties Company Treatment for cd5+ b cell lymphoma
AU2004278014B2 (en) 2003-10-03 2011-04-28 3M Innovative Properties Company Alkoxy substituted imidazoquinolines
US7544697B2 (en) 2003-10-03 2009-06-09 Coley Pharmaceutical Group, Inc. Pyrazolopyridines and analogs thereof
US8598192B2 (en) 2003-11-14 2013-12-03 3M Innovative Properties Company Hydroxylamine substituted imidazoquinolines
JP2007511527A (ja) 2003-11-14 2007-05-10 スリーエム イノベイティブ プロパティズ カンパニー オキシム置換イミダゾ環化合物
WO2005051317A2 (en) 2003-11-25 2005-06-09 3M Innovative Properties Company Substituted imidazo ring systems and methods
WO2005066170A1 (en) 2003-12-29 2005-07-21 3M Innovative Properties Company Arylalkenyl and arylalkynyl substituted imidazoquinolines
CA2551399A1 (en) 2003-12-30 2005-07-21 3M Innovative Properties Company Imidazoquinolinyl, imidazopyridinyl, and imidazonaphthyridinyl sulfonamides
WO2005090316A1 (en) * 2004-03-12 2005-09-29 Wyeth HYDANTOINS HAVING RNase MODULATORY ACTIVITY
US8697873B2 (en) 2004-03-24 2014-04-15 3M Innovative Properties Company Amide substituted imidazopyridines, imidazoquinolines, and imidazonaphthyridines
US8017779B2 (en) 2004-06-15 2011-09-13 3M Innovative Properties Company Nitrogen containing heterocyclyl substituted imidazoquinolines and imidazonaphthyridines
US7897609B2 (en) 2004-06-18 2011-03-01 3M Innovative Properties Company Aryl substituted imidazonaphthyridines
US8026366B2 (en) 2004-06-18 2011-09-27 3M Innovative Properties Company Aryloxy and arylalkyleneoxy substituted thiazoloquinolines and thiazolonaphthyridines
US7915281B2 (en) 2004-06-18 2011-03-29 3M Innovative Properties Company Isoxazole, dihydroisoxazole, and oxadiazole substituted imidazo ring compounds and method
US7648992B2 (en) 2004-07-05 2010-01-19 Astrazeneca Ab Hydantoin derivatives for the treatment of obstructive airway diseases
SE0401762D0 (sv) * 2004-07-05 2004-07-05 Astrazeneca Ab Novel compounds
SE0403085D0 (sv) 2004-12-17 2004-12-17 Astrazeneca Ab Novel componds
SE0403086D0 (sv) * 2004-12-17 2004-12-17 Astrazeneca Ab Compounds
JP5313502B2 (ja) 2004-12-30 2013-10-09 スリーエム イノベイティブ プロパティズ カンパニー 置換キラル縮合［１，２］イミダゾ［４，５−ｃ］環状化合物
JP5543068B2 (ja) 2004-12-30 2014-07-09 スリーエム イノベイティブ プロパティズ カンパニー キラル縮合［１，２］イミダゾ［４，５−ｃ］環状化合物
JP2008530022A (ja) 2005-02-04 2008-08-07 コーリー ファーマシューティカル グループ，インコーポレイテッド 免疫反応調節物質を含む水性ゲル処方物
AU2006213746A1 (en) 2005-02-11 2006-08-17 Coley Pharmaceutical Group, Inc. Oxime and hydroxylamine substituted imidazo(4,5-c) ring compounds and methods
WO2006107853A2 (en) 2005-04-01 2006-10-12 Coley Pharmaceutical Group, Inc. Pyrazolopyridine-1,4-diamines and analogs thereof
AU2006232375A1 (en) 2005-04-01 2006-10-12 Coley Pharmaceutical Group, Inc. 1-substituted pyrazolo (3,4-c) ring compounds as modulators of cytokine biosynthesis for the treatment of viral infections and neoplastic diseases
EP2258359A3 (en) 2005-08-26 2011-04-06 Braincells, Inc. Neurogenesis by muscarinic receptor modulation with sabcomelin
EP1940389A2 (en) 2005-10-21 2008-07-09 Braincells, Inc. Modulation of neurogenesis by pde inhibition
US20070112017A1 (en) 2005-10-31 2007-05-17 Braincells, Inc. Gaba receptor mediated modulation of neurogenesis
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
EP2021000A2 (en) 2006-05-09 2009-02-11 Braincells, Inc. Neurogenesis by modulating angiotensin
MX2008014320A (es) 2006-05-09 2009-03-25 Braincells Inc Neurogenesis mediada por el receptor de 5-hidroxitriptamina.
WO2008008432A2 (en) 2006-07-12 2008-01-17 Coley Pharmaceutical Group, Inc. Substituted chiral fused( 1,2) imidazo (4,5-c) ring compounds and methods
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
TW200831488A (en) * 2006-11-29 2008-08-01 Astrazeneca Ab Novel compounds
EP1969929A1 (de) 2007-03-12 2008-09-17 Bayer CropScience AG Substituierte Phenylamidine und deren Verwendung als Fungizide
US20100216805A1 (en) 2009-02-25 2010-08-26 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
EP2804603A1 (en) 2012-01-10 2014-11-26 President and Fellows of Harvard College Beta-cell replication promoting compounds and methods of their use
RU2769516C2 (ru) 2012-10-02 2022-04-01 Кэлифорниа Инститьют Оф Текнолоджи Восстановительное расщепление ароматических связей c-s активированными силанами
CN107253967B (zh) * 2012-10-02 2021-03-30 加州理工学院 芳族化合物的无过渡金属的甲硅烷基化
EP3705482B1 (en) 2014-08-06 2023-02-22 California Institute of Technology Silylation of aromatic heterocycles by earth abundant transition-metal-free catalysts
WO2016036685A1 (en) 2014-09-02 2016-03-10 California Institute Of Technology Base-catalyzed silylation of terminial alkyne c-h bonds
WO2016100606A1 (en) 2014-12-19 2016-06-23 California Institute Of Technology Silylation of aromatic heterocycles by disilanes using potassium alkoxide catalysts
CN110441434A (zh) * 2019-08-29 2019-11-12 重庆华邦胜凯制药有限公司 Gc-ms分离测定对氨基水杨酸中相关杂质的方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1602188A (en) * 1977-12-01 1981-11-11 Wellcome Found Hydantoin derivatives
JPS6021941B2 (ja) * 1981-01-28 1985-05-30 株式会社村田製作所 圧電性磁器組成物
US4668686A (en) * 1985-04-25 1987-05-26 Bristol-Myers Company Imidazoquinoline antithrombrogenic cardiotonic agents
US4775674A (en) * 1986-05-23 1988-10-04 Bristol-Myers Company Imidazoquinolinylether derivatives useful as phosphodiesterase and blood aggregation inhibitors
US4701459A (en) * 1986-07-08 1987-10-20 Bristol-Myers Company 7-amino-1,3-dihydro-2H-imidazo[4,5-b]quinolin 2-ones and method for inhibiting phosphodiesterase and blood platelet aggregation
US5306822A (en) * 1988-05-25 1994-04-26 Warner-Lambert Company Arylmethylenyl derivatives of oxazolidinone
NZ234186A (en) * 1989-07-07 1991-10-25 Janssen Pharmaceutica Nv Imidazo quinazolin-one derivatives and pharmaceutical compositions
CN1030196C (zh) * 1989-07-07 1995-11-01 詹森药业有限公司 增强收缩力和舒张力的-二氢咪唑并喹唑啉酮衍生物的制备方法
US5043327A (en) * 1989-07-18 1991-08-27 Janssen Pharmaceutica N.V. Positive inotropic and lusitropic 3,5-dihydroimidazo[2,1-b]quinazolin-2(1H)-one derivatives, compositions and use
US4943573A (en) * 1989-11-01 1990-07-24 Bristol-Myers Squibb Company Imidazo[4,5-b]quinolinyloxyalkanoic acid amides with enhanced water solubility
WO1991007177A1 (en) * 1989-11-13 1991-05-30 Pfizer Inc. Pyrimidone derivatives and analogs in the treatment of asthma or certain skin disorders
PH31245A (en) * 1991-10-30 1998-06-18 Janssen Pharmaceutica Nv 1,3-Dihydro-2H-imidazoÄ4,5-BÜ-quinolin-2-one derivatives.

Also Published As

Publication number Publication date
NO300976B1 (no) 1997-08-25
NO941497L (no) 1994-04-25
HUT66453A (en) 1994-11-28
DE69206820D1 (de) 1996-01-25
AU2908392A (en) 1993-06-07
AU660337B2 (en) 1995-06-22
FI942010A0 (fi) 1994-04-29
WO1993009118A1 (en) 1993-05-13
CA2121230C (en) 2003-03-11
JPH07500599A (ja) 1995-01-19
TW249234B (ja) 1995-06-11
US5516908A (en) 1996-05-14
ATE131479T1 (de) 1995-12-15
EP0541153A1 (en) 1993-05-12
NZ244779A (en) 1994-10-26
FI942010A (fi) 1994-04-29
DK0610372T3 (da) 1996-01-29
PH31245A (en) 1998-06-18
ES2083773T3 (es) 1996-04-16
MX9206258A (es) 1993-04-01
EP0610372B1 (en) 1995-12-13
HU220608B1 (hu) 2002-03-28
KR100251895B1 (ko) 2000-09-01
NO941497D0 (ja) 1994-04-25
ZA928373B (en) 1994-04-29
CA2121230A1 (en) 1993-05-13
JP3488922B2 (ja) 2004-01-19
IL103570A (en) 1996-03-31
IL103570A0 (en) 1993-03-15
EP0610372A1 (en) 1994-08-17
GR3018909T3 (en) 1996-05-31
CN1041726C (zh) 1999-01-20
US5521187A (en) 1996-05-28
PL170749B1 (pl) 1997-01-31
HU9401245D0 (en) 1994-08-29
DE69206820T2 (de) 1996-05-15
US5541325A (en) 1996-07-30
CN1072681A (zh) 1993-06-02
RU2127273C1 (ru) 1999-03-10

Similar Documents

Publication Publication Date Title
FI105548B (fi) Menetelmä farmaseuttisesti aktiivisten 1,3-dihydro-2H-imidatso(4,5-b)kinolin-2-onien valmistamiseksi
FI83316B (fi) Foerfarande foer framstaellning av farmaceutiskt aktiva 1,3-dihydro-2h-imidazo/4,5-b/kinolin-2-onderivat.
US5021443A (en) Noval benzimidazole and azabenzimiazole derivatives which are thromboxane receptor antagonists, their methods of preparation and pharmaceutical compositions in which they are present
US5723463A (en) Pyrido 3,2-E!pyrazinones with anti-asthmatic action and processes for their manufacture
JP4339123B2 (ja) ５−ヒドロキシトリプタミン−６リガンドとしてのアザインドリルアルキルアミン誘導体
EP0275888B1 (de) Neue tricyclische Benzimidazole, Verfahren zu ihrer Herstellung und Verwendung als Arzneimittel
SK22099A3 (en) Substituted n-[(aminoiminomethyl or aminomethyl)phenyl]propyl amides
JPH05117239A (ja) 気管支拡張剤および抗炎症剤用フエニルピラゾリジノン
JPH06145170A (ja) ヘテロ環式化合物、その製法及びこれを含有する高血圧及びうつ血性心不全治療用医薬組成物
US5063237A (en) 1,4-dihydro-2-(4-[benzimidazol-l-yl]phenyl)-pyridines as platelet activating factor antagonists
JP3243733B2 (ja) 新規イソキノリン誘導体
SK12222003A3 (sk) Beta-karbolínové deriváty, spôsob ich prípravy, farmaceutická kompozícia s ich obsahom a ich použitia proti depresii a úzkosti
JPH04273878A (ja) 複素環式化合物及びその製法
JPS59101467A (ja) ６，７−ジヒドロ−８−（イミダゾ−ル−１−イル）−５−メチル−１−オキソ−１Ｈ，５Ｈ−ベンゾ〔ｉｊ〕キノリジン−２−カルボン酸およびその誘導体
CA1338599C (en) Imidazole derivatives
JPH07242666A (ja) 複素環化合物
JP2002541145A (ja) アリールおよびヘテロアリール縮合アミノアルキル−イミダゾール誘導体：ブラジキニンｂ２受容体選択性モジュレータ
US5149814A (en) Alkyl 2-benzylidene-4-(2-alkylimidazopyrid-1-yl) benzoylacetate esters as intermediate compounds
US5070205A (en) Alkyl 2-benzylidene-4-(benzimidazol-1-yl) benzoylacetate esters as intermediates
JP2849123B2 (ja) 四置換チオフェン及びその製造方法
US5171858A (en) Preparation of certain 5,6-dihydro-8-phenyl-imidazo[1,5-a]pyridines
EP0462986A1 (en) IMIDAZOPYRIMIDINE ANTIALLERGY AGENTS.
JPS6284A (ja) イミダゾキノリン抗血栓性強心薬
NO893611L (no) Fremstilling av imidazokinolinonderivater.

Legal Events

Date Code Title Description
MA Patent expired