NO300976B1 - 1,3-dihydro-2H-imidazo£4,5-b|kinolin-2-on-derivater, samt mellomprodukter for fremstilling derav - Google Patents

1,3-dihydro-2H-imidazo£4,5-b|kinolin-2-on-derivater, samt mellomprodukter for fremstilling derav Download PDF

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Publication number
NO300976B1
NO300976B1 NO941497A NO941497A NO300976B1 NO 300976 B1 NO300976 B1 NO 300976B1 NO 941497 A NO941497 A NO 941497A NO 941497 A NO941497 A NO 941497A NO 300976 B1 NO300976 B1 NO 300976B1
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NO
Norway
Prior art keywords
formula
alkyl
mixture
compounds
acid
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Application number
NO941497A
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English (en)
Norwegian (no)
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NO941497L (no
NO941497D0 (ja
Inventor
Eddy Jean Edgard Freyne
Alfons Herman Marg Raeymaekers
Didier Robert Guy G Courcelles
Original Assignee
Janssen Pharmaceutica Nv
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Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of NO941497L publication Critical patent/NO941497L/no
Publication of NO941497D0 publication Critical patent/NO941497D0/no
Publication of NO300976B1 publication Critical patent/NO300976B1/no

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/72—Two oxygen atoms, e.g. hydantoin
    • C07D233/76—Two oxygen atoms, e.g. hydantoin with substituted hydrocarbon radicals attached to the third ring carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/96—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
NO941497A 1991-10-30 1994-04-25 1,3-dihydro-2H-imidazo£4,5-b|kinolin-2-on-derivater, samt mellomprodukter for fremstilling derav NO300976B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US78495591A 1991-10-30 1991-10-30
PCT/EP1992/002496 WO1993009118A1 (en) 1991-10-30 1992-10-27 1,3-dihydro-2h-imidazo(4,5-b)quinolin-2-one derivatives as phosphodiesterase inhibitors

Publications (3)

Publication Number Publication Date
NO941497L NO941497L (no) 1994-04-25
NO941497D0 NO941497D0 (ja) 1994-04-25
NO300976B1 true NO300976B1 (no) 1997-08-25

Family

ID=25134048

Family Applications (1)

Application Number Title Priority Date Filing Date
NO941497A NO300976B1 (no) 1991-10-30 1994-04-25 1,3-dihydro-2H-imidazo£4,5-b|kinolin-2-on-derivater, samt mellomprodukter for fremstilling derav

Country Status (24)

Country Link
US (3) US5521187A (ja)
EP (2) EP0541153A1 (ja)
JP (1) JP3488922B2 (ja)
KR (1) KR100251895B1 (ja)
CN (1) CN1041726C (ja)
AT (1) ATE131479T1 (ja)
AU (1) AU660337B2 (ja)
CA (1) CA2121230C (ja)
DE (1) DE69206820T2 (ja)
DK (1) DK0610372T3 (ja)
ES (1) ES2083773T3 (ja)
FI (1) FI105548B (ja)
GR (1) GR3018909T3 (ja)
HU (1) HU220608B1 (ja)
IL (1) IL103570A (ja)
MX (1) MX9206258A (ja)
NO (1) NO300976B1 (ja)
NZ (1) NZ244779A (ja)
PH (1) PH31245A (ja)
PL (1) PL170749B1 (ja)
RU (1) RU2127273C1 (ja)
TW (1) TW249234B (ja)
WO (1) WO1993009118A1 (ja)
ZA (1) ZA928373B (ja)

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Also Published As

Publication number Publication date
CN1072681A (zh) 1993-06-02
IL103570A0 (en) 1993-03-15
WO1993009118A1 (en) 1993-05-13
PL170749B1 (pl) 1997-01-31
CN1041726C (zh) 1999-01-20
FI942010A0 (fi) 1994-04-29
EP0610372B1 (en) 1995-12-13
KR100251895B1 (ko) 2000-09-01
HUT66453A (en) 1994-11-28
PH31245A (en) 1998-06-18
FI942010A (fi) 1994-04-29
HU9401245D0 (en) 1994-08-29
GR3018909T3 (en) 1996-05-31
CA2121230A1 (en) 1993-05-13
EP0541153A1 (en) 1993-05-12
DE69206820D1 (de) 1996-01-25
NZ244779A (en) 1994-10-26
ES2083773T3 (es) 1996-04-16
RU2127273C1 (ru) 1999-03-10
JP3488922B2 (ja) 2004-01-19
US5516908A (en) 1996-05-14
DK0610372T3 (da) 1996-01-29
HU220608B1 (hu) 2002-03-28
AU2908392A (en) 1993-06-07
ATE131479T1 (de) 1995-12-15
TW249234B (ja) 1995-06-11
ZA928373B (en) 1994-04-29
JPH07500599A (ja) 1995-01-19
IL103570A (en) 1996-03-31
NO941497L (no) 1994-04-25
MX9206258A (es) 1993-04-01
DE69206820T2 (de) 1996-05-15
CA2121230C (en) 2003-03-11
US5541325A (en) 1996-07-30
AU660337B2 (en) 1995-06-22
NO941497D0 (ja) 1994-04-25
FI105548B (fi) 2000-09-15
US5521187A (en) 1996-05-28
EP0610372A1 (en) 1994-08-17

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