ES2501942T3 - Implantes oculares biodegradables con características de liberación a largo plazo - Google Patents
Implantes oculares biodegradables con características de liberación a largo plazo Download PDFInfo
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- ES2501942T3 ES2501942T3 ES05735919.2T ES05735919T ES2501942T3 ES 2501942 T3 ES2501942 T3 ES 2501942T3 ES 05735919 T ES05735919 T ES 05735919T ES 2501942 T3 ES2501942 T3 ES 2501942T3
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- implant
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- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61K9/2022—Organic macromolecular compounds
- A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
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Landscapes
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- Chemical & Material Sciences (AREA)
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- Chemical Kinetics & Catalysis (AREA)
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- Rheumatology (AREA)
- Pain & Pain Management (AREA)
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Applications Claiming Priority (3)
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|---|---|---|---|
| US837355 | 1997-04-17 | ||
| US10/837,355 US8685435B2 (en) | 2004-04-30 | 2004-04-30 | Extended release biodegradable ocular implants |
| PCT/US2005/013143 WO2005110362A1 (en) | 2004-04-30 | 2005-04-14 | Biodegradable ocular implants with long-term release characteristics |
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| ES2501942T3 true ES2501942T3 (es) | 2014-10-02 |
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| ES05735919.2T Expired - Lifetime ES2501942T3 (es) | 2004-04-30 | 2005-04-14 | Implantes oculares biodegradables con características de liberación a largo plazo |
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| Country | Link |
|---|---|
| US (6) | US8685435B2 (enExample) |
| EP (2) | EP2777693A1 (enExample) |
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| WO (1) | WO2005110362A1 (enExample) |
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| US6726918B1 (en) | 2000-07-05 | 2004-04-27 | Oculex Pharmaceuticals, Inc. | Methods for treating inflammation-mediated conditions of the eye |
| US6699493B2 (en) | 2000-11-29 | 2004-03-02 | Oculex Pharmaceuticals, Inc. | Method for reducing or preventing transplant rejection in the eye and intraocular implants for use therefor |
| US7431710B2 (en) | 2002-04-08 | 2008-10-07 | Glaukos Corporation | Ocular implants with anchors and methods thereof |
| US20050048099A1 (en) | 2003-01-09 | 2005-03-03 | Allergan, Inc. | Ocular implant made by a double extrusion process |
| US8685435B2 (en) | 2004-04-30 | 2014-04-01 | Allergan, Inc. | Extended release biodegradable ocular implants |
| US7993634B2 (en) | 2004-04-30 | 2011-08-09 | Allergan, Inc. | Oil-in-oil emulsified polymeric implants containing a hypotensive lipid and related methods |
| US7799336B2 (en) | 2004-04-30 | 2010-09-21 | Allergan, Inc. | Hypotensive lipid-containing biodegradable intraocular implants and related methods |
| US8673341B2 (en) | 2004-04-30 | 2014-03-18 | Allergan, Inc. | Intraocular pressure reduction with intracameral bimatoprost implants |
| US8722097B2 (en) | 2004-04-30 | 2014-05-13 | Allergan, Inc. | Oil-in-water method for making polymeric implants containing a hypotensive lipid |
| US8529927B2 (en) * | 2004-04-30 | 2013-09-10 | Allergan, Inc. | Alpha-2 agonist polymeric drug delivery systems |
| US9498457B2 (en) | 2004-04-30 | 2016-11-22 | Allergan, Inc. | Hypotensive prostamide-containing biodegradable intraocular implants and related implants |
| US20050244469A1 (en) | 2004-04-30 | 2005-11-03 | Allergan, Inc. | Extended therapeutic effect ocular implant treatments |
| EP2594259A1 (en) | 2004-08-04 | 2013-05-22 | Brookwood Pharmaceuticals, Inc. | Methods for manufacturing delivery devices and devices thereof |
| AU2014201844B2 (en) * | 2004-08-13 | 2016-06-16 | Allergan, Inc | Ocular implant made by a double extrusion process |
| AU2012216644B2 (en) * | 2004-08-13 | 2014-04-10 | Allergan, Inc. | Ocular implant made by a double extrusion process |
| AU2016228285B2 (en) * | 2004-08-13 | 2018-06-28 | Allergan, Inc. | Ocular implant made by a double extrusion process |
| US7931909B2 (en) * | 2005-05-10 | 2011-04-26 | Allergan, Inc. | Ocular therapy using alpha-2 adrenergic receptor compounds having enhanced anterior clearance rates |
| EP1924292A2 (en) | 2005-09-16 | 2008-05-28 | Allergan, Inc. | Compositions and methods for the intraocular transport of therapeutic agents |
| WO2007038453A2 (en) * | 2005-09-26 | 2007-04-05 | Advanced Ocular Systems Limited | Use of an anti-vascular endothelial growth factor (vegf) agent to ameliorate inflammation |
| EP1959925B1 (en) * | 2005-12-02 | 2016-11-23 | (OSI) Eyetech, Inc. | Controlled release microparticles |
| US20070202186A1 (en) | 2006-02-22 | 2007-08-30 | Iscience Interventional Corporation | Apparatus and formulations for suprachoroidal drug delivery |
| WO2007117687A2 (en) | 2006-04-06 | 2007-10-18 | Nupathe Inc. | Implants for the treatment of dopamine associated states |
| US20070260203A1 (en) * | 2006-05-04 | 2007-11-08 | Allergan, Inc. | Vasoactive agent intraocular implant |
| ATE531366T1 (de) * | 2006-08-07 | 2011-11-15 | Bausch & Lomb | Zusammensetzungen und verfahren zur behandlung, verminderung, verbesserung oder linderung von erkrankungen des hinteren augensegments |
| US20080089923A1 (en) * | 2006-09-29 | 2008-04-17 | Burkstrand Michael J | Biodegradable ocular implants and methods for treating ocular conditions |
| US20080103368A1 (en) * | 2006-10-17 | 2008-05-01 | Ari Craine | Methods, devices, and computer program products for detecting syndromes |
| US8039010B2 (en) | 2006-11-03 | 2011-10-18 | Allergan, Inc. | Sustained release intraocular drug delivery systems comprising a water soluble therapeutic agent and a release modifier |
| US8969415B2 (en) * | 2006-12-01 | 2015-03-03 | Allergan, Inc. | Intraocular drug delivery systems |
| CA2681361A1 (en) * | 2007-03-30 | 2008-10-09 | Fovea Pharmaceuticals Sa | Methods for treating neovascular ocular diseases |
| US8642067B2 (en) | 2007-04-02 | 2014-02-04 | Allergen, Inc. | Methods and compositions for intraocular administration to treat ocular conditions |
| US20080317805A1 (en) * | 2007-06-19 | 2008-12-25 | Mckay William F | Locally administrated low doses of corticosteroids |
| US9125807B2 (en) | 2007-07-09 | 2015-09-08 | Incept Llc | Adhesive hydrogels for ophthalmic drug delivery |
| US20170360609A9 (en) | 2007-09-24 | 2017-12-21 | Ivantis, Inc. | Methods and devices for increasing aqueous humor outflow |
| US8728528B2 (en) | 2007-12-20 | 2014-05-20 | Evonik Corporation | Process for preparing microparticles having a low residual solvent volume |
| JP2011513002A (ja) | 2008-03-05 | 2011-04-28 | イバンティス インコーポレイテッド | 緑内障を治療する方法及び器具 |
| US8946277B2 (en) * | 2008-04-18 | 2015-02-03 | Warsaw Orthopedic, Inc. | Clonidine formulations in a biodegradable polymer carrier |
| US9610243B2 (en) | 2008-04-18 | 2017-04-04 | Warsaw Orthopedic, Inc. | Clonidine compounds in a biodegradable polymer |
| US8889173B2 (en) * | 2008-04-18 | 2014-11-18 | Warsaw Orthopedic, Inc. | Alpha adrenergic receptor agonists for treatment of pain and/or inflammation |
| US8524267B2 (en) * | 2008-04-18 | 2013-09-03 | Warsaw Orthopedic, Inc. | Dexamethasone formulations in a biodegradable material |
| US8557273B2 (en) * | 2008-04-18 | 2013-10-15 | Medtronic, Inc. | Medical devices and methods including polymers having biologically active agents therein |
| USRE48948E1 (en) | 2008-04-18 | 2022-03-01 | Warsaw Orthopedic, Inc. | Clonidine compounds in a biodegradable polymer |
| US9877973B2 (en) | 2008-05-12 | 2018-01-30 | University Of Utah Research Foundation | Intraocular drug delivery device and associated methods |
| US10064819B2 (en) | 2008-05-12 | 2018-09-04 | University Of Utah Research Foundation | Intraocular drug delivery device and associated methods |
| US10588855B2 (en) | 2008-05-12 | 2020-03-17 | University Of Utah Research Foundation | Intraocular drug delivery device and associated methods |
| US9095404B2 (en) | 2008-05-12 | 2015-08-04 | University Of Utah Research Foundation | Intraocular drug delivery device and associated methods |
| EP2276439A4 (en) | 2008-05-12 | 2013-11-27 | Univ Utah Res Found | DEVICE AND CORRESPONDING METHODS FOR INTRAOCULAR MEDICAMENT ADMINISTRATION |
| RS64039B1 (sr) | 2008-11-10 | 2023-04-28 | Alexion Pharma Inc | Metode i kompozicije za lečenje poremećaja povezanih sa komplementom |
| US9943402B2 (en) | 2008-11-20 | 2018-04-17 | Insight Innovations, Llc | Micropatterned intraocular implant |
| EP3127509A1 (en) * | 2008-11-20 | 2017-02-08 | Insight Innovations, Llc | Biocompatible biodegradable intraocular implant system |
| US8551167B2 (en) | 2008-11-20 | 2013-10-08 | Insight Innovations, Llc | Intraocular implant cell migration inhibition system |
| US20120232649A1 (en) | 2008-11-20 | 2012-09-13 | Insight Innovations, Llc | Intraocular Lens Cell Migration Inhibition System |
| US8623395B2 (en) | 2010-01-29 | 2014-01-07 | Forsight Vision4, Inc. | Implantable therapeutic device |
| CA3045436C (en) | 2009-01-29 | 2025-10-07 | Forsight Vision4 Inc | Posterior segment drug delivery |
| EP2396070B1 (en) | 2009-02-12 | 2024-12-04 | Incept Llc | Drug delivery through hydrogel plugs |
| US9636255B2 (en) | 2009-02-13 | 2017-05-02 | Dose Medical Corporation | Uveoscleral drug delivery implant and methods for implanting the same |
| KR20110122846A (ko) | 2009-02-24 | 2011-11-11 | 알렉시온 파마슈티칼스, 인코포레이티드 | 치료용 ｔｐｏ/ｅｐｏ 모방 펩티드를 포함하는 항체 |
| US20100239632A1 (en) | 2009-03-23 | 2010-09-23 | Warsaw Orthopedic, Inc. | Drug depots for treatment of pain and inflammation in sinus and nasal cavities or cardiac tissue |
| US20100278897A1 (en) * | 2009-05-01 | 2010-11-04 | Allergan, Inc. | Intraocular bioactive agent delivery system with molecular partitioning system |
| WO2012071476A2 (en) * | 2010-11-24 | 2012-05-31 | David Haffner | Drug eluting ocular implant |
| US12478503B2 (en) | 2009-05-18 | 2025-11-25 | Glaukos Corporation | Implants with controlled drug delivery features and methods of using same |
| JP5937004B2 (ja) | 2009-05-18 | 2016-06-22 | ドーズ メディカル コーポレーションＤｏｓｅ Ｍｅｄｉｃａｌ Ｃｏｒｐｏｒａｔｉｏｎ | 薬剤溶出眼内インプラント |
| US10206813B2 (en) | 2009-05-18 | 2019-02-19 | Dose Medical Corporation | Implants with controlled drug delivery features and methods of using same |
| US9067384B2 (en) * | 2009-06-10 | 2015-06-30 | Ppg Industries Ohio, Inc. | Microporous material having degradation properties and articles prepared therefrom |
| NZ597259A (en) | 2009-06-23 | 2014-04-30 | Alexion Pharma Inc | Bispecific antibodies that bind to complement proteins |
| CA2766131C (en) | 2009-07-09 | 2017-10-24 | Ivantis, Inc. | Single operator device for delivering an ocular implant |
| EP2451503B1 (en) | 2009-07-09 | 2018-10-24 | Ivantis, Inc. | Ocular implants and methods for delivering ocular implants into the eye |
| WO2011035013A2 (en) * | 2009-09-17 | 2011-03-24 | Surmodics Pharmaceuticals, Inc. | Implant devices that differ by release profile and methods of making and using same |
| BR112012011585A2 (pt) * | 2009-11-02 | 2015-10-13 | Nupathe Inc | métodos para tratamento de doença de parkinson |
| KR20170095402A (ko) | 2009-11-09 | 2017-08-22 | 알러간, 인코포레이티드 | 모발 성장을 촉진하기 위한 조성물 및 방법 |
| US8529492B2 (en) | 2009-12-23 | 2013-09-10 | Trascend Medical, Inc. | Drug delivery devices and methods |
| US10166142B2 (en) | 2010-01-29 | 2019-01-01 | Forsight Vision4, Inc. | Small molecule delivery with implantable therapeutic device |
| WO2011106702A2 (en) | 2010-02-25 | 2011-09-01 | The Johns Hopkins University | Sustained delivery of therapeutic agents to an eye compartment |
| KR101800913B1 (ko) | 2010-04-30 | 2017-12-20 | 알렉시온 파마슈티칼스, 인코포레이티드 | 항-c5a 항체들과 이 항체들을 이용하는 방법 |
| EP2585110A4 (en) | 2010-06-22 | 2014-01-22 | Univ Colorado Regents | ANTIBODIES AGAINST THE C3D FRAGMENT OF THE COMPLEMENT COMPONENT 3 |
| WO2012012541A2 (en) | 2010-07-21 | 2012-01-26 | Allergan, Inc. | SUSTAINED RELEASE siRNA FOR OCULAR DRUG DELIVERY |
| HUE054113T2 (hu) | 2010-08-05 | 2021-08-30 | Forsight Vision4 Inc | Injekciós készülék gyógyszerbejuttatáshoz |
| CN103153316B (zh) | 2010-08-05 | 2015-08-19 | 弗赛特影像4股份有限公司 | 组合药物递送方法和设备 |
| HUE057267T2 (hu) | 2010-08-05 | 2022-05-28 | Forsight Vision4 Inc | Berendezés szem kezelésére |
| BR112013009205A2 (pt) | 2010-10-15 | 2016-07-26 | Iscience Interventional Corp | dispositivo para colocação na esclera de um olho, método para acessar o espaço supracoroidal de um olho, para acessar o espaço subretinal de um olho e para colocar um orifício dentro de um trato escleral em um olho. |
| EP2640360A2 (en) | 2010-11-19 | 2013-09-25 | Forsight Vision4, Inc. | Therapeutic agent formulations for implanted devices |
| JP6150734B2 (ja) | 2011-02-03 | 2017-06-21 | アレクシオン ファーマシューティカルズ， インコーポレイテッド | 同種移植片の生存を長期化するための抗ｃｄ２００抗体の使用 |
| US10245178B1 (en) | 2011-06-07 | 2019-04-02 | Glaukos Corporation | Anterior chamber drug-eluting ocular implant |
| RS60051B1 (sr) * | 2011-06-10 | 2020-04-30 | Ramscor Inc | Formulacije sa produženim oslobađanjem za isporuku proteina u oko i postupci njihove pripreme |
| US8657776B2 (en) | 2011-06-14 | 2014-02-25 | Ivantis, Inc. | Ocular implants for delivery into the eye |
| US10398592B2 (en) | 2011-06-28 | 2019-09-03 | Forsight Vision4, Inc. | Diagnostic methods and apparatus |
| US10226417B2 (en) | 2011-09-16 | 2019-03-12 | Peter Jarrett | Drug delivery systems and applications |
| SI2755600T1 (sl) | 2011-09-16 | 2021-08-31 | Forsight Vision4, Inc. | Naprava za izmenjavo tekočine |
| US8663150B2 (en) | 2011-12-19 | 2014-03-04 | Ivantis, Inc. | Delivering ocular implants into the eye |
| US10010448B2 (en) | 2012-02-03 | 2018-07-03 | Forsight Vision4, Inc. | Insertion and removal methods and apparatus for therapeutic devices |
| WO2013119955A1 (en) | 2012-02-09 | 2013-08-15 | Novus International Inc. | Functionalized polymer compositions |
| US9358156B2 (en) | 2012-04-18 | 2016-06-07 | Invantis, Inc. | Ocular implants for delivery into an anterior chamber of the eye |
| CN107753462B (zh) | 2012-07-12 | 2021-01-08 | 诺华丝国际股份有限公司 | 用于保护生物活性剂的基质和层组合物 |
| AU2013302441B2 (en) | 2012-08-17 | 2018-05-10 | The Regents Of The University Of Colorado, A Body Corporate | Compositions and methods for detecting complement activation |
| US10413620B2 (en) | 2012-08-17 | 2019-09-17 | The Regents Of The University Of Colorado, A Body Corporate | Light-emitting versions of the monoclonal antibody to C3D (MAB 3D29) for imaging |
| TWI663985B (zh) | 2012-09-27 | 2019-07-01 | 美商歐樂根公司 | 用於持續釋放蛋白質之可生物降解的藥物傳遞系統 |
| US20150290170A1 (en) * | 2012-10-26 | 2015-10-15 | Allergan, Inc. | Ketorolac-containing sustained release drug delivery systems |
| WO2014066653A1 (en) * | 2012-10-26 | 2014-05-01 | Allergan, Inc. | Ketorolac-containing sustained release intraocular drug delivery systems |
| WO2014066658A1 (en) * | 2012-10-26 | 2014-05-01 | Allergan, Inc. | Ketorolac-containing sustained release drug delivery systems |
| CA3240136A1 (en) | 2012-11-08 | 2014-05-15 | Clearside Biomedical, Inc. | Methods and devices for the treatment of ocular diseases in human subjects |
| WO2014085450A1 (en) | 2012-11-28 | 2014-06-05 | Ivantis, Inc. | Apparatus for delivering ocular implants into an anterior chamber of the eye |
| AU2014216112B2 (en) | 2013-02-15 | 2019-02-21 | Allergan, Inc. | Sustained drug delivery implant |
| AU2014236455B2 (en) | 2013-03-14 | 2018-07-12 | Forsight Vision4, Inc. | Systems for sustained intraocular delivery of low solubility compounds from a port delivery system implant |
| US10517759B2 (en) | 2013-03-15 | 2019-12-31 | Glaukos Corporation | Glaucoma stent and methods thereof for glaucoma treatment |
| ES2972168T3 (es) | 2013-03-28 | 2024-06-11 | Forsight Vision4 Inc | Implante oftálmico para administración de sustancias terapéuticas |
| WO2014160958A1 (en) | 2013-03-29 | 2014-10-02 | Alexion Pharmaceuticals, Inc. | Compositions and methods for increasing the serum half-life of a therapeutic agent targeting complement c5 |
| SG10201702674PA (en) | 2013-05-03 | 2017-06-29 | Clearside Biomedical Inc | Apparatus and methods for ocular injection |
| EP3003454B1 (en) | 2013-06-03 | 2020-01-08 | Clearside Biomedical, Inc. | Apparatus for drug delivery using multiple reservoirs |
| AU2014306002B2 (en) | 2013-08-07 | 2017-05-25 | Alexion Pharmaceuticals, Inc. | Atypical hemolytic uremic syndrome (aHUS) biomarker proteins |
| JP6543431B2 (ja) * | 2013-10-10 | 2019-07-10 | ユニバーシティー オブ ユタ リサーチ ファウンデーションＵｎｉｖｅｒｓｉｔｙ ｏｆ Ｕｔａｈ Ｒｅｓｅａｒｃｈ Ｆｏｕｎｄａｔｉｏｎ | 眼内薬物送達デバイスおよび付随する方法 |
| TR201802759T4 (tr) | 2013-10-31 | 2018-03-21 | Allergan Inc | Prostamid içeren intraoküler implantlar ve kullanım yöntemleri. |
| ES2869024T3 (es) * | 2013-11-08 | 2021-10-22 | Hollister Inc | Catéteres oleófilos lubricados |
| PT3068403T (pt) * | 2013-11-15 | 2020-09-18 | Allergan Inc | Métodos de tratamento de doenças oculares com um implante de fármaco de libertação controlada |
| NZ631007A (en) | 2014-03-07 | 2015-10-30 | Alexion Pharma Inc | Anti-c5 antibodies having improved pharmacokinetics |
| EP3148491B1 (en) | 2014-05-29 | 2020-07-01 | Glaukos Corporation | Implants with controlled drug delivery features and manufacturing method for said implants |
| EP3157463A4 (en) * | 2014-06-17 | 2018-02-21 | Clearside Biomedical, Inc. | Methods and devices for treating posterior ocular disorders |
| RU2710491C2 (ru) | 2014-06-20 | 2019-12-26 | Клиасайд Байомедикал, Инк. | Устройство для инъекции лекарственного средства в глазную ткань и способ инъекции лекарственного средства в глазную ткань |
| WO2016011056A1 (en) | 2014-07-14 | 2016-01-21 | Ivantis, Inc. | Ocular implant delivery system and method |
| WO2016011191A1 (en) | 2014-07-15 | 2016-01-21 | Forsight Vision4, Inc. | Ocular implant delivery device and method |
| CA2957548A1 (en) | 2014-08-08 | 2016-02-11 | Forsight Vision4, Inc. | Stable and soluble formulations of receptor tyrosine kinase inhibitors, and methods of preparation thereof |
| KR20230042391A (ko) | 2014-10-03 | 2023-03-28 | 나노틱스 엘엘씨 | 가용성 생물분자의 생물학적 활성을 억제하기 위한 조성물 및 방법 |
| BR112017009660A2 (pt) | 2014-11-10 | 2017-12-19 | Forsight Vision4 Inc | dispositivos de administração de fármacos expansíveis e métodos de utilização |
| FR3028410A1 (fr) | 2014-11-18 | 2016-05-20 | Pierre Coulon | Implant capsulaire multifonctionnel |
| EP3233058A1 (en) | 2014-12-15 | 2017-10-25 | The Johns Hopkins University | Sunitinib formulations and methods for use thereof in treatment of glaucoma |
| EP3250588A1 (en) | 2015-01-29 | 2017-12-06 | Board of Trustees of Michigan State University | Cryptic polypeptides and uses thereof |
| MX2017011462A (es) | 2015-03-06 | 2018-06-19 | Envisia Therapeutics Inc | Aplicadores de implante y metodos para administrar implantes. |
| WO2016145389A1 (en) | 2015-03-12 | 2016-09-15 | Board Of Trustees Of Michigan State University | Compositions and methods for measuring c-peptide binding and diagnosing immune-mediated diseases |
| EP3294334B1 (en) | 2015-05-11 | 2020-07-08 | The Johns Hopkins University | Autoimmune antibodies for use in inhibiting cancer cell growth |
| EP4279064A3 (en) | 2015-05-12 | 2024-02-28 | Incept, LLC | Drug delivery from hydrogels |
| WO2017015591A1 (en) | 2015-07-22 | 2017-01-26 | Incept, Llc | Coated punctal plug |
| WO2017015604A1 (en) | 2015-07-23 | 2017-01-26 | Envisia Therapeutics, Inc. | Intravitreal drug delivery systems for the treatment of ocular conditions |
| CN108135470B (zh) | 2015-08-14 | 2021-03-09 | 伊万提斯公司 | 具有压力传感器和输送系统的眼部植入物 |
| US11925578B2 (en) | 2015-09-02 | 2024-03-12 | Glaukos Corporation | Drug delivery implants with bi-directional delivery capacity |
| US11564833B2 (en) | 2015-09-25 | 2023-01-31 | Glaukos Corporation | Punctal implants with controlled drug delivery features and methods of using same |
| GB201519811D0 (en) * | 2015-11-10 | 2015-12-23 | Univ Belfast | Ocular compositions |
| CN108367079B (zh) | 2015-11-12 | 2022-11-22 | 灰色视觉公司 | 用于治疗的聚集性微粒 |
| JP6912475B2 (ja) | 2015-11-20 | 2021-08-04 | フォーサイト・ビジョン フォー・インコーポレーテッドＦｏｒｓｉｇｈｔ Ｖｉｓｉｏｎ４， Ｉｎｃ． | 持続放出性薬物送達機器用の多孔質構造体 |
| US11938058B2 (en) | 2015-12-15 | 2024-03-26 | Alcon Inc. | Ocular implant and delivery system |
| EP3413851B1 (en) | 2016-02-10 | 2023-09-27 | Clearside Biomedical, Inc. | Packaging |
| PT109154B (pt) * | 2016-02-12 | 2019-11-05 | Univ De Coimbra | Tecnologia não-invasiva de inserto ocular para libertação controlada de fármacos |
| AR108177A1 (es) | 2016-04-05 | 2018-07-25 | Forsight Vision4 Inc | Dispositivos de suministro de fármacos oculares implantables |
| WO2017176762A1 (en) | 2016-04-06 | 2017-10-12 | Nanotics, Llc | Particles comprising subparticles or nucleic acid scaffolds |
| JP7003110B2 (ja) | 2016-04-20 | 2022-01-20 | ドーズ メディカル コーポレーション | 生体吸収性眼球薬物送達デバイス |
| JP2019514581A (ja) | 2016-05-02 | 2019-06-06 | クリアサイド バイオメディカル，インコーポレイテッド | 眼の薬物送達のためのシステムおよび方法 |
| JP2019517473A (ja) | 2016-05-27 | 2019-06-24 | アレクシオン ファーマシューティカルズ インコーポレイテッドＡｌｅｘｉｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | 難治性全身型重症筋無力症の処置のための方法 |
| IL264764B2 (en) | 2016-08-12 | 2024-02-01 | Clearside Biomedical Inc | Devices and methods for adjusting the insertion depth of a drug administration needle |
| CA3036993A1 (en) | 2016-09-02 | 2018-03-08 | Aerie Pharmaceuticals, Inc. | Implant applicators |
| CN110662543A (zh) | 2017-03-23 | 2020-01-07 | 灰色视觉公司 | 用于治疗眼部疾病的药物和组合物 |
| WO2018204515A1 (en) | 2017-05-02 | 2018-11-08 | Georgia Tech Research Corporation | Targeted drug delivery methods using a microneedle |
| EP3621654A4 (en) | 2017-05-10 | 2021-02-17 | Graybug Vision, Inc. | PROLONGED-RELEASE MICROPARTICLES AND SUSPENSIONS OF THESE INTENDED FOR MEDICAL THERAPY |
| WO2018231485A1 (en) | 2017-06-13 | 2018-12-20 | Innfocus, Inc. | Systems, methods, and apparatus for treatment of glaucoma |
| WO2018236904A1 (en) | 2017-06-19 | 2018-12-27 | Surface Oncology, Inc. | Combination of anti-cd47 antibodies and cell death-inducing agents, and uses thereof |
| EP3652209A2 (en) | 2017-07-11 | 2020-05-20 | Compass Therapeutics LLC | Agonist antibodies that bind human cd137 and uses thereof |
| ES2965486T3 (es) | 2017-07-27 | 2024-04-15 | Alexion Pharma Inc | Formulaciones de anticuerpos anti-C5 de alta concentración |
| US10584306B2 (en) | 2017-08-11 | 2020-03-10 | Board Of Regents Of The University Of Oklahoma | Surfactant microemulsions |
| EP3684811A2 (en) | 2017-08-17 | 2020-07-29 | Massachusetts Institute of Technology | Multiple specificity binders of cxc chemokines and uses thereof |
| SG11202001379WA (en) | 2017-09-08 | 2020-03-30 | Bristol Myers Squibb Co | Modified fibroblast growth factor 21 (fgf-21) for use in methods for treating nonalcoholic steatohepatitis (nash) |
| WO2019067499A1 (en) | 2017-09-27 | 2019-04-04 | Alexion Pharmaceuticals, Inc. | BIOMARKER SIGNATURE FOR PREDICTING A TUMOR RESPONSE TO ANTI-CD200 THERAPY |
| KR20200070355A (ko) | 2017-10-26 | 2020-06-17 | 알렉시온 파마슈티칼스, 인코포레이티드 | 발작성 야간 혈색소뇨 (pnh) 및 비정형 용혈성 요독 증후군 (ahus)의 치료를 위한 항-c5 항체의 투여량 및 투여 |
| WO2019089753A2 (en) | 2017-10-31 | 2019-05-09 | Compass Therapeutics Llc | Cd137 antibodies and pd-1 antagonists and uses thereof |
| US11851497B2 (en) | 2017-11-20 | 2023-12-26 | Compass Therapeutics Llc | CD137 antibodies and tumor antigen-targeting antibodies and uses thereof |
| CN115607358A (zh) | 2017-11-21 | 2023-01-17 | 弗赛特影像4股份有限公司 | 用于可扩展端口递送系统的流体交换装置及使用方法 |
| EP4371535A3 (en) | 2018-02-22 | 2024-08-14 | Alcon Inc. | Ocular implant |
| MX394121B (es) | 2018-03-14 | 2025-03-24 | Surface Oncology Inc | Anticuerpos que se unen a cd39 y sus usos |
| BR112020018918A2 (pt) | 2018-03-22 | 2021-01-05 | Surface Oncology, Inc. | Anticorpos anti-il-27 e usos dos mesmos |
| WO2019200357A1 (en) | 2018-04-12 | 2019-10-17 | Surface Oncology, Inc. | Biomarker for cd47 targeting therapeutics and uses therefor |
| CN112105733B (zh) | 2018-04-19 | 2024-10-29 | 查美特制药公司 | 合成rig-i样受体激动剂 |
| AU2019272575A1 (en) | 2018-05-21 | 2020-12-10 | Compass Therapeutics Llc | Compositions and methods for enhancing the killing of target cells by NK cells |
| WO2019226658A1 (en) | 2018-05-21 | 2019-11-28 | Compass Therapeutics Llc | Multispecific antigen-binding compositions and methods of use |
| ES2996257T3 (en) | 2018-05-31 | 2025-02-12 | Alexion Pharma Inc | Dosage and administration of anti-c5 antibodies for treatment of paroxysmal nocturnal hemoglobinuria (pnh) in pediatric patients |
| EP3802603A1 (en) | 2018-06-04 | 2021-04-14 | Alexion Pharmaceuticals, Inc. | Dosage and administration of anti-c5 antibodies for treatment of atypical hemolytic uremic syndrome (ahus) in pediatric patients |
| WO2020006266A1 (en) | 2018-06-28 | 2020-01-02 | Alexion Pharmaceuticals, Inc. | Methods of producing anti-c5 antibodies |
| WO2020018715A1 (en) | 2018-07-17 | 2020-01-23 | Massachusetts Institute Of Technology | Soluble multimeric immunoglobulin-scaffold based fusion proteins and uses thereof |
| EP3833443A1 (en) | 2018-08-09 | 2021-06-16 | Compass Therapeutics LLC | Antigen binding agents that bind cd277 and uses thereof |
| WO2020033925A2 (en) | 2018-08-09 | 2020-02-13 | Compass Therapeutics Llc | Antibodies that bind cd277 and uses thereof |
| EP3833442A2 (en) | 2018-08-09 | 2021-06-16 | Compass Therapeutics LLC | Antibodies that bind cd277 and uses thereof |
| US12240893B2 (en) | 2018-10-30 | 2025-03-04 | Alexion Pharmaceuticals, Inc. | Subcutaneous dosage and administration of anti-C5 antibodies for treatment of paroxysmal nocturnal hemoglobinuria (PNH) |
| WO2020097054A1 (en) | 2018-11-06 | 2020-05-14 | Georgetown University | Treating non-alcoholic steatohepatitis with cck inhibitors |
| MX2021005594A (es) | 2018-11-13 | 2021-10-22 | Compass Therapeutics Llc | Constructos multiespecificos de union contra moleculas de puntos de control y usos de los mismos. |
| MA54469A (fr) | 2018-12-13 | 2021-10-20 | Surface Oncology Inc | Anticorps anti-il-27 et leurs utilisations |
| CN120643495A (zh) * | 2018-12-21 | 2025-09-16 | 瑞瓦纳治疗有限公司 | 包被的眼部植入物 |
| US20220111047A1 (en) | 2019-01-16 | 2022-04-14 | Compass Therapeutics Llc | Formulations of antibodies that bind human cd137 and uses thereof |
| WO2020163782A2 (en) | 2019-02-08 | 2020-08-13 | The Uab Research Foundation | Immunotherapy for the treatment and prevention of inflammatory bowel disease |
| US11883525B2 (en) * | 2019-05-31 | 2024-01-30 | Dose Medical Corporation | Bioerodible polyester polymer axitinib ocular implants and related methods of use |
| CA3144406A1 (en) | 2019-06-27 | 2020-12-30 | Layerbio, Inc. | Ocular device delivery methods and systems |
| US12403291B2 (en) | 2019-08-30 | 2025-09-02 | Intersect Ent, Inc. | Submucosal bioresorbable drug eluting platform |
| JP2022548484A (ja) | 2019-09-16 | 2022-11-21 | サーフィス オンコロジー インコーポレイテッド | 抗ｃｄ３９抗体の組成物及び方法 |
| TW202521984A (zh) | 2019-09-25 | 2025-06-01 | 美商表面腫瘤學有限責任公司 | 抗ｉｌ－２７抗體及其用途 |
| WO2021067526A1 (en) | 2019-10-02 | 2021-04-08 | Alexion Pharmaceuticals, Inc. | Complement inhibitors for treating drug-induced complement-mediated response |
| MX2022004825A (es) | 2019-10-23 | 2022-10-10 | Regeneron Pharma | Agonistas sintéticos del receptor similar a rig i. |
| US11459389B2 (en) | 2019-10-24 | 2022-10-04 | Massachusetts Institute Of Technology | Monoclonal antibodies that bind human CD161 |
| US12275986B2 (en) | 2020-01-06 | 2025-04-15 | Duke University | Biomarkers associated with checkpoint immune therapy and methods of using same |
| CA3166738A1 (en) | 2020-02-06 | 2021-08-12 | Charles D. Blizzard | Travoprost compositions and methods for treating ocular diseases |
| FI3884929T3 (fi) | 2020-03-25 | 2023-08-07 | Ocular Therapeutix Inc | Tyrosiinikinaasi-inhibiittoria sisältävä silmäimplantti |
| US12084509B2 (en) | 2020-04-30 | 2024-09-10 | Duke University | Gene signatures for monitoring acute rejection and methods of using same |
| WO2021231720A1 (en) | 2020-05-15 | 2021-11-18 | Alexion Pharmaceuticals, Inc. | Method of using extracellular vesicles to detect complement activation, and uses thereof to assess and/or monitor treatment of a complement-mediated disease |
| BR112023001073A2 (pt) | 2020-07-21 | 2023-03-07 | Allergan Inc | Implante intraocular com alto carregamento de prostamida |
| KR20230130622A (ko) | 2021-01-11 | 2023-09-12 | 알콘 인코포레이티드 | 점탄성 전달을 위한 시스템 및 방법 |
| WO2022236134A1 (en) | 2021-05-07 | 2022-11-10 | Surface Oncology, Inc. | Anti-il-27 antibodies and uses thereof |
| JP2024520497A (ja) | 2021-05-28 | 2024-05-24 | アレクシオン ファーマシューティカルズ， インコーポレイテッド | Ｃｍ－ｔｍａバイオマーカーを検出するための方法 |
| USD1033637S1 (en) | 2022-01-24 | 2024-07-02 | Forsight Vision4, Inc. | Fluid exchange device |
| US20240025987A1 (en) | 2022-05-25 | 2024-01-25 | Surface Oncology, Inc. | Use of anti-il-27 antibodies |
| WO2023230128A1 (en) | 2022-05-25 | 2023-11-30 | Surface Oncology, Inc. | Use of anti-il-27 antibodies |
| JP2025525881A (ja) | 2022-08-16 | 2025-08-07 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 眼内使用するためのニンテダニブの医薬製剤 |
| CA3266977A1 (en) | 2022-09-06 | 2024-03-14 | Alexion Pharma Inc | DIAGNOSTIC AND PROGNOSIS BIOMARKER PROFILES IN PATIENTS WITH HEMATOPOIETIC STEM CELL TRANSPLANT-ASSOCIATED THROMBOTIC MICROANGIOPATHY (HSCT-TMA) |
| WO2024086306A1 (en) * | 2022-10-19 | 2024-04-25 | Vitakey Inc. | Formulated food products |
| CN120897764A (zh) | 2023-04-11 | 2025-11-04 | 视尔普斯眼科公司 | 包含阿西替尼多晶型物iv的眼部植入物 |
| WO2024238421A1 (en) | 2023-05-12 | 2024-11-21 | Alexion Pharmaceuticals, Inc. | Use of biomarkers for the identification and treatment of complement-mediated disorders |
| WO2024238422A1 (en) | 2023-05-12 | 2024-11-21 | Alexion Pharmaceuticals, Inc. | Use of a panel of lectins for detection of complement biomarkers in urine extracellular vesicles |
Family Cites Families (56)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US19098A (en) * | 1858-01-12 | Valve arrangement for steam-engines | ||
| DE430539C (de) | 1922-04-21 | 1926-06-23 | J G Farbenindustrie Akt Ges | Verfahren zur Darstellung von AEthylenchlorid |
| US3986510A (en) * | 1971-09-09 | 1976-10-19 | Alza Corporation | Bioerodible ocular device |
| US3976071A (en) * | 1974-01-07 | 1976-08-24 | Dynatech Corporation | Methods of improving control of release rates and products useful in same |
| US3985510A (en) * | 1974-05-28 | 1976-10-12 | Taylor Fred W | Flash reactor unit |
| US4304765A (en) * | 1980-10-14 | 1981-12-08 | Alza Corporation | Ocular insert housing steroid in two different therapeutic forms |
| US5286763A (en) * | 1983-03-22 | 1994-02-15 | Massachusetts Institute Of Technology | Bioerodible polymers for drug delivery in bone |
| JPS6050051U (ja) | 1983-09-14 | 1985-04-08 | 日産車体株式会社 | 自動車のリヤスピ−カ取付け構造 |
| US6309669B1 (en) * | 1984-03-16 | 2001-10-30 | The United States Of America As Represented By The Secretary Of The Army | Therapeutic treatment and prevention of infections with a bioactive materials encapsulated within a biodegradable-biocompatible polymeric matrix |
| US4966849A (en) * | 1985-09-20 | 1990-10-30 | President And Fellows Of Harvard College | CDNA and genes for human angiogenin (angiogenesis factor) and methods of expression |
| WO1987006129A1 (en) | 1986-04-10 | 1987-10-22 | Daratech Pty. Ltd. | Vaccine and implant |
| US4863457A (en) * | 1986-11-24 | 1989-09-05 | Lee David A | Drug delivery device |
| US4853224A (en) * | 1987-12-22 | 1989-08-01 | Visionex | Biodegradable ocular implants |
| US4997652A (en) * | 1987-12-22 | 1991-03-05 | Visionex | Biodegradable ocular implants |
| JP2702729B2 (ja) | 1988-02-24 | 1998-01-26 | エーザイ株式会社 | 徐放性埋込剤 |
| JPH0216917A (ja) | 1988-07-05 | 1990-01-19 | Iseki & Co Ltd | 脱穀装置の拡散装置 |
| US5164188A (en) * | 1989-11-22 | 1992-11-17 | Visionex, Inc. | Biodegradable ocular implants |
| ATE114661T1 (de) | 1990-04-02 | 1994-12-15 | Pfizer | Benzylphosphonsäure-tyrosinkinaseinhibitoren. |
| KR0185215B1 (ko) | 1990-11-30 | 1999-05-01 | 요시다 쇼오지 | 서방성 안구삽입용 약제 |
| US5378475A (en) * | 1991-02-21 | 1995-01-03 | University Of Kentucky Research Foundation | Sustained release drug delivery devices |
| JPH06503095A (ja) | 1991-05-29 | 1994-04-07 | ファイザー・インコーポレーテッド | 三環式ポリヒドロキシ系のチロシンキナーゼ阻害薬 |
| EP0654024A1 (en) | 1992-08-06 | 1995-05-24 | Warner-Lambert Company | 2-thioindoles (selenoindoles) and related disulfides (selenides) which inhibit protein tyrosine kinases and which have antitumor properties |
| US5330992A (en) * | 1992-10-23 | 1994-07-19 | Sterling Winthrop Inc. | 1-cyclopropyl-4-pyridyl-quinolinones |
| EP1238986B1 (en) | 1992-10-28 | 2008-06-25 | Genentech, Inc. | Use of Vascular endothelial cell growth factor antagonists |
| GB9226855D0 (en) | 1992-12-23 | 1993-02-17 | Erba Carlo Spa | Vinylene-azaindole derivatives and process for their preparation |
| EP0654256B1 (en) | 1993-02-26 | 2000-08-02 | Santen Pharmaceutical Co., Ltd. | Biodegradable sclera plug |
| US5443505A (en) * | 1993-11-15 | 1995-08-22 | Oculex Pharmaceuticals, Inc. | Biocompatible ocular implants |
| JPH11501027A (ja) * | 1995-02-28 | 1999-01-26 | イナファーマ，インコーポレイテッド | 骨粗鬆症の処置のためのエルカトニン制御放出ミクロスフェア処方物 |
| US6369116B1 (en) * | 1995-06-02 | 2002-04-09 | Oculex Pharmaceuticals, Inc. | Composition and method for treating glaucoma |
| US5869079A (en) * | 1995-06-02 | 1999-02-09 | Oculex Pharmaceuticals, Inc. | Formulation for controlled release of drugs by combining hydrophilic and hydrophobic agents |
| US6046187A (en) * | 1996-09-16 | 2000-04-04 | Children's Medical Center Corporation | Formulations and methods for providing prolonged local anesthesia |
| JPH1170138A (ja) * | 1997-07-02 | 1999-03-16 | Santen Pharmaceut Co Ltd | ポリ乳酸強膜プラグ |
| EP0992244A4 (en) | 1997-07-02 | 2001-01-17 | Santen Pharmaceutical Co Ltd | SCLERAL PLUGS OF POLYLACTIC ACID |
| US6306426B1 (en) * | 1997-08-11 | 2001-10-23 | Allergan Sales, Inc. | Implant device with a retinoid for improved biocompatibility |
| US6217895B1 (en) * | 1999-03-22 | 2001-04-17 | Control Delivery Systems | Method for treating and/or preventing retinal diseases with sustained release corticosteroids |
| US6331313B1 (en) * | 1999-10-22 | 2001-12-18 | Oculex Pharmaceticals, Inc. | Controlled-release biocompatible ocular drug delivery implant devices and methods |
| US20040208910A1 (en) * | 2000-04-26 | 2004-10-21 | Control Delivery Systems, Inc. | Sustained release device and method for ocular delivery of adrenergic agents |
| US6726918B1 (en) * | 2000-07-05 | 2004-04-27 | Oculex Pharmaceuticals, Inc. | Methods for treating inflammation-mediated conditions of the eye |
| US6699493B2 (en) | 2000-11-29 | 2004-03-02 | Oculex Pharmaceuticals, Inc. | Method for reducing or preventing transplant rejection in the eye and intraocular implants for use therefor |
| EP1550471A1 (en) | 2000-11-29 | 2005-07-06 | Allergan Inc. | Intraocular implants for preventing transplant rejection in the eye |
| ES2358319T3 (es) * | 2001-02-27 | 2011-05-09 | Senju Pharmaceutical Co., Ltd. | Sistema de liberación de fármaco del tipo polímero biodegradable. |
| US6713081B2 (en) * | 2001-03-15 | 2004-03-30 | The United States Of America As Represented By The Department Of Health And Human Services | Ocular therapeutic agent delivery devices and methods for making and using such devices |
| WO2003000156A1 (en) | 2001-06-22 | 2003-01-03 | Southern Biosystems, Inc. | Zero-order prolonged release coaxial implants |
| US6488952B1 (en) * | 2001-08-28 | 2002-12-03 | John P. Kennedy | Semisolid therapeutic delivery system and combination semisolid, multiparticulate, therapeutic delivery system |
| US20030134810A1 (en) | 2001-10-09 | 2003-07-17 | Chris Springate | Methods and compositions comprising biocompatible materials useful for the administration of therapeutic agents |
| WO2003051328A1 (en) | 2001-12-18 | 2003-06-26 | Novo Nordisk A/S | Solid dose micro implant |
| US6541504B1 (en) * | 2002-04-03 | 2003-04-01 | Allergan Sales, Llc | (3Z)-3-(2,3-dihydro-1H-inden-1-ylidene)-1,3-dihydro-2H-indol-2-ones as kinase inhibitors |
| MXPA04011004A (es) * | 2002-05-07 | 2005-01-25 | Control Delivery Sys Inc | Procesos para formar un dispositivo de administracion de farmaco. |
| PL223153B1 (pl) | 2002-09-18 | 2016-10-31 | Allergan Inc | Urządzenie do wszczepiania implantu okulistycznego |
| BR0315304A (pt) * | 2002-11-06 | 2005-08-16 | Alza Corp | Formulações com depósito para liberação controlada |
| US20040137059A1 (en) | 2003-01-09 | 2004-07-15 | Thierry Nivaggioli | Biodegradable ocular implant |
| US20050244500A1 (en) * | 2004-04-30 | 2005-11-03 | Allergan, Inc. | Intravitreal implants in conjuction with photodynamic therapy to improve vision |
| US8685435B2 (en) | 2004-04-30 | 2014-04-01 | Allergan, Inc. | Extended release biodegradable ocular implants |
| US20050244466A1 (en) * | 2004-04-30 | 2005-11-03 | Allergan, Inc. | Photodynamic therapy in conjunction with intraocular implants |
| US8119154B2 (en) * | 2004-04-30 | 2012-02-21 | Allergan, Inc. | Sustained release intraocular implants and related methods |
| US20050244469A1 (en) | 2004-04-30 | 2005-11-03 | Allergan, Inc. | Extended therapeutic effect ocular implant treatments |
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2004
- 2004-04-30 US US10/837,355 patent/US8685435B2/en active Active
-
2005
- 2005-04-14 CA CA2565329A patent/CA2565329C/en not_active Expired - Lifetime
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- 2005-04-14 BR BRPI0509332-5A patent/BRPI0509332A/pt not_active IP Right Cessation
- 2005-04-29 TW TW094113990A patent/TW200603838A/zh unknown
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| US10154960B2 (en) | 2018-12-18 |
| AR048773A1 (es) | 2006-05-24 |
| WO2005110362A1 (en) | 2005-11-24 |
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