AR048773A1 - Sistema de administracion de droga (por ejemplo,dexametasona) para tratar una condicion ocular, implante bio-erosionable de liberacion prolongada comprendido en el anterior y uso de este ultimo para la fabricacion de dicho sistema de administracion de droga - Google Patents

Sistema de administracion de droga (por ejemplo,dexametasona) para tratar una condicion ocular, implante bio-erosionable de liberacion prolongada comprendido en el anterior y uso de este ultimo para la fabricacion de dicho sistema de administracion de droga

Info

Publication number
AR048773A1
AR048773A1 ARP050101753A ARP050101753A AR048773A1 AR 048773 A1 AR048773 A1 AR 048773A1 AR P050101753 A ARP050101753 A AR P050101753A AR P050101753 A ARP050101753 A AR P050101753A AR 048773 A1 AR048773 A1 AR 048773A1
Authority
AR
Argentina
Prior art keywords
bio
active agent
erodible
administration system
implant
Prior art date
Application number
ARP050101753A
Other languages
English (en)
Original Assignee
Allergan Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34966124&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR048773(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Allergan Inc filed Critical Allergan Inc
Publication of AR048773A1 publication Critical patent/AR048773A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A61K9/0051—Ocular inserts, ocular implants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
    • A61K9/204—Polyesters, e.g. poly(lactide-co-glycolide)

Abstract

Un sistema de administracion de droga para tratar una condicion ocular que comprende: (a) al menos un implante bio-erosionable adecuado para insertar en una region o sitio ocular, el implante bio-erosionable comprendiendo: (i) un agente activo, y (ii) un polímero bio-erosionable, donde el implante bio-erosionable puede liberar un nivel terapéutico del agente activo en la region o sitio ocular durante un período de tiempo entre alrededor de 30 días y alrededor 1 ano. Un implante bio- erosionable para tratar una condicion ocular comprendido en el sistema de administracion de droga descripto, que comprende: (a) una dispersion que comprende un agente activo dispersado con un primer polímero bio-erosionable, (b) una partícula que comprende el agente activo y un segundo polímero bio-erosionable; donde la partícula tiene una característica de liberacion del agente activo que difiere de la característica de liberacion del agente activo de la dispersion. Uso de al menos un implante bio-erosionable adecuado para insertar en una region o sitio ocular para la fabricacion de un sistema de administracion de droga para tratar una condicion ocular, mediante el implante en una region o sitio ocular dicho sistema de administracion de droga, en donde el implante bio-erosionable puede liberar un nivel terapéutico del agente activo a una velocidad substancialmente continua sobre el inserto en una region o sitio ocular durante un período de tiempo entre alrededor de 50 días alrededor de un ano. El agente activo es un agente anti-inflamatorio y el polímero bio-erosionable es un co-polímero PLGA.
ARP050101753A 2004-04-30 2005-05-02 Sistema de administracion de droga (por ejemplo,dexametasona) para tratar una condicion ocular, implante bio-erosionable de liberacion prolongada comprendido en el anterior y uso de este ultimo para la fabricacion de dicho sistema de administracion de droga AR048773A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US10/837,355 US8685435B2 (en) 2004-04-30 2004-04-30 Extended release biodegradable ocular implants

Publications (1)

Publication Number Publication Date
AR048773A1 true AR048773A1 (es) 2006-05-24

Family

ID=34966124

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP050101753A AR048773A1 (es) 2004-04-30 2005-05-02 Sistema de administracion de droga (por ejemplo,dexametasona) para tratar una condicion ocular, implante bio-erosionable de liberacion prolongada comprendido en el anterior y uso de este ultimo para la fabricacion de dicho sistema de administracion de droga

Country Status (10)

Country Link
US (6) US8685435B2 (es)
EP (2) EP1740153B2 (es)
JP (4) JP5128274B2 (es)
AR (1) AR048773A1 (es)
AU (1) AU2005244195B2 (es)
BR (1) BRPI0509332A (es)
CA (1) CA2565329C (es)
ES (1) ES2501942T3 (es)
TW (1) TW200603838A (es)
WO (1) WO2005110362A1 (es)

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