JP5128274B2 - 長時間放出特性を有する生分解性眼インプラント - Google Patents

長時間放出特性を有する生分解性眼インプラント Download PDF

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Publication number
JP5128274B2
JP5128274B2 JP2007510790A JP2007510790A JP5128274B2 JP 5128274 B2 JP5128274 B2 JP 5128274B2 JP 2007510790 A JP2007510790 A JP 2007510790A JP 2007510790 A JP2007510790 A JP 2007510790A JP 5128274 B2 JP5128274 B2 JP 5128274B2
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Prior art keywords
implant
dexamethasone
release
polymer
active agent
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Expired - Fee Related
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JP2007510790A
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Japanese (ja)
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JP2007535535A5 (enExample
JP2007535535A (ja
Inventor
ティエリー・ニバジョリ
シアー・ジェーン・グオ
キン・リン
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Allergan Inc
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Allergan Inc
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Publication of JP2007535535A5 publication Critical patent/JP2007535535A5/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A61K9/0051—Ocular inserts, ocular implants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
    • A61K9/204—Polyesters, e.g. poly(lactide-co-glycolide)

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Inorganic Chemistry (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
JP2007510790A 2004-04-30 2005-04-14 長時間放出特性を有する生分解性眼インプラント Expired - Fee Related JP5128274B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10/837,355 US8685435B2 (en) 2004-04-30 2004-04-30 Extended release biodegradable ocular implants
US10/837,355 2004-04-30
PCT/US2005/013143 WO2005110362A1 (en) 2004-04-30 2005-04-14 Biodegradable ocular implants with long-term release characteristics

Related Child Applications (2)

Application Number Title Priority Date Filing Date
JP2011216499A Division JP5552102B2 (ja) 2004-04-30 2011-09-30 長時間放出特性を有する生分解性眼インプラント
JP2012144950A Division JP2012207028A (ja) 2004-04-30 2012-06-28 長時間放出特性を有する生分解性眼インプラント

Publications (3)

Publication Number Publication Date
JP2007535535A JP2007535535A (ja) 2007-12-06
JP2007535535A5 JP2007535535A5 (enExample) 2008-05-29
JP5128274B2 true JP5128274B2 (ja) 2013-01-23

Family

ID=34966124

Family Applications (4)

Application Number Title Priority Date Filing Date
JP2007510790A Expired - Fee Related JP5128274B2 (ja) 2004-04-30 2005-04-14 長時間放出特性を有する生分解性眼インプラント
JP2011216499A Expired - Lifetime JP5552102B2 (ja) 2004-04-30 2011-09-30 長時間放出特性を有する生分解性眼インプラント
JP2012144950A Pending JP2012207028A (ja) 2004-04-30 2012-06-28 長時間放出特性を有する生分解性眼インプラント
JP2014091044A Expired - Fee Related JP5706020B2 (ja) 2004-04-30 2014-04-25 生分解性眼インプラントの製造方法

Family Applications After (3)

Application Number Title Priority Date Filing Date
JP2011216499A Expired - Lifetime JP5552102B2 (ja) 2004-04-30 2011-09-30 長時間放出特性を有する生分解性眼インプラント
JP2012144950A Pending JP2012207028A (ja) 2004-04-30 2012-06-28 長時間放出特性を有する生分解性眼インプラント
JP2014091044A Expired - Fee Related JP5706020B2 (ja) 2004-04-30 2014-04-25 生分解性眼インプラントの製造方法

Country Status (10)

Country Link
US (6) US8685435B2 (enExample)
EP (2) EP2777693A1 (enExample)
JP (4) JP5128274B2 (enExample)
AR (1) AR048773A1 (enExample)
AU (1) AU2005244195B2 (enExample)
BR (1) BRPI0509332A (enExample)
CA (1) CA2565329C (enExample)
ES (1) ES2501942T3 (enExample)
TW (1) TW200603838A (enExample)
WO (1) WO2005110362A1 (enExample)

Families Citing this family (208)

* Cited by examiner, † Cited by third party
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