ES2300402T3 - Procedimiento para la preparacion de perindopril, de analogos y de sales del mismo utilizando 2,5-dioxo-oxazolidinas como intermedios. - Google Patents

Procedimiento para la preparacion de perindopril, de analogos y de sales del mismo utilizando 2,5-dioxo-oxazolidinas como intermedios. Download PDF

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Publication number
ES2300402T3
ES2300402T3 ES02016262T ES02016262T ES2300402T3 ES 2300402 T3 ES2300402 T3 ES 2300402T3 ES 02016262 T ES02016262 T ES 02016262T ES 02016262 T ES02016262 T ES 02016262T ES 2300402 T3 ES2300402 T3 ES 2300402T3
Authority
ES
Spain
Prior art keywords
formula
compound
perindopril
reaction
quad
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES02016262T
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English (en)
Spanish (es)
Inventor
Pau Cid
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Institut Servier de Medecine Translationnelle SARL
Original Assignee
ADIR SARL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8183486&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2300402(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by ADIR SARL filed Critical ADIR SARL
Application granted granted Critical
Publication of ES2300402T3 publication Critical patent/ES2300402T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/44—Two oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Cephalosporin Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
ES02016262T 2001-07-24 2002-07-23 Procedimiento para la preparacion de perindopril, de analogos y de sales del mismo utilizando 2,5-dioxo-oxazolidinas como intermedios. Expired - Lifetime ES2300402T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01500197 2001-07-24
EP01500197 2001-07-24

Publications (1)

Publication Number Publication Date
ES2300402T3 true ES2300402T3 (es) 2008-06-16

Family

ID=8183486

Family Applications (1)

Application Number Title Priority Date Filing Date
ES02016262T Expired - Lifetime ES2300402T3 (es) 2001-07-24 2002-07-23 Procedimiento para la preparacion de perindopril, de analogos y de sales del mismo utilizando 2,5-dioxo-oxazolidinas como intermedios.

Country Status (23)

Country Link
US (1) US20040248814A1 (enExample)
EP (1) EP1279665B1 (enExample)
JP (1) JP4083118B2 (enExample)
KR (1) KR100694528B1 (enExample)
CN (1) CN100503568C (enExample)
AR (1) AR036187A1 (enExample)
AT (1) ATE386717T1 (enExample)
AU (1) AU2002328954B2 (enExample)
BR (1) BR0211422A (enExample)
CY (1) CY1107403T1 (enExample)
DE (1) DE60225092T2 (enExample)
DK (1) DK1279665T3 (enExample)
EA (1) EA007000B1 (enExample)
ES (1) ES2300402T3 (enExample)
HU (1) HUP0202414A3 (enExample)
MX (1) MXPA04000649A (enExample)
NO (1) NO20040278L (enExample)
NZ (1) NZ530578A (enExample)
PL (1) PL355161A1 (enExample)
PT (1) PT1279665E (enExample)
SI (1) SI1279665T1 (enExample)
WO (1) WO2003010142A2 (enExample)
ZA (1) ZA200400323B (enExample)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1333026T3 (da) 2002-01-30 2007-10-22 Servier Lab Fremgangsmåde til fremstilling af perindopril med höj renhed og nyttige mellemforbindelser til syntesen
PT1603558E (pt) 2003-02-28 2008-08-19 Servier S A Lab Processo para a preparação de perindopril e dos seus sais
ATE422895T1 (de) 2003-04-16 2009-03-15 Bristol Myers Squibb Co Makrocyclische isochinolinpeptidinhibitoren des hepatitis-c-virus
SI21506A (sl) * 2003-05-08 2004-12-31 LEK farmacevtska dru�ba d.d. Postopek za pripravo perindoprila
SI21507A (sl) * 2003-05-16 2004-12-31 LEK farmacevtska dru�ba d.d. Postopek za pripravo spojin z ace inhibitornim delovanjem
AU2003263584A1 (en) * 2003-08-21 2005-03-10 Hetero Drugs Limited Process for pure perindopril tert-butylamine salt
PT1675827E (pt) * 2003-10-21 2010-02-15 Servier Lab Novo processo para preparação de perindopril erbumina cristalina
SI21703A (en) 2004-01-14 2005-08-31 Lek Farmacevtska Druzba Dd Inclusion complexes of perindopril, procedure of their preparation, pharmaceutical compositions containing these complexes and their application in treatment of hypertensia
SI21881A (sl) 2004-10-15 2006-04-30 Diagen, Smartno Pri Ljubljani, D.O.O. Nove kristalne oblike perindopril erbumin hidratov, postopek za njihovo pripravo in farmacevtske oblike, ki vsebujejo te spojine
ES2255872B1 (es) * 2004-12-31 2007-08-16 Quimica Sintetica, S.A. Procedimiento para la preparacion de perindopril erbumina.
US7291745B2 (en) 2005-03-21 2007-11-06 Glenmark Pharmaceuticals Limited Process for the preparation of perindopril
JP2006290825A (ja) * 2005-04-13 2006-10-26 Shiono Chemical Co Ltd アルファ型ペリンドプリルエルブミンの製造法
WO2006137082A1 (en) * 2005-06-23 2006-12-28 Ramesh Babu Potluri Process for industrially viable preparation of perindopril erbumine
FR2894825B1 (fr) * 2005-12-21 2010-12-03 Servier Lab Nouvelle association d'un inhibiteur du courant if sinusal et d'un inhibiteur de l'enzyme de conversion et les compositions pharmaceutiques qui la contiennent
US7960558B2 (en) 2006-05-12 2011-06-14 Egis Gyogyszergyar Nyilvanosan Mukodo Reszvenytarsasag Pharmaceutical intermediate for synthesizing ACE inhibitors and the use thereof
JP2008019214A (ja) * 2006-07-13 2008-01-31 Shiono Chemical Co Ltd ペリンドプリルまたはその誘導体の製造方法
US8420683B2 (en) 2007-06-06 2013-04-16 Dsm Sinochem Pharmaceuticals Netherlands B.V. 5 substituted hydantoins
FR2985512B1 (fr) * 2012-01-05 2014-06-20 Servier Lab Procede de preparation du sel de l-arginine du perindopril
PH12018502155B1 (en) 2016-04-20 2024-03-27 Servier Lab Pharmaceutical composition comprising a beta blocker, a converting enzyme inhibitor and an antihypertensive or an nsaid
CN111116709B (zh) * 2019-12-31 2022-06-24 北京鑫开元医药科技有限公司 一种培哚普利制备方法
MX2024002590A (es) * 2021-09-01 2024-03-22 Springworks Therapeutics Inc Sintesis de nirogacestat.

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4508729A (en) * 1979-12-07 1985-04-02 Adir Substituted iminodiacids, their preparation and pharmaceutical compositions containing them
FR2487829A2 (fr) * 1979-12-07 1982-02-05 Science Union & Cie Nouveaux imino acides substitues, leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme
US4350704A (en) * 1980-10-06 1982-09-21 Warner-Lambert Company Substituted acyl derivatives of octahydro-1H-indole-2-carboxylic acids
LU88621I2 (fr) * 1980-10-23 1995-09-01 Schering Corp Sandopril
ZA817261B (en) * 1980-10-23 1982-09-29 Schering Corp Carboxyalkyl dipeptides,processes for their production and pharmaceutical compositions containing them
US4496542A (en) * 1981-03-30 1985-01-29 Usv Pharmaceutical Corporation N-substituted-amido-amino acids
US4558038A (en) 1981-03-30 1985-12-10 Usv Pharmaceutical Corp. N-Substituted-amindo-amino acids
US4686295A (en) * 1982-03-10 1987-08-11 Usv Pharmaceutical Corporation N-carboxy anhydride intermediates
US4885293A (en) * 1984-09-24 1989-12-05 Schering Corporation Antiglaucoma agents
JPS6248696A (ja) 1985-08-27 1987-03-03 Kanegafuchi Chem Ind Co Ltd Ｎ−〔１（ｓ）−エトキシカルボニル−３−フエニルプロピル〕−ｌ−アラニル−ｌ−プロリンの製造法
ES2004804A6 (es) * 1987-08-13 1989-02-01 Pharma Investi S A Un procedimiento para preparar derivados de carboxialquildipeptidos
FR2620699B1 (fr) * 1987-09-17 1990-06-01 Adir Procede de synthese d'alpha amino acides n alkyles et de leurs esters. application a la synthese de carboxyalkyl dipeptides
FR2620700B1 (fr) * 1987-09-17 1990-06-01 Adir Procede de synthese d'alpha amino acides n alkyles et leurs esters. application a la synthese de carboxyalkyl dipeptides
FR2620709B1 (fr) * 1987-09-17 1990-09-07 Adir Procede de synthese industrielle du perindopril et de ses principaux intermediaires de synthese
FR2620703B1 (fr) * 1987-09-17 1991-10-04 Adir Procede de synthese industrielle de l'acide perhydroindole carboxylique - 2(2s, 3as, 7as). application a la synthese de carboxyalkyl dipeptides
US5258525A (en) * 1991-03-27 1993-11-02 Mcneilab, Inc. Processes for preparing [2S-(2α,3aβ,7aβ)]octahydro-1H-indole-2-carboxylic acid and esters
SI9200213A (en) * 1992-09-16 1994-03-31 Krka Process for preparing alkyl-l-alanil-l-proline derivates
IN184759B (enExample) 1997-07-22 2000-09-23 Kaneka Corp
SE0000382D0 (sv) * 2000-02-07 2000-02-07 Astrazeneca Ab New process

Also Published As

Publication number Publication date
AR036187A1 (es) 2004-08-18
WO2003010142A3 (en) 2003-08-28
BR0211422A (pt) 2004-08-17
JP4083118B2 (ja) 2008-04-30
US20040248814A1 (en) 2004-12-09
SI1279665T1 (sl) 2008-06-30
EP1279665B1 (en) 2008-02-20
KR100694528B1 (ko) 2007-03-13
EA007000B1 (ru) 2006-06-30
HU0202414D0 (enExample) 2002-09-28
DE60225092D1 (de) 2008-04-03
JP2005501829A (ja) 2005-01-20
EA200400129A1 (ru) 2004-08-26
CN1529694A (zh) 2004-09-15
EP1279665A3 (en) 2003-03-12
PL355161A1 (en) 2003-01-13
PT1279665E (pt) 2008-03-28
HUP0202414A2 (hu) 2003-02-28
WO2003010142A2 (en) 2003-02-06
ATE386717T1 (de) 2008-03-15
HUP0202414A3 (en) 2003-05-28
KR20040029378A (ko) 2004-04-06
MXPA04000649A (es) 2004-10-27
NO20040278L (no) 2004-01-21
CY1107403T1 (el) 2012-12-19
EP1279665A2 (en) 2003-01-29
ZA200400323B (en) 2005-03-30
HK1067129A1 (en) 2005-04-01
CN100503568C (zh) 2009-06-24
DE60225092T2 (de) 2009-02-19
DK1279665T3 (da) 2008-06-23
AU2002328954B2 (en) 2007-10-04
NZ530578A (en) 2007-02-23

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