ES2248915T3 - Preparados de aerosol acuosos que contienen macromoleculas biologicamente activas y procedimiento para producir aerosoles correspondientes. - Google Patents

Preparados de aerosol acuosos que contienen macromoleculas biologicamente activas y procedimiento para producir aerosoles correspondientes.

Info

Publication number
ES2248915T3
ES2248915T3 ES98943814T ES98943814T ES2248915T3 ES 2248915 T3 ES2248915 T3 ES 2248915T3 ES 98943814 T ES98943814 T ES 98943814T ES 98943814 T ES98943814 T ES 98943814T ES 2248915 T3 ES2248915 T3 ES 2248915T3
Authority
ES
Spain
Prior art keywords
factor
interleukin
waterproof
hormone
procedure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES98943814T
Other languages
English (en)
Inventor
Herbert Lamche
Christopher John Montagu Meade
Bernd Zierenberg
Ralph Christian Reimholz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH and Co KG
Original Assignee
Boehringer Ingelheim Pharma GmbH and Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma GmbH and Co KG filed Critical Boehringer Ingelheim Pharma GmbH and Co KG
Application granted granted Critical
Publication of ES2248915T3 publication Critical patent/ES2248915T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/12—Aerosols; Foams
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/44—Oxidoreductases (1)
    • A61K38/446—Superoxide dismutase (1.15)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Dispersion Chemistry (AREA)
  • Zoology (AREA)
  • Pulmonology (AREA)
  • Otolaryngology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

Nebulizador exento de gas propulsor que contiene un preparado de aerosol en forma de una solución con agua o una mezcla de agua y etanol como disolvente, que contiene una sustancia activa en una concentración entre 25 y 100 mg/ml, elegido del grupo de oligonucleótidos antisentido orexinas eritropoyetina factor de necrosis de tumores-alfa factor de necrosis de tumores-beta GM-CSF ("factor estimulador de colonias de granulocitos y macrófagos" de "granulocyte- macrophage colony stimulating factor") anexinas calcitonina leptinas hormonas paratiroideas fragmentos de hormonas paratiroideas interleuquinas tales como p.ej. interleuquina 2, interleuquina 10 e interleuquina 12 insulina superóxido dismutasa un interferón ICAM ("molécula de adhesión intercelular", de "intercellular adhesion molecule") soluble somatostatina somatotropina tPA ("activador de plasminógeno de tipo tisular", de "tissue plasminogen activator") TNK-tPA antígenos asociados a tumores (en forma de péptido, proteína o ADN) antagonistas del péptido bradiquinina urodilatina GHRH ("hormona liberadora de la hormona del crecimiento", de "growth hormone releasing hormone") CRF ("factor de liberación de corticotropina", de "corticotropin releasing factor") EMAP II heparina receptores de interleuquinas solubles, tales como el receptor de sIL-1 vacunas, tales como la vacuna de hepatitis o la vacuna de sarampión polinucleótidos antisentido factores de transcripción, en donde el nebulizador exento de gas propulsor es adecuado para medir en una cámara de medición una cantidad terapéuticamente eficaz de una dosificación individual del preparado de aerosol y de atomizar bajo alta presión, entre 100 y 500 bares, a través de por lo menos una boquilla con un diámetro hidráulico de 1 a 12 micrómetros para formar gotitas inhalables con un tamaño medio de partículas menor que 10 micrómetros.
ES98943814T 1997-08-04 1998-07-31 Preparados de aerosol acuosos que contienen macromoleculas biologicamente activas y procedimiento para producir aerosoles correspondientes. Expired - Lifetime ES2248915T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19733651A DE19733651A1 (de) 1997-08-04 1997-08-04 Wässrige Aerosolzubereitungen enthaltend biologisch aktive Markomoleküle und Verfahren zur Erzeugung entsprechender Aerosole

Publications (1)

Publication Number Publication Date
ES2248915T3 true ES2248915T3 (es) 2006-03-16

Family

ID=7837935

Family Applications (1)

Application Number Title Priority Date Filing Date
ES98943814T Expired - Lifetime ES2248915T3 (es) 1997-08-04 1998-07-31 Preparados de aerosol acuosos que contienen macromoleculas biologicamente activas y procedimiento para producir aerosoles correspondientes.

Country Status (36)

Country Link
US (1) US20030064032A1 (es)
EP (2) EP1003478B1 (es)
JP (1) JP2001513492A (es)
KR (1) KR20010022636A (es)
CN (1) CN1177581C (es)
AR (1) AR016581A1 (es)
AT (1) ATE301987T1 (es)
AU (1) AU753673B2 (es)
BG (1) BG64966B1 (es)
BR (1) BR9811827A (es)
CA (1) CA2297174A1 (es)
CO (1) CO4960637A1 (es)
DE (2) DE19733651A1 (es)
DK (1) DK1003478T3 (es)
EA (1) EA002255B1 (es)
EE (1) EE05053B1 (es)
ES (1) ES2248915T3 (es)
HK (1) HK1027749A1 (es)
HR (1) HRP980425B1 (es)
HU (1) HUP0003805A3 (es)
ID (1) ID24200A (es)
IL (2) IL134115A0 (es)
MY (1) MY132852A (es)
NO (1) NO20000553L (es)
NZ (1) NZ503160A (es)
PL (1) PL338421A1 (es)
PT (1) PT1003478E (es)
RS (1) RS49705B (es)
SI (1) SI1003478T1 (es)
SK (1) SK285637B6 (es)
TR (1) TR200000312T2 (es)
TW (1) TWI222887B (es)
UA (1) UA73076C2 (es)
UY (1) UY25122A1 (es)
WO (1) WO1999007340A1 (es)
ZA (1) ZA986931B (es)

Families Citing this family (71)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030215396A1 (en) 1999-09-15 2003-11-20 Boehringer Ingelheim Pharma Kg Method for the production of propellant gas-free aerosols from aqueous medicament preparations
US7963955B2 (en) 1998-02-27 2011-06-21 Boehringer Ingelheim International Gmbh Container for a medicinal liquid
SE9801495D0 (sv) * 1998-04-28 1998-04-28 Astra Ab Protein formulationa
US20060171899A1 (en) * 1998-12-10 2006-08-03 Akwete Adjei Water-stabilized aerosol formulation system and method of making
RU2140285C1 (ru) * 1999-01-25 1999-10-27 Гапонюк Петр Яковлевич Противовирусное средство - капли в нос "гриппферон"
US6350432B1 (en) * 1999-03-19 2002-02-26 Generex Pharmaceuticals Incorporated Pressurized container having an aerosolized pharmaceutical composition
NZ519403A (en) * 2001-06-21 2005-03-24 Pfizer Prod Inc Use of insulin in a medicament to reduce weight gain in a diabetic patient who is using exogenous insulin to control blood sugar levels
DE102004001451A1 (de) 2004-01-08 2005-08-11 Boehringer Ingelheim International Gmbh Vorrichtung zum Haltern eines fluidischen Bauteiles
DE102004011381A1 (de) 2004-03-05 2005-09-15 Boehringer Ingelheim Pharma Gmbh & Co. Kg Impaktionsdüse für treibgasbetriebene Dosieraerosole
US7723306B2 (en) 2004-05-10 2010-05-25 Boehringer Ingelheim Pharma Gmbh & Co. Kg Spray-dried powder comprising at least one 1,4 O-linked saccharose-derivative and methods for their preparation
US7611709B2 (en) 2004-05-10 2009-11-03 Boehringer Ingelheim Pharma Gmbh And Co. Kg 1,4 O-linked saccharose derivatives for stabilization of antibodies or antibody derivatives
US7727962B2 (en) 2004-05-10 2010-06-01 Boehringer Ingelheim Pharma Gmbh & Co. Kg Powder comprising new compositions of oligosaccharides and methods for their preparation
DE102005024439A1 (de) 2005-05-24 2006-12-07 Boehringer Ingelheim International Gmbh Zerstäuber
DE102005029746B4 (de) 2005-06-24 2017-10-26 Boehringer Ingelheim International Gmbh Zerstäuber
CN101247845B (zh) * 2005-06-27 2013-04-24 世界卫生组织 疫苗喷雾器
BRPI0614852B1 (pt) 2005-08-24 2019-06-18 Boehringer Ingelheim International Gmbh Pulverizador
DE102006009637A1 (de) 2005-10-28 2007-05-03 Boehringer Ingelheim Pharma Gmbh & Co. Kg Inhalator mit Mundstück mit mikrobiologischer Schutzfunktion
AP2008004447A0 (en) * 2005-11-30 2008-04-30 Generex Pharm Inc Orally absorbed pharmaceutical formulation and method of administration
EP1792660A1 (en) 2005-12-02 2007-06-06 Boehringer Ingelheim Pharma GmbH & Co. KG Dispensing device
DE102006014433A1 (de) 2006-03-27 2007-10-04 Boehringer Ingelheim Pharma Gmbh & Co. Kg Dosieraerosole für die Verabreichung von pharmazeutischen Zubereitungen
DE102006016901A1 (de) 2006-04-11 2007-10-25 Boehringer Ingelheim Pharma Gmbh & Co. Kg Mundstück für einen Inhalator
DE102006016903A1 (de) 2006-04-11 2007-10-25 Boehringer Ingelheim Pharma Gmbh & Co. Kg Inhalator
EP1844808A1 (de) 2006-04-13 2007-10-17 BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG Medikamenten-Ausgabevorrichtung
EP1844807A1 (de) 2006-04-13 2007-10-17 BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG Medikamentenmagazin, sowie Vorrichtung und Verfahren zum Öffnen desselben; Mehrdosispulverinhalator
EP1844809A1 (de) 2006-04-13 2007-10-17 Boehringer Ingelheim Pharma GmbH & Co. KG Medikamentenmagazin für einen Inhalator, sowie Mehrdosispulverinhalator
US7841338B2 (en) 2006-04-13 2010-11-30 Boehringer Ingelheim International Gmbh Dispensing device
DE102006022002A1 (de) 2006-05-10 2007-11-15 Boehringer Ingelheim International Gmbh Zerstäuber und Verfahren zur Zerstäubung von Fluid
DE102006043637A1 (de) 2006-05-18 2007-11-22 Boehringer Ingelheim Pharma Gmbh & Co. Kg Zerstäuber
US8061350B2 (en) 2006-06-02 2011-11-22 Boehringer Ingelheim Pharma Gmbh & Co. Kg Process and device for dosing pharmaceutical agents
DE102007020578A1 (de) * 2007-05-02 2008-11-06 Boehringer Ingelheim Pharma Gmbh & Co. Kg Wässrige Aerosolzubereitungen enthaltend therapeutisch wirksame Mikroorganismen oder Teile von Mikroorganismen und Verfahren zur Erzeugung entsprechender Aerosole
DE102007023012A1 (de) 2007-05-15 2008-11-20 Boehringer Ingelheim Pharma Gmbh & Co. Kg Zerstäuber und Filter
JP5504156B2 (ja) 2007-06-15 2014-05-28 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 吸入器
EP2011536A1 (en) 2007-07-06 2009-01-07 Boehringer Ingelheim Pharma GmbH & Co. KG Inhaler
CN100593424C (zh) * 2007-07-18 2010-03-10 北京万生药业有限责任公司 一种氧气湿化及输送装置
DE102007033860A1 (de) 2007-07-20 2009-01-22 Boehringer Ingelheim Pharma Gmbh & Co. Kg Prüfvorrichtung
DE102007033861A1 (de) 2007-07-20 2009-07-02 Boehringer Ingelheim Pharma Gmbh & Co. Kg Pulverinhalator
DE102007036411A1 (de) 2007-07-20 2009-02-12 Boehringer Ingelheim Pharma Gmbh & Co. Kg Pulverinhalator
DE102007036413A1 (de) 2007-08-02 2009-02-05 Boehringer Ingelheim Pharma Gmbh & Co. Kg Vorrichtung und Verfahren zur Bestimmung des Feuchtegehalts eines Verpackungsmaterials
DE102007034156A1 (de) 2007-07-21 2009-01-22 Boehringer Ingelheim Pharma Gmbh & Co. Kg Vorrichtung und Verfahren zur Bestimmung des Feuchtegehalts eines Verpackungsmaterials
DE102007052871A1 (de) 2007-11-02 2009-05-07 Boehringer Ingelheim Pharma Gmbh & Co. Kg Kapsel zur Aufnahme von pharmazeutischen Wirkstoffformulierungen
DE102007058112A1 (de) 2007-12-03 2009-06-04 Boehringer Ingelheim Pharma Gmbh & Co. Kg Pulverinhalator mit Wirkstofftablette
EP2077132A1 (en) 2008-01-02 2009-07-08 Boehringer Ingelheim Pharma GmbH & Co. KG Dispensing device, storage device and method for dispensing a formulation
KR20110003495A (ko) 2008-03-17 2011-01-12 베링거 인겔하임 인터내셔날 게엠베하 저장조 및 분무기
EP2135632A1 (de) 2008-06-20 2009-12-23 Boehringer Ingelheim International Gmbh Inhalator
EP2198972A1 (de) 2008-12-18 2010-06-23 Boehringer Ingelheim International GmbH Reservoir und Zerstäuber
WO2010076012A1 (de) 2009-01-02 2010-07-08 Boehringer Ingelheim International Gmbh Bauteil und inhalator sowie verfahren zur herstellung eines bauteils
WO2010105776A1 (en) 2009-03-17 2010-09-23 Boehringer Ingelheim International Gmbh Dispensing device, storage device and method for dispensing a formulation
EP2408571B1 (de) 2009-03-17 2015-09-16 Boehringer Ingelheim International GmbH Reservoir und zerstäuber
EP2414560B1 (de) 2009-03-31 2013-10-23 Boehringer Ingelheim International GmbH Verfahren zur beschichtung einer oberfläche eines bauteils
JP5812354B2 (ja) 2009-04-28 2015-11-11 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 吸入器具
WO2010133294A2 (de) 2009-05-18 2010-11-25 Boehringer Ingelheim International Gmbh Adapter, inhalationseinrichtung und zerstäuber
CN104799969B (zh) 2009-06-25 2018-11-06 贝林格尔·英格海姆维特梅迪卡有限公司 吸入器
US8746244B2 (en) 2009-10-02 2014-06-10 Boehringer Ingelheim International Gmbh Powder inhaler
JP5658268B2 (ja) 2009-11-25 2015-01-21 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ネブライザ
CN102686260B (zh) 2009-11-25 2014-10-01 贝林格尔.英格海姆国际有限公司 喷雾器
US10016568B2 (en) 2009-11-25 2018-07-10 Boehringer Ingelheim International Gmbh Nebulizer
US9943654B2 (en) 2010-06-24 2018-04-17 Boehringer Ingelheim International Gmbh Nebulizer
WO2012130757A1 (de) 2011-04-01 2012-10-04 Boehringer Ingelheim International Gmbh Medizinisches gerät mit behälter
US9827384B2 (en) 2011-05-23 2017-11-28 Boehringer Ingelheim International Gmbh Nebulizer
WO2013152894A1 (de) 2012-04-13 2013-10-17 Boehringer Ingelheim International Gmbh Zerstäuber mit kodiermitteln
CN103386125A (zh) * 2012-05-08 2013-11-13 刘江秋 肾综合征出血热鼻黏膜免疫气溶胶疫苗的研制
ES2836977T3 (es) 2013-08-09 2021-06-28 Boehringer Ingelheim Int Nebulizador
US9744313B2 (en) 2013-08-09 2017-08-29 Boehringer Ingelheim International Gmbh Nebulizer
CN103575718A (zh) * 2013-11-21 2014-02-12 中国人民解放军63975部队 用量子点荧光传感体系测定蛋白喷剂雾化效果的方法
ES2874029T3 (es) 2014-05-07 2021-11-04 Boehringer Ingelheim Int Nebulizador
EP3139979B1 (en) 2014-05-07 2023-07-05 Boehringer Ingelheim International GmbH Unit, nebulizer and method
UA121114C2 (uk) 2014-05-07 2020-04-10 Бьорінгер Інгельхайм Інтернаціональ Гмбх Небулайзер, індикаторний пристрій і контейнер
CN104474534A (zh) * 2014-12-22 2015-04-01 哈德逊（天津）生物技术有限责任公司 白介素-18抗病毒口腔喷剂
EP3563894B1 (en) * 2018-05-04 2021-12-22 Boehringer Ingelheim International GmbH Nebulizer and container
US20240009227A1 (en) * 2020-08-14 2024-01-11 Istanbul Universitesi Rektorlugu Use of a heparin composition in the treatment of viral lung diseases, acute and/or chronic lung diseases by soft mist inhaler or vibration mesh technology nebulizer through inhalation route
CN114712336B (zh) * 2020-12-22 2023-11-07 黄嘉若 一种用于肺部给药的水性气溶胶、制备方法和用途

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4153689A (en) * 1975-06-13 1979-05-08 Takeda Chemical Industries, Ltd. Stable insulin preparation for nasal administration
WO1983000288A1 (en) * 1981-07-17 1983-02-03 Balschmidt, Per A stable aqueous, therapeutic insulin preparation and a process for preparing it
ES520249A0 (es) * 1982-03-03 1984-04-16 Nordisk Insulinlab Procedimiento de producir preparaciones de insulina.
US4476116A (en) * 1982-12-10 1984-10-09 Syntex (U.S.A.) Inc. Polypeptides/chelating agent nasal compositions having enhanced peptide absorption
DE3827121A1 (de) * 1988-08-10 1990-02-15 Hoechst Ag Verfahren zur herstellung von des-b30-insulinen und des-b30-insulinderivaten
CA2050905A1 (en) * 1989-02-23 1990-08-24 George R. Felt Therapeutic aerosol formulations
JP2704546B2 (ja) * 1989-04-04 1998-01-26 光利 太良 Ａｔｌｌ治療用吸入剤
SG45171A1 (en) * 1990-03-21 1998-01-16 Boehringer Ingelheim Int Atomising devices and methods
US5230884A (en) * 1990-09-11 1993-07-27 University Of Wales College Of Cardiff Aerosol formulations including proteins and peptides solubilized in reverse micelles and process for making the aerosol formulations
IL99699A (en) * 1990-10-10 2002-04-21 Autoimmune Inc Drug with the option of oral, intra-intestinal, or inhaled dosing for suppression of autoimmune response associated with type I diabetes
NZ241954A (en) * 1991-03-15 1994-01-26 Amgen Inc Compositions of g-csf for pulmonary administration.
DE4117078A1 (de) * 1991-05-25 1992-11-26 Boehringer Ingelheim Kg Verfahren zur herstellung therapeutisch anwendbarer aerosole
US5888477A (en) * 1993-01-29 1999-03-30 Aradigm Corporation Use of monomeric insulin as a means for improving the bioavailability of inhaled insulin
US5354934A (en) * 1993-02-04 1994-10-11 Amgen Inc. Pulmonary administration of erythropoietin
JP3689422B2 (ja) * 1993-02-12 2005-08-31 アーヴァント イミュノセラピューティクス インコーポレイテッド ｓＣＲ１およびその他の補体阻害蛋白の肺内投与
IL109112A0 (en) * 1993-03-24 1994-06-24 Boehringer Ingelheim Pharma Pharmaceutical compositions containing human manganese superoxide dismutase
CA2167538A1 (en) * 1993-07-19 1995-02-02 Tsutomu Arakawa Stabilization of aerosolized proteins
JPH07165613A (ja) * 1993-10-19 1995-06-27 Dot:Kk 経鼻吸収薬物用キャリヤおよび生理活性ペプチド組成物
JP3414539B2 (ja) * 1994-05-11 2003-06-09 有限会社ドット 経鼻吸収用組成物
US5541569A (en) * 1995-02-28 1996-07-30 Jang; Huey J. Switch having a circuit breaker
DE19536902A1 (de) * 1995-10-04 1997-04-10 Boehringer Ingelheim Int Vorrichtung zur Hochdruckerzeugung in einem Fluid in Miniaturausführung
US5780440A (en) * 1996-06-17 1998-07-14 Protease Sciences Inc. Treatment of pulmonary disease with protease inhibitors
DE19653969A1 (de) * 1996-12-20 1998-06-25 Boehringer Ingelheim Kg Neue wässrige Arzneimittelzubereitung zur Erzeugung treibgasfreier Aerosole

Also Published As

Publication number Publication date
JP2001513492A (ja) 2001-09-04
IL134115A (en) 2006-04-10
NZ503160A (en) 2001-12-21
MY132852A (en) 2007-10-31
US20030064032A1 (en) 2003-04-03
ATE301987T1 (de) 2005-09-15
BG104130A (en) 2000-09-29
DK1003478T3 (da) 2005-10-24
RS49705B (sr) 2007-12-31
EE200000065A (et) 2000-10-16
EE05053B1 (et) 2008-08-15
EA200000190A1 (ru) 2000-10-30
EP1003478B1 (de) 2005-08-17
BR9811827A (pt) 2000-08-15
NO20000553D0 (no) 2000-02-03
WO1999007340A1 (de) 1999-02-18
EP1527771A3 (de) 2007-02-07
SK1502000A3 (en) 2000-07-11
HRP980425B1 (en) 2006-10-31
CN1265583A (zh) 2000-09-06
AU9157798A (en) 1999-03-01
SI1003478T1 (sl) 2006-02-28
HUP0003805A3 (en) 2002-04-29
UA73076C2 (en) 2005-06-15
EP1003478A1 (de) 2000-05-31
SK285637B6 (sk) 2007-05-03
TR200000312T2 (tr) 2000-07-21
BG64966B1 (bg) 2006-11-30
UY25122A1 (es) 2000-12-29
AU753673B2 (en) 2002-10-24
HK1027749A1 (en) 2001-01-23
YU5600A (sh) 2002-08-12
IL134115A0 (en) 2001-04-30
PL338421A1 (en) 2000-11-06
DE59813014D1 (de) 2005-09-22
EA002255B1 (ru) 2002-02-28
ZA986931B (en) 1999-07-05
DE19733651A1 (de) 1999-02-18
CN1177581C (zh) 2004-12-01
PT1003478E (pt) 2005-11-30
CO4960637A1 (es) 2000-09-25
KR20010022636A (ko) 2001-03-26
NO20000553L (no) 2000-04-03
TWI222887B (en) 2004-11-01
EP1527771A2 (de) 2005-05-04
AR016581A1 (es) 2001-07-25
HRP980425A2 (en) 1999-04-30
ID24200A (id) 2000-07-13
CA2297174A1 (en) 1999-02-18
HUP0003805A2 (en) 2001-03-28

Similar Documents

Publication Publication Date Title
ES2248915T3 (es) Preparados de aerosol acuosos que contienen macromoleculas biologicamente activas y procedimiento para producir aerosoles correspondientes.
JP2001513492A5 (es)
US8530412B2 (en) Ejection liquid, ejection method, method of making droplets from liquid, cartridge and ejection device
RU2342948C1 (ru) Эжектируемая жидкость, способ эжекции, способ формирования капелек жидкости, кассета для эжекции жидкости и эжекционное устройство
WO2007014391B1 (en) Tight junction modulating peptide components for enhancing mucosal delivery of therapeutic agents
CN101027077B (zh) 喷射液、喷射设备、喷射盒以及从液体制备液滴的方法
RU2367466C2 (ru) Эжекционная жидкость, способ эжекции, способ формирования капель жидкости, картридж для эжекции жидкости и эжекторное устройство
ES2268044T3 (es) Composiciones para la administracion de proteinas por la via pulmonar.
US20050271733A1 (en) Particle delivery techniques
RU95112536A (ru) Способы пульсирующего системного введения активного фрагмента паратиреоидного гормона (ртн) и фармацевтические композиции, содержащие биологически активный n-концевой фрагмент паратиреоидного гормона (ртн)
US20110268668A1 (en) Process for nebulizing aqueous compositions containing highly concentrated insulin
ES2234016T3 (es) Administracion de particulas de acido nucleico.
Kuo et al. Preparation of DNA dry powder for non‐viral gene delivery by spray‐freeze drying: effect of protective agents (polyethyleneimine and sugars) on the stability of DNA
US6350432B1 (en) Pressurized container having an aerosolized pharmaceutical composition
US20020107505A1 (en) Modification of polypeptide drugs to increase electrotransport flux
JP2004506678A (ja) 全身性疾患を治療する方法
JP4564936B2 (ja) 吐出用液体、吐出方法、液滴化方法、液体吐出カートリッジ及び吐出装置
CN101547684A (zh) 喷射液体和喷射方法
MXPA00001171A (es) Preparados de aerosoles acuosos que contienen macromoleculas biologicamente activas y procedimientos para la generacion de aerosoles correspondientes
JPH0651642B2 (ja) インターフェロン経鼻投与用製剤