CO4960637A1 - Preparadores de aerosoles acuosos que contienen macromolecu- las biologicamente activas y procedimiento para la genera- cion de aerosoles correspondientes - Google Patents
Preparadores de aerosoles acuosos que contienen macromolecu- las biologicamente activas y procedimiento para la genera- cion de aerosoles correspondientesInfo
- Publication number
- CO4960637A1 CO4960637A1 CO98044242A CO98044242A CO4960637A1 CO 4960637 A1 CO4960637 A1 CO 4960637A1 CO 98044242 A CO98044242 A CO 98044242A CO 98044242 A CO98044242 A CO 98044242A CO 4960637 A1 CO4960637 A1 CO 4960637A1
- Authority
- CO
- Colombia
- Prior art keywords
- colony stimulating
- biologically active
- granulocyte
- stimulating factor
- aqueous aerosol
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/12—Aerosols; Foams
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/21—Interferons [IFN]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/44—Oxidoreductases (1)
- A61K38/446—Superoxide dismutase (1.15)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Dispersion Chemistry (AREA)
- Zoology (AREA)
- Pulmonology (AREA)
- Otolaryngology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Obesity (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
Preparado de aerosol acuoso para la aplicación por inhalaciónde macromoléculas biológicamente activas como sustancia activa, estando caracterizado el preparado de aerosol acuoso porque contiene macromoléculas biológicamente activas altamente concentradas y la sustancia activa en una concentración entre 3 mg/ml y 150 mg/ml, preferiblemente entre 25 y 100 mg/ml, de los siguientes compuestos seleccionados entre el siguiente grupo: Oligonucleótidos antisentido Ovexinas Eritropoyetina Factor de necrosis de tumores-alfa Factor de necrosis de de tumores-beta G-CSF ("Factor estimulador de colonias de granulocitos", de "granulocyte colony stimulating factor"). GM-CSF ("Factor estimulador de colonias de granulocitos y macrófagos" de "granulocyte-macrophage colony stimulating factor"). Anexinas Calcitonina Leptinas Hormonas paratiroideasfragmentos de hormonas paratiroideasInterleuquinas tales como p. ej. interleuquina 2,interleuquina 10 e interleuquina 12 ICAM ("molécula de adhesión intercelular", de "intercellular adhesión molecule") soluble SomatostatinaSomatotropina tPA ("Activador de plasminógeno de tipo tisular", de "tissue plasminogen activator"). ...
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19733651A DE19733651A1 (de) | 1997-08-04 | 1997-08-04 | Wässrige Aerosolzubereitungen enthaltend biologisch aktive Markomoleküle und Verfahren zur Erzeugung entsprechender Aerosole |
Publications (1)
Publication Number | Publication Date |
---|---|
CO4960637A1 true CO4960637A1 (es) | 2000-09-25 |
Family
ID=7837935
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CO98044242A CO4960637A1 (es) | 1997-08-04 | 1998-08-03 | Preparadores de aerosoles acuosos que contienen macromolecu- las biologicamente activas y procedimiento para la genera- cion de aerosoles correspondientes |
Country Status (36)
Country | Link |
---|---|
US (1) | US20030064032A1 (es) |
EP (2) | EP1003478B1 (es) |
JP (1) | JP2001513492A (es) |
KR (1) | KR20010022636A (es) |
CN (1) | CN1177581C (es) |
AR (1) | AR016581A1 (es) |
AT (1) | ATE301987T1 (es) |
AU (1) | AU753673B2 (es) |
BG (1) | BG64966B1 (es) |
BR (1) | BR9811827A (es) |
CA (1) | CA2297174A1 (es) |
CO (1) | CO4960637A1 (es) |
DE (2) | DE19733651A1 (es) |
DK (1) | DK1003478T3 (es) |
EA (1) | EA002255B1 (es) |
EE (1) | EE05053B1 (es) |
ES (1) | ES2248915T3 (es) |
HK (1) | HK1027749A1 (es) |
HR (1) | HRP980425B1 (es) |
HU (1) | HUP0003805A3 (es) |
ID (1) | ID24200A (es) |
IL (2) | IL134115A0 (es) |
MY (1) | MY132852A (es) |
NO (1) | NO20000553L (es) |
NZ (1) | NZ503160A (es) |
PL (1) | PL338421A1 (es) |
PT (1) | PT1003478E (es) |
RS (1) | RS49705B (es) |
SI (1) | SI1003478T1 (es) |
SK (1) | SK285637B6 (es) |
TR (1) | TR200000312T2 (es) |
TW (1) | TWI222887B (es) |
UA (1) | UA73076C2 (es) |
UY (1) | UY25122A1 (es) |
WO (1) | WO1999007340A1 (es) |
ZA (1) | ZA986931B (es) |
Families Citing this family (71)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20030215396A1 (en) | 1999-09-15 | 2003-11-20 | Boehringer Ingelheim Pharma Kg | Method for the production of propellant gas-free aerosols from aqueous medicament preparations |
US7963955B2 (en) | 1998-02-27 | 2011-06-21 | Boehringer Ingelheim International Gmbh | Container for a medicinal liquid |
SE9801495D0 (sv) * | 1998-04-28 | 1998-04-28 | Astra Ab | Protein formulationa |
US20060171899A1 (en) * | 1998-12-10 | 2006-08-03 | Akwete Adjei | Water-stabilized aerosol formulation system and method of making |
RU2140285C1 (ru) * | 1999-01-25 | 1999-10-27 | Гапонюк Петр Яковлевич | Противовирусное средство - капли в нос "гриппферон" |
US6350432B1 (en) * | 1999-03-19 | 2002-02-26 | Generex Pharmaceuticals Incorporated | Pressurized container having an aerosolized pharmaceutical composition |
NZ519403A (en) * | 2001-06-21 | 2005-03-24 | Pfizer Prod Inc | Use of insulin in a medicament to reduce weight gain in a diabetic patient who is using exogenous insulin to control blood sugar levels |
DE102004001451A1 (de) | 2004-01-08 | 2005-08-11 | Boehringer Ingelheim International Gmbh | Vorrichtung zum Haltern eines fluidischen Bauteiles |
DE102004011381A1 (de) | 2004-03-05 | 2005-09-15 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Impaktionsdüse für treibgasbetriebene Dosieraerosole |
US7723306B2 (en) | 2004-05-10 | 2010-05-25 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Spray-dried powder comprising at least one 1,4 O-linked saccharose-derivative and methods for their preparation |
US7611709B2 (en) | 2004-05-10 | 2009-11-03 | Boehringer Ingelheim Pharma Gmbh And Co. Kg | 1,4 O-linked saccharose derivatives for stabilization of antibodies or antibody derivatives |
US7727962B2 (en) | 2004-05-10 | 2010-06-01 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Powder comprising new compositions of oligosaccharides and methods for their preparation |
DE102005024439A1 (de) | 2005-05-24 | 2006-12-07 | Boehringer Ingelheim International Gmbh | Zerstäuber |
DE102005029746B4 (de) | 2005-06-24 | 2017-10-26 | Boehringer Ingelheim International Gmbh | Zerstäuber |
CN101247845B (zh) * | 2005-06-27 | 2013-04-24 | 世界卫生组织 | 疫苗喷雾器 |
BRPI0614852B1 (pt) | 2005-08-24 | 2019-06-18 | Boehringer Ingelheim International Gmbh | Pulverizador |
DE102006009637A1 (de) | 2005-10-28 | 2007-05-03 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Inhalator mit Mundstück mit mikrobiologischer Schutzfunktion |
AP2008004447A0 (en) * | 2005-11-30 | 2008-04-30 | Generex Pharm Inc | Orally absorbed pharmaceutical formulation and method of administration |
EP1792660A1 (en) | 2005-12-02 | 2007-06-06 | Boehringer Ingelheim Pharma GmbH & Co. KG | Dispensing device |
DE102006014433A1 (de) | 2006-03-27 | 2007-10-04 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Dosieraerosole für die Verabreichung von pharmazeutischen Zubereitungen |
DE102006016901A1 (de) | 2006-04-11 | 2007-10-25 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Mundstück für einen Inhalator |
DE102006016903A1 (de) | 2006-04-11 | 2007-10-25 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Inhalator |
EP1844808A1 (de) | 2006-04-13 | 2007-10-17 | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG | Medikamenten-Ausgabevorrichtung |
EP1844807A1 (de) | 2006-04-13 | 2007-10-17 | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG | Medikamentenmagazin, sowie Vorrichtung und Verfahren zum Öffnen desselben; Mehrdosispulverinhalator |
EP1844809A1 (de) | 2006-04-13 | 2007-10-17 | Boehringer Ingelheim Pharma GmbH & Co. KG | Medikamentenmagazin für einen Inhalator, sowie Mehrdosispulverinhalator |
US7841338B2 (en) | 2006-04-13 | 2010-11-30 | Boehringer Ingelheim International Gmbh | Dispensing device |
DE102006022002A1 (de) | 2006-05-10 | 2007-11-15 | Boehringer Ingelheim International Gmbh | Zerstäuber und Verfahren zur Zerstäubung von Fluid |
DE102006043637A1 (de) | 2006-05-18 | 2007-11-22 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Zerstäuber |
US8061350B2 (en) | 2006-06-02 | 2011-11-22 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Process and device for dosing pharmaceutical agents |
DE102007020578A1 (de) * | 2007-05-02 | 2008-11-06 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Wässrige Aerosolzubereitungen enthaltend therapeutisch wirksame Mikroorganismen oder Teile von Mikroorganismen und Verfahren zur Erzeugung entsprechender Aerosole |
DE102007023012A1 (de) | 2007-05-15 | 2008-11-20 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Zerstäuber und Filter |
JP5504156B2 (ja) | 2007-06-15 | 2014-05-28 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 吸入器 |
EP2011536A1 (en) | 2007-07-06 | 2009-01-07 | Boehringer Ingelheim Pharma GmbH & Co. KG | Inhaler |
CN100593424C (zh) * | 2007-07-18 | 2010-03-10 | 北京万生药业有限责任公司 | 一种氧气湿化及输送装置 |
DE102007033860A1 (de) | 2007-07-20 | 2009-01-22 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Prüfvorrichtung |
DE102007033861A1 (de) | 2007-07-20 | 2009-07-02 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Pulverinhalator |
DE102007036411A1 (de) | 2007-07-20 | 2009-02-12 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Pulverinhalator |
DE102007036413A1 (de) | 2007-08-02 | 2009-02-05 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Vorrichtung und Verfahren zur Bestimmung des Feuchtegehalts eines Verpackungsmaterials |
DE102007034156A1 (de) | 2007-07-21 | 2009-01-22 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Vorrichtung und Verfahren zur Bestimmung des Feuchtegehalts eines Verpackungsmaterials |
DE102007052871A1 (de) | 2007-11-02 | 2009-05-07 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Kapsel zur Aufnahme von pharmazeutischen Wirkstoffformulierungen |
DE102007058112A1 (de) | 2007-12-03 | 2009-06-04 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Pulverinhalator mit Wirkstofftablette |
EP2077132A1 (en) | 2008-01-02 | 2009-07-08 | Boehringer Ingelheim Pharma GmbH & Co. KG | Dispensing device, storage device and method for dispensing a formulation |
KR20110003495A (ko) | 2008-03-17 | 2011-01-12 | 베링거 인겔하임 인터내셔날 게엠베하 | 저장조 및 분무기 |
EP2135632A1 (de) | 2008-06-20 | 2009-12-23 | Boehringer Ingelheim International Gmbh | Inhalator |
EP2198972A1 (de) | 2008-12-18 | 2010-06-23 | Boehringer Ingelheim International GmbH | Reservoir und Zerstäuber |
WO2010076012A1 (de) | 2009-01-02 | 2010-07-08 | Boehringer Ingelheim International Gmbh | Bauteil und inhalator sowie verfahren zur herstellung eines bauteils |
WO2010105776A1 (en) | 2009-03-17 | 2010-09-23 | Boehringer Ingelheim International Gmbh | Dispensing device, storage device and method for dispensing a formulation |
EP2408571B1 (de) | 2009-03-17 | 2015-09-16 | Boehringer Ingelheim International GmbH | Reservoir und zerstäuber |
EP2414560B1 (de) | 2009-03-31 | 2013-10-23 | Boehringer Ingelheim International GmbH | Verfahren zur beschichtung einer oberfläche eines bauteils |
JP5812354B2 (ja) | 2009-04-28 | 2015-11-11 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 吸入器具 |
WO2010133294A2 (de) | 2009-05-18 | 2010-11-25 | Boehringer Ingelheim International Gmbh | Adapter, inhalationseinrichtung und zerstäuber |
CN104799969B (zh) | 2009-06-25 | 2018-11-06 | 贝林格尔·英格海姆维特梅迪卡有限公司 | 吸入器 |
US8746244B2 (en) | 2009-10-02 | 2014-06-10 | Boehringer Ingelheim International Gmbh | Powder inhaler |
JP5658268B2 (ja) | 2009-11-25 | 2015-01-21 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ネブライザ |
CN102686260B (zh) | 2009-11-25 | 2014-10-01 | 贝林格尔.英格海姆国际有限公司 | 喷雾器 |
US10016568B2 (en) | 2009-11-25 | 2018-07-10 | Boehringer Ingelheim International Gmbh | Nebulizer |
US9943654B2 (en) | 2010-06-24 | 2018-04-17 | Boehringer Ingelheim International Gmbh | Nebulizer |
WO2012130757A1 (de) | 2011-04-01 | 2012-10-04 | Boehringer Ingelheim International Gmbh | Medizinisches gerät mit behälter |
US9827384B2 (en) | 2011-05-23 | 2017-11-28 | Boehringer Ingelheim International Gmbh | Nebulizer |
WO2013152894A1 (de) | 2012-04-13 | 2013-10-17 | Boehringer Ingelheim International Gmbh | Zerstäuber mit kodiermitteln |
CN103386125A (zh) * | 2012-05-08 | 2013-11-13 | 刘江秋 | 肾综合征出血热鼻黏膜免疫气溶胶疫苗的研制 |
ES2836977T3 (es) | 2013-08-09 | 2021-06-28 | Boehringer Ingelheim Int | Nebulizador |
US9744313B2 (en) | 2013-08-09 | 2017-08-29 | Boehringer Ingelheim International Gmbh | Nebulizer |
CN103575718A (zh) * | 2013-11-21 | 2014-02-12 | 中国人民解放军63975部队 | 用量子点荧光传感体系测定蛋白喷剂雾化效果的方法 |
ES2874029T3 (es) | 2014-05-07 | 2021-11-04 | Boehringer Ingelheim Int | Nebulizador |
EP3139979B1 (en) | 2014-05-07 | 2023-07-05 | Boehringer Ingelheim International GmbH | Unit, nebulizer and method |
UA121114C2 (uk) | 2014-05-07 | 2020-04-10 | Бьорінгер Інгельхайм Інтернаціональ Гмбх | Небулайзер, індикаторний пристрій і контейнер |
CN104474534A (zh) * | 2014-12-22 | 2015-04-01 | 哈德逊(天津)生物技术有限责任公司 | 白介素-18抗病毒口腔喷剂 |
EP3563894B1 (en) * | 2018-05-04 | 2021-12-22 | Boehringer Ingelheim International GmbH | Nebulizer and container |
US20240009227A1 (en) * | 2020-08-14 | 2024-01-11 | Istanbul Universitesi Rektorlugu | Use of a heparin composition in the treatment of viral lung diseases, acute and/or chronic lung diseases by soft mist inhaler or vibration mesh technology nebulizer through inhalation route |
CN114712336B (zh) * | 2020-12-22 | 2023-11-07 | 黄嘉若 | 一种用于肺部给药的水性气溶胶、制备方法和用途 |
Family Cites Families (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4153689A (en) * | 1975-06-13 | 1979-05-08 | Takeda Chemical Industries, Ltd. | Stable insulin preparation for nasal administration |
WO1983000288A1 (en) * | 1981-07-17 | 1983-02-03 | Balschmidt, Per | A stable aqueous, therapeutic insulin preparation and a process for preparing it |
ES520249A0 (es) * | 1982-03-03 | 1984-04-16 | Nordisk Insulinlab | Procedimiento de producir preparaciones de insulina. |
US4476116A (en) * | 1982-12-10 | 1984-10-09 | Syntex (U.S.A.) Inc. | Polypeptides/chelating agent nasal compositions having enhanced peptide absorption |
DE3827121A1 (de) * | 1988-08-10 | 1990-02-15 | Hoechst Ag | Verfahren zur herstellung von des-b30-insulinen und des-b30-insulinderivaten |
CA2050905A1 (en) * | 1989-02-23 | 1990-08-24 | George R. Felt | Therapeutic aerosol formulations |
JP2704546B2 (ja) * | 1989-04-04 | 1998-01-26 | 光利 太良 | Atll治療用吸入剤 |
SG45171A1 (en) * | 1990-03-21 | 1998-01-16 | Boehringer Ingelheim Int | Atomising devices and methods |
US5230884A (en) * | 1990-09-11 | 1993-07-27 | University Of Wales College Of Cardiff | Aerosol formulations including proteins and peptides solubilized in reverse micelles and process for making the aerosol formulations |
IL99699A (en) * | 1990-10-10 | 2002-04-21 | Autoimmune Inc | Drug with the option of oral, intra-intestinal, or inhaled dosing for suppression of autoimmune response associated with type I diabetes |
NZ241954A (en) * | 1991-03-15 | 1994-01-26 | Amgen Inc | Compositions of g-csf for pulmonary administration. |
DE4117078A1 (de) * | 1991-05-25 | 1992-11-26 | Boehringer Ingelheim Kg | Verfahren zur herstellung therapeutisch anwendbarer aerosole |
US5888477A (en) * | 1993-01-29 | 1999-03-30 | Aradigm Corporation | Use of monomeric insulin as a means for improving the bioavailability of inhaled insulin |
US5354934A (en) * | 1993-02-04 | 1994-10-11 | Amgen Inc. | Pulmonary administration of erythropoietin |
JP3689422B2 (ja) * | 1993-02-12 | 2005-08-31 | アーヴァント イミュノセラピューティクス インコーポレイテッド | sCR1およびその他の補体阻害蛋白の肺内投与 |
IL109112A0 (en) * | 1993-03-24 | 1994-06-24 | Boehringer Ingelheim Pharma | Pharmaceutical compositions containing human manganese superoxide dismutase |
CA2167538A1 (en) * | 1993-07-19 | 1995-02-02 | Tsutomu Arakawa | Stabilization of aerosolized proteins |
JPH07165613A (ja) * | 1993-10-19 | 1995-06-27 | Dot:Kk | 経鼻吸収薬物用キャリヤおよび生理活性ペプチド組成物 |
JP3414539B2 (ja) * | 1994-05-11 | 2003-06-09 | 有限会社ドット | 経鼻吸収用組成物 |
US5541569A (en) * | 1995-02-28 | 1996-07-30 | Jang; Huey J. | Switch having a circuit breaker |
DE19536902A1 (de) * | 1995-10-04 | 1997-04-10 | Boehringer Ingelheim Int | Vorrichtung zur Hochdruckerzeugung in einem Fluid in Miniaturausführung |
US5780440A (en) * | 1996-06-17 | 1998-07-14 | Protease Sciences Inc. | Treatment of pulmonary disease with protease inhibitors |
DE19653969A1 (de) * | 1996-12-20 | 1998-06-25 | Boehringer Ingelheim Kg | Neue wässrige Arzneimittelzubereitung zur Erzeugung treibgasfreier Aerosole |
-
1997
- 1997-08-04 DE DE19733651A patent/DE19733651A1/de not_active Ceased
-
1998
- 1998-07-31 ES ES98943814T patent/ES2248915T3/es not_active Expired - Lifetime
- 1998-07-31 KR KR1020007001230A patent/KR20010022636A/ko not_active Application Discontinuation
- 1998-07-31 JP JP2000506934A patent/JP2001513492A/ja active Pending
- 1998-07-31 TR TR2000/00312T patent/TR200000312T2/xx unknown
- 1998-07-31 EP EP98943814A patent/EP1003478B1/de not_active Expired - Lifetime
- 1998-07-31 ID IDW20000210A patent/ID24200A/id unknown
- 1998-07-31 CN CNB988078953A patent/CN1177581C/zh not_active Expired - Fee Related
- 1998-07-31 EE EEP200000065A patent/EE05053B1/xx not_active IP Right Cessation
- 1998-07-31 PL PL98338421A patent/PL338421A1/xx not_active Application Discontinuation
- 1998-07-31 NZ NZ503160A patent/NZ503160A/en unknown
- 1998-07-31 EP EP05002747A patent/EP1527771A3/de not_active Withdrawn
- 1998-07-31 EA EA200000190A patent/EA002255B1/ru not_active IP Right Cessation
- 1998-07-31 PT PT98943814T patent/PT1003478E/pt unknown
- 1998-07-31 RS YUP-56/00A patent/RS49705B/sr unknown
- 1998-07-31 AU AU91577/98A patent/AU753673B2/en not_active Ceased
- 1998-07-31 DE DE59813014T patent/DE59813014D1/de not_active Expired - Lifetime
- 1998-07-31 SK SK150-2000A patent/SK285637B6/sk not_active IP Right Cessation
- 1998-07-31 DK DK98943814T patent/DK1003478T3/da active
- 1998-07-31 HU HU0003805A patent/HUP0003805A3/hu unknown
- 1998-07-31 IL IL13411598A patent/IL134115A0/xx active IP Right Grant
- 1998-07-31 BR BR9811827-7A patent/BR9811827A/pt not_active Application Discontinuation
- 1998-07-31 SI SI9830799T patent/SI1003478T1/sl unknown
- 1998-07-31 WO PCT/EP1998/004803 patent/WO1999007340A1/de not_active Application Discontinuation
- 1998-07-31 UA UA2000031252A patent/UA73076C2/uk unknown
- 1998-07-31 CA CA002297174A patent/CA2297174A1/en not_active Abandoned
- 1998-07-31 AT AT98943814T patent/ATE301987T1/de active
- 1998-08-03 CO CO98044242A patent/CO4960637A1/es unknown
- 1998-08-03 HR HR980425A patent/HRP980425B1/xx not_active IP Right Cessation
- 1998-08-03 AR ARP980103825A patent/AR016581A1/es not_active Suspension/Interruption
- 1998-08-03 ZA ZA9806931A patent/ZA986931B/xx unknown
- 1998-08-03 MY MYPI98003548A patent/MY132852A/en unknown
- 1998-08-03 UY UY25122A patent/UY25122A1/es not_active IP Right Cessation
-
1999
- 1999-03-12 TW TW087112723A patent/TWI222887B/zh not_active IP Right Cessation
-
2000
- 2000-01-18 IL IL134115A patent/IL134115A/en not_active IP Right Cessation
- 2000-02-03 NO NO20000553A patent/NO20000553L/no not_active Application Discontinuation
- 2000-02-04 BG BG104130A patent/BG64966B1/bg active Active
- 2000-10-26 HK HK00106819A patent/HK1027749A1/xx not_active IP Right Cessation
-
2002
- 2002-11-06 US US10/288,770 patent/US20030064032A1/en not_active Abandoned
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CO4960637A1 (es) | Preparadores de aerosoles acuosos que contienen macromolecu- las biologicamente activas y procedimiento para la genera- cion de aerosoles correspondientes | |
DE69733618T2 (de) | Biokonjugate und verabreichung von bioaktiven substanzen | |
ES2153367T3 (es) | Derivados de clorofila y de bacterioclorofila, su preparacion y composiciones farmaceuticas que los contienen. | |
AU600069B2 (en) | Wound healing and bone regeneration | |
RU2217432C2 (ru) | Эктеинасцидины, фармацевтическая композиция, содержащая их и способ лечения опухолей | |
TW428026B (en) | Bifunctional protein, preparation and use | |
WO2003068144A3 (en) | Cytotoxic agents | |
Bayer et al. | Triggered liposomal release through a synthetic phosphatidylcholine analogue bearing a photocleavable moiety embedded within the sn‐2 acyl chain | |
WO2001082932A3 (en) | Methods and compositions for enhancing cellular function through protection of tissue components | |
MY134422A (en) | Platinum derivative pharmaceutical formulations. | |
EP0971705A4 (en) | MEDICINE FORMULATIONS FOR HORMONE REPLACEMENT THERAPY FOR TOPICAL APPLICATION ON THE SKIN | |
ATE349438T1 (de) | Cytotoxische wirkstoffe enthaltend taxane und deren therapeutische anwendung | |
BR0016879A (pt) | Métodos para transferência de interleucina-2 por via pulmonar | |
PT799059E (pt) | Anfifilos cationicos e plasmideos para administracao intracelular de moleculas terapeuticas | |
WO2006007712A8 (en) | Methods comprising polyethylene glycol-lipid conjugates for delivery of therapeutic agents | |
WO2004013093A3 (en) | Cytotoxic agents containing novel potent taxanes and their therapeutic use | |
EP2301531A3 (en) | Combinations and modes of administration of therapeutic agents and combination therapy | |
US20070281036A1 (en) | System and method of delivering a desired material to a cell | |
Khoza et al. | Photodynamic therapy activity of phthalocyanine-silver nanoparticles on melanoma cancer cells | |
WO2003008430A3 (en) | Porphyrin derivatives for photodynamic therapy | |
ES2187972T3 (es) | Metodos para la modulacion del crecimiento de arterias colaterales y/u otras arterias a partir de conexiones arteriolares preexistentes. | |
DE60015957T2 (de) | Selen enthaltendes vorstufearzneimittel für krebstherapie | |
CN107148410B (zh) | 用于核酸递送的阳离子脂质 | |
YU77002A (sh) | Postupak i preparat za tretiranje kancera putem davanja hemoterapeutskog agensa koji indukuje apoptozis | |
IL145592A0 (en) | Polyethyleneimine: dna formulations for aerosol delivery |