ES2237576T3 - Antagonistas del receptor a2a de adenosina. - Google Patents

Antagonistas del receptor a2a de adenosina.

Info

Publication number
ES2237576T3
ES2237576T3 ES01945991T ES01945991T ES2237576T3 ES 2237576 T3 ES2237576 T3 ES 2237576T3 ES 01945991 T ES01945991 T ES 01945991T ES 01945991 T ES01945991 T ES 01945991T ES 2237576 T3 ES2237576 T3 ES 2237576T3
Authority
ES
Spain
Prior art keywords
alkyl
alkoxy
compound
formula
mmol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES01945991T
Other languages
English (en)
Spanish (es)
Inventor
Bernard R. Neustadt
Neil A. Lindo
William J. Greenlee
Deen Tulshian
Lisa S. Silverman
Yan Xia
Craig D. Boyle
Samuel Chackalamannil
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme LLC
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Application granted granted Critical
Publication of ES2237576T3 publication Critical patent/ES2237576T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
ES01945991T 2000-05-26 2001-05-24 Antagonistas del receptor a2a de adenosina. Expired - Lifetime ES2237576T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US20714300P 2000-05-26 2000-05-26
US207143P 2000-05-26

Publications (1)

Publication Number Publication Date
ES2237576T3 true ES2237576T3 (es) 2005-08-01

Family

ID=22769372

Family Applications (1)

Application Number Title Priority Date Filing Date
ES01945991T Expired - Lifetime ES2237576T3 (es) 2000-05-26 2001-05-24 Antagonistas del receptor a2a de adenosina.

Country Status (31)

Country Link
US (4) US6630475B2 (OSRAM)
EP (1) EP1283839B1 (OSRAM)
JP (3) JP4574112B2 (OSRAM)
KR (1) KR100520907B1 (OSRAM)
CN (2) CN1247588C (OSRAM)
AR (1) AR028621A1 (OSRAM)
AT (1) ATE293627T1 (OSRAM)
AU (2) AU2001268089C1 (OSRAM)
BR (1) BRPI0111015B8 (OSRAM)
CA (1) CA2410237C (OSRAM)
CZ (1) CZ303790B6 (OSRAM)
DE (1) DE60110219T2 (OSRAM)
DK (1) DK1283839T3 (OSRAM)
EC (1) ECSP024364A (OSRAM)
ES (1) ES2237576T3 (OSRAM)
HK (1) HK1049007B (OSRAM)
HU (1) HU230420B1 (OSRAM)
IL (3) IL152726A0 (OSRAM)
MX (1) MXPA02011625A (OSRAM)
MY (1) MY132006A (OSRAM)
NO (1) NO325008B1 (OSRAM)
NZ (1) NZ522326A (OSRAM)
PE (1) PE20020062A1 (OSRAM)
PL (1) PL218764B1 (OSRAM)
PT (1) PT1283839E (OSRAM)
RU (1) RU2315053C2 (OSRAM)
SI (1) SI1283839T1 (OSRAM)
SK (1) SK287748B6 (OSRAM)
TW (1) TWI288137B (OSRAM)
WO (1) WO2001092264A1 (OSRAM)
ZA (1) ZA200208898B (OSRAM)

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JP5539717B2 (ja) * 2006-07-14 2014-07-02 塩野義製薬株式会社 オキシム化合物およびその使用
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TWI829857B (zh) 2019-01-29 2024-01-21 美商英塞特公司 作為a2a / a2b抑制劑之吡唑并吡啶及三唑并吡啶
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JP2022540583A (ja) * 2019-07-17 2022-09-16 テオン セラピューティクス，インク． アデノシンａ２ａ受容体アンタゴニスト及びその使用
CN112574214B (zh) 2019-07-30 2021-09-28 杭州阿诺生物医药科技有限公司 腺苷受体拮抗剂的制备方法
CN112625050B (zh) 2019-07-30 2021-10-01 杭州阿诺生物医药科技有限公司 一种a2a和/或a2b受体抑制剂的制备方法
CN111072675A (zh) * 2019-12-12 2020-04-28 广东东阳光药业有限公司 含氮稠合三环衍生物及其用途
CN113773327B (zh) * 2021-09-13 2022-07-15 八叶草健康产业研究院(厦门)有限公司 一种吡唑并嘧啶并三唑环类化合物的制备方法
CN118812544A (zh) * 2024-06-19 2024-10-22 厦门大学 一种腺苷a2ar靶向小分子化合物、核素标记探针及其制备方法、应用和药物组合物
CN118812539B (zh) * 2024-06-19 2025-11-28 苏州大学 一种5-氨基三唑并嘧啶衍生物及其制备方法

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Also Published As

Publication number Publication date
SK287748B6 (sk) 2011-08-04
CA2410237C (en) 2008-01-08
AU6808901A (en) 2001-12-11
PL360472A1 (en) 2004-09-06
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