NO20025651L - Adenosin A2A-reseptorantagonister - Google Patents

Adenosin A2A-reseptorantagonister

Info

Publication number
NO20025651L
NO20025651L NO20025651A NO20025651A NO20025651L NO 20025651 L NO20025651 L NO 20025651L NO 20025651 A NO20025651 A NO 20025651A NO 20025651 A NO20025651 A NO 20025651A NO 20025651 L NO20025651 L NO 20025651L
Authority
NO
Norway
Prior art keywords
optionally substituted
phenyl
parkinson
heteroaryl
disease
Prior art date
Application number
NO20025651A
Other languages
English (en)
Other versions
NO20025651D0 (no
NO325008B1 (no
Inventor
Bernard R Neustadt
Neil A Lindo
William J Greenlee
Deen Tulshian
Lisa S Silverman
Yan Xia
Craig D Boyle
Samuel Chackalamannil
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of NO20025651D0 publication Critical patent/NO20025651D0/no
Publication of NO20025651L publication Critical patent/NO20025651L/no
Publication of NO325008B1 publication Critical patent/NO325008B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Det beskrives forbindelser med strukturformelen (I). eller et farmasøytisk aksepterbart salt derav, hvori R er om ønskelig substituert fenyl, sykloalkenyl eller heteroaryl, X er alkylen eller -C(0)CH-, Y er -N(R)CHCHN(R)-, - OCHCHN(R)-, -O-, -S-, -CHS-, -(CH)-NH-, eller eventuelt substituert, (Ia),m og n er 2-3, og Q er nitrogen eller eventuelt substituert karbon, og Z er eventuelt substituert fenyl, fenylalkyl eller heteroaryl, difenylmetyl, RC(0)-, R6-S02-, R6-OC(0)-, RN(R)-C(0)-, RN(R)-C(S)-, fenyl-CH(OH)- eller fenyl- C(=NOR) -, eller dersom Q er CH, a),. fenylamino eller pyridylamino, eller hvori Z og Y sammen er substituert piperidinyl eller substituert fenyl, og R, R, R, Rog Rer som definert i beskrivelsen, anvendelse av disse ved behandling av Parkinsons sykdom, alene eller i kombinasjon med andre midler for behandling av Parkinsons sykdom, og farmasøytiske preparater som inneholder dem; videre beskrives en fremgangsmåte for fremstilling av intermediater som er anvendbare for fremstilling av forbindelser med formel (I).
NO20025651A 2000-05-26 2002-11-25 Adenosin A2A-reseptorantagonister NO325008B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US20714300P 2000-05-26 2000-05-26
PCT/US2001/016954 WO2001092264A1 (en) 2000-05-26 2001-05-24 Adenosine a2a receptor antagonists

Publications (3)

Publication Number Publication Date
NO20025651D0 NO20025651D0 (no) 2002-11-25
NO20025651L true NO20025651L (no) 2003-01-23
NO325008B1 NO325008B1 (no) 2008-01-14

Family

ID=22769372

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20025651A NO325008B1 (no) 2000-05-26 2002-11-25 Adenosin A2A-reseptorantagonister

Country Status (31)

Country Link
US (4) US6630475B2 (no)
EP (1) EP1283839B1 (no)
JP (3) JP4574112B2 (no)
KR (1) KR100520907B1 (no)
CN (2) CN1247588C (no)
AR (1) AR028621A1 (no)
AT (1) ATE293627T1 (no)
AU (2) AU2001268089C1 (no)
BR (1) BRPI0111015B8 (no)
CA (1) CA2410237C (no)
CZ (1) CZ303790B6 (no)
DE (1) DE60110219T2 (no)
DK (1) DK1283839T3 (no)
EC (1) ECSP024364A (no)
ES (1) ES2237576T3 (no)
HK (1) HK1049007B (no)
HU (1) HU230420B1 (no)
IL (3) IL152726A0 (no)
MX (1) MXPA02011625A (no)
MY (1) MY132006A (no)
NO (1) NO325008B1 (no)
NZ (1) NZ522326A (no)
PE (1) PE20020062A1 (no)
PL (1) PL218764B1 (no)
PT (1) PT1283839E (no)
RU (1) RU2315053C2 (no)
SI (1) SI1283839T1 (no)
SK (1) SK287748B6 (no)
TW (1) TWI288137B (no)
WO (1) WO2001092264A1 (no)
ZA (1) ZA200208898B (no)

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AU6808901A (en) 2001-12-11
MY132006A (en) 2007-09-28
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CN1800186A (zh) 2006-07-12
HK1049007A1 (en) 2003-04-25
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