HK1049007B - Adenosine a2a receptor antagonists - Google Patents

Adenosine a2a receptor antagonists Download PDF

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Publication number
HK1049007B
HK1049007B HK03101315.3A HK03101315A HK1049007B HK 1049007 B HK1049007 B HK 1049007B HK 03101315 A HK03101315 A HK 03101315A HK 1049007 B HK1049007 B HK 1049007B
Authority
HK
Hong Kong
Prior art keywords
alkyl
alkoxy
formula
compound
mmol
Prior art date
Application number
HK03101315.3A
Other languages
German (de)
English (en)
French (fr)
Chinese (zh)
Other versions
HK1049007A1 (en
Inventor
R. Neustadt Bernard
A. Lindo Neil
J. Greenlee William
Tulshian Deen
S. Silverman Lisa
Xia Yan
D. Boyle Craig
Chackalamannil Samuel
Original Assignee
Merck Sharp & Dohme Corp.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp & Dohme Corp. filed Critical Merck Sharp & Dohme Corp.
Publication of HK1049007A1 publication Critical patent/HK1049007A1/en
Publication of HK1049007B publication Critical patent/HK1049007B/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
HK03101315.3A 2000-05-26 2001-05-24 Adenosine a2a receptor antagonists HK1049007B (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US20714300P 2000-05-26 2000-05-26
US60/207,143 2000-05-26
PCT/US2001/016954 WO2001092264A1 (en) 2000-05-26 2001-05-24 Adenosine a2a receptor antagonists

Publications (2)

Publication Number Publication Date
HK1049007A1 HK1049007A1 (en) 2003-04-25
HK1049007B true HK1049007B (en) 2005-09-16

Family

ID=22769372

Family Applications (1)

Application Number Title Priority Date Filing Date
HK03101315.3A HK1049007B (en) 2000-05-26 2001-05-24 Adenosine a2a receptor antagonists

Country Status (31)

Country Link
US (4) US6630475B2 (OSRAM)
EP (1) EP1283839B1 (OSRAM)
JP (3) JP4574112B2 (OSRAM)
KR (1) KR100520907B1 (OSRAM)
CN (2) CN1247588C (OSRAM)
AR (1) AR028621A1 (OSRAM)
AT (1) ATE293627T1 (OSRAM)
AU (2) AU2001268089C1 (OSRAM)
BR (1) BRPI0111015B8 (OSRAM)
CA (1) CA2410237C (OSRAM)
CZ (1) CZ303790B6 (OSRAM)
DE (1) DE60110219T2 (OSRAM)
DK (1) DK1283839T3 (OSRAM)
EC (1) ECSP024364A (OSRAM)
ES (1) ES2237576T3 (OSRAM)
HK (1) HK1049007B (OSRAM)
HU (1) HU230420B1 (OSRAM)
IL (3) IL152726A0 (OSRAM)
MX (1) MXPA02011625A (OSRAM)
MY (1) MY132006A (OSRAM)
NO (1) NO325008B1 (OSRAM)
NZ (1) NZ522326A (OSRAM)
PE (1) PE20020062A1 (OSRAM)
PL (1) PL218764B1 (OSRAM)
PT (1) PT1283839E (OSRAM)
RU (1) RU2315053C2 (OSRAM)
SI (1) SI1283839T1 (OSRAM)
SK (1) SK287748B6 (OSRAM)
TW (1) TWI288137B (OSRAM)
WO (1) WO2001092264A1 (OSRAM)
ZA (1) ZA200208898B (OSRAM)

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JP2022540583A (ja) * 2019-07-17 2022-09-16 テオン セラピューティクス，インク． アデノシンａ２ａ受容体アンタゴニスト及びその使用
CN112574214B (zh) 2019-07-30 2021-09-28 杭州阿诺生物医药科技有限公司 腺苷受体拮抗剂的制备方法
CN112625050B (zh) 2019-07-30 2021-10-01 杭州阿诺生物医药科技有限公司 一种a2a和/或a2b受体抑制剂的制备方法
CN111072675A (zh) * 2019-12-12 2020-04-28 广东东阳光药业有限公司 含氮稠合三环衍生物及其用途
CN113773327B (zh) * 2021-09-13 2022-07-15 八叶草健康产业研究院(厦门)有限公司 一种吡唑并嘧啶并三唑环类化合物的制备方法
CN118812544A (zh) * 2024-06-19 2024-10-22 厦门大学 一种腺苷a2ar靶向小分子化合物、核素标记探针及其制备方法、应用和药物组合物
CN118812539B (zh) * 2024-06-19 2025-11-28 苏州大学 一种5-氨基三唑并嘧啶衍生物及其制备方法

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Publication number Publication date
SK287748B6 (sk) 2011-08-04
CA2410237C (en) 2008-01-08
AU6808901A (en) 2001-12-11
PL360472A1 (en) 2004-09-06
EP1283839A1 (en) 2003-02-19
SI1283839T1 (OSRAM) 2005-08-31
PE20020062A1 (es) 2002-02-02
CA2410237A1 (en) 2001-12-06
NZ522326A (en) 2006-03-31
JP2007145875A (ja) 2007-06-14
AU2001268089B2 (en) 2005-04-28
CN1247588C (zh) 2006-03-29
ECSP024364A (es) 2003-03-31
IL220174A0 (en) 2012-07-31
USRE44205E1 (en) 2013-05-07
SK16712002A3 (sk) 2003-08-05
EP1283839B1 (en) 2005-04-20
AR028621A1 (es) 2003-05-14
NO20025651L (no) 2003-01-23
PT1283839E (pt) 2005-08-31
US20050026932A1 (en) 2005-02-03
BRPI0111015B1 (pt) 2017-11-07
BR0111015A (pt) 2005-01-11
US7067655B2 (en) 2006-06-27
IL152726A (en) 2012-07-31
RU2315053C2 (ru) 2008-01-20
WO2001092264A1 (en) 2001-12-06
JP4574112B2 (ja) 2010-11-04
CN1451007A (zh) 2003-10-22
JP2006219497A (ja) 2006-08-24
HK1049007A1 (en) 2003-04-25
AU2001268089C1 (en) 2006-04-13
MY132006A (en) 2007-09-28
US6897216B2 (en) 2005-05-24
US20020099061A1 (en) 2002-07-25
CZ303790B6 (cs) 2013-05-09
NO20025651D0 (no) 2002-11-25
ES2237576T3 (es) 2005-08-01
ATE293627T1 (de) 2005-05-15
US6630475B2 (en) 2003-10-07
CN1800186A (zh) 2006-07-12
DK1283839T3 (da) 2005-07-25
BRPI0111015B8 (pt) 2021-05-25
IL220174A (en) 2015-07-30
CZ20023886A3 (cs) 2003-02-12
HUP0600239A3 (en) 2008-06-30
CN100384847C (zh) 2008-04-30
TWI288137B (en) 2007-10-11
KR20030003746A (ko) 2003-01-10
HU230420B1 (hu) 2016-05-30
IL152726A0 (en) 2003-06-24
JP2003535094A (ja) 2003-11-25
HUP0600239A2 (en) 2006-07-28
DE60110219D1 (de) 2005-05-25
DE60110219T2 (de) 2006-03-09
KR100520907B1 (ko) 2005-10-11
PL218764B1 (pl) 2015-01-30
ZA200208898B (en) 2004-03-01
JP4938348B2 (ja) 2012-05-23
MXPA02011625A (es) 2003-03-27
NO325008B1 (no) 2008-01-14
US20040023997A1 (en) 2004-02-05

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