AR028621A1 - Antagonistas receptores de adenosina a2a - Google Patents

Antagonistas receptores de adenosina a2a

Info

Publication number
AR028621A1
AR028621A1 ARP010102483A ARP010102483A AR028621A1 AR 028621 A1 AR028621 A1 AR 028621A1 AR P010102483 A ARP010102483 A AR P010102483A AR P010102483 A ARP010102483 A AR P010102483A AR 028621 A1 AR028621 A1 AR 028621A1
Authority
AR
Argentina
Prior art keywords
adenosine
antagonists
receiving
receiving antagonists
Prior art date
Application number
ARP010102483A
Other languages
English (en)
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of AR028621A1 publication Critical patent/AR028621A1/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/08Antiepileptics; Anticonvulsants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
ARP010102483A 2000-05-26 2001-05-24 Antagonistas receptores de adenosina a2a AR028621A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US20714300P 2000-05-26 2000-05-26

Publications (1)

Publication Number Publication Date
AR028621A1 true AR028621A1 (es) 2003-05-14

Family

ID=22769372

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP010102483A AR028621A1 (es) 2000-05-26 2001-05-24 Antagonistas receptores de adenosina a2a

Country Status (31)

Country Link
US (4) US6630475B2 (es)
EP (1) EP1283839B1 (es)
JP (3) JP4574112B2 (es)
KR (1) KR100520907B1 (es)
CN (2) CN1247588C (es)
AR (1) AR028621A1 (es)
AT (1) ATE293627T1 (es)
AU (2) AU6808901A (es)
BR (1) BRPI0111015B8 (es)
CA (1) CA2410237C (es)
CZ (1) CZ303790B6 (es)
DE (1) DE60110219T2 (es)
DK (1) DK1283839T3 (es)
EC (1) ECSP024364A (es)
ES (1) ES2237576T3 (es)
HK (1) HK1049007B (es)
HU (1) HU230420B1 (es)
IL (3) IL152726A0 (es)
MX (1) MXPA02011625A (es)
MY (1) MY132006A (es)
NO (1) NO325008B1 (es)
NZ (1) NZ522326A (es)
PE (1) PE20020062A1 (es)
PL (1) PL218764B1 (es)
PT (1) PT1283839E (es)
RU (1) RU2315053C2 (es)
SI (1) SI1283839T1 (es)
SK (1) SK287748B6 (es)
TW (1) TWI288137B (es)
WO (1) WO2001092264A1 (es)
ZA (1) ZA200208898B (es)

Families Citing this family (84)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE293627T1 (de) * 2000-05-26 2005-05-15 Schering Corp Adenosin a2a rezeptor antagonisten
CA2459304A1 (en) * 2001-09-13 2003-03-20 Schering Corporation Combination of an adenosine a2a receptor antagonist and an antidepressant or anxiolytic
IL160878A0 (en) 2001-10-15 2004-08-31 Schering Corp Imidazo (4,3-e)-1,2,4-triazolo (1,5-c) pyrimidines as adenosine a2a receptor antagonists
FR2832405B1 (fr) * 2001-11-19 2004-12-10 Sanofi Synthelabo Tetrahydropyridyl-alkyl-heterocycles azotes, procede pour leur preparation et compositions pharmaceutiques les contenant
DE60234951D1 (de) * 2001-11-30 2010-02-11 Schering Corp Adenosin a2a rezeptor antagonisten
AR038366A1 (es) 2001-11-30 2005-01-12 Schering Corp Compuestos de 1,2,4-triazolo [1,5-c] pirimidinas sustituidas, antagonistas del receptor de adenosina a2a, composiciones farmaceuticas, el uso de dichos compuestos para la manufactura de un medicamento para el tratamiento de enfermedades del sistema nervioso central y un kit que comprende combinacion
EP1453836B1 (en) 2001-11-30 2007-03-28 Schering Corporation BICYCLIC [1,2,4] -TRIAZOLE ADENOSINE A2a RECEPTOR ANTAGONISTS
EP2942082B1 (en) 2002-01-28 2019-03-06 Kyowa Hakko Kogyo Co., Ltd A2a receptor antogonists for use in the treatment of movement disorders
KR20040111324A (ko) 2002-05-30 2004-12-31 킹 파머슈티칼스 리서치 앤드 디벨로프먼트 아이엔씨 트리사이클릭 파이라졸로트리아졸로피리미딘 링 구조를지닌 약제학적 활성화합물 및 사용 방법
US20060106040A1 (en) * 2002-12-19 2006-05-18 Michael Grzelak Adenosine A2a receptor antagonists for the treatment of extra-pyramidal syndrome and other movement disorders
CN100415217C (zh) * 2002-12-19 2008-09-03 先灵公司 腺苷A2a受体拮抗剂的应用
WO2004092172A2 (en) 2003-04-09 2004-10-28 Biogen Idec Ma Inc. Triazolo[1,5-c]pyrimidines and pyrazolo[1,5-c]pyrimidines useful as a2a adenosin e receptor antagonists
MY139344A (en) * 2003-04-23 2009-09-30 Schering Corp 2-alkynyl-and 2-alkenyl-pyrazolo-[4,3-e]-1,2,4-triazolo-[1,5-c]-pyrimidine adenosine a2a receptor antagonists
BRPI0411120A (pt) * 2003-06-10 2006-07-18 Kyowa Hakko Kogyo Kk método para tratar de um distúrbio de ansiedade, composição, agente para tratar de um distúrbio de ansiedade, e, usos de um composto e de um derivado de xantina
JP2006527212A (ja) * 2003-06-12 2006-11-30 ノボ ノルディスク アクティーゼルスカブ ホルモン感受性リパーゼの阻害剤として使用するための、置換ピペラジンカルバメート
JP4800216B2 (ja) * 2003-10-24 2011-10-26 エグゼリクシス, インコーポレイテッド p70S6キナーゼモジュレーターおよび使用方法
ES2278353T3 (es) 2003-10-28 2007-08-01 Schering Corporation Procedimiento para preparar 5-amino-pirazolo-(4,3-e)-1,2,4-triazolo(1,5-c)pirimidinas sustituidas.
ES2293380T3 (es) * 2003-12-01 2008-03-16 Schering Corporation Procedimiento para preparar 5-amino-pirazolo-(4,3-e)-1,2,4-triazolo(1,5-c)pirimidinas sustituidos.
NZ547557A (en) * 2003-12-19 2010-07-30 Schering Corp Pharmaceutical compositions containing a cationic A2A receptor antagonist
US7709492B2 (en) * 2004-04-21 2010-05-04 Schering Corporation Pyrazolo-[4,3-e]-1,2,4-triazolo-[1,5-c]-pyrimidine adenosine A2a receptor antagonists
ES2385702T3 (es) * 2005-06-07 2012-07-30 Kyowa Hakko Kirin Co., Ltd. Antagonistas de A2A para uso en el tratamiento de trastornos de la motricidad
EP1934227B1 (en) 2005-09-19 2011-12-21 Schering Corporation 2-HETEROARYL-PYRAZOLO-[4, 3-e]-1, 2, 4-TRIAZOLO-[1,5-c]-PYRIMIDINE AS ADENOSINE A2a RECEPTOR ANTAGONISTS
PE20070521A1 (es) 2005-09-23 2007-07-13 Schering Corp 7-[2-[4-(6-FLUORO-3-METIL-1,2-BENCISOXAZOL-5-IL)-1-PIPERAZINIL]ETIL]-2-(1-PROPINIL)-7H-PIRAZOL-[4,3-E]-[1,2,4]-TRIAZOL-[1,5-C]-PIRIMIDIN-5-AMINA COMO ANTAGONISTA DEL RECEPTOR DE ADENOSINA A2a
ES2273599B1 (es) 2005-10-14 2008-06-01 Universidad De Barcelona Compuestos para el tratamiento de la fibrilacion auricular.
EP2040698A4 (en) * 2006-07-14 2011-08-10 Shionogi & Co OXIM CONNECTIONS AND ITS USE
TW200840566A (en) * 2006-12-22 2008-10-16 Esteve Labor Dr Heterocyclyl-substituted-ethylamino-phenyl derivatives, their preparation and use as medicaments
US7723343B2 (en) * 2007-03-30 2010-05-25 King Pharmaceuticals Research And Development, Inc. Adenosine A2A receptor antagonists
US8669260B2 (en) * 2008-02-29 2014-03-11 Albert Einstein College Of Medicine Of Yeshiva University Ketoconazole-derivative antagonist of human pregnane X receptor and uses thereof
EP2262811B1 (en) 2008-03-04 2016-04-27 Merck Sharp & Dohme Corp. 1,2,4-triazolo[4,3-c]pyrimidin-3-one and pyrazolo [4,3-e]-1,2,4-triazolo [4,3-c]pyrimidin-3-one compounds for use as adenosine a2a receptor antagonists
US20110064671A1 (en) 2008-03-10 2011-03-17 Cornell University Modulation of blood brain barrier permeability
TWI473614B (zh) * 2008-05-29 2015-02-21 Kyowa Hakko Kirin Co Ltd Anti-analgesic inhibitors
EA023267B1 (ru) 2008-07-23 2016-05-31 Киова Хакко Кирин Ко., Лтд. Способ для лечения и/или предотвращения мигрени
US20100093702A1 (en) * 2008-10-13 2010-04-15 Barbay J Kent METHYLENE AMINES OF THIENO[2,3-d]PYRIMIDINE AND THEIR USE AS ADENOSINE A2a RECEPTOR ANTAGONISTS
TW201036614A (en) 2008-12-30 2010-10-16 Arqule Inc Substituted 1H-pyrazolo[3,4-d]pyrimidine-6-amine compounds
MX2011007678A (es) 2009-01-20 2011-08-08 Schering Corp Metodos para aliviar o tratar señales y/o sintomas asociados con enfermedad de parkinson de moderada a severa.
WO2010084160A1 (en) 2009-01-21 2010-07-29 Oryzon Genomics S.A. Phenylcyclopropylamine derivatives and their medical use
WO2010103547A2 (en) 2009-03-13 2010-09-16 Advinus Therapeutics Private Limited Substituted fused pyrimidine compounds
WO2010114894A1 (en) 2009-03-31 2010-10-07 Arqule, Inc. Substituted heterocyclic compounds
WO2010147941A1 (en) 2009-06-15 2010-12-23 Marvell World Trade Ltd. System and methods for gamut bounded saturation adaptive color enhancement
EP2462144B1 (en) 2009-08-07 2017-09-20 Merck Sharp & Dohme Corp. PROCESS FOR PREPARING A 2-ALKYNYL SUBSTITUTED 5-AMINO-PYRAZOLO-[4,3-e]-1,2,4-TRIAZOLO[1,5-c]PYRIMIDINE
MX338041B (es) 2009-09-25 2016-03-30 Oryzon Genomics Sa Inhibidores de demetilasa-1 especificos de lisina y su uso.
EP2486002B1 (en) 2009-10-09 2019-03-27 Oryzon Genomics, S.A. Substituted heteroaryl- and aryl- cyclopropylamine acetamides and their use
WO2011101861A1 (en) 2010-01-29 2011-08-25 Msn Laboratories Limited Process for preparation of dpp-iv inhibitors
US9186337B2 (en) 2010-02-24 2015-11-17 Oryzon Genomics S.A. Lysine demethylase inhibitors for diseases and disorders associated with Hepadnaviridae
US9616058B2 (en) 2010-02-24 2017-04-11 Oryzon Genomics, S.A. Potent selective LSD1 inhibitors and dual LSD1/MAO-B inhibitors for antiviral use
KR101794020B1 (ko) 2010-04-19 2017-11-06 오리존 지노믹스 에스.에이. 라이신 특이적 디메틸라아제-1 억제제 및 이의 용도
US9181198B2 (en) 2010-07-29 2015-11-10 Oryzon Genomics S.A. Arylcyclopropylamine based demethylase inhibitors of LSD1 and their medical use
WO2012013727A1 (en) 2010-07-29 2012-02-02 Oryzon Genomics S.A. Cyclopropylamine derivatives useful as lsd1 inhibitors
AU2011306358B2 (en) * 2010-09-24 2014-08-14 Impetis Biosciences Ltd. Fused tricyclic compounds as adenosine receptor antagonist
WO2012045883A1 (en) 2010-10-08 2012-04-12 Oryzon Genomics S.A. Cyclopropylamine inhibitors of oxidases
WO2012072713A2 (en) 2010-11-30 2012-06-07 Oryzon Genomics, S.A. Lysine demethylase inhibitors for diseases and disorders associated with flaviviridae
EP2712315B1 (en) 2011-02-08 2021-11-24 Oryzon Genomics, S.A. Lysine demethylase inhibitors for myeloproliferative disorders
WO2012127472A1 (en) * 2011-03-22 2012-09-27 Mapi Pharma Ltd. Process and intermediates for the preparation of preladenant and related compounds
WO2012129381A1 (en) * 2011-03-22 2012-09-27 Concert Pharmaceuticals Inc. Deuterated preladenant
WO2013024474A1 (en) * 2011-08-18 2013-02-21 Mapi Phrarma Ltd. Polymorphs of preladenant
CN107266345B (zh) 2011-10-20 2021-08-17 奥瑞泽恩基因组学股份有限公司 作为lsd1抑制剂的(杂)芳基环丙胺化合物
RS58475B1 (sr) 2011-10-20 2019-04-30 Oryzon Genomics Sa Jedinjenja (hetero)aril ciklopropilamina kao lsd1 inhibitori
WO2014071512A1 (en) * 2012-11-06 2014-05-15 Universite Laval Combination therapy and methods for the treatment of respiratory diseases
WO2014101120A1 (en) 2012-12-28 2014-07-03 Merck Sharp & Dohme Corp. Heterobicyclo-substituted-7-methoxy-[1,2,4]triazolo[1,5-c]quinazolin-5-amine compounds with a2a antagonist properties
US10472347B2 (en) 2014-11-18 2019-11-12 Merck Sharp & Dohme Corp. Aminopyrazine compounds with A2A antagonist properties
WO2016126570A1 (en) 2015-02-06 2016-08-11 Merck Sharp & Dohme Corp. Aminoquinazoline compounds as a2a antagonist
US10688082B2 (en) 2015-06-11 2020-06-23 Merck Sharp & Dohme Corp. Aminopyrazine compounds with A2A antagonist properties
WO2017008205A1 (en) 2015-07-10 2017-01-19 Merck Sharp & Dohme Corp. Substituted aminoquinazoline compounds as a2a antagonist
US9675585B1 (en) 2016-03-24 2017-06-13 Ezra Pharma Extended release pharmaceutical formulations
US9687475B1 (en) 2016-03-24 2017-06-27 Ezra Pharma Llc Extended release pharmaceutical formulations with controlled impurity levels
WO2018178338A1 (en) * 2017-03-30 2018-10-04 Iteos Therapeutics 2-oxo-thiazole derivatives as a2a inhibitors and compounds for use in the treatment of cancers
EP3723754A4 (en) 2017-12-13 2021-05-19 Merck Sharp & Dohme Corp. IMIDAZO [1,2-C] QUINAZOLIN-5-AMINE COMPOUNDS WITH A2A ANTAGONIST PROPERTIES
US11407758B2 (en) 2018-01-04 2022-08-09 Impetis Biosciences Ltd. Tricyclic compounds, compositions and medicinal applications thereof
CN112384515A (zh) 2018-02-27 2021-02-19 因赛特公司 作为a2a/a2b抑制剂的咪唑并嘧啶和三唑并嘧啶
CN108276345A (zh) * 2018-03-22 2018-07-13 重庆奥舍生物化工有限公司 一种药物中间体嘧啶-5-甲醛的制备方法
MX2020010618A (es) * 2018-04-08 2020-11-12 Beigene Ltd Derivados de pirazolotriazolopiriminina como antagonista del receptor a2a.
MX2020012376A (es) 2018-05-18 2021-03-09 Incyte Corp Derivados de pirimidina fusionados como inhibidores de los receptores de adenosina a2a/a2b.
CN108864114B (zh) * 2018-06-04 2020-11-06 应世生物科技(南京)有限公司 选择性a2a受体拮抗剂
EP3818063A1 (en) 2018-07-05 2021-05-12 Incyte Corporation Fused pyrazine derivatives as a2a / a2b inhibitors
CN110742893B (zh) * 2018-07-23 2024-04-05 百济神州(北京)生物科技有限公司 A2a受体拮抗剂治疗癌症的方法
TWI829857B (zh) 2019-01-29 2024-01-21 美商英塞特公司 作為a2a / a2b抑制劑之吡唑并吡啶及三唑并吡啶
WO2020227156A1 (en) * 2019-05-03 2020-11-12 Nektar Therapeutics Adenosine 2 receptor antagonists
DE102019116986A1 (de) 2019-06-24 2020-12-24 Helmholtz-Zentrum Dresden-Rossendorf E. V. Deuterierte 7-(3-(4-(2-([18F]Fluor)ethoxy)phenyl)propyl)-2-(furan-2-yl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amin-Derivate
EP3999513A4 (en) * 2019-07-17 2022-12-21 Teon Therapeutics, Inc. ADENOSINE A2A RECEPTOR ANTAGONISTS AND THEIR USES
CN112608316B (zh) 2019-07-30 2022-10-21 厦门宝太生物科技股份有限公司 一种吡唑并三嗪类腺苷受体拮抗剂
CN112592354B (zh) 2019-07-30 2022-05-27 厦门宝太生物科技股份有限公司 一种异噁唑并嘧啶类杂环化合物的制备方法
CN111072675A (zh) * 2019-12-12 2020-04-28 广东东阳光药业有限公司 含氮稠合三环衍生物及其用途
JP7431665B2 (ja) 2020-05-20 2024-02-15 Ykk Ap株式会社 接合構造および建具
CN113773327B (zh) * 2021-09-13 2022-07-15 八叶草健康产业研究院(厦门)有限公司 一种吡唑并嘧啶并三唑环类化合物的制备方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU466232A1 (ru) * 1973-05-23 1975-04-05 Киевский Ордена Ленина Государственный Университет Им.Т.Г.Шевченко Споссоб получени конденсированных пиримидо- -триазиниевых соединений с мостиковыми атомами азота
EP0217748B1 (en) 1985-09-30 1991-02-06 Ciba-Geigy Ag 2-Substituted-e-fused-[1,2,4,]triazolo-[1,5-c]pyrimidines pharmaceutical compositions and uses thereof
SU1739850A3 (ru) * 1987-08-31 1992-06-07 Такеда Кемикал Индастриз, Лтд (Фирма) Способ получени конденсированных производных пиразоло[3,4- @ ]пиримидина
IT1264901B1 (it) * 1993-06-29 1996-10-17 Schering Plough S P A Analoghi eterociclici di 1,2,4-triazolo(15-c)pirimidine ad attivita' antagonista per il recettore a2 dell'adenosina
WO1995003806A1 (fr) 1993-07-27 1995-02-09 Kyowa Hakko Kogyo Co., Ltd. Remede contre la maladie de parkinson
IT1277392B1 (it) 1995-07-28 1997-11-10 Schering Plough S P A Analoghi eterociclici di 1,2,4-triazolo(1,5-c]pirimidine ad attivita' antagonista per il recettore a2a dell'adenosina
IT1291372B1 (it) * 1997-05-21 1999-01-07 Schering Plough S P A Uso di analoghi eterociclici di 1,2,4-triazolo (1,5-c) pirimidine per la preparazione di medicamenti utili per il trattamento delle malattie
ATE293627T1 (de) * 2000-05-26 2005-05-15 Schering Corp Adenosin a2a rezeptor antagonisten
DE60234951D1 (de) * 2001-11-30 2010-02-11 Schering Corp Adenosin a2a rezeptor antagonisten
CN100415217C (zh) * 2002-12-19 2008-09-03 先灵公司 腺苷A2a受体拮抗剂的应用
ES2278353T3 (es) * 2003-10-28 2007-08-01 Schering Corporation Procedimiento para preparar 5-amino-pirazolo-(4,3-e)-1,2,4-triazolo(1,5-c)pirimidinas sustituidas.
ES2293380T3 (es) * 2003-12-01 2008-03-16 Schering Corporation Procedimiento para preparar 5-amino-pirazolo-(4,3-e)-1,2,4-triazolo(1,5-c)pirimidinas sustituidos.
US7709492B2 (en) * 2004-04-21 2010-05-04 Schering Corporation Pyrazolo-[4,3-e]-1,2,4-triazolo-[1,5-c]-pyrimidine adenosine A2a receptor antagonists
EP1934227B1 (en) * 2005-09-19 2011-12-21 Schering Corporation 2-HETEROARYL-PYRAZOLO-[4, 3-e]-1, 2, 4-TRIAZOLO-[1,5-c]-PYRIMIDINE AS ADENOSINE A2a RECEPTOR ANTAGONISTS

Also Published As

Publication number Publication date
NO20025651D0 (no) 2002-11-25
HUP0600239A3 (en) 2008-06-30
US7067655B2 (en) 2006-06-27
IL220174A (en) 2015-07-30
SK287748B6 (sk) 2011-08-04
BRPI0111015B1 (pt) 2017-11-07
BR0111015A (pt) 2005-01-11
EP1283839A1 (en) 2003-02-19
BRPI0111015B8 (pt) 2021-05-25
CA2410237A1 (en) 2001-12-06
IL152726A0 (en) 2003-06-24
AU2001268089B2 (en) 2005-04-28
TWI288137B (en) 2007-10-11
CN100384847C (zh) 2008-04-30
ZA200208898B (en) 2004-03-01
HUP0600239A2 (en) 2006-07-28
ES2237576T3 (es) 2005-08-01
HU230420B1 (hu) 2016-05-30
RU2315053C2 (ru) 2008-01-20
US6897216B2 (en) 2005-05-24
PL360472A1 (en) 2004-09-06
JP4574112B2 (ja) 2010-11-04
CZ20023886A3 (cs) 2003-02-12
SK16712002A3 (sk) 2003-08-05
SI1283839T1 (es) 2005-08-31
JP4938348B2 (ja) 2012-05-23
NO325008B1 (no) 2008-01-14
CN1800186A (zh) 2006-07-12
US6630475B2 (en) 2003-10-07
KR20030003746A (ko) 2003-01-10
EP1283839B1 (en) 2005-04-20
AU6808901A (en) 2001-12-11
KR100520907B1 (ko) 2005-10-11
DK1283839T3 (da) 2005-07-25
HK1049007B (zh) 2005-09-16
WO2001092264A1 (en) 2001-12-06
PL218764B1 (pl) 2015-01-30
MY132006A (en) 2007-09-28
JP2006219497A (ja) 2006-08-24
PE20020062A1 (es) 2002-02-02
ECSP024364A (es) 2003-03-31
AU2001268089C1 (en) 2006-04-13
CA2410237C (en) 2008-01-08
IL152726A (en) 2012-07-31
US20050026932A1 (en) 2005-02-03
CN1451007A (zh) 2003-10-22
CZ303790B6 (cs) 2013-05-09
US20020099061A1 (en) 2002-07-25
NZ522326A (en) 2006-03-31
PT1283839E (pt) 2005-08-31
JP2007145875A (ja) 2007-06-14
DE60110219D1 (de) 2005-05-25
JP2003535094A (ja) 2003-11-25
NO20025651L (no) 2003-01-23
CN1247588C (zh) 2006-03-29
US20040023997A1 (en) 2004-02-05
IL220174A0 (en) 2012-07-31
DE60110219T2 (de) 2006-03-09
ATE293627T1 (de) 2005-05-15
MXPA02011625A (es) 2003-03-27
HK1049007A1 (en) 2003-04-25
USRE44205E1 (en) 2013-05-07

Similar Documents

Publication Publication Date Title
AR028621A1 (es) Antagonistas receptores de adenosina a2a
DE60119492D1 (de) Purinderivate
ATE317844T1 (de) Adenosine a2a receptor antagonisten
ATE267836T1 (de) Purinderivate
NO20006520L (no) Adenosinderivater
CY2011002I1 (el) N-πυρραζολικοι αγωνιστες του α2α υποδοχεα
DK1303496T3 (da) Pyrimidinderivater
DE60026861D1 (de) Purin-derivate
ATE238336T1 (de) Purin-derivate
EE200100681A (et) Puriinderivaadid
IL161716A0 (en) ADENOSINE A2a RECEPTOR ANTAGONISTS
PT1192170E (pt) Agonistas de receptor a2a de propargilfenileter
NO20020979D0 (no) Selektive A2B-adenosin reseptorantagonister
DE60132068D1 (de) Empfangsgerät
NO20032291D0 (no) Pyrimidinderivater
DK1090019T3 (da) Adenosinderivater
EP1295891A4 (en) nucleoside
TH109999B (th) นิวคลีโอไซด์
SE9901473D0 (sv) Nucleosides
GB0021285D0 (en) Nucleoside derivatives
GB0026611D0 (en) Nucleoside derivatives

Legal Events

Date Code Title Description
FG Grant, registration