DE60234951D1 - Adenosin a2a rezeptor antagonisten - Google Patents

Adenosin a2a rezeptor antagonisten

Info

Publication number
DE60234951D1
DE60234951D1 DE60234951T DE60234951T DE60234951D1 DE 60234951 D1 DE60234951 D1 DE 60234951D1 DE 60234951 T DE60234951 T DE 60234951T DE 60234951 T DE60234951 T DE 60234951T DE 60234951 D1 DE60234951 D1 DE 60234951D1
Authority
DE
Germany
Prior art keywords
adenosine
receptor antagonists
antagonists
receptor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60234951T
Other languages
English (en)
Inventor
Craig D Boyle
Samuel Chackalamannil
William J Greenlee
Unmesh G Shah
Yan Xia
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme LLC
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Application granted granted Critical
Publication of DE60234951D1 publication Critical patent/DE60234951D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
DE60234951T 2001-11-30 2002-11-26 Adenosin a2a rezeptor antagonisten Expired - Lifetime DE60234951D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US33434201P 2001-11-30 2001-11-30
PCT/US2002/037710 WO2003048165A1 (en) 2001-11-30 2002-11-26 ADENOSINE A2a RECEPTOR ANTAGONISTS

Publications (1)

Publication Number Publication Date
DE60234951D1 true DE60234951D1 (de) 2010-02-11

Family

ID=23306779

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60234951T Expired - Lifetime DE60234951D1 (de) 2001-11-30 2002-11-26 Adenosin a2a rezeptor antagonisten

Country Status (19)

Country Link
US (1) US6916811B2 (de)
EP (1) EP1448565B1 (de)
JP (2) JP4284182B2 (de)
KR (1) KR20050044593A (de)
CN (1) CN1692116A (de)
AR (1) AR037680A1 (de)
AT (1) ATE453647T1 (de)
AU (1) AU2002346503A1 (de)
CA (1) CA2468649C (de)
DE (1) DE60234951D1 (de)
ES (1) ES2336435T3 (de)
HK (1) HK1063780A1 (de)
HU (1) HUP0402018A3 (de)
IL (1) IL161716A0 (de)
MX (1) MXPA04005209A (de)
PE (1) PE20030665A1 (de)
TW (1) TW200306837A (de)
WO (1) WO2003048165A1 (de)
ZA (1) ZA200404161B (de)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100384847C (zh) * 2000-05-26 2008-04-30 先灵公司 腺苷A2a受体拮抗剂
US6964288B2 (en) * 2001-07-06 2005-11-15 Ksaria Corporation Apparatus and method for automated preparation of an optical fiber
CA2463598C (en) 2001-10-15 2009-09-08 Schering Corporation Imidazo (4,3-e)-1,2,4-triazolo(1,5-c) pyrimidines as adenosine a2a receptor antagonists
JP2005527635A (ja) * 2002-05-30 2005-09-15 キング・ファーマシューティカルズ・リサーチ・アンド・デベロプメント・インコーポレイティッド 三環ピラゾロトリアゾロピリミジン環構造を有する薬学的に活性な化合物及び使用方法
ES2354875T3 (es) * 2002-12-19 2011-03-18 Schering Corporation Uso de antagonistas del receptor a2a de la adenosina para el tratamiento o prevención del síndrome extrapiramidal.
EP1678168B1 (de) * 2003-10-24 2012-07-11 Exelixis, Inc. Modulatoren von p70s6-kinase und anwendungsverfahren
ES2278353T3 (es) * 2003-10-28 2007-08-01 Schering Corporation Procedimiento para preparar 5-amino-pirazolo-(4,3-e)-1,2,4-triazolo(1,5-c)pirimidinas sustituidas.
KR20060111581A (ko) * 2003-12-19 2006-10-27 쉐링 코포레이션 약제학적 조성물
ATE556712T1 (de) * 2005-06-07 2012-05-15 Kyowa Hakko Kirin Co Ltd A2a antagonisten zur behandlung von motorischen störungen
ES2273599B1 (es) 2005-10-14 2008-06-01 Universidad De Barcelona Compuestos para el tratamiento de la fibrilacion auricular.
PE20080145A1 (es) * 2006-03-21 2008-02-11 Janssen Pharmaceutica Nv Tetrahidro-pirimidoazepinas como moduladores de trpv1
US7723343B2 (en) * 2007-03-30 2010-05-25 King Pharmaceuticals Research And Development, Inc. Adenosine A2A receptor antagonists
PE20091102A1 (es) 2007-12-17 2009-07-25 Janssen Pharmaceutica Nv Moduladores imidazolo-, oxazolo-, y tiazolopirimidina del trpv1
US20100203165A1 (en) 2008-08-01 2010-08-12 Gerald Horn Compositions and methods for treatment of disorders or conditions of the eye
SI2320911T1 (sl) 2008-08-01 2014-12-31 Eye Therapies Llc Vazokonstrikcijski sestavki in metode uporabe
US8952011B2 (en) 2008-08-01 2015-02-10 Eye Therapies Llc Compositions and methods for the treatment of nasal conditions
CA2748174A1 (en) 2008-12-30 2010-07-08 Arqule, Inc. Substituted 1h-pyrazolo[3,4-d]pyrimidine-6-amine compounds
TW201100427A (en) 2009-03-31 2011-01-01 Arqule Inc Substituted heterocyclic compounds
US8987270B2 (en) 2009-07-27 2015-03-24 Eye Therapies Llc Formulations of selective alpha-2 agonists and methods of use thereof
US20110152271A1 (en) * 2009-12-17 2011-06-23 Gerald Horn Compositions and methods for ophthalmic delivery of nasal decongestants
US8445526B2 (en) 2011-02-03 2013-05-21 Glaucoma & Nasal Therapies Llc Compositions and methods for treatment of glaucoma
US8999938B2 (en) 2013-06-21 2015-04-07 Gnt Llc Ophthalmic lipophilic drug delivery vehicle formulations
CN110742893B (zh) * 2018-07-23 2024-04-05 百济神州(北京)生物科技有限公司 A2a受体拮抗剂治疗癌症的方法
MX2021006329A (es) 2018-11-30 2021-08-11 Merck Sharp & Dohme Llc Derivados de amino triazolo quinazolina 9-sustituidos como antagonistas del receptor de adenosina, composiciones farmaceuticas y su uso.
DE102019116986A1 (de) 2019-06-24 2020-12-24 Helmholtz-Zentrum Dresden-Rossendorf E. V. Deuterierte 7-(3-(4-(2-([18F]Fluor)ethoxy)phenyl)propyl)-2-(furan-2-yl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amin-Derivate
EP3999513A4 (de) * 2019-07-17 2022-12-21 Teon Therapeutics, Inc. Adenosin-a2a-rezeptorantagonisten und verwendungen davon
CN111825698B (zh) 2019-07-30 2021-10-15 杭州阿诺生物医药科技有限公司 腺苷受体拮抗剂
CN112028891B (zh) 2019-07-30 2022-07-05 厦门宝太生物科技股份有限公司 腺苷受体拮抗剂

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1264901B1 (it) 1993-06-29 1996-10-17 Schering Plough S P A Analoghi eterociclici di 1,2,4-triazolo(15-c)pirimidine ad attivita' antagonista per il recettore a2 dell'adenosina
US5565460A (en) * 1993-07-27 1996-10-15 Kyowa Hakko Koygo Co., Ltd. Therapeutic purine agents for parkinson's disease
IT1277392B1 (it) * 1995-07-28 1997-11-10 Schering Plough S P A Analoghi eterociclici di 1,2,4-triazolo(1,5-c]pirimidine ad attivita' antagonista per il recettore a2a dell'adenosina
IT1291372B1 (it) 1997-05-21 1999-01-07 Schering Plough S P A Uso di analoghi eterociclici di 1,2,4-triazolo (1,5-c) pirimidine per la preparazione di medicamenti utili per il trattamento delle malattie
US6921825B2 (en) * 1998-09-16 2005-07-26 King Pharmaceuticuals Research & Development, Inc. Adenosine A3 receptor modulators
US6448253B1 (en) * 1998-09-16 2002-09-10 King Pharmaceuticals Research And Development, Inc. Adenosine A3 receptor modulators
CN100384847C (zh) 2000-05-26 2008-04-30 先灵公司 腺苷A2a受体拮抗剂
JP2005527635A (ja) * 2002-05-30 2005-09-15 キング・ファーマシューティカルズ・リサーチ・アンド・デベロプメント・インコーポレイティッド 三環ピラゾロトリアゾロピリミジン環構造を有する薬学的に活性な化合物及び使用方法
ES2326270T3 (es) * 2003-04-23 2009-10-06 Schering Corporation Antagonistas del receptor de la adenosina a2a 2-alquinil- y 2-alquenil-pirazolo-(4,3-e)-1,2,4-triazolo-(1,5-c)-pirimidina.

Also Published As

Publication number Publication date
JP2005511699A (ja) 2005-04-28
CN1692116A (zh) 2005-11-02
ES2336435T3 (es) 2010-04-13
PE20030665A1 (es) 2003-08-08
ATE453647T1 (de) 2010-01-15
US20030212059A1 (en) 2003-11-13
HK1063780A1 (en) 2005-01-14
AR037680A1 (es) 2004-12-01
JP2008260776A (ja) 2008-10-30
HUP0402018A3 (en) 2008-06-30
EP1448565A1 (de) 2004-08-25
CA2468649C (en) 2009-03-10
KR20050044593A (ko) 2005-05-12
WO2003048165A1 (en) 2003-06-12
CA2468649A1 (en) 2003-06-12
HUP0402018A2 (hu) 2005-02-28
EP1448565B1 (de) 2009-12-30
US6916811B2 (en) 2005-07-12
AU2002346503A1 (en) 2003-06-17
ZA200404161B (en) 2005-11-30
TW200306837A (en) 2003-12-01
JP4284182B2 (ja) 2009-06-24
IL161716A0 (en) 2004-09-27
MXPA04005209A (es) 2004-08-19

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