ATE394402T1 - Kondensierte purinderivate als a1- adenosinrezeptorantagonisten - Google Patents

Kondensierte purinderivate als a1- adenosinrezeptorantagonisten

Info

Publication number
ATE394402T1
ATE394402T1 AT01998550T AT01998550T ATE394402T1 AT E394402 T1 ATE394402 T1 AT E394402T1 AT 01998550 T AT01998550 T AT 01998550T AT 01998550 T AT01998550 T AT 01998550T AT E394402 T1 ATE394402 T1 AT E394402T1
Authority
AT
Austria
Prior art keywords
receptor antagonists
adenosine receptor
purine derivatives
condensed purine
condensed
Prior art date
Application number
AT01998550T
Other languages
English (en)
Inventor
Ko-Chung Lin
Chi Vu
Original Assignee
Biogen Idec Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biogen Idec Inc filed Critical Biogen Idec Inc
Application granted granted Critical
Publication of ATE394402T1 publication Critical patent/ATE394402T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
AT01998550T 2000-12-01 2001-11-30 Kondensierte purinderivate als a1- adenosinrezeptorantagonisten ATE394402T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US25065800P 2000-12-01 2000-12-01

Publications (1)

Publication Number Publication Date
ATE394402T1 true ATE394402T1 (de) 2008-05-15

Family

ID=22948640

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01998550T ATE394402T1 (de) 2000-12-01 2001-11-30 Kondensierte purinderivate als a1- adenosinrezeptorantagonisten

Country Status (33)

Country Link
US (2) US6605601B2 (de)
EP (1) EP1347981B1 (de)
JP (2) JP2004514723A (de)
KR (1) KR20040011439A (de)
CN (1) CN100497340C (de)
AR (1) AR035400A1 (de)
AT (1) ATE394402T1 (de)
AU (2) AU2002219977B2 (de)
BG (1) BG107849A (de)
BR (1) BR0115833A (de)
CA (1) CA2430508C (de)
CZ (1) CZ20031513A3 (de)
DE (1) DE60133931D1 (de)
EA (1) EA009814B1 (de)
EE (1) EE200300260A (de)
ES (1) ES2305139T3 (de)
GE (1) GEP20094697B (de)
HK (1) HK1059927A1 (de)
HU (1) HUP0400530A3 (de)
IL (1) IL156046A0 (de)
IS (1) IS6821A (de)
MX (1) MXPA03004857A (de)
MY (1) MY127120A (de)
NO (1) NO20032483L (de)
NZ (1) NZ526511A (de)
PL (1) PL362642A1 (de)
SK (1) SK6552003A3 (de)
TR (1) TR200300766T2 (de)
TW (1) TWI293301B (de)
UA (1) UA75625C2 (de)
WO (1) WO2002044182A1 (de)
YU (1) YU42903A (de)
ZA (2) ZA200304067B (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2395414A1 (en) * 1999-12-24 2001-07-05 Kyowa Hakko Kogyo Co., Ltd Condensed purine derivative
AU2002219977B2 (en) * 2000-12-01 2008-01-24 Biogen Idec Ma Inc. Condensed purine derivatives as A1 adenosine receptor antagonists
JP2006518390A (ja) * 2003-02-19 2006-08-10 エンダシア，インコーポレイテッド Ａ１アデノシンレセプターアンタゴニスト
US20040229901A1 (en) * 2003-02-24 2004-11-18 Lauren Otsuki Method of treatment of disease using an adenosine A1 receptor antagonist
NZ543109A (en) * 2003-04-25 2008-06-30 Novacardia Inc Method of improved diuresis in individuals with impaired renal function
AU2004234245A1 (en) * 2003-04-25 2004-11-11 Kyowa Hakko Kogyo Co., Ltd. Fused pyrimidine derivative
US7247639B2 (en) * 2003-06-06 2007-07-24 Endacea, Inc. A1 adenosine receptor antagonists
EP1863815A1 (de) * 2005-03-11 2007-12-12 Aderis Pharmaceuticals, Inc. Substituierte 9-alkyladenine und deren verwendung
US7795427B2 (en) * 2006-02-14 2010-09-14 New York University Methods for inhibiting osteoclast differentiation, formation, or function and for increasing bone mass
WO2007117549A2 (en) * 2006-04-06 2007-10-18 Novacardia, Inc. Co-administration of adenosine a1 receptor antagonists and anticonvulsants
ES2525076T3 (es) 2006-05-19 2014-12-17 Abbvie Bahamas Ltd. Derivados de alcanos azabicíclicos sustituidos con bicicloheterociclos condensados activos en el SNC
EP2035009A1 (de) * 2006-06-16 2009-03-18 Novacardia, Inc. Dauerhafte verbesserung der nierenfunktion mit seltener verabreichung eines aa1ra
EP2044074A2 (de) 2006-06-23 2009-04-08 Incyte Corporation Purinonderivate als hm74a-agonisten
WO2007150026A2 (en) 2006-06-23 2007-12-27 Incyte Corporation Purinone derivatives as hm74a agonists
US20090197900A1 (en) * 2007-03-29 2009-08-06 Howard Dittrich Methods of treating heart failure and renal dysfunction in individuals with an adenosine a1 receptor antagonist
US20080242684A1 (en) * 2007-03-29 2008-10-02 Howard Dittrich Methods of administration of adenosine a1 receptor antagonists
WO2011063268A2 (en) * 2009-11-19 2011-05-26 Biogen Idec Ma Inc Novel synthetic methods
US20130109645A1 (en) 2010-03-31 2013-05-02 The united States of America,as represented by Secretary,Dept.,of Health and Human Services Adenosine receptor agonists for the treatment and prevention of vascular or joint capsule calcification disorders
US11407758B2 (en) 2018-01-04 2022-08-09 Impetis Biosciences Ltd. Tricyclic compounds, compositions and medicinal applications thereof

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06102662B2 (ja) * 1989-09-01 1994-12-14 協和醗酵工業株式会社 キサンチン誘導体
EP0423805B1 (de) 1989-10-20 2000-08-23 Kyowa Hakko Kogyo Kabushiki Kaisha Kondensierte Purinderivate
CA2098478C (en) 1991-09-23 1999-09-14 Robert A. Holton Preparation of substituted isoserine esters using metal alkoxides and .beta.-lactams
WO1998015555A1 (fr) * 1996-10-07 1998-04-16 Kyowa Hakko Kogyo Co., Ltd. Derives de purine fondue
EP1014995A4 (de) 1997-06-18 2005-02-16 Aderis Pharmaceuticals Inc Zusammensetzungen und verfahren zur verhütung von restenosis nach wiedergefässbildung
AU4396899A (en) 1998-07-02 2000-01-24 Kyowa Hakko Kogyo Co. Ltd. Remedies for diabetes
CA2395414A1 (en) * 1999-12-24 2001-07-05 Kyowa Hakko Kogyo Co., Ltd Condensed purine derivative
AU2002219977B2 (en) * 2000-12-01 2008-01-24 Biogen Idec Ma Inc. Condensed purine derivatives as A1 adenosine receptor antagonists

Also Published As

Publication number Publication date
PL362642A1 (en) 2004-11-02
UA75625C2 (en) 2006-05-15
SK6552003A3 (en) 2003-12-02
EA200300629A1 (ru) 2003-12-25
BG107849A (bg) 2004-01-30
YU42903A (sh) 2006-05-25
ES2305139T3 (es) 2008-11-01
EP1347981A1 (de) 2003-10-01
EE200300260A (et) 2003-08-15
HUP0400530A3 (en) 2007-05-29
NO20032483D0 (no) 2003-06-02
US6605601B2 (en) 2003-08-12
US20020111333A1 (en) 2002-08-15
MY127120A (en) 2006-11-30
CA2430508A1 (en) 2002-06-06
JP2010053148A (ja) 2010-03-11
IL156046A0 (en) 2003-12-23
ZA200408755B (en) 2005-07-27
GEP20094697B (en) 2009-06-10
MXPA03004857A (es) 2003-08-19
CN1481387A (zh) 2004-03-10
NZ526511A (en) 2005-04-29
JP2004514723A (ja) 2004-05-20
NO20032483L (no) 2003-07-30
BR0115833A (pt) 2003-10-28
EA009814B1 (ru) 2008-04-28
TR200300766T2 (tr) 2004-09-21
HUP0400530A2 (hu) 2004-06-28
IS6821A (is) 2003-05-20
CA2430508C (en) 2010-05-18
CN100497340C (zh) 2009-06-10
AU1997702A (en) 2002-06-11
AU2002219977B2 (en) 2008-01-24
WO2002044182A1 (en) 2002-06-06
HK1059927A1 (en) 2004-07-23
TWI293301B (en) 2008-02-11
DE60133931D1 (de) 2008-06-19
AR035400A1 (es) 2004-05-26
CZ20031513A3 (cs) 2003-09-17
US7022686B2 (en) 2006-04-04
US20030220358A1 (en) 2003-11-27
EP1347981B1 (de) 2008-05-07
KR20040011439A (ko) 2004-02-05
ZA200304067B (en) 2005-05-30

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Legal Events

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