HUP0400530A3 - Condensed purine derivatives as a1 adenosine receptor antagonists - Google Patents

Condensed purine derivatives as a1 adenosine receptor antagonists

Info

Publication number
HUP0400530A3
HUP0400530A3 HU0400530A HUP0400530A HUP0400530A3 HU P0400530 A3 HUP0400530 A3 HU P0400530A3 HU 0400530 A HU0400530 A HU 0400530A HU P0400530 A HUP0400530 A HU P0400530A HU P0400530 A3 HUP0400530 A3 HU P0400530A3
Authority
HU
Hungary
Prior art keywords
receptor antagonists
adenosine receptor
purine derivatives
condensed purine
condensed
Prior art date
Application number
HU0400530A
Other languages
English (en)
Original Assignee
Biogen Idec Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biogen Idec Inc filed Critical Biogen Idec Inc
Publication of HUP0400530A2 publication Critical patent/HUP0400530A2/hu
Publication of HUP0400530A3 publication Critical patent/HUP0400530A3/hu

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Hospice & Palliative Care (AREA)
  • Emergency Medicine (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
HU0400530A 2000-12-01 2001-11-30 Condensed purine derivatives as a1 adenosine receptor antagonists HUP0400530A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25065800P 2000-12-01 2000-12-01
PCT/US2001/044991 WO2002044182A1 (en) 2000-12-01 2001-11-30 Condensed purine derivatives as a1 adenosine receptor antagonists

Publications (2)

Publication Number Publication Date
HUP0400530A2 HUP0400530A2 (hu) 2004-06-28
HUP0400530A3 true HUP0400530A3 (en) 2007-05-29

Family

ID=22948640

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0400530A HUP0400530A3 (en) 2000-12-01 2001-11-30 Condensed purine derivatives as a1 adenosine receptor antagonists

Country Status (33)

Country Link
US (2) US6605601B2 (hu)
EP (1) EP1347981B1 (hu)
JP (2) JP2004514723A (hu)
KR (1) KR20040011439A (hu)
CN (1) CN100497340C (hu)
AR (1) AR035400A1 (hu)
AT (1) ATE394402T1 (hu)
AU (2) AU1997702A (hu)
BG (1) BG107849A (hu)
BR (1) BR0115833A (hu)
CA (1) CA2430508C (hu)
CZ (1) CZ20031513A3 (hu)
DE (1) DE60133931D1 (hu)
EA (1) EA009814B1 (hu)
EE (1) EE200300260A (hu)
ES (1) ES2305139T3 (hu)
GE (1) GEP20094697B (hu)
HK (1) HK1059927A1 (hu)
HU (1) HUP0400530A3 (hu)
IL (1) IL156046A0 (hu)
IS (1) IS6821A (hu)
MX (1) MXPA03004857A (hu)
MY (1) MY127120A (hu)
NO (1) NO20032483L (hu)
NZ (1) NZ526511A (hu)
PL (1) PL362642A1 (hu)
SK (1) SK6552003A3 (hu)
TR (1) TR200300766T2 (hu)
TW (1) TWI293301B (hu)
UA (1) UA75625C2 (hu)
WO (1) WO2002044182A1 (hu)
YU (1) YU42903A (hu)
ZA (2) ZA200304067B (hu)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2238335T3 (es) * 1999-12-24 2005-09-01 Kyowa Hakko Kogyo Co., Ltd. Derivados de purina condensados.
AU1997702A (en) * 2000-12-01 2002-06-11 Biogen Inc Condensed purine derivatives as A<sub>1</sub> adenosine receptor antagonists
US7202252B2 (en) * 2003-02-19 2007-04-10 Endacea, Inc. A1 adenosine receptor antagonists
US20040229901A1 (en) * 2003-02-24 2004-11-18 Lauren Otsuki Method of treatment of disease using an adenosine A1 receptor antagonist
AU2004233852A1 (en) 2003-04-25 2004-11-11 Novacardia, Inc. Method of improved diuresis in individuals with impaired renal function
JPWO2004096812A1 (ja) * 2003-04-25 2006-07-13 協和醗酵工業株式会社 縮合ピリミジン誘導体
WO2005009343A2 (en) * 2003-06-06 2005-02-03 Endacea, Inc. A1 adenosine receptor antogonists
CA2601032A1 (en) * 2005-03-11 2006-09-21 Aderis Pharmaceuticals, Inc. Substituted 9-alkyladenines and the use thereof
US7795427B2 (en) * 2006-02-14 2010-09-14 New York University Methods for inhibiting osteoclast differentiation, formation, or function and for increasing bone mass
AU2007235372A1 (en) * 2006-04-06 2007-10-18 Novacardia, Inc. Co-administration of adenosine A1 receptor antagonists and anticonvulsants
JP5420398B2 (ja) 2006-05-19 2014-02-19 アッヴィ・バハマズ・リミテッド Ｃｎｓ活性縮合ビシクロ複素環置換アザ二環式アルカン誘導体
JP2009540003A (ja) * 2006-06-16 2009-11-19 ノヴァカーディア，インク． Ａａ１ｒａの低頻度投与を含む腎機能の長期間にわたる改善
KR20090025262A (ko) 2006-06-23 2009-03-10 인사이트 코포레이션 Ｈｍ７４ａ 아고니스트로서 푸리논 유도체
CA2656039A1 (en) 2006-06-23 2007-12-27 Incyte Corporation Purinone derivatives as hm74a agonists
US20090197900A1 (en) * 2007-03-29 2009-08-06 Howard Dittrich Methods of treating heart failure and renal dysfunction in individuals with an adenosine a1 receptor antagonist
US20080242684A1 (en) * 2007-03-29 2008-10-02 Howard Dittrich Methods of administration of adenosine a1 receptor antagonists
WO2011063268A2 (en) * 2009-11-19 2011-05-26 Biogen Idec Ma Inc Novel synthetic methods
WO2011123518A1 (en) 2010-03-31 2011-10-06 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Adenosine receptor agonists for the treatment and prevention of vascular or joint capsule calcification disorders
EP3735413B1 (en) 2018-01-04 2022-07-06 Impetis Biosciences Ltd. Tricyclic compounds, compositions and medicinal applications thereof

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06102662B2 (ja) * 1989-09-01 1994-12-14 協和醗酵工業株式会社 キサンチン誘導体
EP0423805B1 (en) * 1989-10-20 2000-08-23 Kyowa Hakko Kogyo Kabushiki Kaisha Condensed purine derivatives
HU226369B1 (en) 1991-09-23 2008-09-29 Univ Florida State Process for preparing substituted isoserine-esters using metal alkoxides and beta-lactams
CA2239881A1 (en) * 1996-10-07 1998-04-16 Nobuo Kosaka Condensed purine derivatives
CA2295195C (en) * 1997-06-18 2009-12-15 Discovery Therapeutics, Inc. Compositions and methods for preventing restenosis following revascularization procedures
AU4396899A (en) * 1998-07-02 2000-01-24 Kyowa Hakko Kogyo Co. Ltd. Remedies for diabetes
ES2238335T3 (es) * 1999-12-24 2005-09-01 Kyowa Hakko Kogyo Co., Ltd. Derivados de purina condensados.
AU1997702A (en) * 2000-12-01 2002-06-11 Biogen Inc Condensed purine derivatives as A<sub>1</sub> adenosine receptor antagonists

Also Published As

Publication number Publication date
JP2004514723A (ja) 2004-05-20
NO20032483D0 (no) 2003-06-02
IL156046A0 (en) 2003-12-23
ZA200408755B (en) 2005-07-27
JP2010053148A (ja) 2010-03-11
BR0115833A (pt) 2003-10-28
CN1481387A (zh) 2004-03-10
UA75625C2 (en) 2006-05-15
GEP20094697B (en) 2009-06-10
ATE394402T1 (de) 2008-05-15
TR200300766T2 (tr) 2004-09-21
IS6821A (is) 2003-05-20
EE200300260A (et) 2003-08-15
US7022686B2 (en) 2006-04-04
DE60133931D1 (de) 2008-06-19
CN100497340C (zh) 2009-06-10
CA2430508A1 (en) 2002-06-06
US6605601B2 (en) 2003-08-12
MXPA03004857A (es) 2003-08-19
ES2305139T3 (es) 2008-11-01
NO20032483L (no) 2003-07-30
US20020111333A1 (en) 2002-08-15
MY127120A (en) 2006-11-30
NZ526511A (en) 2005-04-29
AR035400A1 (es) 2004-05-26
BG107849A (bg) 2004-01-30
KR20040011439A (ko) 2004-02-05
WO2002044182A1 (en) 2002-06-06
EA200300629A1 (ru) 2003-12-25
EA009814B1 (ru) 2008-04-28
CZ20031513A3 (cs) 2003-09-17
AU2002219977B2 (en) 2008-01-24
US20030220358A1 (en) 2003-11-27
CA2430508C (en) 2010-05-18
EP1347981A1 (en) 2003-10-01
SK6552003A3 (en) 2003-12-02
HUP0400530A2 (hu) 2004-06-28
YU42903A (sh) 2006-05-25
AU1997702A (en) 2002-06-11
PL362642A1 (en) 2004-11-02
ZA200304067B (en) 2005-05-30
HK1059927A1 (en) 2004-07-23
TWI293301B (en) 2008-02-11
EP1347981B1 (en) 2008-05-07

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Legal Events

Date Code Title Description
FD9A Lapse of provisional protection due to non-payment of fees