ZA200304067B - Condensed purine derivatives as A1 adenosine receptor antagonists. - Google Patents
Condensed purine derivatives as A1 adenosine receptor antagonists. Download PDFInfo
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- ZA200304067B ZA200304067B ZA200304067A ZA200304067A ZA200304067B ZA 200304067 B ZA200304067 B ZA 200304067B ZA 200304067 A ZA200304067 A ZA 200304067A ZA 200304067 A ZA200304067 A ZA 200304067A ZA 200304067 B ZA200304067 B ZA 200304067B
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- South Africa
- Prior art keywords
- group
- alkyl
- substituted
- amino
- compound
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- A61K31/00—Medicinal preparations containing organic active ingredients
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
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- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
- A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
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- A—HUMAN NECESSITIES
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- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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- A—HUMAN NECESSITIES
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
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- Oncology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (1)
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| US25065800P | 2000-12-01 | 2000-12-01 |
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| ZA200408755A ZA200408755B (en) | 2000-12-01 | 2004-10-28 | Condensed purine derivatives as A1 adenosine receptor antagonists. |
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| ZA200408755A ZA200408755B (en) | 2000-12-01 | 2004-10-28 | Condensed purine derivatives as A1 adenosine receptor antagonists. |
Country Status (33)
| Country | Link |
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| US (2) | US6605601B2 (de) |
| EP (1) | EP1347981B1 (de) |
| JP (2) | JP2004514723A (de) |
| KR (1) | KR20040011439A (de) |
| CN (1) | CN100497340C (de) |
| AR (1) | AR035400A1 (de) |
| AT (1) | ATE394402T1 (de) |
| AU (2) | AU1997702A (de) |
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| BR (1) | BR0115833A (de) |
| CA (1) | CA2430508C (de) |
| CZ (1) | CZ20031513A3 (de) |
| DE (1) | DE60133931D1 (de) |
| EA (1) | EA009814B1 (de) |
| EE (1) | EE200300260A (de) |
| ES (1) | ES2305139T3 (de) |
| GE (1) | GEP20094697B (de) |
| HK (1) | HK1059927A1 (de) |
| HU (1) | HUP0400530A3 (de) |
| IL (1) | IL156046A0 (de) |
| IS (1) | IS6821A (de) |
| MX (1) | MXPA03004857A (de) |
| MY (1) | MY127120A (de) |
| NO (1) | NO20032483L (de) |
| NZ (1) | NZ526511A (de) |
| PL (1) | PL362642A1 (de) |
| SK (1) | SK6552003A3 (de) |
| TR (1) | TR200300766T2 (de) |
| TW (1) | TWI293301B (de) |
| UA (1) | UA75625C2 (de) |
| WO (1) | WO2002044182A1 (de) |
| YU (1) | YU42903A (de) |
| ZA (2) | ZA200304067B (de) |
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|---|---|---|---|---|
| DE60018216T2 (de) * | 1999-12-24 | 2006-02-16 | Kyowa Hakko Kogyo Co., Ltd. | Kondensierte purinderivate |
| EA009814B1 (ru) * | 2000-12-01 | 2008-04-28 | Байоджен Айдек Ма Инк. | Конденсированные производные пурина как антагонисты рецепторов аденозина а |
| EP1601649A4 (de) * | 2003-02-19 | 2009-03-04 | Endacea Inc | A1-adenosinrezeptorantagonisten |
| US20040229901A1 (en) * | 2003-02-24 | 2004-11-18 | Lauren Otsuki | Method of treatment of disease using an adenosine A1 receptor antagonist |
| JPWO2004096812A1 (ja) * | 2003-04-25 | 2006-07-13 | 協和醗酵工業株式会社 | 縮合ピリミジン誘導体 |
| RU2367442C2 (ru) * | 2003-04-25 | 2009-09-20 | Новокардия, Инк. | Способ нормализации мочеиспускания при нарушении функции почек |
| CA2528385C (en) * | 2003-06-06 | 2011-03-15 | Endacea, Inc. | A1 adenosine receptor antogonists |
| US20080161327A1 (en) * | 2005-03-11 | 2008-07-03 | Aderis Pharmaceuticals, Inc. | Substituted 9-Alkyladenines and the Use Thereof |
| US7795427B2 (en) * | 2006-02-14 | 2010-09-14 | New York University | Methods for inhibiting osteoclast differentiation, formation, or function and for increasing bone mass |
| CN101420958A (zh) * | 2006-04-06 | 2009-04-29 | 挪瓦卡尔迪阿公司 | 共投与腺苷a1受体拮抗剂和抗惊厥药 |
| EP2018380B1 (de) | 2006-05-19 | 2011-10-19 | Abbott Laboratories | CNS-aktivierte kondensierte bi- und heterocyclisch substituierte azabicyklische Alkanderivate |
| JP2009540003A (ja) * | 2006-06-16 | 2009-11-19 | ノヴァカーディア，インク． | Ａａ１ｒａの低頻度投与を含む腎機能の長期間にわたる改善 |
| BRPI0713619A2 (pt) | 2006-06-23 | 2013-01-15 | Incyte Corp | composto ou prà-droga ou sal farmaceuticamente aceitÁvel do mesmo, composiÇço, e, uso do composto. |
| WO2007150026A2 (en) | 2006-06-23 | 2007-12-27 | Incyte Corporation | Purinone derivatives as hm74a agonists |
| WO2008121882A1 (en) * | 2007-03-29 | 2008-10-09 | Novacardia, Inc. | Improved methods of administration of adenosine a1 receptor antagonists |
| US20090197900A1 (en) * | 2007-03-29 | 2009-08-06 | Howard Dittrich | Methods of treating heart failure and renal dysfunction in individuals with an adenosine a1 receptor antagonist |
| WO2011063268A2 (en) * | 2009-11-19 | 2011-05-26 | Biogen Idec Ma Inc | Novel synthetic methods |
| US20130109645A1 (en) | 2010-03-31 | 2013-05-02 | The united States of America,as represented by Secretary,Dept.,of Health and Human Services | Adenosine receptor agonists for the treatment and prevention of vascular or joint capsule calcification disorders |
| CN111770926B (zh) * | 2018-01-04 | 2023-07-21 | 因佩蒂斯生物科学有限公司 | 三环化合物、组合物及其医药应用 |
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|---|---|---|---|---|
| JPH06102662B2 (ja) | 1989-09-01 | 1994-12-14 | 協和醗酵工業株式会社 | キサンチン誘導体 |
| DE69033614T2 (de) * | 1989-10-20 | 2001-04-19 | Kyowa Hakko Kogyo Kk | Kondensierte Purinderivate |
| SG52496A1 (en) | 1991-09-23 | 1998-09-28 | Univ Florida State | Preparation of substituted isoserine esters using metal alkoxides and beta-lactams |
| AU4471297A (en) * | 1996-10-07 | 1998-05-05 | Kyowa Hakko Kogyo Co. Ltd. | Fused purine derivatives |
| AU740770B2 (en) * | 1997-06-18 | 2001-11-15 | Aderis Pharmaceuticals, Inc. | Compositions and methods for preventing restenosis following revascularization procedures |
| ES2284256T3 (es) * | 1998-07-02 | 2007-11-01 | Kyowa Hakko Kogyo Co., Ltd. | Medicamentos para la diabetes. |
| DE60018216T2 (de) * | 1999-12-24 | 2006-02-16 | Kyowa Hakko Kogyo Co., Ltd. | Kondensierte purinderivate |
| EA009814B1 (ru) * | 2000-12-01 | 2008-04-28 | Байоджен Айдек Ма Инк. | Конденсированные производные пурина как антагонисты рецепторов аденозина а |
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- 2001-11-30 TR TR2003/00766T patent/TR200300766T2/xx unknown
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- 2001-11-30 KR KR10-2003-7007322A patent/KR20040011439A/ko active IP Right Grant
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- 2001-11-30 DE DE60133931T patent/DE60133931D1/de not_active Expired - Lifetime
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2003
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2004
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2009
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