ES2204555T3 - Procedimiento mejorado para la preparacion de sales no higroscopicas de l(-)-carnitina. - Google Patents

Procedimiento mejorado para la preparacion de sales no higroscopicas de l(-)-carnitina.

Info

Publication number
ES2204555T3
ES2204555T3 ES00920506T ES00920506T ES2204555T3 ES 2204555 T3 ES2204555 T3 ES 2204555T3 ES 00920506 T ES00920506 T ES 00920506T ES 00920506 T ES00920506 T ES 00920506T ES 2204555 T3 ES2204555 T3 ES 2204555T3
Authority
ES
Spain
Prior art keywords
carnitine
acid
weight
granulate
powder
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES00920506T
Other languages
English (en)
Spanish (es)
Inventor
Claudio Cavazza
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sigma Tau Industrie Farmaceutiche Riunite SpA
Original Assignee
Sigma Tau Industrie Farmaceutiche Riunite SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma Tau Industrie Farmaceutiche Riunite SpA filed Critical Sigma Tau Industrie Farmaceutiche Riunite SpA
Application granted granted Critical
Publication of ES2204555T3 publication Critical patent/ES2204555T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/22Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C07C227/18Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
ES00920506T 1999-03-19 2000-03-16 Procedimiento mejorado para la preparacion de sales no higroscopicas de l(-)-carnitina. Expired - Lifetime ES2204555T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT1999MI000551A IT1312018B1 (it) 1999-03-19 1999-03-19 Procedimento migliorato per la produzione di sali non igroscopicidella l(-)-carnitina.
ITMI990551 1999-03-19

Publications (1)

Publication Number Publication Date
ES2204555T3 true ES2204555T3 (es) 2004-05-01

Family

ID=11382333

Family Applications (1)

Application Number Title Priority Date Filing Date
ES00920506T Expired - Lifetime ES2204555T3 (es) 1999-03-19 2000-03-16 Procedimiento mejorado para la preparacion de sales no higroscopicas de l(-)-carnitina.

Country Status (22)

Country Link
US (1) US6372940B1 (cs)
EP (1) EP1163207B1 (cs)
JP (1) JP2002540094A (cs)
KR (1) KR100664560B1 (cs)
CN (1) CN1147462C (cs)
AR (1) AR023101A1 (cs)
AT (1) ATE247627T1 (cs)
AU (1) AU4105800A (cs)
CA (1) CA2359106A1 (cs)
CZ (1) CZ299312B6 (cs)
DE (1) DE60004649T2 (cs)
DK (1) DK1163207T3 (cs)
ES (1) ES2204555T3 (cs)
HK (1) HK1042468A1 (cs)
HU (1) HUP0200402A3 (cs)
IT (1) IT1312018B1 (cs)
NZ (1) NZ512640A (cs)
PL (1) PL199614B1 (cs)
PT (1) PT1163207E (cs)
SI (1) SI1163207T1 (cs)
SK (1) SK13312001A3 (cs)
WO (1) WO2000056701A1 (cs)

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ITRM20010030A1 (it) * 2001-01-23 2002-07-23 Aldo Fassi Sali di carnitine utili come integratori dietetici/nutrizionali o come farmaci, composizioni che li contengono e procedimenti per la loro pr
HU230382B1 (hu) * 2001-02-24 2016-03-29 Boehringer Ingelheim Pharma Gmbh & Co. Kg Xantinszármazékok, előállításuk és alkalmazásuk gyógyszerként
US7407955B2 (en) 2002-08-21 2008-08-05 Boehringer Ingelheim Pharma Gmbh & Co., Kg 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions
US7501426B2 (en) 2004-02-18 2009-03-10 Boehringer Ingelheim International Gmbh 8-[3-amino-piperidin-1-yl]-xanthines, their preparation and their use as pharmaceutical compositions
DE102004054054A1 (de) 2004-11-05 2006-05-11 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verfahren zur Herstellung chiraler 8-(3-Amino-piperidin-1-yl)-xanthine
DE102005035891A1 (de) * 2005-07-30 2007-02-08 Boehringer Ingelheim Pharma Gmbh & Co. Kg 8-(3-Amino-piperidin-1-yl)-xanthine, deren Herstellung und deren Verwendung als Arzneimittel
PE20110235A1 (es) * 2006-05-04 2011-04-14 Boehringer Ingelheim Int Combinaciones farmaceuticas que comprenden linagliptina y metmorfina
EP1852108A1 (en) 2006-05-04 2007-11-07 Boehringer Ingelheim Pharma GmbH & Co.KG DPP IV inhibitor formulations
EP2016079A1 (de) 2006-05-04 2009-01-21 Boehringer Ingelheim International GmbH Polymorphe
CN101209975B (zh) * 2006-12-29 2010-12-01 沈阳科硕营养科技有限公司 左旋肉碱富马酸钙及其制备方法与用途
WO2009024542A2 (en) * 2007-08-17 2009-02-26 Boehringer Ingelheim International Gmbh Purin derivatives for use in the treatment of fab-related diseases
PE20091730A1 (es) 2008-04-03 2009-12-10 Boehringer Ingelheim Int Formulaciones que comprenden un inhibidor de dpp4
PE20100156A1 (es) * 2008-06-03 2010-02-23 Boehringer Ingelheim Int Tratamiento de nafld
UY32030A (es) 2008-08-06 2010-03-26 Boehringer Ingelheim Int "tratamiento para diabetes en pacientes inapropiados para terapia con metformina"
KR20200118243A (ko) 2008-08-06 2020-10-14 베링거 인겔하임 인터내셔날 게엠베하 메트포르민 요법이 부적합한 환자에서의 당뇨병 치료
EA031225B1 (ru) * 2008-08-15 2018-12-28 Бёрингер Ингельхайм Интернациональ Гмбх Ингибиторы дпп-4 для заживления ран
WO2010029089A2 (en) 2008-09-10 2010-03-18 Boehringer Ingelheim International Gmbh Combination therapy for the treatment of diabetes and related conditions
US20200155558A1 (en) 2018-11-20 2020-05-21 Boehringer Ingelheim International Gmbh Treatment for diabetes in patients with insufficient glycemic control despite therapy with an oral antidiabetic drug
EA022310B1 (ru) 2008-12-23 2015-12-30 Бёрингер Ингельхайм Интернациональ Гмбх Солевые формы органического соединения
AR074990A1 (es) 2009-01-07 2011-03-02 Boehringer Ingelheim Int Tratamiento de diabetes en pacientes con un control glucemico inadecuado a pesar de la terapia con metformina
NZ599298A (en) 2009-11-27 2014-11-28 Boehringer Ingelheim Int Treatment of genotyped diabetic patients with dpp-iv inhibitors such as linagliptin
MX366325B (es) 2010-05-05 2019-07-05 Boehringer Ingelheim Int Terapia de combinacion.
KR20190050871A (ko) 2010-06-24 2019-05-13 베링거 인겔하임 인터내셔날 게엠베하 당뇨병 요법
EP2425834A1 (en) * 2010-09-06 2012-03-07 Lonza Ltd. Process for the production of l-carnitine tartrate
JP2012092036A (ja) * 2010-10-26 2012-05-17 Mitsubishi Rayon Co Ltd カルニチンの塩の製造方法
AR083878A1 (es) 2010-11-15 2013-03-27 Boehringer Ingelheim Int Terapia antidiabetica vasoprotectora y cardioprotectora, linagliptina, metodo de tratamiento
EP3517539B1 (en) 2011-07-15 2022-12-14 Boehringer Ingelheim International GmbH Substituted dimeric quinazoline derivative, its preparation and its use in pharmaceutical compositions for the treatment of type i and ii diabetes
US9555001B2 (en) 2012-03-07 2017-01-31 Boehringer Ingelheim International Gmbh Pharmaceutical composition and uses thereof
ES2929025T3 (es) 2012-05-14 2022-11-24 Boehringer Ingelheim Int Linagliptina, un derivado de xantina como inhibidor de dpp-4, para su uso en el tratamiento del SRIS y/o de la septicemia
EP3685839A1 (en) 2012-05-14 2020-07-29 Boehringer Ingelheim International GmbH Linagliptin for use in the treatment of albuminuria and kidney related diseases
WO2013174767A1 (en) 2012-05-24 2013-11-28 Boehringer Ingelheim International Gmbh A xanthine derivative as dpp -4 inhibitor for use in modifying food intake and regulating food preference
US20140316156A1 (en) * 2013-04-18 2014-10-23 Deborah Warner Method of producing therapeutic agent
ES2950384T3 (es) 2014-02-28 2023-10-09 Boehringer Ingelheim Int Uso médico de un inhibidor de DPP-4
CA3022202A1 (en) 2016-06-10 2017-12-14 Boehringer Ingelheim International Gmbh Combinations of linagliptin and metformin
CN106748845B (zh) * 2016-12-23 2018-11-20 东北制药集团股份有限公司 一种左旋肉碱盐微粉的制备方法
KR20190017310A (ko) 2017-08-10 2019-02-20 주식회사 셀트리온화학연구소 약제학적 성질이 개선된 l-카르니틴 화합물의 염, 이의 제조방법, 이를 함유하는 약학 조성물
JP6964876B2 (ja) * 2017-11-27 2021-11-10 株式会社古川リサーチオフィス オロット酸−カルニチン混合体粉体又はフマル酸−カルニチン混合体粉体の製造方法
CN108383741A (zh) * 2018-03-16 2018-08-10 开原亨泰化工有限公司 一种制备左旋肉碱成盐的新方法
CN109096129B (zh) * 2018-09-30 2021-04-27 东北制药集团股份有限公司 一种左旋肉碱酒石酸盐的制备方法
CN109535022B (zh) * 2018-11-12 2022-03-01 天津大学 一种提高左旋肉碱富马酸盐流动性的制备方法
US20240217920A1 (en) * 2022-12-28 2024-07-04 Hubei Xujie Pharmaceutical Co., Ltd. Process for producing l-carnitine
US20240228429A1 (en) * 2023-01-04 2024-07-11 Hubei Xujie Pharmaceutical Co., Ltd Process for producing l-carnitine
CN118638020B (zh) * 2024-08-08 2024-11-19 杭州海尔希畜牧科技有限公司 L-天门冬氨酸l(-)肉碱(1:1)的制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1172394B (it) * 1983-12-28 1987-06-18 Sigma Tau Ind Farmaceuti Sali della l-carnitina e di alcuni alcanoil derivati della l-carnitina e procedimento per la loro preparazione
DE3463261D1 (en) * 1983-12-28 1987-05-27 Sigma Tau Ind Farmaceuti Salts of l-carnitine and alkanoyl l-carnitines and process for preparing same
US5073376A (en) 1989-12-22 1991-12-17 Lonza Ltd. Preparations containing l-carnitine
IT1289974B1 (it) 1997-02-25 1998-10-19 Aldo Fassi Procedimento per la produzione di sali stabili e non igroscopici di l(-)carnitina e di alcanoli l(-)-carnitine
CN1177807C (zh) * 1996-05-31 2004-12-01 希格马托制药工业公司 稳定的、非吸湿性的l(-)肉碱和链烷酰基l(-)肉碱的盐和其制备方法以及含有此盐的固体口服组合物

Also Published As

Publication number Publication date
CN1147462C (zh) 2004-04-28
CZ299312B6 (cs) 2008-06-18
PT1163207E (pt) 2003-12-31
DE60004649D1 (de) 2003-09-25
HK1042468A1 (zh) 2002-08-16
CN1339023A (zh) 2002-03-06
AU4105800A (en) 2000-10-09
KR20010102288A (ko) 2001-11-15
HUP0200402A2 (hu) 2002-05-29
KR100664560B1 (ko) 2007-01-03
WO2000056701A1 (en) 2000-09-28
IT1312018B1 (it) 2002-04-04
ATE247627T1 (de) 2003-09-15
US6372940B1 (en) 2002-04-16
PL199614B1 (pl) 2008-10-31
CA2359106A1 (en) 2000-09-28
JP2002540094A (ja) 2002-11-26
CZ20013376A3 (cs) 2002-02-13
NZ512640A (en) 2003-03-28
PL349894A1 (en) 2002-09-23
EP1163207A1 (en) 2001-12-19
HUP0200402A3 (en) 2002-11-28
EP1163207B1 (en) 2003-08-20
ITMI990551A1 (it) 2000-09-19
AR023101A1 (es) 2002-09-04
SI1163207T1 (en) 2003-12-31
SK13312001A3 (sk) 2002-05-09
DE60004649T2 (de) 2004-03-18
DK1163207T3 (da) 2003-12-01

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