AR023101A1 - Un proceso mejorado para la preparacion de sales no higroscopicas de l(-)-carnitina - Google Patents

Un proceso mejorado para la preparacion de sales no higroscopicas de l(-)-carnitina

Info

Publication number
AR023101A1
AR023101A1 ARP000101222A ARP000101222A AR023101A1 AR 023101 A1 AR023101 A1 AR 023101A1 AR P000101222 A ARP000101222 A AR P000101222A AR P000101222 A ARP000101222 A AR P000101222A AR 023101 A1 AR023101 A1 AR 023101A1
Authority
AR
Argentina
Prior art keywords
carnitine
preparation
improved process
hygroscopic salts
hygroscopic
Prior art date
Application number
ARP000101222A
Other languages
English (en)
Original Assignee
Sigma Tau Ind Farmaceuti
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma Tau Ind Farmaceuti filed Critical Sigma Tau Ind Farmaceuti
Publication of AR023101A1 publication Critical patent/AR023101A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/22—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters

Abstract

Un proceso mejorado para la preparacion de sales no higroscopicas de L(-)-carnitina, en el cual el paso de caracterizacion comprende el calentamiento deuna mezcla que comprende una sal interna de L(-)-carnitina y de un ácido salificante.
ARP000101222A 1999-03-19 2000-03-17 Un proceso mejorado para la preparacion de sales no higroscopicas de l(-)-carnitina AR023101A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT1999MI000551A IT1312018B1 (it) 1999-03-19 1999-03-19 Procedimento migliorato per la produzione di sali non igroscopicidella l(-)-carnitina.

Publications (1)

Publication Number Publication Date
AR023101A1 true AR023101A1 (es) 2002-09-04

Family

ID=11382333

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP000101222A AR023101A1 (es) 1999-03-19 2000-03-17 Un proceso mejorado para la preparacion de sales no higroscopicas de l(-)-carnitina

Country Status (22)

Country Link
US (1) US6372940B1 (es)
EP (1) EP1163207B1 (es)
JP (1) JP2002540094A (es)
KR (1) KR100664560B1 (es)
CN (1) CN1147462C (es)
AR (1) AR023101A1 (es)
AT (1) ATE247627T1 (es)
AU (1) AU4105800A (es)
CA (1) CA2359106A1 (es)
CZ (1) CZ299312B6 (es)
DE (1) DE60004649T2 (es)
DK (1) DK1163207T3 (es)
ES (1) ES2204555T3 (es)
HK (1) HK1042468A1 (es)
HU (1) HUP0200402A3 (es)
IT (1) IT1312018B1 (es)
NZ (1) NZ512640A (es)
PL (1) PL199614B1 (es)
PT (1) PT1163207E (es)
SI (1) SI1163207T1 (es)
SK (1) SK13312001A3 (es)
WO (1) WO2000056701A1 (es)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2631569B1 (fr) * 1988-05-20 1990-07-27 Renault Automation Detecteur de proximite magnetique destine notamment a la decoupe laser
ITRM20010030A1 (it) * 2001-01-23 2002-07-23 Aldo Fassi Sali di carnitine utili come integratori dietetici/nutrizionali o come farmaci, composizioni che li contengono e procedimenti per la loro pr
KR100883277B1 (ko) * 2001-02-24 2009-02-12 베링거 잉겔하임 파르마 게엠베하 운트 코 카게 크산틴 유도체 및 이의 제조방법
US7407955B2 (en) 2002-08-21 2008-08-05 Boehringer Ingelheim Pharma Gmbh & Co., Kg 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions
US7501426B2 (en) 2004-02-18 2009-03-10 Boehringer Ingelheim International Gmbh 8-[3-amino-piperidin-1-yl]-xanthines, their preparation and their use as pharmaceutical compositions
DE102004054054A1 (de) 2004-11-05 2006-05-11 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verfahren zur Herstellung chiraler 8-(3-Amino-piperidin-1-yl)-xanthine
DE102005035891A1 (de) * 2005-07-30 2007-02-08 Boehringer Ingelheim Pharma Gmbh & Co. Kg 8-(3-Amino-piperidin-1-yl)-xanthine, deren Herstellung und deren Verwendung als Arzneimittel
CN101437823B (zh) 2006-05-04 2014-12-10 勃林格殷格翰国际有限公司 多晶型
PE20110235A1 (es) * 2006-05-04 2011-04-14 Boehringer Ingelheim Int Combinaciones farmaceuticas que comprenden linagliptina y metmorfina
EP1852108A1 (en) 2006-05-04 2007-11-07 Boehringer Ingelheim Pharma GmbH & Co.KG DPP IV inhibitor formulations
CN101209975B (zh) * 2006-12-29 2010-12-01 沈阳科硕营养科技有限公司 左旋肉碱富马酸钙及其制备方法与用途
CN101784278A (zh) * 2007-08-17 2010-07-21 贝林格尔.英格海姆国际有限公司 用于治疗fab-相关的疾病的嘌呤衍生物
PE20091730A1 (es) 2008-04-03 2009-12-10 Boehringer Ingelheim Int Formulaciones que comprenden un inhibidor de dpp4
PE20100156A1 (es) * 2008-06-03 2010-02-23 Boehringer Ingelheim Int Tratamiento de nafld
UY32030A (es) 2008-08-06 2010-03-26 Boehringer Ingelheim Int "tratamiento para diabetes en pacientes inapropiados para terapia con metformina"
BRPI0916997A2 (pt) 2008-08-06 2020-12-15 Boehringer Ingelheim International Gmbh Inibidor de dpp-4 e seu uso
JP5906086B2 (ja) * 2008-08-15 2016-04-20 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｆａｂ関連疾患の治療に用いるためのプリン誘導体
KR20110067096A (ko) 2008-09-10 2011-06-21 베링거 인겔하임 인터내셔날 게엠베하 당뇨병 및 관련 상태를 치료하기 위한 병용 요법
US20200155558A1 (en) 2018-11-20 2020-05-21 Boehringer Ingelheim International Gmbh Treatment for diabetes in patients with insufficient glycemic control despite therapy with an oral antidiabetic drug
KR20110103968A (ko) 2008-12-23 2011-09-21 베링거 인겔하임 인터내셔날 게엠베하 유기 화합물의 염 형태
AR074990A1 (es) 2009-01-07 2011-03-02 Boehringer Ingelheim Int Tratamiento de diabetes en pacientes con un control glucemico inadecuado a pesar de la terapia con metformina
EA034869B1 (ru) 2009-11-27 2020-03-31 Бёрингер Ингельхайм Интернациональ Гмбх Лечение генотипированных пациентов с диабетом ингибиторами дпп-4, такими как линаглиптин
BR112012028136A2 (pt) 2010-05-05 2016-08-09 Boehringer Ingelheim Int terapia de combinaçao
KR20130093012A (ko) 2010-06-24 2013-08-21 베링거 인겔하임 인터내셔날 게엠베하 당뇨병 요법
EP2425834A1 (en) * 2010-09-06 2012-03-07 Lonza Ltd. Process for the production of l-carnitine tartrate
JP2012092036A (ja) * 2010-10-26 2012-05-17 Mitsubishi Rayon Co Ltd カルニチンの塩の製造方法
US9034883B2 (en) 2010-11-15 2015-05-19 Boehringer Ingelheim International Gmbh Vasoprotective and cardioprotective antidiabetic therapy
EP2731947B1 (en) 2011-07-15 2019-01-16 Boehringer Ingelheim International GmbH Substituted dimeric quinazoline derivative, its preparation and its use in pharmaceutical compositions for the treatment of type i and ii diabetes
US9555001B2 (en) 2012-03-07 2017-01-31 Boehringer Ingelheim International Gmbh Pharmaceutical composition and uses thereof
JP6224084B2 (ja) 2012-05-14 2017-11-01 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 糸球体上皮細胞関連障害及び／又はネフローゼ症候群の治療に用いるｄｐｐ−４阻害薬としてのキサンチン誘導体
WO2013174767A1 (en) 2012-05-24 2013-11-28 Boehringer Ingelheim International Gmbh A xanthine derivative as dpp -4 inhibitor for use in modifying food intake and regulating food preference
US20140316156A1 (en) * 2013-04-18 2014-10-23 Deborah Warner Method of producing therapeutic agent
ES2950384T3 (es) 2014-02-28 2023-10-09 Boehringer Ingelheim Int Uso médico de un inhibidor de DPP-4
US10155000B2 (en) 2016-06-10 2018-12-18 Boehringer Ingelheim International Gmbh Medical use of pharmaceutical combination or composition
CN106748845B (zh) * 2016-12-23 2018-11-20 东北制药集团股份有限公司 一种左旋肉碱盐微粉的制备方法
KR20190017310A (ko) 2017-08-10 2019-02-20 주식회사 셀트리온화학연구소 약제학적 성질이 개선된 l-카르니틴 화합물의 염, 이의 제조방법, 이를 함유하는 약학 조성물
JP6964876B2 (ja) * 2017-11-27 2021-11-10 株式会社古川リサーチオフィス オロット酸−カルニチン混合体粉体又はフマル酸−カルニチン混合体粉体の製造方法
CN108383741A (zh) * 2018-03-16 2018-08-10 开原亨泰化工有限公司 一种制备左旋肉碱成盐的新方法
CN109096129B (zh) * 2018-09-30 2021-04-27 东北制药集团股份有限公司 一种左旋肉碱酒石酸盐的制备方法
CN109535022B (zh) * 2018-11-12 2022-03-01 天津大学 一种提高左旋肉碱富马酸盐流动性的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0150688B1 (en) * 1983-12-28 1987-04-22 Sigma-Tau Industrie Farmaceutiche Riunite S.p.A. Salts of l-carnitine and alkanoyl l-carnitines and process for preparing same
US5073376A (en) * 1989-12-22 1991-12-17 Lonza Ltd. Preparations containing l-carnitine
IT1289974B1 (it) * 1997-02-25 1998-10-19 Aldo Fassi Procedimento per la produzione di sali stabili e non igroscopici di l(-)carnitina e di alcanoli l(-)-carnitine
IL127266A (en) * 1996-05-31 2002-09-12 Sigma Tau Ind Farmaceuti Stable, non-hygroscopic mucate salts of l(-) carnitine and alkanoyl l(-) carnitines, a process for their preparation and solid, orally administrable compositions containing such salts

Also Published As

Publication number Publication date
CN1147462C (zh) 2004-04-28
AU4105800A (en) 2000-10-09
EP1163207B1 (en) 2003-08-20
US6372940B1 (en) 2002-04-16
PL199614B1 (pl) 2008-10-31
CN1339023A (zh) 2002-03-06
HUP0200402A3 (en) 2002-11-28
ATE247627T1 (de) 2003-09-15
CZ299312B6 (cs) 2008-06-18
PL349894A1 (en) 2002-09-23
WO2000056701A1 (en) 2000-09-28
SK13312001A3 (sk) 2002-05-09
KR20010102288A (ko) 2001-11-15
CZ20013376A3 (cs) 2002-02-13
IT1312018B1 (it) 2002-04-04
SI1163207T1 (en) 2003-12-31
JP2002540094A (ja) 2002-11-26
ITMI990551A1 (it) 2000-09-19
CA2359106A1 (en) 2000-09-28
EP1163207A1 (en) 2001-12-19
HUP0200402A2 (hu) 2002-05-29
PT1163207E (pt) 2003-12-31
DK1163207T3 (da) 2003-12-01
DE60004649T2 (de) 2004-03-18
DE60004649D1 (de) 2003-09-25
KR100664560B1 (ko) 2007-01-03
NZ512640A (en) 2003-03-28
HK1042468A1 (zh) 2002-08-16
ES2204555T3 (es) 2004-05-01

Similar Documents

Publication Publication Date Title
AR023101A1 (es) Un proceso mejorado para la preparacion de sales no higroscopicas de l(-)-carnitina
CY1119742T1 (el) Βιολογικα συστηματα μεταφορας πολλαπλου-συστατικου
CO5280050A1 (es) Desnaturalizantes para las sales aminas simpaticomimeticas
EP0931788A3 (en) Metalloprotease inhibitors
ATE469164T1 (de) Modifizierte l-nukleinsäure
UY25242A1 (es) Inhibidores de benzotiazol de la proteína tirosina cinasa
ES2184408T3 (es) Sistema transdermico que contiene un antioxidante.
ECSP034437A (es) Sales estables de acido o-acetilsalicilico con aminoacidos basicos
SG149879A1 (en) OPTICALLY ACTIVE QUATERNARY AMMONIUM SALT HAVING AXIAL ASYMMETRY AND PROCESS FOR PRODUCING α - AMINO ACID AND DERIVATIVE THEREOF WITH THE SAME
MXPA02010068A (es) Derivados halogenados de acido-2-amino-5,6-heptenoico utiles como inhibidores de la oxido nitrico sintasa.
BRPI0417674A (pt) método para tratar a inflamação aguda em animais, com inibidores de quinase map p38
AR031180A1 (es) Alimento para animales compuesto por subproducto liquido de procesos agricolas y porcion fibrosa de la molienda
PT1267915E (pt) Metodos para tratar doencas com proteina c activada
BRPI0411691A (pt) l-lisina de aztreonam e seus métodos de preparação
WO2002024001A3 (de) Tierfuttersupplement enthaltend d-pantothensäure und/oder deren salze, verbessertes verfahren zu dessen herstellung sowie dessen verwendung
HN1999000043A (es) Procedimiento para alquilar sulfonamidas impedidas estericamente.
IL157402A0 (en) Method for producing d-pantothenic acid and/or salts therefor as an additive for animal feed
WO2002036166A8 (en) Compositions for stimulating cd45 and thereby suppressing microglial activation associated with alzheimer's disease
PT1007498E (pt) Processo para o fabrico de 2-halogenoindano-1-onas
PT973724E (pt) Processo novo para a preparacao de (+/-)3- (3,4-diclorofenil)-2-dimetilamino-2-metilpropan-1-ol ou cericlamina (dci)
TR200200455T2 (tr) İzotretinoin hazırlama işlemi
BR0008953B1 (pt) método para detectar ácido chiquìmico em uma solução aquosa.
FI982630A (fi) Menetelmä 2,6-dimetyylinaftaleenin valmistamiseksi
AR028442A1 (es) Metodo para preparar sales de sulfonil-benzoilguanidina
EA200601402A1 (ru) L-(+)-тартрат l-(-)- мопролола