HUP0200402A3 - An improved process for the preparation of non-hygroscopic salts of l(-)-carnitine - Google Patents
An improved process for the preparation of non-hygroscopic salts of l(-)-carnitineInfo
- Publication number
- HUP0200402A3 HUP0200402A3 HU0200402A HUP0200402A HUP0200402A3 HU P0200402 A3 HUP0200402 A3 HU P0200402A3 HU 0200402 A HU0200402 A HU 0200402A HU P0200402 A HUP0200402 A HU P0200402A HU P0200402 A3 HUP0200402 A3 HU P0200402A3
- Authority
- HU
- Hungary
- Prior art keywords
- carnitine
- preparation
- improved process
- hygroscopic salts
- hygroscopic
- Prior art date
Links
- PHIQHXFUZVPYII-UHFFFAOYSA-N carnitine Chemical class C[N+](C)(C)CC(O)CC([O-])=O PHIQHXFUZVPYII-UHFFFAOYSA-N 0.000 title 1
- 150000003839 salts Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
- C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/22—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by oxygen atoms
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT1999MI000551A IT1312018B1 (it) | 1999-03-19 | 1999-03-19 | Procedimento migliorato per la produzione di sali non igroscopicidella l(-)-carnitina. |
Publications (2)
Publication Number | Publication Date |
---|---|
HUP0200402A2 HUP0200402A2 (hu) | 2002-05-29 |
HUP0200402A3 true HUP0200402A3 (en) | 2002-11-28 |
Family
ID=11382333
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU0200402A HUP0200402A3 (en) | 1999-03-19 | 2000-03-16 | An improved process for the preparation of non-hygroscopic salts of l(-)-carnitine |
Country Status (22)
Country | Link |
---|---|
US (1) | US6372940B1 (hu) |
EP (1) | EP1163207B1 (hu) |
JP (1) | JP2002540094A (hu) |
KR (1) | KR100664560B1 (hu) |
CN (1) | CN1147462C (hu) |
AR (1) | AR023101A1 (hu) |
AT (1) | ATE247627T1 (hu) |
AU (1) | AU4105800A (hu) |
CA (1) | CA2359106A1 (hu) |
CZ (1) | CZ299312B6 (hu) |
DE (1) | DE60004649T2 (hu) |
DK (1) | DK1163207T3 (hu) |
ES (1) | ES2204555T3 (hu) |
HK (1) | HK1042468A1 (hu) |
HU (1) | HUP0200402A3 (hu) |
IT (1) | IT1312018B1 (hu) |
NZ (1) | NZ512640A (hu) |
PL (1) | PL199614B1 (hu) |
PT (1) | PT1163207E (hu) |
SI (1) | SI1163207T1 (hu) |
SK (1) | SK13312001A3 (hu) |
WO (1) | WO2000056701A1 (hu) |
Families Citing this family (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2631569B1 (fr) * | 1988-05-20 | 1990-07-27 | Renault Automation | Detecteur de proximite magnetique destine notamment a la decoupe laser |
ITRM20010030A1 (it) * | 2001-01-23 | 2002-07-23 | Aldo Fassi | Sali di carnitine utili come integratori dietetici/nutrizionali o come farmaci, composizioni che li contengono e procedimenti per la loro pr |
PT1368349E (pt) * | 2001-02-24 | 2007-04-30 | Boehringer Ingelheim Pharma | Derivados de xantina, sua preparação e sua utilização como medicamento |
US7407955B2 (en) | 2002-08-21 | 2008-08-05 | Boehringer Ingelheim Pharma Gmbh & Co., Kg | 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions |
US7501426B2 (en) | 2004-02-18 | 2009-03-10 | Boehringer Ingelheim International Gmbh | 8-[3-amino-piperidin-1-yl]-xanthines, their preparation and their use as pharmaceutical compositions |
DE102004054054A1 (de) | 2004-11-05 | 2006-05-11 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verfahren zur Herstellung chiraler 8-(3-Amino-piperidin-1-yl)-xanthine |
DE102005035891A1 (de) | 2005-07-30 | 2007-02-08 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | 8-(3-Amino-piperidin-1-yl)-xanthine, deren Herstellung und deren Verwendung als Arzneimittel |
MX2008014024A (es) | 2006-05-04 | 2008-11-14 | Boehringer Ingelheim Int | Formas poliformas. |
EP1852108A1 (en) | 2006-05-04 | 2007-11-07 | Boehringer Ingelheim Pharma GmbH & Co.KG | DPP IV inhibitor formulations |
PE20080251A1 (es) | 2006-05-04 | 2008-04-25 | Boehringer Ingelheim Int | Usos de inhibidores de dpp iv |
CN101209975B (zh) * | 2006-12-29 | 2010-12-01 | 沈阳科硕营养科技有限公司 | 左旋肉碱富马酸钙及其制备方法与用途 |
US20110112069A1 (en) * | 2007-08-17 | 2011-05-12 | Boehringer Ingelheim International Gmbh | Purin derivatives for use in the treatment of fab-related diseases |
PE20091730A1 (es) | 2008-04-03 | 2009-12-10 | Boehringer Ingelheim Int | Formulaciones que comprenden un inhibidor de dpp4 |
PE20100156A1 (es) * | 2008-06-03 | 2010-02-23 | Boehringer Ingelheim Int | Tratamiento de nafld |
BRPI0916997A2 (pt) | 2008-08-06 | 2020-12-15 | Boehringer Ingelheim International Gmbh | Inibidor de dpp-4 e seu uso |
UY32030A (es) | 2008-08-06 | 2010-03-26 | Boehringer Ingelheim Int | "tratamiento para diabetes en pacientes inapropiados para terapia con metformina" |
WO2010018217A2 (en) * | 2008-08-15 | 2010-02-18 | Boehringer Ingelheim International Gmbh | Organic compounds for wound healing |
US8513264B2 (en) | 2008-09-10 | 2013-08-20 | Boehringer Ingelheim International Gmbh | Combination therapy for the treatment of diabetes and related conditions |
US20200155558A1 (en) | 2018-11-20 | 2020-05-21 | Boehringer Ingelheim International Gmbh | Treatment for diabetes in patients with insufficient glycemic control despite therapy with an oral antidiabetic drug |
CN107011345A (zh) | 2008-12-23 | 2017-08-04 | 勃林格殷格翰国际有限公司 | 有机化合物的盐形式 |
AR074990A1 (es) | 2009-01-07 | 2011-03-02 | Boehringer Ingelheim Int | Tratamiento de diabetes en pacientes con un control glucemico inadecuado a pesar de la terapia con metformina |
EP3646859A1 (en) | 2009-11-27 | 2020-05-06 | Boehringer Ingelheim International GmbH | Treatment of genotyped diabetic patients with dpp-iv inhibitors such as linagliptin |
AU2011249722B2 (en) | 2010-05-05 | 2015-09-17 | Boehringer Ingelheim International Gmbh | Combination therapy |
BR112012032579B1 (pt) | 2010-06-24 | 2021-05-11 | Boehringer Ingelheim International Gmbh | uso de linagliptina e composição farmacêutica compreendendo linagliptina e insulina basal de longa duração |
EP2425834A1 (en) * | 2010-09-06 | 2012-03-07 | Lonza Ltd. | Process for the production of l-carnitine tartrate |
JP2012092036A (ja) * | 2010-10-26 | 2012-05-17 | Mitsubishi Rayon Co Ltd | カルニチンの塩の製造方法 |
US9034883B2 (en) | 2010-11-15 | 2015-05-19 | Boehringer Ingelheim International Gmbh | Vasoprotective and cardioprotective antidiabetic therapy |
HUE043540T2 (hu) | 2011-07-15 | 2019-08-28 | Boehringer Ingelheim Int | Szubsztituált dimer kinazolin-származék, elõállítása, valamint alkalmazása 1-es és 2-es típusú cukorbetegség kezelésére szolgáló gyógyászati készítményekben |
US9555001B2 (en) | 2012-03-07 | 2017-01-31 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition and uses thereof |
EP3685839A1 (en) | 2012-05-14 | 2020-07-29 | Boehringer Ingelheim International GmbH | Linagliptin for use in the treatment of albuminuria and kidney related diseases |
WO2013174767A1 (en) | 2012-05-24 | 2013-11-28 | Boehringer Ingelheim International Gmbh | A xanthine derivative as dpp -4 inhibitor for use in modifying food intake and regulating food preference |
US20140316156A1 (en) * | 2013-04-18 | 2014-10-23 | Deborah Warner | Method of producing therapeutic agent |
ES2950384T3 (es) | 2014-02-28 | 2023-10-09 | Boehringer Ingelheim Int | Uso médico de un inhibidor de DPP-4 |
BR112018072401A2 (pt) | 2016-06-10 | 2019-02-19 | Boehringer Ingelheim International Gmbh | combinações de linagliptina e metformina |
CN106748845B (zh) * | 2016-12-23 | 2018-11-20 | 东北制药集团股份有限公司 | 一种左旋肉碱盐微粉的制备方法 |
KR20190017310A (ko) | 2017-08-10 | 2019-02-20 | 주식회사 셀트리온화학연구소 | 약제학적 성질이 개선된 l-카르니틴 화합물의 염, 이의 제조방법, 이를 함유하는 약학 조성물 |
JP6964876B2 (ja) * | 2017-11-27 | 2021-11-10 | 株式会社古川リサーチオフィス | オロット酸−カルニチン混合体粉体又はフマル酸−カルニチン混合体粉体の製造方法 |
CN108383741A (zh) * | 2018-03-16 | 2018-08-10 | 开原亨泰化工有限公司 | 一种制备左旋肉碱成盐的新方法 |
CN109096129B (zh) * | 2018-09-30 | 2021-04-27 | 东北制药集团股份有限公司 | 一种左旋肉碱酒石酸盐的制备方法 |
CN109535022B (zh) * | 2018-11-12 | 2022-03-01 | 天津大学 | 一种提高左旋肉碱富马酸盐流动性的制备方法 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3463261D1 (en) * | 1983-12-28 | 1987-05-27 | Sigma Tau Ind Farmaceuti | Salts of l-carnitine and alkanoyl l-carnitines and process for preparing same |
US5073376A (en) * | 1989-12-22 | 1991-12-17 | Lonza Ltd. | Preparations containing l-carnitine |
PT914315E (pt) * | 1996-05-31 | 2001-07-31 | Sigma Tau Ind Farmaceuti | Sais nao higroscopicos estaveis de l(-)carnitina e alcanoil l(-)carnitinas processo para a sua preparacao e composicoes solidas administraveis oralmente contendo tais sais |
IT1289974B1 (it) * | 1997-02-25 | 1998-10-19 | Aldo Fassi | Procedimento per la produzione di sali stabili e non igroscopici di l(-)carnitina e di alcanoli l(-)-carnitine |
-
1999
- 1999-03-19 IT IT1999MI000551A patent/IT1312018B1/it active
-
2000
- 2000-03-16 US US09/868,980 patent/US6372940B1/en not_active Expired - Fee Related
- 2000-03-16 KR KR1020017010602A patent/KR100664560B1/ko not_active IP Right Cessation
- 2000-03-16 CZ CZ20013376A patent/CZ299312B6/cs not_active IP Right Cessation
- 2000-03-16 PT PT00920506T patent/PT1163207E/pt unknown
- 2000-03-16 DK DK00920506T patent/DK1163207T3/da active
- 2000-03-16 AT AT00920506T patent/ATE247627T1/de not_active IP Right Cessation
- 2000-03-16 WO PCT/EP2000/002344 patent/WO2000056701A1/en active IP Right Grant
- 2000-03-16 PL PL349894A patent/PL199614B1/pl not_active IP Right Cessation
- 2000-03-16 JP JP2000606564A patent/JP2002540094A/ja not_active Ceased
- 2000-03-16 NZ NZ512640A patent/NZ512640A/xx unknown
- 2000-03-16 CN CNB008034001A patent/CN1147462C/zh not_active Expired - Fee Related
- 2000-03-16 EP EP00920506A patent/EP1163207B1/en not_active Expired - Lifetime
- 2000-03-16 CA CA002359106A patent/CA2359106A1/en not_active Abandoned
- 2000-03-16 DE DE60004649T patent/DE60004649T2/de not_active Expired - Lifetime
- 2000-03-16 ES ES00920506T patent/ES2204555T3/es not_active Expired - Lifetime
- 2000-03-16 SK SK1331-2001A patent/SK13312001A3/sk unknown
- 2000-03-16 AU AU41058/00A patent/AU4105800A/en not_active Abandoned
- 2000-03-16 HU HU0200402A patent/HUP0200402A3/hu unknown
- 2000-03-16 SI SI200030176T patent/SI1163207T1/xx unknown
- 2000-03-17 AR ARP000101222A patent/AR023101A1/es unknown
-
2002
- 2002-05-31 HK HK02104080.1A patent/HK1042468A1/zh unknown
Also Published As
Publication number | Publication date |
---|---|
PT1163207E (pt) | 2003-12-31 |
JP2002540094A (ja) | 2002-11-26 |
DE60004649T2 (de) | 2004-03-18 |
HUP0200402A2 (hu) | 2002-05-29 |
PL199614B1 (pl) | 2008-10-31 |
PL349894A1 (en) | 2002-09-23 |
EP1163207A1 (en) | 2001-12-19 |
HK1042468A1 (zh) | 2002-08-16 |
ATE247627T1 (de) | 2003-09-15 |
WO2000056701A1 (en) | 2000-09-28 |
DK1163207T3 (da) | 2003-12-01 |
CN1339023A (zh) | 2002-03-06 |
CZ20013376A3 (cs) | 2002-02-13 |
CN1147462C (zh) | 2004-04-28 |
ES2204555T3 (es) | 2004-05-01 |
CZ299312B6 (cs) | 2008-06-18 |
IT1312018B1 (it) | 2002-04-04 |
CA2359106A1 (en) | 2000-09-28 |
NZ512640A (en) | 2003-03-28 |
US6372940B1 (en) | 2002-04-16 |
ITMI990551A1 (it) | 2000-09-19 |
AR023101A1 (es) | 2002-09-04 |
AU4105800A (en) | 2000-10-09 |
KR20010102288A (ko) | 2001-11-15 |
SK13312001A3 (sk) | 2002-05-09 |
SI1163207T1 (en) | 2003-12-31 |
DE60004649D1 (de) | 2003-09-25 |
KR100664560B1 (ko) | 2007-01-03 |
EP1163207B1 (en) | 2003-08-20 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD9A | Lapse of provisional protection due to non-payment of fees |