PT1163207E - Processo melhorado para a preparacao de sais nao hidroscopicos de l(-)carnitina - Google Patents

Processo melhorado para a preparacao de sais nao hidroscopicos de l(-)carnitina

Info

Publication number
PT1163207E
PT1163207E PT00920506T PT00920506T PT1163207E PT 1163207 E PT1163207 E PT 1163207E PT 00920506 T PT00920506 T PT 00920506T PT 00920506 T PT00920506 T PT 00920506T PT 1163207 E PT1163207 E PT 1163207E
Authority
PT
Portugal
Prior art keywords
carnitine
preparation
improved process
hydroscopic salts
hydroscopic
Prior art date
Application number
PT00920506T
Other languages
English (en)
Inventor
Claudio Cavazza
Original Assignee
Sigma Tau Ind Farmaceuti
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma Tau Ind Farmaceuti filed Critical Sigma Tau Ind Farmaceuti
Publication of PT1163207E publication Critical patent/PT1163207E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/22—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
PT00920506T 1999-03-19 2000-03-16 Processo melhorado para a preparacao de sais nao hidroscopicos de l(-)carnitina PT1163207E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT1999MI000551A IT1312018B1 (it) 1999-03-19 1999-03-19 Procedimento migliorato per la produzione di sali non igroscopicidella l(-)-carnitina.

Publications (1)

Publication Number Publication Date
PT1163207E true PT1163207E (pt) 2003-12-31

Family

ID=11382333

Family Applications (1)

Application Number Title Priority Date Filing Date
PT00920506T PT1163207E (pt) 1999-03-19 2000-03-16 Processo melhorado para a preparacao de sais nao hidroscopicos de l(-)carnitina

Country Status (22)

Country Link
US (1) US6372940B1 (pt)
EP (1) EP1163207B1 (pt)
JP (1) JP2002540094A (pt)
KR (1) KR100664560B1 (pt)
CN (1) CN1147462C (pt)
AR (1) AR023101A1 (pt)
AT (1) ATE247627T1 (pt)
AU (1) AU4105800A (pt)
CA (1) CA2359106A1 (pt)
CZ (1) CZ299312B6 (pt)
DE (1) DE60004649T2 (pt)
DK (1) DK1163207T3 (pt)
ES (1) ES2204555T3 (pt)
HK (1) HK1042468A1 (pt)
HU (1) HUP0200402A3 (pt)
IT (1) IT1312018B1 (pt)
NZ (1) NZ512640A (pt)
PL (1) PL199614B1 (pt)
PT (1) PT1163207E (pt)
SI (1) SI1163207T1 (pt)
SK (1) SK13312001A3 (pt)
WO (1) WO2000056701A1 (pt)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2631569B1 (fr) * 1988-05-20 1990-07-27 Renault Automation Detecteur de proximite magnetique destine notamment a la decoupe laser
ITRM20010030A1 (it) * 2001-01-23 2002-07-23 Aldo Fassi Sali di carnitine utili come integratori dietetici/nutrizionali o come farmaci, composizioni che li contengono e procedimenti per la loro pr
PT1953162E (pt) * 2001-02-24 2012-07-13 Boehringer Ingelheim Pharma Derivados de xantina, sua preparação e sua utilização como produto farmacêutico
US7407955B2 (en) 2002-08-21 2008-08-05 Boehringer Ingelheim Pharma Gmbh & Co., Kg 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions
US7501426B2 (en) 2004-02-18 2009-03-10 Boehringer Ingelheim International Gmbh 8-[3-amino-piperidin-1-yl]-xanthines, their preparation and their use as pharmaceutical compositions
DE102004054054A1 (de) 2004-11-05 2006-05-11 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verfahren zur Herstellung chiraler 8-(3-Amino-piperidin-1-yl)-xanthine
DE102005035891A1 (de) 2005-07-30 2007-02-08 Boehringer Ingelheim Pharma Gmbh & Co. Kg 8-(3-Amino-piperidin-1-yl)-xanthine, deren Herstellung und deren Verwendung als Arzneimittel
EA015687B1 (ru) 2006-05-04 2011-10-31 Бёрингер Ингельхайм Интернациональ Гмбх Полиморфы
EP1852108A1 (en) 2006-05-04 2007-11-07 Boehringer Ingelheim Pharma GmbH & Co.KG DPP IV inhibitor formulations
PE20110235A1 (es) 2006-05-04 2011-04-14 Boehringer Ingelheim Int Combinaciones farmaceuticas que comprenden linagliptina y metmorfina
CN101209975B (zh) * 2006-12-29 2010-12-01 沈阳科硕营养科技有限公司 左旋肉碱富马酸钙及其制备方法与用途
US20110112069A1 (en) * 2007-08-17 2011-05-12 Boehringer Ingelheim International Gmbh Purin derivatives for use in the treatment of fab-related diseases
PE20091730A1 (es) * 2008-04-03 2009-12-10 Boehringer Ingelheim Int Formulaciones que comprenden un inhibidor de dpp4
PE20100156A1 (es) * 2008-06-03 2010-02-23 Boehringer Ingelheim Int Tratamiento de nafld
KR20200118243A (ko) 2008-08-06 2020-10-14 베링거 인겔하임 인터내셔날 게엠베하 메트포르민 요법이 부적합한 환자에서의 당뇨병 치료
UY32030A (es) 2008-08-06 2010-03-26 Boehringer Ingelheim Int "tratamiento para diabetes en pacientes inapropiados para terapia con metformina"
MX2011001525A (es) * 2008-08-15 2011-03-29 Boehringer Ingelheim Int Derivados de purina para su uso en el tratamiento de enfermedades relacionadas con fab.
MX2011002558A (es) 2008-09-10 2011-04-26 Boehringer Ingelheim Int Terapia de combinacion para el tratamiento de diabetes y estados relacionados.
US20200155558A1 (en) 2018-11-20 2020-05-21 Boehringer Ingelheim International Gmbh Treatment for diabetes in patients with insufficient glycemic control despite therapy with an oral antidiabetic drug
CA2745037C (en) 2008-12-23 2020-06-23 Boehringer Ingelheim International Gmbh Salt forms of 1-[(4-methyl-quinazolin-2-yl)methyl]-3-methyl-7-(2-butyn-1-yl)-8(3-(r)-amino-piperidin-1-yl)-xanthine
TW201036975A (en) 2009-01-07 2010-10-16 Boehringer Ingelheim Int Treatment for diabetes in patients with inadequate glycemic control despite metformin therapy
CN107115530A (zh) 2009-11-27 2017-09-01 勃林格殷格翰国际有限公司 基因型糖尿病患者利用dpp‑iv抑制剂例如利拉利汀的治疗
AU2011249722B2 (en) 2010-05-05 2015-09-17 Boehringer Ingelheim International Gmbh Combination therapy
KR20220025926A (ko) 2010-06-24 2022-03-03 베링거 인겔하임 인터내셔날 게엠베하 당뇨병 요법
EP2425834A1 (en) * 2010-09-06 2012-03-07 Lonza Ltd. Process for the production of l-carnitine tartrate
JP2012092036A (ja) * 2010-10-26 2012-05-17 Mitsubishi Rayon Co Ltd カルニチンの塩の製造方法
AR083878A1 (es) 2010-11-15 2013-03-27 Boehringer Ingelheim Int Terapia antidiabetica vasoprotectora y cardioprotectora, linagliptina, metodo de tratamiento
KR101985384B1 (ko) 2011-07-15 2019-06-03 베링거 인겔하임 인터내셔날 게엠베하 치환된 퀴나졸린, 이의 제조 및 약제학적 조성물에서의 이의 용도
US9555001B2 (en) 2012-03-07 2017-01-31 Boehringer Ingelheim International Gmbh Pharmaceutical composition and uses thereof
EP2849755A1 (en) 2012-05-14 2015-03-25 Boehringer Ingelheim International GmbH A xanthine derivative as dpp -4 inhibitor for use in the treatment of podocytes related disorders and/or nephrotic syndrome
WO2013174767A1 (en) 2012-05-24 2013-11-28 Boehringer Ingelheim International Gmbh A xanthine derivative as dpp -4 inhibitor for use in modifying food intake and regulating food preference
US20140316156A1 (en) * 2013-04-18 2014-10-23 Deborah Warner Method of producing therapeutic agent
JP6615109B2 (ja) 2014-02-28 2019-12-04 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｄｐｐ−４阻害薬の医学的使用
CA3022202A1 (en) 2016-06-10 2017-12-14 Boehringer Ingelheim International Gmbh Combinations of linagliptin and metformin
CN106748845B (zh) * 2016-12-23 2018-11-20 东北制药集团股份有限公司 一种左旋肉碱盐微粉的制备方法
KR20190017310A (ko) 2017-08-10 2019-02-20 주식회사 셀트리온화학연구소 약제학적 성질이 개선된 l-카르니틴 화합물의 염, 이의 제조방법, 이를 함유하는 약학 조성물
JP6964876B2 (ja) * 2017-11-27 2021-11-10 株式会社古川リサーチオフィス オロット酸−カルニチン混合体粉体又はフマル酸−カルニチン混合体粉体の製造方法
CN108383741A (zh) * 2018-03-16 2018-08-10 开原亨泰化工有限公司 一种制备左旋肉碱成盐的新方法
CN109096129B (zh) * 2018-09-30 2021-04-27 东北制药集团股份有限公司 一种左旋肉碱酒石酸盐的制备方法
CN109535022B (zh) * 2018-11-12 2022-03-01 天津大学 一种提高左旋肉碱富马酸盐流动性的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3463261D1 (en) * 1983-12-28 1987-05-27 Sigma Tau Ind Farmaceuti Salts of l-carnitine and alkanoyl l-carnitines and process for preparing same
US5073376A (en) * 1989-12-22 1991-12-17 Lonza Ltd. Preparations containing l-carnitine
US5952379A (en) * 1996-05-31 1999-09-14 Sigma-Tau Industrie Farmaceutiche Stable, non-hygroscopic salts of L(-)carnitine and alkanoyl L(-)carnitines, a process for their preparation and solid, orally administrable compositions containing such salts
IT1289974B1 (it) 1997-02-25 1998-10-19 Aldo Fassi Procedimento per la produzione di sali stabili e non igroscopici di l(-)carnitina e di alcanoli l(-)-carnitine

Also Published As

Publication number Publication date
KR20010102288A (ko) 2001-11-15
IT1312018B1 (it) 2002-04-04
NZ512640A (en) 2003-03-28
JP2002540094A (ja) 2002-11-26
HK1042468A1 (zh) 2002-08-16
DE60004649D1 (de) 2003-09-25
WO2000056701A1 (en) 2000-09-28
ATE247627T1 (de) 2003-09-15
DK1163207T3 (da) 2003-12-01
EP1163207B1 (en) 2003-08-20
CA2359106A1 (en) 2000-09-28
AR023101A1 (es) 2002-09-04
DE60004649T2 (de) 2004-03-18
CN1339023A (zh) 2002-03-06
EP1163207A1 (en) 2001-12-19
ITMI990551A1 (it) 2000-09-19
AU4105800A (en) 2000-10-09
ES2204555T3 (es) 2004-05-01
PL349894A1 (en) 2002-09-23
CZ299312B6 (cs) 2008-06-18
SK13312001A3 (sk) 2002-05-09
KR100664560B1 (ko) 2007-01-03
CZ20013376A3 (cs) 2002-02-13
HUP0200402A2 (hu) 2002-05-29
US6372940B1 (en) 2002-04-16
HUP0200402A3 (en) 2002-11-28
PL199614B1 (pl) 2008-10-31
SI1163207T1 (en) 2003-12-31
CN1147462C (zh) 2004-04-28

Similar Documents

Publication Publication Date Title
PT1163207E (pt) Processo melhorado para a preparacao de sais nao hidroscopicos de l(-)carnitina
PT1303478E (pt) Processo para a preparacao de alcanoilamidas substituidas
BR0008823B1 (pt) processo para a preparação de ácido acrìlico.
BR0012774B1 (pt) processo para preparação de poliamida.
PT1105382E (pt) Metodo para a preparacao de citalopran
BR9809112B1 (pt) processo para preparação de clopidogrel.
PT1147075E (pt) Processo para a preparacao de cloridrato de l-fenilefrina
BR0011702B1 (pt) processo para preparação de derivados herbicidas.
PT1353923E (pt) Processo melhorado para a sintese de carbapenems
AR028002A1 (es) Metodos para la produccion de ansamitocina
PT1272489E (pt) Processo para a preparacao da forma i cristalina de cabergolina
PT1345939E (pt) Processo para a preparacao de imidazotriazinonas substituidas por sulfonamida
PT1313698E (pt) Processo para a preparacao de fenilacetonitrilos substituidos
PT1432682E (pt) Processo para a preparacao de repaglinida
FR2788234B1 (fr) Procede de chanfreinage
BR0213561B1 (pt) processo para a preparaÇço de amidas de Ácido 2-halopiridincarboxÍlico.
PT1362040E (pt) Processo para a preparacao de mesilatos de derivados de piperazina
PT1343750E (pt) Processo para a preparacao de derivados de fenetilamina
PT1210318E (pt) Processo para producao de adrenalina
PT1200414E (pt) Processo para a preparacao de pirimidnas substituidas
PT1198466E (pt) Processo para producao de glifosatos ou um dos seus sais
PT1292586E (pt) Processo para a preparacao de pirazolopirimidinonas
BR0013751B1 (pt) processo para produÇço de derivados de Ácido naftiridina-3-carboxÍlico.
PT1294694E (pt) Processo para a preparacao de derivados de quinolina
PT1240173E (pt) Processo para a preparacao de n-fosfonometilglicina