ES2191103T5 - Procedimientos de prevencion o de tratamiento de alergia. - Google Patents
Procedimientos de prevencion o de tratamiento de alergia. Download PDFInfo
- Publication number
- ES2191103T5 ES2191103T5 ES96918707T ES96918707T ES2191103T5 ES 2191103 T5 ES2191103 T5 ES 2191103T5 ES 96918707 T ES96918707 T ES 96918707T ES 96918707 T ES96918707 T ES 96918707T ES 2191103 T5 ES2191103 T5 ES 2191103T5
- Authority
- ES
- Spain
- Prior art keywords
- formula
- lactobacillus
- casein
- protein hydrolyzate
- allergy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 206010020751 Hypersensitivity Diseases 0.000 title claims abstract description 23
- 238000011282 treatment Methods 0.000 title claims abstract description 22
- 238000000034 method Methods 0.000 title claims abstract description 18
- 208000026935 allergic disease Diseases 0.000 title claims abstract description 11
- 230000007815 allergy Effects 0.000 title claims abstract description 11
- 230000002265 prevention Effects 0.000 title claims abstract description 7
- 241000186660 Lactobacillus Species 0.000 claims abstract description 44
- 229940039696 lactobacillus Drugs 0.000 claims abstract description 40
- 238000004519 manufacturing process Methods 0.000 claims abstract description 21
- 235000020247 cow milk Nutrition 0.000 claims abstract description 16
- 102000004169 proteins and genes Human genes 0.000 claims abstract description 11
- 108090000623 proteins and genes Proteins 0.000 claims abstract description 11
- 235000013305 food Nutrition 0.000 claims abstract description 10
- 239000003531 protein hydrolysate Substances 0.000 claims description 27
- 238000002360 preparation method Methods 0.000 claims description 21
- 239000000427 antigen Substances 0.000 claims description 17
- 108091007433 antigens Proteins 0.000 claims description 17
- 102000036639 antigens Human genes 0.000 claims description 17
- 102000004190 Enzymes Human genes 0.000 claims description 16
- 108090000790 Enzymes Proteins 0.000 claims description 16
- 229940088598 enzyme Drugs 0.000 claims description 16
- 102000057297 Pepsin A Human genes 0.000 claims description 12
- 108090000284 Pepsin A Proteins 0.000 claims description 12
- 102000004142 Trypsin Human genes 0.000 claims description 12
- 108090000631 Trypsin Proteins 0.000 claims description 12
- 230000001580 bacterial effect Effects 0.000 claims description 12
- 229940111202 pepsin Drugs 0.000 claims description 12
- 239000012588 trypsin Substances 0.000 claims description 12
- 201000010859 Milk allergy Diseases 0.000 claims description 10
- 210000000936 intestine Anatomy 0.000 claims description 10
- 208000009793 Milk Hypersensitivity Diseases 0.000 claims description 8
- 230000007423 decrease Effects 0.000 claims description 8
- 230000004044 response Effects 0.000 claims description 7
- 230000004888 barrier function Effects 0.000 claims description 6
- 230000003301 hydrolyzing effect Effects 0.000 claims description 6
- 238000000338 in vitro Methods 0.000 claims description 5
- 235000016709 nutrition Nutrition 0.000 claims description 2
- 241000894006 Bacteria Species 0.000 abstract description 13
- 230000000968 intestinal effect Effects 0.000 abstract description 8
- 238000006243 chemical reaction Methods 0.000 abstract description 6
- 210000001035 gastrointestinal tract Anatomy 0.000 abstract description 6
- 239000006041 probiotic Substances 0.000 abstract description 6
- 235000018291 probiotics Nutrition 0.000 abstract description 6
- 208000004262 Food Hypersensitivity Diseases 0.000 abstract description 5
- 235000020932 food allergy Nutrition 0.000 abstract description 5
- 230000028993 immune response Effects 0.000 abstract description 5
- 230000000529 probiotic effect Effects 0.000 abstract description 4
- 206010016946 Food allergy Diseases 0.000 abstract description 3
- 235000005911 diet Nutrition 0.000 abstract description 2
- 230000008030 elimination Effects 0.000 abstract description 2
- 238000003379 elimination reaction Methods 0.000 abstract description 2
- 230000002496 gastric effect Effects 0.000 abstract description 2
- 230000037213 diet Effects 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 230000009610 hypersensitivity Effects 0.000 abstract 1
- 230000010585 negative regulation of hypersensitivity Effects 0.000 abstract 1
- 230000003014 reinforcing effect Effects 0.000 abstract 1
- 239000005018 casein Substances 0.000 description 50
- 235000013350 formula milk Nutrition 0.000 description 46
- 102000011632 Caseins Human genes 0.000 description 35
- 108010076119 Caseins Proteins 0.000 description 35
- 235000021240 caseins Nutrition 0.000 description 33
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 description 32
- 238000012360 testing method Methods 0.000 description 19
- 206010012438 Dermatitis atopic Diseases 0.000 description 18
- 201000008937 atopic dermatitis Diseases 0.000 description 17
- 102000004388 Interleukin-4 Human genes 0.000 description 11
- 108090000978 Interleukin-4 Proteins 0.000 description 11
- 210000002966 serum Anatomy 0.000 description 10
- 206010003645 Atopy Diseases 0.000 description 9
- 208000010668 atopic eczema Diseases 0.000 description 9
- 108010050122 alpha 1-Antitrypsin Proteins 0.000 description 8
- 102000015395 alpha 1-Antitrypsin Human genes 0.000 description 8
- 229940024142 alpha 1-antitrypsin Drugs 0.000 description 8
- 238000002474 experimental method Methods 0.000 description 8
- 210000003819 peripheral blood mononuclear cell Anatomy 0.000 description 8
- 235000018102 proteins Nutrition 0.000 description 8
- 241000283690 Bos taurus Species 0.000 description 7
- 239000012980 RPMI-1640 medium Substances 0.000 description 6
- 230000007062 hydrolysis Effects 0.000 description 6
- 238000006460 hydrolysis reaction Methods 0.000 description 6
- 210000004369 blood Anatomy 0.000 description 5
- 239000008280 blood Substances 0.000 description 5
- 230000000694 effects Effects 0.000 description 5
- 210000004698 lymphocyte Anatomy 0.000 description 5
- 239000003226 mitogen Substances 0.000 description 5
- 239000000047 product Substances 0.000 description 5
- 239000006228 supernatant Substances 0.000 description 5
- 102000009366 Alpha-s1 casein Human genes 0.000 description 4
- 108050000244 Alpha-s1 casein Proteins 0.000 description 4
- 108010047620 Phytohemagglutinins Proteins 0.000 description 4
- 108060008682 Tumor Necrosis Factor Proteins 0.000 description 4
- 210000004027 cell Anatomy 0.000 description 4
- 230000002550 fecal effect Effects 0.000 description 4
- 239000001963 growth medium Substances 0.000 description 4
- 230000001885 phytohemagglutinin Effects 0.000 description 4
- 230000035755 proliferation Effects 0.000 description 4
- 230000009885 systemic effect Effects 0.000 description 4
- MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 description 3
- 206010061218 Inflammation Diseases 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 description 3
- 206010052428 Wound Diseases 0.000 description 3
- 230000000172 allergic effect Effects 0.000 description 3
- 229940021722 caseins Drugs 0.000 description 3
- 239000003246 corticosteroid Substances 0.000 description 3
- 230000003247 decreasing effect Effects 0.000 description 3
- 238000011161 development Methods 0.000 description 3
- 238000010790 dilution Methods 0.000 description 3
- 239000012895 dilution Substances 0.000 description 3
- 230000004054 inflammatory process Effects 0.000 description 3
- 230000000813 microbial effect Effects 0.000 description 3
- 230000001629 suppression Effects 0.000 description 3
- 230000009466 transformation Effects 0.000 description 3
- 101710081722 Antitrypsin Proteins 0.000 description 2
- 206010003445 Ascites Diseases 0.000 description 2
- 201000004624 Dermatitis Diseases 0.000 description 2
- 206010012735 Diarrhoea Diseases 0.000 description 2
- 238000008157 ELISA kit Methods 0.000 description 2
- NTYJJOPFIAHURM-UHFFFAOYSA-N Histamine Chemical compound NCCC1=CN=CN1 NTYJJOPFIAHURM-UHFFFAOYSA-N 0.000 description 2
- 244000199866 Lactobacillus casei Species 0.000 description 2
- 235000013958 Lactobacillus casei Nutrition 0.000 description 2
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 2
- 102000035195 Peptidases Human genes 0.000 description 2
- 108091005804 Peptidases Proteins 0.000 description 2
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 239000005862 Whey Substances 0.000 description 2
- 102000007544 Whey Proteins Human genes 0.000 description 2
- 108010046377 Whey Proteins Proteins 0.000 description 2
- 239000003242 anti bacterial agent Substances 0.000 description 2
- 230000001475 anti-trypsic effect Effects 0.000 description 2
- 229940088710 antibiotic agent Drugs 0.000 description 2
- 238000003556 assay Methods 0.000 description 2
- 229960001334 corticosteroids Drugs 0.000 description 2
- 230000007123 defense Effects 0.000 description 2
- 230000007071 enzymatic hydrolysis Effects 0.000 description 2
- 238000006047 enzymatic hydrolysis reaction Methods 0.000 description 2
- 239000000284 extract Substances 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 230000005847 immunogenicity Effects 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 210000004347 intestinal mucosa Anatomy 0.000 description 2
- 230000003870 intestinal permeability Effects 0.000 description 2
- 229940017800 lactobacillus casei Drugs 0.000 description 2
- 210000004877 mucosa Anatomy 0.000 description 2
- 230000004682 mucosal barrier function Effects 0.000 description 2
- 230000002093 peripheral effect Effects 0.000 description 2
- 230000009696 proliferative response Effects 0.000 description 2
- 230000009467 reduction Effects 0.000 description 2
- 230000035945 sensitivity Effects 0.000 description 2
- 230000020192 tolerance induction in gut-associated lymphoid tissue Effects 0.000 description 2
- 239000002753 trypsin inhibitor Substances 0.000 description 2
- JKMHFZQWWAIEOD-UHFFFAOYSA-N 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid Chemical compound OCC[NH+]1CCN(CCS([O-])(=O)=O)CC1 JKMHFZQWWAIEOD-UHFFFAOYSA-N 0.000 description 1
- 206010067484 Adverse reaction Diseases 0.000 description 1
- 208000012657 Atopic disease Diseases 0.000 description 1
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 1
- 102000017420 CD3 protein, epsilon/gamma/delta subunit Human genes 0.000 description 1
- 241000700198 Cavia Species 0.000 description 1
- 102000004127 Cytokines Human genes 0.000 description 1
- 108090000695 Cytokines Proteins 0.000 description 1
- 102000057955 Eosinophil Cationic Human genes 0.000 description 1
- 101710191360 Eosinophil cationic protein Proteins 0.000 description 1
- 206010015150 Erythema Diseases 0.000 description 1
- 208000035874 Excoriation Diseases 0.000 description 1
- 208000018522 Gastrointestinal disease Diseases 0.000 description 1
- CEAZRRDELHUEMR-URQXQFDESA-N Gentamicin Chemical compound O1[C@H](C(C)NC)CC[C@@H](N)[C@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](NC)[C@@](C)(O)CO2)O)[C@H](N)C[C@@H]1N CEAZRRDELHUEMR-URQXQFDESA-N 0.000 description 1
- 229930182566 Gentamicin Natural products 0.000 description 1
- 101001002709 Homo sapiens Interleukin-4 Proteins 0.000 description 1
- 108060003951 Immunoglobulin Proteins 0.000 description 1
- ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 description 1
- 229930182816 L-glutamine Natural products 0.000 description 1
- 241000194034 Lactococcus lactis subsp. cremoris Species 0.000 description 1
- 206010024438 Lichenification Diseases 0.000 description 1
- 238000000585 Mann–Whitney U test Methods 0.000 description 1
- 102000014171 Milk Proteins Human genes 0.000 description 1
- 108010011756 Milk Proteins Proteins 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- 206010033733 Papule Diseases 0.000 description 1
- 108010009736 Protein Hydrolysates Proteins 0.000 description 1
- 208000003251 Pruritus Diseases 0.000 description 1
- 241000700159 Rattus Species 0.000 description 1
- 206010039085 Rhinitis allergic Diseases 0.000 description 1
- 239000006146 Roswell Park Memorial Institute medium Substances 0.000 description 1
- 235000021248 S1-casein Nutrition 0.000 description 1
- 206010070834 Sensitisation Diseases 0.000 description 1
- 206010058679 Skin oedema Diseases 0.000 description 1
- 235000014962 Streptococcus cremoris Nutrition 0.000 description 1
- 210000001744 T-lymphocyte Anatomy 0.000 description 1
- 206010054094 Tumour necrosis Diseases 0.000 description 1
- 206010047700 Vomiting Diseases 0.000 description 1
- 230000001594 aberrant effect Effects 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 230000006838 adverse reaction Effects 0.000 description 1
- 239000013566 allergen Substances 0.000 description 1
- 230000002009 allergenic effect Effects 0.000 description 1
- 230000009285 allergic inflammation Effects 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 230000000890 antigenic effect Effects 0.000 description 1
- 208000006673 asthma Diseases 0.000 description 1
- 230000005549 barrier dysfunction Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 210000000601 blood cell Anatomy 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 210000002421 cell wall Anatomy 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 230000001276 controlling effect Effects 0.000 description 1
- 239000012228 culture supernatant Substances 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 230000000593 degrading effect Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 230000000378 dietary effect Effects 0.000 description 1
- 235000021196 dietary intervention Nutrition 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
- 235000020883 elimination diet Nutrition 0.000 description 1
- 239000003974 emollient agent Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- YQGOJNYOYNNSMM-UHFFFAOYSA-N eosin Chemical compound [Na+].OC(=O)C1=CC=CC=C1C1=C2C=C(Br)C(=O)C(Br)=C2OC2=C(Br)C(O)=C(Br)C=C21 YQGOJNYOYNNSMM-UHFFFAOYSA-N 0.000 description 1
- 210000000981 epithelium Anatomy 0.000 description 1
- 231100000321 erythema Toxicity 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 230000007717 exclusion Effects 0.000 description 1
- 239000012894 fetal calf serum Substances 0.000 description 1
- 239000012997 ficoll-paque Substances 0.000 description 1
- 210000000245 forearm Anatomy 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 229960002518 gentamicin Drugs 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 208000037824 growth disorder Diseases 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 210000002443 helper t lymphocyte Anatomy 0.000 description 1
- 229960001340 histamine Drugs 0.000 description 1
- 229960004931 histamine dihydrochloride Drugs 0.000 description 1
- PPZMYIBUHIPZOS-UHFFFAOYSA-N histamine dihydrochloride Chemical compound Cl.Cl.NCCC1=CN=CN1 PPZMYIBUHIPZOS-UHFFFAOYSA-N 0.000 description 1
- 102000055229 human IL4 Human genes 0.000 description 1
- 235000020256 human milk Nutrition 0.000 description 1
- 210000004251 human milk Anatomy 0.000 description 1
- 230000001900 immune effect Effects 0.000 description 1
- 238000003018 immunoassay Methods 0.000 description 1
- 102000018358 immunoglobulin Human genes 0.000 description 1
- 229940099472 immunoglobulin a Drugs 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 210000005027 intestinal barrier Anatomy 0.000 description 1
- 230000007358 intestinal barrier function Effects 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000035800 maturation Effects 0.000 description 1
- 239000002609 medium Substances 0.000 description 1
- 244000005706 microflora Species 0.000 description 1
- 230000002297 mitogenic effect Effects 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- 238000010979 pH adjustment Methods 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 235000019371 penicillin G benzathine Nutrition 0.000 description 1
- 229940056360 penicillin g Drugs 0.000 description 1
- 210000005259 peripheral blood Anatomy 0.000 description 1
- 239000011886 peripheral blood Substances 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 239000000902 placebo Substances 0.000 description 1
- 229940068196 placebo Drugs 0.000 description 1
- 239000013641 positive control Substances 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000000750 progressive effect Effects 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 235000019833 protease Nutrition 0.000 description 1
- 230000007065 protein hydrolysis Effects 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 230000009257 reactivity Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000004043 responsiveness Effects 0.000 description 1
- 238000012552 review Methods 0.000 description 1
- 230000008313 sensitization Effects 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 238000000527 sonication Methods 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 230000003614 tolerogenic effect Effects 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 102000003390 tumor necrosis factor Human genes 0.000 description 1
- 230000008673 vomiting Effects 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
- 235000021249 α-casein Nutrition 0.000 description 1
- 235000021246 κ-casein Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/01—Hydrolysed proteins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/01—Hydrolysed proteins; Derivatives thereof
- A61K38/012—Hydrolysed proteins; Derivatives thereof from animals
- A61K38/018—Hydrolysed proteins; Derivatives thereof from animals from milk
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23J—PROTEIN COMPOSITIONS FOR FOODSTUFFS; WORKING-UP PROTEINS FOR FOODSTUFFS; PHOSPHATIDE COMPOSITIONS FOR FOODSTUFFS
- A23J3/00—Working-up of proteins for foodstuffs
- A23J3/30—Working-up of proteins for foodstuffs by hydrolysis
- A23J3/32—Working-up of proteins for foodstuffs by hydrolysis using chemical agents
- A23J3/34—Working-up of proteins for foodstuffs by hydrolysis using chemical agents using enzymes
- A23J3/341—Working-up of proteins for foodstuffs by hydrolysis using chemical agents using enzymes of animal proteins
- A23J3/343—Working-up of proteins for foodstuffs by hydrolysis using chemical agents using enzymes of animal proteins of dairy proteins
- A23J3/344—Working-up of proteins for foodstuffs by hydrolysis using chemical agents using enzymes of animal proteins of dairy proteins of casein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/741—Probiotics
- A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
- A61K35/747—Lactobacilli, e.g. L. acidophilus or L. brevis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Zoology (AREA)
- Mycology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Polymers & Plastics (AREA)
- Food Science & Technology (AREA)
- Nutrition Science (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pulmonology (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Dairy Products (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FI952926A FI104465B (fi) | 1995-06-14 | 1995-06-14 | Proteiinihydrolysaatteja allergioiden hoitamiseksi tai estämiseksi, niiden valmistus ja käyttö |
| FI952926 | 1995-06-14 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES2191103T3 ES2191103T3 (es) | 2003-09-01 |
| ES2191103T5 true ES2191103T5 (es) | 2009-11-03 |
Family
ID=8543602
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES96918707T Expired - Lifetime ES2191103T5 (es) | 1995-06-14 | 1996-06-12 | Procedimientos de prevencion o de tratamiento de alergia. |
Country Status (26)
| Country | Link |
|---|---|
| US (2) | US6506380B1 (enExample) |
| EP (1) | EP0833649B2 (enExample) |
| JP (1) | JP3983804B2 (enExample) |
| KR (1) | KR100494741B1 (enExample) |
| CN (1) | CN1154506C (enExample) |
| AR (1) | AR003960A1 (enExample) |
| AT (1) | ATE230606T1 (enExample) |
| BG (1) | BG63153B1 (enExample) |
| BR (1) | BR9607827A (enExample) |
| CA (1) | CA2224320C (enExample) |
| CZ (1) | CZ291904B6 (enExample) |
| DE (1) | DE69625690T3 (enExample) |
| DK (1) | DK0833649T4 (enExample) |
| EE (1) | EE03424B1 (enExample) |
| ES (1) | ES2191103T5 (enExample) |
| FI (1) | FI104465B (enExample) |
| IL (1) | IL122577A0 (enExample) |
| MX (1) | MX9710109A (enExample) |
| MY (1) | MY113912A (enExample) |
| NO (1) | NO321504B1 (enExample) |
| NZ (1) | NZ310478A (enExample) |
| PL (1) | PL185123B1 (enExample) |
| RO (1) | RO120243B1 (enExample) |
| SK (1) | SK284245B6 (enExample) |
| WO (1) | WO1997000078A1 (enExample) |
| ZA (1) | ZA965088B (enExample) |
Families Citing this family (174)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FI104465B (fi) * | 1995-06-14 | 2000-02-15 | Valio Oy | Proteiinihydrolysaatteja allergioiden hoitamiseksi tai estämiseksi, niiden valmistus ja käyttö |
| CA2292536A1 (en) * | 1997-06-03 | 1998-12-10 | Ganeden Biotech, Inc. | Probiotic lactic acid bacterium to treat bacterial infections associated with sids |
| JP2002534965A (ja) | 1999-01-19 | 2002-10-22 | マキシジェン, インコーポレイテッド | 所望の特徴を有する文字ストリング、ポリヌクレオチドおよびポリペプチドを作製するための方法 |
| PT1353681E (pt) | 1999-08-05 | 2008-02-25 | Nestle Sa | ''bifidobactérias capazes de evitar a diarreia'' |
| ATE425244T1 (de) | 1999-08-05 | 2009-03-15 | Nestle Sa | Bifidobacteria zum vorbeugen von diarrhöe infolge pathogener bakterien |
| WO2001057534A2 (en) * | 2000-02-04 | 2001-08-09 | Bioseek | Compositions and methods for reducing autoimmunity |
| FI110668B (fi) * | 2000-06-20 | 2003-03-14 | Aboatech Ab Oy | Probioottien käyttö atooppisten sairauksien primaariseen ehkäisyyn |
| CA2420160A1 (en) * | 2000-09-25 | 2002-03-28 | Societe Des Produits Nestle S.A. | Lactic acid bacteria capable of reducing an individual's tendency to develop allergic reactions |
| ATE490776T1 (de) | 2000-10-06 | 2010-12-15 | Nestec Sa | Verwendung von probiotischen milchsäure- produzierende bakterien zur zum schutz der haut gegen uv-induzierter allergischen reaktionen und entzündungskrankheiten oder immunsuppression |
| FI109602B (fi) * | 2001-01-25 | 2002-09-13 | Valio Oy | Probioottiyhdistelmä |
| EP1228707A1 (en) * | 2001-02-01 | 2002-08-07 | Campina Melkunie B.V. | Use of alpha-lactalbumin as prebiotic agent |
| BR0207948A (pt) * | 2001-03-09 | 2004-07-27 | Produits Nestel S A Soc D | Composição que melhora os déficits fisiológicos relacionados com a idade e que aumenta a longevidade |
| JP2003137804A (ja) * | 2001-10-31 | 2003-05-14 | Morinaga Milk Ind Co Ltd | インターロイキン−18誘導剤 |
| EP1364586A1 (en) * | 2002-05-24 | 2003-11-26 | Nestec S.A. | Probiotics and oral tolerance |
| EP1509609B1 (en) | 2002-06-04 | 2015-04-22 | DSM IP Assets B.V. | Protein hydrolysate rich in tripeptides |
| SI1565547T2 (sl) | 2002-06-28 | 2013-02-28 | Biosearch S.A. | Probiotiäśni sevi, postopek za izbiranje le-teh, njihovi sestavki in njihova uporaba |
| EP1384483A1 (en) * | 2002-07-23 | 2004-01-28 | Nestec S.A. | Probiotics for treatment of irritable bowel disease (IBS) through improvement of gut neuromuscular function |
| US7105336B2 (en) * | 2002-10-07 | 2006-09-12 | Biogaia Ab | Selection and use of lactic acid bacteria for reducing inflammation caused by Helicobacter |
| US20040208863A1 (en) * | 2003-01-30 | 2004-10-21 | James Versalovic | Anti-inflammatory activity from lactic acid bacteria |
| CN1863463B (zh) * | 2003-06-23 | 2011-05-04 | 雀巢技术公司 | 用于促进肠道屏障成熟的营养组合物 |
| KR20120035233A (ko) | 2004-02-25 | 2012-04-13 | 파이어니어 하이 부렛드 인터내쇼날 인코포레이팃드 | 신규한 바실루스 투링기엔시스 결정 폴리펩티드, 폴리뉴클레오티드, 및 이의 조성물 |
| US20050265946A1 (en) * | 2004-05-28 | 2005-12-01 | Kao Corporation | Elastase inhibitor |
| US7862808B2 (en) * | 2004-07-01 | 2011-01-04 | Mead Johnson Nutrition Company | Method for preventing or treating respiratory infections and acute otitis media in infants using Lactobacillus rhamnosus LGG and Bifidobacterium lactis Bb-12 |
| AU2006233918B2 (en) | 2005-04-13 | 2012-06-21 | Nestec S.A. | Infant formula with probiotics |
| US20060233762A1 (en) * | 2005-04-15 | 2006-10-19 | Mcmahon Robert J | Method for treating or preventing systemic inflammation in formula-fed infants |
| US7303745B2 (en) * | 2005-04-15 | 2007-12-04 | Bristol-Myers Squibb Company | Method for preventing or treating the development of respiratory allergies |
| AU2006313660B2 (en) * | 2005-11-14 | 2012-07-19 | Nestec S.A. | Oral tolerance promotion with glycated proteins |
| AU2007216461B2 (en) | 2006-02-15 | 2012-08-30 | Société des Produits Nestlé S.A. | Use of bifidobacterium longum for the prevention and treatment of inflammation |
| US9005682B2 (en) | 2006-03-07 | 2015-04-14 | Nestec S.A. | Synbiotic mixture |
| AU2007259231B2 (en) * | 2006-06-15 | 2013-05-09 | Nestec S.A. | Induction of tolerance to egg proteins |
| US9408818B2 (en) * | 2007-02-28 | 2016-08-09 | Mead Johnson Nutrition Company | Method for the utilization of and product containing inactivated probiotic |
| EP1974735A1 (en) | 2007-03-28 | 2008-10-01 | Nestec S.A. | Reduction of risk of diarrhoea |
| EP1974743A1 (en) | 2007-03-28 | 2008-10-01 | Nestec S.A. | Probiotics to Improve Gut Microbiota |
| CN101273738B (zh) * | 2007-03-28 | 2011-06-01 | 哈尔滨正方科技有限公司 | 在常温下保持高活菌数的调配型酸性乳饮料的制备方法 |
| EP1974734A1 (en) † | 2007-03-28 | 2008-10-01 | Nestec S.A. | Probiotics for reduction of risk of obesity |
| JP2010536385A (ja) | 2007-08-24 | 2010-12-02 | コデクシス, インコーポレイテッド | (r)−3−ヒドロキシチオランの立体選択的生成のための改善されたケトレダクターゼポリペプチド |
| EP2072052A1 (en) | 2007-12-17 | 2009-06-24 | Nestec S.A. | Prevention of opportunistic infections in immune-compromised subjects |
| MY177280A (en) | 2008-01-24 | 2020-09-10 | Nestle Sa | Capsule containing nutritional ingredients and method of delivery of a nutritional liquid from the capsule |
| SI2244734T1 (sl) | 2008-02-01 | 2016-11-30 | Murdoch Childrens Research Institute | Postopek induciranja tolerance na alergen |
| EP2265135B1 (en) | 2008-03-14 | 2017-12-20 | Nestec S.A. | Synbiotic mixture |
| EP2127661A1 (en) | 2008-05-27 | 2009-12-02 | Nestec S.A. | Probiotics to improve gut microbiotica |
| ES2705694T3 (es) | 2008-06-13 | 2019-03-26 | Codexis Inc | Método de síntesis de variantes de polinucleótidos |
| US20090312196A1 (en) | 2008-06-13 | 2009-12-17 | Codexis, Inc. | Method of synthesizing polynucleotide variants |
| EP2481737A1 (en) | 2008-06-24 | 2012-08-01 | Merck Sharp & Dohme Corp. | Biocatalytic processes for the preparation of substantially stereomerically pure fused bicyclic proline compounds |
| EP2147678A1 (en) | 2008-07-21 | 2010-01-27 | Nestec S.A. | Probiotics to increase IgA secretion in infants born by caesarean section |
| RU2392001C2 (ru) * | 2008-08-04 | 2010-06-20 | Государственное образовательное учреждение высшего профессионального образования "Нижегородская государственная медицинская академия Федерального агентства по здравоохранению и социальному развитию" | Способ лечения желтушных форм вирусного гепатита а у детей с пищевой аллергией |
| WO2010025238A2 (en) | 2008-08-27 | 2010-03-04 | Codexis, Inc. | Ketoreductase polypeptides for the production of a 3-aryl-3-hydroxypropanamine from a 3-aryl-3-ketopropanamine |
| HUE036104T2 (hu) | 2009-01-08 | 2018-06-28 | Codexis Inc | Transzamináz polipeptidek |
| BRPI1013886A2 (pt) | 2009-03-17 | 2016-10-11 | Codexis Inc | variantes de endoglucanases, polinucleotídeos e usos a elas relacionados |
| CN102428170B (zh) | 2009-03-31 | 2015-03-18 | 科德克希思公司 | 改良的内切葡聚糖酶 |
| CA2762616C (en) | 2009-06-16 | 2015-08-18 | Codexis, Inc. | Beta-glucosidase variant enzymes and related polynucleotides |
| HUE055413T2 (hu) | 2009-06-22 | 2021-11-29 | Codexis Inc | Ketoreduktáz-közvetített sztereoszelektív útvonal alfa-klóralkoholokhoz |
| US8614081B2 (en) | 2009-07-23 | 2013-12-24 | Codexis, Inc. | Nitrilase biocatalysts |
| MX2012002039A (es) * | 2009-08-18 | 2012-04-11 | Nestec Sa | Una composicion nutricional que comprende cepas de lactococcus y que reduce los sintomas de la alergia, especialmente en infantes y en niños. |
| MY163002A (en) | 2009-08-18 | 2017-07-31 | Nestec Sa | A nutritional composition comprising bifidobacterium longum strains and reducing food allergy symptoms, especially in infants and children |
| WO2011022548A2 (en) | 2009-08-19 | 2011-02-24 | Codexis, Inc. | Ketoreductase polypeptides for the preparation of phenylephrine |
| WO2011028708A1 (en) | 2009-09-04 | 2011-03-10 | Codexis, Inc. | Variant cbh2 cellulases and related polynucleotides |
| EP2295535A1 (en) * | 2009-09-11 | 2011-03-16 | Mead Johnson Nutrition Company | Probiotic material |
| DK3301208T3 (da) | 2009-09-18 | 2020-12-14 | Codexis Inc | Reduceret codon-mutagenese |
| ES2455269T3 (es) | 2009-11-25 | 2014-04-15 | Codexis, Inc. | Variantes de beta-glucosidasa recombinante para la producción de azúcares solubles de biomasa celulósica |
| US8652813B2 (en) | 2009-11-25 | 2014-02-18 | Codexis, Inc. | Recombinant Thermoascus aurantiacus β-glucosidase variants |
| EP2509429A1 (en) | 2009-12-08 | 2012-10-17 | Nestec S.A. | Infant formula with probiotics and milk fat globule membrane components |
| WO2011071982A2 (en) | 2009-12-08 | 2011-06-16 | Codexis, Inc. | Synthesis of prazole compounds |
| WO2011082304A1 (en) | 2009-12-31 | 2011-07-07 | Pioneer Hi-Bred International, Inc. | Engineering plant resistance to diseases caused by pathogens |
| HUE026367T2 (en) | 2010-05-04 | 2016-06-28 | Codexis Inc | Biocatalysts for ezetimibe synthesis |
| EP2569331A1 (en) | 2010-05-10 | 2013-03-20 | Perseid Therapeutics LLC | Polypeptide inhibitors of vla4 |
| EP2576804B1 (en) | 2010-05-28 | 2016-12-14 | Codexis, Inc. | Pentose fermentation by a recombinant microorganism |
| DK2582799T3 (en) | 2010-06-17 | 2018-02-12 | Codexis Inc | BIOCATALATORS AND PROCEDURES FOR THE SYNTHESIS OF (S) -3- (1-AMINOETHYL) -PHENOL |
| US8574878B2 (en) | 2010-06-28 | 2013-11-05 | Behnaz Behrouzian | Fatty alcohol forming acyl reductases (FARs) and methods of use thereof |
| US8420364B2 (en) | 2010-06-30 | 2013-04-16 | Codexis, Inc. | Highly stable beta-class carbonic anhydrases useful in carbon capture systems |
| WO2012024100A2 (en) | 2010-08-16 | 2012-02-23 | Merck Sharp & Dohme Corp. | Process for preparing aminocyclohexyl ether compounds |
| ES2623288T3 (es) | 2010-08-20 | 2017-07-10 | Codexis, Inc. | Uso de proteínas de la familia de glicólido hidrolasa 61 en el procesamiento de celulosa |
| DK2649187T3 (da) | 2010-12-08 | 2018-01-29 | Codexis Inc | Biokatalysatorer og fremgangsmåder til syntesen af armodafinil |
| EE05721B1 (et) | 2011-02-25 | 2014-08-15 | OÜ Tervisliku Piima Biotehnoloogiate Arenduskeskus | Isoleeritud mikroorganismi tüvi L. plantarum MCC1 DSM 23881 ja selle kasutamine |
| US8663962B2 (en) | 2011-03-30 | 2014-03-04 | Codexis, Inc. | Pentose fermentation by a recombinant microorganism |
| HUE038800T2 (hu) | 2011-04-13 | 2018-11-28 | Codexis Inc | Biokatalitikus eljárás eszlikarbazepin és ennek analógjai elõállítására |
| UA111078C2 (uk) * | 2011-05-03 | 2016-03-25 | Нестек С.А. | Гідролізат білкового субстрату і спосіб його виготовлення |
| US8778652B2 (en) | 2011-06-30 | 2014-07-15 | Codexis, Inc. | Pentose fermentation by a recombinant microorganism |
| WO2013028701A1 (en) | 2011-08-22 | 2013-02-28 | Codexis, Inc. | Gh61 glycoside hydrolase protein variants and cofactors that enhance gh61 activity |
| EP2753640B1 (en) | 2011-09-08 | 2016-03-09 | Codexis, Inc. | Biocatalysts and methods for the synthesis of substituted lactams |
| EP2760997A4 (en) | 2011-09-30 | 2015-02-11 | Codexis Inc | MUSHROOM PROTEASE |
| WO2013052101A1 (en) * | 2011-10-03 | 2013-04-11 | Kelly Foods Corporation | Probiotic composition for pets and method of providing the same |
| US20130089638A1 (en) * | 2011-10-11 | 2013-04-11 | Mead Johnson Nutrition Company | Compositions Comprising Maltotriose And Methods Of Using Same To Inhibit Damage Caused By Dehydration Processes |
| CN106479990B (zh) | 2011-11-18 | 2020-09-18 | 科德克希思公司 | 用于制备羟基取代的氨基甲酸酯的生物催化剂 |
| US9611462B2 (en) | 2011-12-20 | 2017-04-04 | Codexis, Inc. | Endoglucanase 1B (EG1B) variants |
| WO2013142770A1 (en) | 2012-03-23 | 2013-09-26 | Codexis, Inc. | Biocatalysts and methods for synthesizing derivatives of tryptamine and tryptamine analogs |
| US20130251829A1 (en) * | 2012-03-23 | 2013-09-26 | Mead Johnson Nutrition Company | Probiotic derived non-viable material for infection prevention and treatment |
| WO2013169725A2 (en) | 2012-05-08 | 2013-11-14 | Codexis, Inc. | Biocatalysts and methods for hydroxylation of chemical compounds |
| WO2013170050A1 (en) | 2012-05-11 | 2013-11-14 | Codexis, Inc. | Engineered imine reductases and methods for the reductive amination of ketone and amine compounds |
| US8980578B2 (en) | 2012-06-11 | 2015-03-17 | Codexis, Inc. | Fungal beta-xylosidase variants |
| US9611515B2 (en) | 2012-11-20 | 2017-04-04 | Codexis, Inc. | Pentose fermentation by a recombinant microorganism |
| DK2928865T3 (en) | 2012-12-07 | 2018-06-18 | Merck Sharp & Dohme | BIOCATALYTIC TRANSAMINATION PROCEDURE |
| SG11201504752YA (en) | 2012-12-21 | 2015-07-30 | Codexis Inc | Engineered biocatalysts and methods for synthesizing chiral amines |
| CN105051180B (zh) | 2013-01-18 | 2020-06-12 | 科德克希思公司 | 用于碳青霉烯类合成的工程化的生物催化剂 |
| US9617573B2 (en) | 2013-02-28 | 2017-04-11 | Codexis, Inc. | Engineered transaminase polypeptides for industrial biocatalysis |
| CN103355405A (zh) * | 2013-04-07 | 2013-10-23 | 苏州旭优食品科技有限公司 | 一种低过敏性含乳制品的加工工艺 |
| PL2986722T3 (pl) | 2013-04-18 | 2019-10-31 | Codexis Inc | Skonstruowane polipeptydy amoniakoliazy fenyloalaniny |
| CN106232619B (zh) | 2013-11-13 | 2022-09-09 | 科德克希思公司 | 工程化的亚胺还原酶和用于酮和胺化合物的还原胺化的方法 |
| EP3145536B1 (en) | 2014-04-16 | 2021-10-27 | Codexis, Inc. | Engineered tyrosine ammonia lyase |
| US9708587B2 (en) | 2014-07-09 | 2017-07-18 | Codexis, Inc. | P450-BM3 variants with improved activity |
| MA41020A (fr) | 2014-11-25 | 2017-10-03 | Evelo Biosciences Inc | Compositions probiotiques et prébiotiques, et leurs procédés d'utilisation pour la modulation du microbiome |
| CN107002050A (zh) | 2014-11-25 | 2017-08-01 | 科德克希思公司 | 工程化亚胺还原酶和用于酮和胺化合物的还原胺化的方法 |
| CA2970638A1 (en) | 2014-12-22 | 2016-06-30 | Codexis, Inc. | Human alpha-galactosidase variants |
| DK3256577T3 (da) | 2015-02-10 | 2020-09-14 | Codexis Inc | Ketoreduktase polypeptider til syntesen af chirale forbindelser |
| CN107531762A (zh) | 2015-05-07 | 2018-01-02 | 科德克希思公司 | 青霉素g酰化酶 |
| JP6691558B2 (ja) | 2015-07-07 | 2020-04-28 | コデクシス, インコーポレイテッド | 改善された活性を持つ新規のp450−bm3バリアント |
| KR102382489B1 (ko) | 2016-05-05 | 2022-04-01 | 코덱시스, 인코포레이티드 | 페니실린 g 아실라제 |
| IL263448B2 (en) | 2016-06-09 | 2023-10-01 | Codexis Inc | Biological catalysts and methods for hydroxylation of chemical compounds |
| EP3471744A4 (en) | 2016-06-15 | 2020-07-29 | Codexis, Inc. | REVISED BETA-GLUCOSIDASES AND GLUCOSYLATION PROCESSES |
| WO2018038906A1 (en) | 2016-08-26 | 2018-03-01 | Codexis, Inc. | Engineered imine reductases and methods for the reductive amination of ketone and amine compounds |
| KR102696584B1 (ko) | 2017-01-05 | 2024-08-19 | 코덱시스, 인코포레이티드 | 페니실린 g 아실라아제 |
| KR20260006703A (ko) | 2017-02-03 | 2026-01-13 | 테이트 앤드 라일 솔루션스 유에스에이 엘엘씨 | 조작된 글리코실트랜스퍼라제 및 스테비올 글리코시드 글루코실화 방법 |
| AU2018217495B2 (en) | 2017-02-13 | 2021-03-04 | Codexis, Inc. | Engineered phenylalanine ammonia lyase polypeptides |
| WO2018200517A1 (en) | 2017-04-24 | 2018-11-01 | Tesaro, Inc. | Methods of manufacturing of niraparib |
| JP7045725B2 (ja) | 2017-04-27 | 2022-04-01 | コデクシス, インコーポレイテッド | ケトレダクターゼポリペプチドおよびポリヌクレオチド |
| CA3062550A1 (en) | 2017-05-08 | 2018-11-15 | Codexis, Inc. | Engineered ligase variants |
| WO2018231462A1 (en) | 2017-06-14 | 2018-12-20 | Codexis, Inc. | Engineered transaminase polypeptides for industrial biocatalysis |
| EP3645713A4 (en) | 2017-06-27 | 2021-06-30 | Codexis, Inc. | PENICILLIN-G ACYLASES |
| JP2020530267A (ja) | 2017-06-30 | 2020-10-22 | コデクシス, インコーポレイテッド | T7 rnaポリメラーゼバリアント |
| KR102773542B1 (ko) | 2017-06-30 | 2025-02-25 | 코덱시스, 인코포레이티드 | T7 rna 폴리머라제 변이체 |
| SG11202003094PA (en) | 2017-11-07 | 2020-05-28 | Codexis Inc | Transglutaminase variants |
| AU2018383752B2 (en) | 2017-12-13 | 2025-01-30 | Codexis, Inc. | Carboxyesterase polypeptides for amide coupling |
| CN111465688A (zh) | 2017-12-13 | 2020-07-28 | 葛兰素史密斯克莱知识产权发展有限公司 | 羧酸酯酶催化剂 |
| EP3807409A4 (en) | 2018-06-12 | 2022-08-03 | Codexis, Inc. | Engineered tyrosine ammonia lyase |
| JP7461658B2 (ja) | 2018-07-09 | 2024-04-04 | コデクシス, インコーポレイテッド | 操作されたプリンヌクレオシドホスホリラーゼバリアント酵素 |
| EP3821000A4 (en) | 2018-07-09 | 2022-07-20 | Codexis, Inc. | MANIPULATED GALACTOSE OXIDASE ENZYME VARIANTS |
| JP7491588B2 (ja) | 2018-07-09 | 2024-05-28 | コデクシス, インコーポレイテッド | 操作されたパントテン酸キナーゼ改変体酵素 |
| CN112673105A (zh) | 2018-07-09 | 2021-04-16 | 科德克希思公司 | 工程化脱氧核糖磷酸醛缩酶 |
| AU2019302422B2 (en) | 2018-07-09 | 2022-08-04 | Codexis, Inc. | Engineered phosphopentomutase variant enzymes |
| EP3820833A4 (en) | 2018-07-12 | 2022-08-03 | Codexis, Inc. | MODIFIED AMMONIA-LYASE PHENYLALANINE POLYPEPTIDES |
| IL319918A (en) | 2018-07-30 | 2025-05-01 | Tate & Lyle Solutions Usa Llc | Engineered glycosyltransferases and methods for glycosylation of steviol glycoside |
| JP7780186B2 (ja) | 2018-10-29 | 2025-12-04 | コデクシス, インコーポレイテッド | 操作されたdnaポリメラーゼバリアント |
| AU2019397401A1 (en) | 2018-12-14 | 2021-06-17 | Codexis, Inc. | Engineered tyrosine ammonia lyase |
| MY207075A (en) | 2018-12-20 | 2025-01-28 | Codexis Inc | Human alpha-galactosidase variants |
| CN113396218B (zh) | 2019-01-15 | 2025-02-18 | 科德克希思公司 | 工程化转氨酶多肽 |
| US12215359B2 (en) | 2019-05-01 | 2025-02-04 | Codexis, Inc. | Engineered glucose dehydrogenases and methods for the reductive amination of ketone and amine compounds |
| EP3963057A4 (en) | 2019-05-01 | 2023-06-14 | Codexis, Inc. | MANIPULATED IMINE REDUCTASES AND METHODS FOR THE REDUCTIVE AMINATION OF KETONE AND AMINE COMPOUNDS |
| KR20220025884A (ko) | 2019-07-02 | 2022-03-03 | 코덱시스, 인코포레이티드 | 조작된 아세테이트 키나제 변이체 효소 |
| AU2020300454A1 (en) | 2019-07-02 | 2021-12-23 | Codexis, Inc. | Engineered sucrose phosphorylase variant enzymes |
| CN114144078B (zh) | 2019-07-23 | 2024-06-11 | 菲仕兰坎皮纳荷兰公司 | 包含乳脂肪和免疫球蛋白的营养组合物 |
| BR112022003705A2 (pt) | 2019-08-30 | 2022-05-24 | Codexis Inc | Lipase recombinante, composição, sequência de polinucleotídeo recombinante, vetor de expressão, composição farmacêutica para o tratamento de insuficiência pancreática, célula hospedeira, métodos para produzir uma lipase recombinante e para tratar e/ou prevenir os sintomas de insuficiência pancreática, e, uso |
| CN114760980B (zh) | 2019-09-12 | 2024-10-18 | 科德克希思公司 | 针对10-乙酰基-3,7-二羟基吩噁嗪的过氧化物酶活性 |
| JP7739271B2 (ja) | 2019-10-02 | 2025-09-16 | アボット ダイアベティス ケア インコーポレイテッド | タンパク質スイッチによる分析物の検出 |
| IL293038A (en) | 2019-11-26 | 2022-07-01 | Codexis Inc | Biocatalysts and methods for hydroxylation of chemical compounds |
| MX2022007399A (es) | 2019-12-20 | 2022-09-19 | Codexis Inc | Variantes de alfa-glucosidasa ácida diseñadas. |
| CA3161935A1 (en) | 2019-12-23 | 2021-07-01 | Mimi Lai-Kuan Tang | Oral immunotherapy comprising peanut allergens |
| EP4103711A4 (en) | 2020-02-04 | 2024-02-28 | Codexis, Inc. | Engineered leucine decarboxylases |
| CA3179679A1 (en) | 2020-04-10 | 2021-10-14 | Codexis, Inc. | Carboxyesterase polypeptides for kinetic resolution |
| US11788071B2 (en) | 2020-04-10 | 2023-10-17 | Codexis, Inc. | Engineered transaminase polypeptides |
| JP2023539634A (ja) | 2020-08-28 | 2023-09-15 | コデクシス, インコーポレイテッド | 操作されたアミラーゼバリアント |
| AU2021334371A1 (en) | 2020-08-28 | 2023-03-09 | Codexis, Inc. | Engineered protease variants |
| CN116209754A (zh) | 2020-09-28 | 2023-06-02 | 科德克希思公司 | 用于合成手性胺的工程化生物催化剂及方法 |
| CN116710558A (zh) | 2020-10-07 | 2023-09-05 | 科德克希思公司 | 工程化磷酸戊糖变位酶变体酶 |
| WO2022125960A1 (en) | 2020-12-11 | 2022-06-16 | Willow Biosciences, Inc. | Recombinant acyl activating enzyme (aae) genes for enhanced biosynthesis of cannabinoids and cannabinoid precursors |
| WO2022133289A2 (en) | 2020-12-18 | 2022-06-23 | Codexis, Inc. | Engineered uridine phosphorylase variant enzymes |
| WO2022212832A1 (en) | 2021-04-02 | 2022-10-06 | Codexis, Inc. | Engineered cyclic gmp-amp synthase (cgas) variant enzymes |
| EP4314261A1 (en) | 2021-04-02 | 2024-02-07 | Codexis, Inc. | Engineered acetate kinase variant enzymes |
| US11913037B2 (en) | 2021-04-02 | 2024-02-27 | Codexis, Inc. | Engineered adenylate kinase variant enzymes |
| IL305922A (en) | 2021-04-02 | 2023-11-01 | Codexis Inc | Transgenic enzymes of variant guanylate kinase |
| AU2022279241A1 (en) | 2021-05-21 | 2023-11-30 | Syntis Bio, Inc. | Engineered methionine gamma lyase variants |
| WO2023010083A2 (en) | 2021-07-30 | 2023-02-02 | Willow Biosciences, Inc. | Recombinant prenyltransferase polypeptides engineered for enhanced biosynthesis of cannabinoids |
| WO2023023621A1 (en) | 2021-08-19 | 2023-02-23 | Willow Biosciences, Inc. | Recombinant olivetolic acid cyclase polypeptides engineered for enhanced biosynthesis of cannabinoids |
| WO2023064938A1 (en) | 2021-10-15 | 2023-04-20 | Codexis, Inc. | Engineered dna polymerase variants |
| WO2023069865A1 (en) | 2021-10-15 | 2023-04-27 | Codexis, Inc. | Engineered terminal deoxynucleotidyl transferase variants |
| WO2023069921A1 (en) | 2021-10-19 | 2023-04-27 | Epimeron Usa, Inc. | Recombinant thca synthase polypeptides engineered for enhanced biosynthesis of cannabinoids |
| JP2024540358A (ja) | 2021-11-01 | 2024-10-31 | シンティス バイオ,インコーポレイティド | 工学操作ロイシン脱炭酸酵素 |
| JP2025510621A (ja) | 2022-03-31 | 2025-04-15 | 青島清原化合物有限公司 | モノアミン酸化酵素及びその応用 |
| WO2024040020A1 (en) | 2022-08-15 | 2024-02-22 | Absci Corporation | Quantitative affinity activity specific cell enrichment |
| IL322082A (en) | 2023-01-12 | 2025-09-01 | Novartis Ag | Engineered ketoreductase polypeptides |
| WO2025061911A1 (en) | 2023-09-22 | 2025-03-27 | Glaxosmithkline Intellectual Property Development Limited | Methods of producing nucleotide triphosphates (ntps) |
| WO2025144700A1 (en) | 2023-12-27 | 2025-07-03 | Absci Corporation | Nanobody library screening using bacterial surface display |
| WO2025235589A1 (en) | 2024-05-08 | 2025-11-13 | Codexis, Inc. | Dna polymerase variants |
| WO2025242702A1 (en) | 2024-05-23 | 2025-11-27 | Glaxosmithkline Intellectual Property Development Limited | Enzymatic process for producing n-acetyl galactosamine clusters |
| CN121450551A (zh) * | 2026-01-07 | 2026-02-03 | 善恩康生物科技(苏州)有限公司 | 具有抗炎活性的沙棘源益生菌及其在肠炎治疗中的应用和产品 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3886288A (en) * | 1970-06-15 | 1975-05-27 | Swift & Co | Cheese manufacture using highly active proteolytic enzymes |
| JPS5279086A (en) | 1975-12-25 | 1977-07-02 | Nippon Soda Co Ltd | Preparation of antibiotic tunicamycin |
| JPS5279083A (en) * | 1975-12-26 | 1977-07-02 | Morinaga Milk Industry Co Ltd | Production of protein decomposed substance not having bitterness and antigen property |
| JPS6041751B2 (ja) | 1976-06-22 | 1985-09-18 | ジエコ−株式会社 | デジタル電子時計 |
| JPS548785A (en) | 1977-06-21 | 1979-01-23 | Kikkoman Corp | Preparation of protein hydrolyzate |
| US4839281A (en) † | 1985-04-17 | 1989-06-13 | New England Medical Center Hospitals, Inc. | Lactobacillus strains and methods of selection |
| DK589785A (da) | 1985-12-18 | 1987-06-19 | Samuelsson Ernst Gunnar | Peptidpraeparat, fremgangsmaade til fremstilling deraf samt anvendelse af peptidpraeparatet |
| EP0322589B1 (fr) † | 1987-12-23 | 1993-01-20 | Societe Des Produits Nestle S.A. | Procédé de préparation d'un hydrolysat de protéines de lactosérum et d'un aliment hypoallergéniques |
| DD281540A5 (de) | 1988-08-08 | 1990-08-15 | Berlin Chemie Veb | Verfahren zur herstellung von nutritiva |
| ATE113441T1 (de) † | 1989-10-02 | 1994-11-15 | Sandoz Nutrition Ltd | Proteinhydrolysaten. |
| JP3071877B2 (ja) † | 1991-06-27 | 2000-07-31 | 財団法人糧食研究会 | 経口寛容誘導能を有する低アレルゲン性酵素分解ペプチド組成物 |
| US5952034A (en) * | 1991-10-12 | 1999-09-14 | The Regents Of The University Of California | Increasing the digestibility of food proteins by thioredoxin reduction |
| ATE161181T1 (de) * | 1992-07-06 | 1998-01-15 | Nestle Sa | Lactobacillus acidophilus enthaltende antigastritis-mittel |
| FI94089C (fi) | 1992-12-10 | 1995-07-25 | Valio Oy | Menetelmä allergiaa aiheuttavien yhdisteiden poistamiseksi proteiinipitoisista koostumuksista |
| RU2031586C1 (ru) | 1993-02-05 | 1995-03-27 | Тамара Георгиевна Извекова | Биологически активный кисломолочный продукт "ацидолакт-наринэ" и способ его получения |
| GB9312369D0 (en) | 1993-06-16 | 1993-07-28 | Sandoz Nutrition Ltd | Organic compounds |
| WO1995014485A1 (en) | 1993-11-23 | 1995-06-01 | Kabushiki Kaisha Wado Doctors Group | Intestinal flora improver composition, and apparatus and system for producing the same |
| FI104465B (fi) * | 1995-06-14 | 2000-02-15 | Valio Oy | Proteiinihydrolysaatteja allergioiden hoitamiseksi tai estämiseksi, niiden valmistus ja käyttö |
-
1995
- 1995-06-14 FI FI952926A patent/FI104465B/fi not_active IP Right Cessation
-
1996
- 1996-06-11 MY MYPI96002357A patent/MY113912A/en unknown
- 1996-06-12 JP JP50267197A patent/JP3983804B2/ja not_active Expired - Lifetime
- 1996-06-12 CZ CZ19973997A patent/CZ291904B6/cs not_active IP Right Cessation
- 1996-06-12 CA CA2224320A patent/CA2224320C/en not_active Expired - Lifetime
- 1996-06-12 DE DE69625690T patent/DE69625690T3/de not_active Expired - Lifetime
- 1996-06-12 IL IL12257796A patent/IL122577A0/xx not_active IP Right Cessation
- 1996-06-12 KR KR1019970709383A patent/KR100494741B1/ko not_active Expired - Lifetime
- 1996-06-12 RO RO97-02328A patent/RO120243B1/ro unknown
- 1996-06-12 CN CNB961947527A patent/CN1154506C/zh not_active Expired - Lifetime
- 1996-06-12 WO PCT/FI1996/000350 patent/WO1997000078A1/en not_active Ceased
- 1996-06-12 US US08/973,963 patent/US6506380B1/en not_active Expired - Lifetime
- 1996-06-12 PL PL96324010A patent/PL185123B1/pl unknown
- 1996-06-12 EE EE9700339A patent/EE03424B1/xx unknown
- 1996-06-12 NZ NZ310478A patent/NZ310478A/xx not_active IP Right Cessation
- 1996-06-12 BR BR9607827-8A patent/BR9607827A/pt not_active Application Discontinuation
- 1996-06-12 EP EP96918707A patent/EP0833649B2/en not_active Expired - Lifetime
- 1996-06-12 DK DK96918707T patent/DK0833649T4/da active
- 1996-06-12 AT AT96918707T patent/ATE230606T1/de active
- 1996-06-12 SK SK1715-97A patent/SK284245B6/sk not_active IP Right Cessation
- 1996-06-12 ES ES96918707T patent/ES2191103T5/es not_active Expired - Lifetime
- 1996-06-13 AR ARP960103134A patent/AR003960A1/es unknown
- 1996-06-14 ZA ZA965088A patent/ZA965088B/xx unknown
-
1997
- 1997-12-11 MX MX9710109A patent/MX9710109A/es unknown
- 1997-12-11 NO NO19975832A patent/NO321504B1/no not_active IP Right Cessation
- 1997-12-23 BG BG102144A patent/BG63153B1/bg unknown
-
2002
- 2002-12-18 US US10/321,661 patent/US7172756B2/en not_active Expired - Fee Related
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CA2224320C (en) | Method of promoting hypoallergenicity or tolerogenic immune response and compositions therefor | |
| Sütas et al. | Suppression of lymphocyte proliferation in vitro by bovine caseins hydrolyzed with Lactobacillus casei GG–derived enzymes | |
| AU781013B2 (en) | A hypoallergenic composition containing tolerogenic peptides inducing oral tolerance | |
| ES2966808T3 (es) | Hidrolizados de proteínas a base de leche y fórmulas para lactantes y composiciones nutricionales hechas a partir de los mismos | |
| JP2005538703A (ja) | プロバイオティクス及び経口免疫寛容 | |
| Vandenplas et al. | Symptoms, diagnosis, and treatment of cow's milk allergy | |
| ES2918577T3 (es) | Péptidos recientemente identificados para uso en la inducción de tolerancia oral | |
| Prioult et al. | Allergenicity of acidic peptides from bovine β-lactoglobulin is reduced by hydrolysis with Bifidobacterium lactis NCC362 enzymes | |
| AU2013407963A1 (en) | Newly identified peptides for use in the induction of oral tolerance in young mammals | |
| KR100575022B1 (ko) | 인터루킨-18 유도제 | |
| Heyman et al. | Hypersensitivity reaction in an infant fed hydrolyzed lactalbumin contained in a semielemental formula | |
| RU2174012C2 (ru) | Способы профилактики или лечения аллергии | |
| HK1010081B (en) | Methods of preventing or treating allergies | |
| US20230020917A1 (en) | Egg allergy preventing agent or the like, and food composition containing same | |
| CZ22359U1 (cs) | Hypoalergenní mléčný přípravek pro dospívající a dospělou populaci | |
| Kaddouri et al. | Cow’s Milk: a Food and a Potential Source of Allergens |