ES2189232T3 - Microgranulos de omeprazol protegidos gastricamente, procedimiento para su preparacion y preparaciones farmaceuticas. - Google Patents

Microgranulos de omeprazol protegidos gastricamente, procedimiento para su preparacion y preparaciones farmaceuticas.

Info

Publication number
ES2189232T3
ES2189232T3 ES98942718T ES98942718T ES2189232T3 ES 2189232 T3 ES2189232 T3 ES 2189232T3 ES 98942718 T ES98942718 T ES 98942718T ES 98942718 T ES98942718 T ES 98942718T ES 2189232 T3 ES2189232 T3 ES 2189232T3
Authority
ES
Spain
Prior art keywords
microgranules
omeprazol
gastrically
protected
procedure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES98942718T
Other languages
English (en)
Other versions
ES2189232T5 (es
Inventor
Patrice Debregeas
Gerard Leduc
Pascal Oury
Pascal Suplie
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ethypharm SAS
Original Assignee
Ethypharm SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9522415&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2189232(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ethypharm SAS filed Critical Ethypharm SAS
Publication of ES2189232T3 publication Critical patent/ES2189232T3/es
Application granted granted Critical
Publication of ES2189232T5 publication Critical patent/ES2189232T5/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants

Abstract

Microgránulos de omeprazol que comprenden cada uno una capa activa que contiene el principio activo, y una capa externa de protección gástrica que contiene un agente de protección gástrica, caracterizados porque los microgránulos están desprovistos de compuestos alcalinos en forma de sales y porque la capa activa contiene una sustancia hidrófoba.
ES98942718T 1998-01-30 1998-08-10 Microgránulos de omeprazol protegidos gástricamente, procedimiento de obtención y preparaciones farmacéuticas Expired - Lifetime ES2189232T5 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR9801098A FR2774288B1 (fr) 1998-01-30 1998-01-30 Microgranules d'omeprazole gastroproteges, procede d'obtention et preparations pharmaceutiques
FR9801098 1998-01-30
PCT/FR1998/001783 WO1999038511A1 (fr) 1998-01-30 1998-08-10 Microgranules d'omeprazole gastroproteges, procede d'obtention et preparations pharmaceutiques

Publications (2)

Publication Number Publication Date
ES2189232T3 true ES2189232T3 (es) 2003-07-01
ES2189232T5 ES2189232T5 (es) 2012-11-07

Family

ID=9522415

Family Applications (1)

Application Number Title Priority Date Filing Date
ES98942718T Expired - Lifetime ES2189232T5 (es) 1998-01-30 1998-08-10 Microgránulos de omeprazol protegidos gástricamente, procedimiento de obtención y preparaciones farmacéuticas

Country Status (32)

Country Link
US (1) US6551621B1 (es)
EP (1) EP1051174B2 (es)
JP (1) JP4286452B2 (es)
KR (1) KR100510366B1 (es)
CN (1) CN1114405C (es)
AT (1) ATE232100T1 (es)
AU (1) AU755882B2 (es)
BG (1) BG65087B1 (es)
BR (1) BR9814924B1 (es)
CA (1) CA2319015C (es)
CZ (1) CZ299192B6 (es)
DE (1) DE69811278T3 (es)
DK (1) DK1051174T4 (es)
EA (1) EA002879B1 (es)
EE (1) EE05620B1 (es)
ES (1) ES2189232T5 (es)
FR (1) FR2774288B1 (es)
GE (1) GEP20032941B (es)
HK (1) HK1032354A1 (es)
HU (1) HU229956B1 (es)
IL (1) IL137536A0 (es)
IS (1) IS2866B (es)
NO (1) NO330144B1 (es)
NZ (1) NZ505998A (es)
PL (1) PL200043B1 (es)
PT (1) PT1051174E (es)
RS (1) RS50245B (es)
SI (1) SI1051174T2 (es)
SK (1) SK285666B6 (es)
TR (1) TR200002214T2 (es)
UA (1) UA61988C2 (es)
WO (1) WO1999038511A1 (es)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2790668B1 (fr) * 1999-03-12 2002-07-26 D B F Granules contenant une substance vegetale et leur procede de preparation
FR2793688B1 (fr) * 1999-05-21 2003-06-13 Ethypharm Lab Prod Ethiques Microgranules gastroproteges, procede d'obtention et preparations pharmaceutiques
FR2845289B1 (fr) * 2002-10-04 2004-12-03 Ethypharm Sa Spheroides, procede de preparation et compositions pharmaceutiques.
US20050220870A1 (en) * 2003-02-20 2005-10-06 Bonnie Hepburn Novel formulation, omeprazole antacid complex-immediate release for rapid and sustained suppression of gastric acid
WO2004073654A2 (en) * 2003-02-20 2004-09-02 Santarus, Inc. A novel formulation, omeprazole antacid complex-immediate release for rapid and sustained supression of gastric acid
ES2234393B2 (es) * 2003-04-29 2006-09-01 Laboratorios Belmac, S.A. "formulaciones de pelets de compuestos bencimidazolicos antiulcerosos y labiles al acido".
EP1648416A4 (en) * 2003-07-18 2012-03-28 Santarus Inc PHARMACEUTICAL FORMULATIONS FOR INHIBITING THE ACIDIC ACIDIFICATION AND MANUFACTURING AND USE METHOD
US8993599B2 (en) * 2003-07-18 2015-03-31 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
CA2531566C (en) * 2003-07-18 2013-05-07 Santarus, Inc. Pharmaceutical formulation and method for treating acid-caused gastrointestinal disorders
CN1874764B (zh) * 2003-10-10 2012-08-01 埃法尔姆公司 含有银杏提取物的持续释放微粒及其制备方法
US20070292498A1 (en) * 2003-11-05 2007-12-20 Warren Hall Combinations of proton pump inhibitors, sleep aids, buffers and pain relievers
US20050249806A1 (en) * 2004-02-10 2005-11-10 Santarus, Inc. Combination of proton pump inhibitor, buffering agent, and nonsteroidal anti-inflammatory drug
CA2561700A1 (en) * 2004-04-16 2005-12-15 Santarus, Inc. Combination of proton pump inhibitor, buffering agent, and prokinetic agent
US8815916B2 (en) * 2004-05-25 2014-08-26 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
US8906940B2 (en) * 2004-05-25 2014-12-09 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
AU2005264864B2 (en) 2004-06-16 2011-08-11 Takeda Pharmaceutical Company Limited Multiple PPI dosage form
WO2007078874A2 (en) * 2005-12-30 2007-07-12 Cogentus Pharmaceuticals, Inc. Oral pharmaceutical formulations containing non-steroidal anti-inflammatory drugs and acid inhibitors
SG170826A1 (en) 2006-04-04 2011-05-30 Kg Acquisition Llc Oral dosage forms including an antiplatelet agent and an acid inhibitor
JP2009538901A (ja) * 2006-06-01 2009-11-12 デクセル ファーマ テクノロジーズ エルティーディー． 複式ユニット製薬的製剤
US20090092658A1 (en) * 2007-10-05 2009-04-09 Santarus, Inc. Novel formulations of proton pump inhibitors and methods of using these formulations
CA2667039A1 (en) * 2006-10-17 2008-04-24 Ranbaxy Laboratories Limited Multiple unit tablet compositions of benzimidazole compounds
EA028049B1 (ru) 2011-12-28 2017-10-31 Поузен Инк. Улучшенные композиции и способы доставки омепразола и ацетилсалициловой кислоты
EP3288556A4 (en) 2015-04-29 2018-09-19 Dexcel Pharma Technologies Ltd. Orally disintegrating compositions
HRP20230250T1 (hr) 2015-07-17 2023-04-14 BE Pharbel Manufacturing Višeslojni farmaceutski aktivne mikročestice, koje otpuštaju spoj u tekućem obliku doziranja
EP3117824A1 (en) 2015-07-17 2017-01-18 BE Pharbel Manufacturing Multilayered pharmaceutically active compound-releasing microparticles in a liquid dosage form
US10736855B2 (en) 2016-02-25 2020-08-11 Dexcel Pharma Technologies Ltd. Compositions comprising proton pump inhibitors
US10076494B2 (en) 2016-06-16 2018-09-18 Dexcel Pharma Technologies Ltd. Stable orally disintegrating pharmaceutical compositions
FR3078630B1 (fr) 2018-03-08 2021-05-14 Karim Ioualalen Mode de formulation sous forme de solide divise hydrophobe

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2189698A (en) 1986-04-30 1987-11-04 Haessle Ab Coated omeprazole tablets
JPH0768125B2 (ja) * 1988-05-18 1995-07-26 エーザイ株式会社 酸不安定化合物の内服用製剤
FR2692146B1 (fr) * 1992-06-16 1995-06-02 Ethypharm Sa Compositions stables de microgranules d'omeprazole gastro-protégés et leur procédé d'obtention.
SE9302396D0 (sv) * 1993-07-09 1993-07-09 Ab Astra A novel compound form
SE9402431D0 (sv) * 1994-07-08 1994-07-08 Astra Ab New tablet formulation
DE69527364T2 (de) * 1994-09-30 2003-03-13 Medical Security Corp Verfahren zum reinigen und rutschfesten behandlung von oberflächenbelägen
ES2094694B1 (es) † 1995-02-01 1997-12-16 Esteve Quimica Sa Nueva formulacion farmaceuticamente estable de un compuesto de bencimidazol y su proceso de obtencion.
CH687810A5 (de) 1995-05-24 1997-02-28 Mepha Ag Pelletformulierung mit Omeprazol.
DE69631981T2 (de) * 1995-09-21 2005-04-14 Pharma Pass Ii Llc, Irvine Lansoprazolhaltige Arzneizusammensetzung und Herstellungsverfahren
DE69729950T2 (de) * 1996-11-06 2005-07-28 Wockhardt Europe Ltd. Arzneimittel-Zuführsystem mit verzögerter Freisetzung für säurelabile Arzneistoffe
GB9710800D0 (en) 1997-05-23 1997-07-23 Cipla Limited Pharmaceutical composition and method of preparing it
SE9704870D0 (sv) * 1997-12-22 1997-12-22 Astra Ab New pharmaceutical formulation I
SE9704869D0 (sv) * 1997-12-22 1997-12-22 Astra Ab New pharmaceutical formulaton II

Also Published As

Publication number Publication date
BG104634A (bg) 2001-02-28
EA200000797A1 (ru) 2001-02-26
IS2866B (is) 2014-01-15
BR9814924B1 (pt) 2010-07-13
TR200002214T2 (tr) 2000-12-21
EE200000466A (et) 2002-04-15
EP1051174A1 (fr) 2000-11-15
NO20004654L (no) 2000-09-18
FR2774288B1 (fr) 2001-09-07
HUP0100347A2 (hu) 2001-10-28
SI1051174T1 (en) 2003-06-30
CZ20002709A3 (cs) 2000-12-13
PT1051174E (pt) 2003-06-30
DE69811278T2 (de) 2003-11-27
DE69811278T3 (de) 2012-11-29
ES2189232T5 (es) 2012-11-07
CZ299192B6 (cs) 2008-05-14
EP1051174B2 (fr) 2012-07-04
KR100510366B1 (ko) 2005-08-24
AU9074898A (en) 1999-08-16
IS5577A (is) 2000-07-25
US6551621B1 (en) 2003-04-22
SI1051174T2 (sl) 2013-01-31
BR9814924A (pt) 2000-10-17
CN1284877A (zh) 2001-02-21
ATE232100T1 (de) 2003-02-15
WO1999038511A1 (fr) 1999-08-05
JP4286452B2 (ja) 2009-07-01
NO330144B1 (no) 2011-02-21
DK1051174T4 (da) 2012-10-01
IL137536A0 (en) 2001-07-24
HUP0100347A3 (en) 2002-12-28
PL200043B1 (pl) 2008-11-28
YU48400A (sh) 2003-02-28
AU755882B2 (en) 2003-01-02
CA2319015A1 (fr) 1999-08-05
SK285666B6 (sk) 2007-05-03
JP2002501895A (ja) 2002-01-22
EP1051174B1 (fr) 2003-02-05
GEP20032941B (en) 2003-04-25
CN1114405C (zh) 2003-07-16
FR2774288A1 (fr) 1999-08-06
UA61988C2 (uk) 2003-12-15
KR20010040502A (ko) 2001-05-15
NZ505998A (en) 2003-11-28
SK11412000A3 (sk) 2001-04-09
CA2319015C (fr) 2008-08-05
RS50245B (sr) 2009-07-15
DK1051174T3 (da) 2003-05-26
DE69811278D1 (de) 2003-03-13
HK1032354A1 (en) 2001-07-20
EE05620B1 (et) 2013-02-15
EA002879B1 (ru) 2002-10-31
BG65087B1 (bg) 2007-02-28
PL342044A1 (en) 2001-05-21
NO20004654D0 (no) 2000-09-18
HU229956B1 (hu) 2015-03-02

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