EA200000797A1 - Микрогранулы омепразола, защищенные от желудочного сока, способ их получения и фармацевтические препараты - Google Patents

Микрогранулы омепразола, защищенные от желудочного сока, способ их получения и фармацевтические препараты

Info

Publication number
EA200000797A1
EA200000797A1 EA200000797A EA200000797A EA200000797A1 EA 200000797 A1 EA200000797 A1 EA 200000797A1 EA 200000797 A EA200000797 A EA 200000797A EA 200000797 A EA200000797 A EA 200000797A EA 200000797 A1 EA200000797 A1 EA 200000797A1
Authority
EA
Eurasian Patent Office
Prior art keywords
gastric juice
microgranules
omeprazol
protected
receiving
Prior art date
Application number
EA200000797A
Other languages
English (en)
Other versions
EA002879B1 (ru
Inventor
Патрис Дебрежеа
Жерар Ледюк
Паскаль Ури
Паскаль Сюпли
Original Assignee
Этифарм
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9522415&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA200000797(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Этифарм filed Critical Этифарм
Publication of EA200000797A1 publication Critical patent/EA200000797A1/ru
Publication of EA002879B1 publication Critical patent/EA002879B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants

Landscapes

  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Настоящее изобретение касается микрогранул омепразола, состоящих каждая из активного слоя, содержащего активное начало, и внешнего защищающего от желудочного сока слоя, содержащего защищающий от желудочного сока агент, отличающихся тем, что омепразол ассоциирован, по меньшей мере, с одним гидрофобным веществом.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200000797A 1998-01-30 1998-08-10 Микрогранулы омепразола, защищенные от желудочного сока, способ их получения и фармацевтические препараты EA002879B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9801098A FR2774288B1 (fr) 1998-01-30 1998-01-30 Microgranules d'omeprazole gastroproteges, procede d'obtention et preparations pharmaceutiques
PCT/FR1998/001783 WO1999038511A1 (fr) 1998-01-30 1998-08-10 Microgranules d'omeprazole gastroproteges, procede d'obtention et preparations pharmaceutiques

Publications (2)

Publication Number Publication Date
EA200000797A1 true EA200000797A1 (ru) 2001-02-26
EA002879B1 EA002879B1 (ru) 2002-10-31

Family

ID=9522415

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200000797A EA002879B1 (ru) 1998-01-30 1998-08-10 Микрогранулы омепразола, защищенные от желудочного сока, способ их получения и фармацевтические препараты

Country Status (32)

Country Link
US (1) US6551621B1 (ru)
EP (1) EP1051174B2 (ru)
JP (1) JP4286452B2 (ru)
KR (1) KR100510366B1 (ru)
CN (1) CN1114405C (ru)
AT (1) ATE232100T1 (ru)
AU (1) AU755882B2 (ru)
BG (1) BG65087B1 (ru)
BR (1) BR9814924B1 (ru)
CA (1) CA2319015C (ru)
CZ (1) CZ299192B6 (ru)
DE (1) DE69811278T3 (ru)
DK (1) DK1051174T4 (ru)
EA (1) EA002879B1 (ru)
EE (1) EE05620B1 (ru)
ES (1) ES2189232T5 (ru)
FR (1) FR2774288B1 (ru)
GE (1) GEP20032941B (ru)
HK (1) HK1032354A1 (ru)
HU (1) HU229956B1 (ru)
IL (1) IL137536A0 (ru)
IS (1) IS2866B (ru)
NO (1) NO330144B1 (ru)
NZ (1) NZ505998A (ru)
PL (1) PL200043B1 (ru)
PT (1) PT1051174E (ru)
RS (1) RS50245B (ru)
SI (1) SI1051174T2 (ru)
SK (1) SK285666B6 (ru)
TR (1) TR200002214T2 (ru)
UA (1) UA61988C2 (ru)
WO (1) WO1999038511A1 (ru)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2790668B1 (fr) * 1999-03-12 2002-07-26 D B F Granules contenant une substance vegetale et leur procede de preparation
FR2793688B1 (fr) 1999-05-21 2003-06-13 Ethypharm Lab Prod Ethiques Microgranules gastroproteges, procede d'obtention et preparations pharmaceutiques
FR2845289B1 (fr) * 2002-10-04 2004-12-03 Ethypharm Sa Spheroides, procede de preparation et compositions pharmaceutiques.
JP2006518751A (ja) * 2003-02-20 2006-08-17 サンタラス インコーポレイティッド 胃酸の急速かつ持続的な抑制のための新規製剤、オメプラゾール制酸剤複合体−即時放出物
US20050220870A1 (en) * 2003-02-20 2005-10-06 Bonnie Hepburn Novel formulation, omeprazole antacid complex-immediate release for rapid and sustained suppression of gastric acid
ES2234393B2 (es) * 2003-04-29 2006-09-01 Laboratorios Belmac, S.A. "formulaciones de pelets de compuestos bencimidazolicos antiulcerosos y labiles al acido".
US8993599B2 (en) * 2003-07-18 2015-03-31 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
TWI337877B (en) * 2003-07-18 2011-03-01 Santarus Inc Pharmaceutical formulation and method for treating acid-caused gastrointestinal disorders
TWI398273B (zh) * 2003-07-18 2013-06-11 Santarus Inc 用於抑制酸分泌之醫藥調配物及其製備及使用之方法
CA2541578C (en) * 2003-10-10 2014-03-25 Ethypharm Sustained-release microgranules containing gingko biloba extract and the process for manufacturing these
US20070292498A1 (en) * 2003-11-05 2007-12-20 Warren Hall Combinations of proton pump inhibitors, sleep aids, buffers and pain relievers
CA2554271A1 (en) * 2004-02-10 2005-08-25 Santarus, Inc. Combination of proton pump inhibitor, buffering agent, and nonsteroidal anti-inflammatory agent
MXPA06011820A (es) * 2004-04-16 2006-12-15 Santarus Inc Combinacion de inhibidor de bomba de proton, agente regulador del ph y agente procinetico.
US8815916B2 (en) * 2004-05-25 2014-08-26 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
US8906940B2 (en) * 2004-05-25 2014-12-09 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
JP5563735B2 (ja) * 2004-06-16 2014-07-30 タケダ ファーマシューティカルズ ユー．エス．エー． インコーポレイティド Ｐｐｉ多回剤形
EP1965774A2 (en) * 2005-12-30 2008-09-10 Cogentus Pharmaceuticals, Inc. Oral pharmaceutical formulations containing non-steroidal anti-inflammatory drugs and acid inhibitors
PL2007362T3 (pl) 2006-04-04 2019-02-28 Kg Acquisition Llc Doustne postacie leku obejmujące czynnik przeciwpłytkowy i inhibitor kwasu
US20100297226A1 (en) * 2006-06-01 2010-11-25 Dexcel Pharma Technologies Ltd. Multiple unit pharmaceutical formulation
US20090092658A1 (en) * 2007-10-05 2009-04-09 Santarus, Inc. Novel formulations of proton pump inhibitors and methods of using these formulations
EP2081546A2 (en) * 2006-10-17 2009-07-29 Ranbaxy Laboratories Limited Multiple unit tablet compositions of benzimidazole compounds
CN104519888A (zh) 2011-12-28 2015-04-15 波曾公司 用于递送奥美拉唑和乙酰水杨酸的改良组合物和方法
US20170042806A1 (en) 2015-04-29 2017-02-16 Dexcel Pharma Technologies Ltd. Orally disintegrating compositions
FI3324948T3 (fi) 2015-07-17 2023-05-05 Be Pharbel Mfg Monikerroksisia farmaseuttisesti aktiivista yhdistettä vapauttavia mikropartikkeleita nestemäisessä annosmuodossa
EP3117824A1 (en) 2015-07-17 2017-01-18 BE Pharbel Manufacturing Multilayered pharmaceutically active compound-releasing microparticles in a liquid dosage form
US10736855B2 (en) 2016-02-25 2020-08-11 Dexcel Pharma Technologies Ltd. Compositions comprising proton pump inhibitors
US10076494B2 (en) 2016-06-16 2018-09-18 Dexcel Pharma Technologies Ltd. Stable orally disintegrating pharmaceutical compositions
FR3078630B1 (fr) 2018-03-08 2021-05-14 Karim Ioualalen Mode de formulation sous forme de solide divise hydrophobe

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2189698A (en) 1986-04-30 1987-11-04 Haessle Ab Coated omeprazole tablets
JPH0768125B2 (ja) * 1988-05-18 1995-07-26 エーザイ株式会社 酸不安定化合物の内服用製剤
FR2692146B1 (fr) † 1992-06-16 1995-06-02 Ethypharm Sa Compositions stables de microgranules d'omeprazole gastro-protégés et leur procédé d'obtention.
SE9302396D0 (sv) * 1993-07-09 1993-07-09 Ab Astra A novel compound form
SE9402431D0 (sv) * 1994-07-08 1994-07-08 Astra Ab New tablet formulation
DE69527364T2 (de) * 1994-09-30 2003-03-13 Medical Security Corp., Portland Verfahren zum reinigen und rutschfesten behandlung von oberflächenbelägen
ES2094694B1 (es) † 1995-02-01 1997-12-16 Esteve Quimica Sa Nueva formulacion farmaceuticamente estable de un compuesto de bencimidazol y su proceso de obtencion.
CH687810A5 (de) 1995-05-24 1997-02-28 Mepha Ag Pelletformulierung mit Omeprazol.
ES2220989T3 (es) * 1995-09-21 2004-12-16 Pharma Pass Ii Llc Nueva composicion que contiene benzimidazol labil al acido y procedimiento para su preparacion.
WO1998019668A1 (en) * 1996-11-06 1998-05-14 Sharmatek, Inc. Delayed delivery system for acid-sensitive drugs
GB9710800D0 (en) 1997-05-23 1997-07-23 Cipla Limited Pharmaceutical composition and method of preparing it
SE9704869D0 (sv) * 1997-12-22 1997-12-22 Astra Ab New pharmaceutical formulaton II
SE9704870D0 (sv) * 1997-12-22 1997-12-22 Astra Ab New pharmaceutical formulation I

Also Published As

Publication number Publication date
ES2189232T3 (es) 2003-07-01
BG104634A (bg) 2001-02-28
SI1051174T1 (en) 2003-06-30
EE200000466A (et) 2002-04-15
SI1051174T2 (sl) 2013-01-31
FR2774288B1 (fr) 2001-09-07
CZ299192B6 (cs) 2008-05-14
CN1114405C (zh) 2003-07-16
HUP0100347A2 (hu) 2001-10-28
DE69811278T2 (de) 2003-11-27
BG65087B1 (bg) 2007-02-28
EP1051174B2 (fr) 2012-07-04
IS5577A (is) 2000-07-25
KR100510366B1 (ko) 2005-08-24
WO1999038511A1 (fr) 1999-08-05
HUP0100347A3 (en) 2002-12-28
JP4286452B2 (ja) 2009-07-01
SK285666B6 (sk) 2007-05-03
NO20004654L (no) 2000-09-18
TR200002214T2 (tr) 2000-12-21
IL137536A0 (en) 2001-07-24
US6551621B1 (en) 2003-04-22
EP1051174B1 (fr) 2003-02-05
UA61988C2 (ru) 2003-12-15
DK1051174T3 (da) 2003-05-26
DE69811278D1 (de) 2003-03-13
HK1032354A1 (en) 2001-07-20
DE69811278T3 (de) 2012-11-29
PL200043B1 (pl) 2008-11-28
PT1051174E (pt) 2003-06-30
ATE232100T1 (de) 2003-02-15
KR20010040502A (ko) 2001-05-15
CZ20002709A3 (cs) 2000-12-13
SK11412000A3 (sk) 2001-04-09
NO20004654D0 (no) 2000-09-18
BR9814924A (pt) 2000-10-17
CN1284877A (zh) 2001-02-21
DK1051174T4 (da) 2012-10-01
FR2774288A1 (fr) 1999-08-06
GEP20032941B (en) 2003-04-25
IS2866B (is) 2014-01-15
EP1051174A1 (fr) 2000-11-15
RS50245B (sr) 2009-07-15
CA2319015C (fr) 2008-08-05
NZ505998A (en) 2003-11-28
JP2002501895A (ja) 2002-01-22
ES2189232T5 (es) 2012-11-07
CA2319015A1 (fr) 1999-08-05
HU229956B1 (hu) 2015-03-02
AU755882B2 (en) 2003-01-02
EA002879B1 (ru) 2002-10-31
BR9814924B1 (pt) 2010-07-13
EE05620B1 (et) 2013-02-15
NO330144B1 (no) 2011-02-21
PL342044A1 (en) 2001-05-21
AU9074898A (en) 1999-08-16
YU48400A (sh) 2003-02-28

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MK4A Patent expired

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