DE69811278T2 - Gegen magensaft geschützte omeprazol-mikrogranülen, herstellungsverfahren und pharmazeutische zubereitungen - Google Patents

Gegen magensaft geschützte omeprazol-mikrogranülen, herstellungsverfahren und pharmazeutische zubereitungen

Info

Publication number
DE69811278T2
DE69811278T2 DE69811278T DE69811278T DE69811278T2 DE 69811278 T2 DE69811278 T2 DE 69811278T2 DE 69811278 T DE69811278 T DE 69811278T DE 69811278 T DE69811278 T DE 69811278T DE 69811278 T2 DE69811278 T2 DE 69811278T2
Authority
DE
Germany
Prior art keywords
manufacturing process
pharmaceutical preparations
gastric juice
omeprazole microgranules
microgranules
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69811278T
Other languages
English (en)
Other versions
DE69811278D1 (de
DE69811278T3 (de
Inventor
Patrice Debregeas
Gerard Leduc
Pascal Oury
Pascal Suplie
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ETHYPHARM MADRID
Ethypharm SAS
Original Assignee
ETHYPHARM MADRID
Ethypharm SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9522415&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69811278(T2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by ETHYPHARM MADRID, Ethypharm SAS filed Critical ETHYPHARM MADRID
Publication of DE69811278D1 publication Critical patent/DE69811278D1/de
Publication of DE69811278T2 publication Critical patent/DE69811278T2/de
Application granted granted Critical
Publication of DE69811278T3 publication Critical patent/DE69811278T3/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants

Landscapes

  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE69811278T 1998-01-30 1998-08-10 Gegen magensaft geschützte omeprazol-mikrogranülen, herstellungsverfahren und pharmazeutische zubereitungen Expired - Lifetime DE69811278T3 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
FR9801098A FR2774288B1 (fr) 1998-01-30 1998-01-30 Microgranules d'omeprazole gastroproteges, procede d'obtention et preparations pharmaceutiques
FR9801098 1998-01-30
EP98942718A EP1051174B2 (de) 1998-01-30 1998-08-10 Gegen magensaft geschützte omeprazol-mikrogranülen, herstellungsverfahren und pharmazeutische zubereitungen
PCT/FR1998/001783 WO1999038511A1 (fr) 1998-01-30 1998-08-10 Microgranules d'omeprazole gastroproteges, procede d'obtention et preparations pharmaceutiques

Publications (3)

Publication Number Publication Date
DE69811278D1 DE69811278D1 (de) 2003-03-13
DE69811278T2 true DE69811278T2 (de) 2003-11-27
DE69811278T3 DE69811278T3 (de) 2012-11-29

Family

ID=9522415

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69811278T Expired - Lifetime DE69811278T3 (de) 1998-01-30 1998-08-10 Gegen magensaft geschützte omeprazol-mikrogranülen, herstellungsverfahren und pharmazeutische zubereitungen

Country Status (32)

Country Link
US (1) US6551621B1 (de)
EP (1) EP1051174B2 (de)
JP (1) JP4286452B2 (de)
KR (1) KR100510366B1 (de)
CN (1) CN1114405C (de)
AT (1) ATE232100T1 (de)
AU (1) AU755882B2 (de)
BG (1) BG65087B1 (de)
BR (1) BR9814924B1 (de)
CA (1) CA2319015C (de)
CZ (1) CZ299192B6 (de)
DE (1) DE69811278T3 (de)
DK (1) DK1051174T4 (de)
EA (1) EA002879B1 (de)
EE (1) EE05620B1 (de)
ES (1) ES2189232T5 (de)
FR (1) FR2774288B1 (de)
GE (1) GEP20032941B (de)
HK (1) HK1032354A1 (de)
HU (1) HU229956B1 (de)
IL (1) IL137536A0 (de)
IS (1) IS2866B (de)
NO (1) NO330144B1 (de)
NZ (1) NZ505998A (de)
PL (1) PL200043B1 (de)
PT (1) PT1051174E (de)
RS (1) RS50245B (de)
SI (1) SI1051174T2 (de)
SK (1) SK285666B6 (de)
TR (1) TR200002214T2 (de)
UA (1) UA61988C2 (de)
WO (1) WO1999038511A1 (de)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2790668B1 (fr) * 1999-03-12 2002-07-26 D B F Granules contenant une substance vegetale et leur procede de preparation
FR2793688B1 (fr) * 1999-05-21 2003-06-13 Ethypharm Lab Prod Ethiques Microgranules gastroproteges, procede d'obtention et preparations pharmaceutiques
FR2845289B1 (fr) * 2002-10-04 2004-12-03 Ethypharm Sa Spheroides, procede de preparation et compositions pharmaceutiques.
WO2004073654A2 (en) * 2003-02-20 2004-09-02 Santarus, Inc. A novel formulation, omeprazole antacid complex-immediate release for rapid and sustained supression of gastric acid
US20050220870A1 (en) * 2003-02-20 2005-10-06 Bonnie Hepburn Novel formulation, omeprazole antacid complex-immediate release for rapid and sustained suppression of gastric acid
ES2234393B2 (es) * 2003-04-29 2006-09-01 Laboratorios Belmac, S.A. "formulaciones de pelets de compuestos bencimidazolicos antiulcerosos y labiles al acido".
AR045062A1 (es) * 2003-07-18 2005-10-12 Santarus Inc Formulaciones farmaceuticas para inhibir la secrecion de acido y metodos para preparar y utilizarlas
TWI337877B (en) * 2003-07-18 2011-03-01 Santarus Inc Pharmaceutical formulation and method for treating acid-caused gastrointestinal disorders
US8993599B2 (en) * 2003-07-18 2015-03-31 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
CN1874764B (zh) * 2003-10-10 2012-08-01 埃法尔姆公司 含有银杏提取物的持续释放微粒及其制备方法
US20070292498A1 (en) * 2003-11-05 2007-12-20 Warren Hall Combinations of proton pump inhibitors, sleep aids, buffers and pain relievers
WO2005076987A2 (en) * 2004-02-10 2005-08-25 Santarus, Inc. Combination of proton pump inhibitor, buffering agent, and nonsteroidal anti-inflammatory agent
US20050239845A1 (en) * 2004-04-16 2005-10-27 Santarus, Inc. Combination of proton pump inhibitor, buffering agent, and prokinetic agent
US8815916B2 (en) * 2004-05-25 2014-08-26 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
US8906940B2 (en) * 2004-05-25 2014-12-09 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
AU2005264864B2 (en) * 2004-06-16 2011-08-11 Takeda Pharmaceutical Company Limited Multiple PPI dosage form
US20070154542A1 (en) * 2005-12-30 2007-07-05 Cogentus Pharmaceuticals, Inc. Oral pharmaceutical formulations containing non-steroidal anti-inflammatory drugs and acid inhibitors
MX349787B (es) 2006-04-04 2017-08-11 Kg Acquisition Llc Formas de dosis oral que incluyen un agente antiplaqueta y un inhibidor de ácido.
JP2009538901A (ja) * 2006-06-01 2009-11-12 デクセル ファーマ テクノロジーズ エルティーディー． 複式ユニット製薬的製剤
US20090092658A1 (en) * 2007-10-05 2009-04-09 Santarus, Inc. Novel formulations of proton pump inhibitors and methods of using these formulations
BRPI0717613A2 (pt) * 2006-10-17 2013-10-22 Ranbaxy Lab Ltd Composição em comprimido de múltiplas unidades, processo para o preparo do mesmo e método para inibir a secreção de ácido gástrico
BR112014016085A8 (pt) 2011-12-28 2017-07-04 Pozen Inc composições aprimoradas e métodos para distribuição de omeprazol mais ácido acetilsalicílico
EP3288556A4 (de) 2015-04-29 2018-09-19 Dexcel Pharma Technologies Ltd. Oral zerfallende zusammensetzungen
CN108348475B (zh) 2015-07-17 2022-01-04 比利时法贝尔制造股份有限公司 处于液体剂型的多层药学活性化合物释放微粒
EP3117824A1 (de) 2015-07-17 2017-01-18 BE Pharbel Manufacturing Mehrschichtige mikropartikel zur freigabe einer pharmazeutisch aktiven verbindung in einer flüssigen verabreichungsform
US10736855B2 (en) 2016-02-25 2020-08-11 Dexcel Pharma Technologies Ltd. Compositions comprising proton pump inhibitors
US10076494B2 (en) 2016-06-16 2018-09-18 Dexcel Pharma Technologies Ltd. Stable orally disintegrating pharmaceutical compositions
FR3078630B1 (fr) 2018-03-08 2021-05-14 Karim Ioualalen Mode de formulation sous forme de solide divise hydrophobe

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2189698A (en) 1986-04-30 1987-11-04 Haessle Ab Coated omeprazole tablets
JPH0768125B2 (ja) * 1988-05-18 1995-07-26 エーザイ株式会社 酸不安定化合物の内服用製剤
FR2692146B1 (fr) * 1992-06-16 1995-06-02 Ethypharm Sa Compositions stables de microgranules d'omeprazole gastro-protégés et leur procédé d'obtention.
SE9302396D0 (sv) * 1993-07-09 1993-07-09 Ab Astra A novel compound form
SE9402431D0 (sv) * 1994-07-08 1994-07-08 Astra Ab New tablet formulation
EP0785984B1 (de) * 1994-09-30 2002-07-10 Medical Security Corporation Verfahren zum reinigen und rutschfesten behandlung von oberflächenbelägen
ES2094694B1 (es) † 1995-02-01 1997-12-16 Esteve Quimica Sa Nueva formulacion farmaceuticamente estable de un compuesto de bencimidazol y su proceso de obtencion.
CH687810A5 (de) 1995-05-24 1997-02-28 Mepha Ag Pelletformulierung mit Omeprazol.
DK1092434T3 (da) * 1995-09-21 2004-07-26 Pharma Pass Ii Llc Hidtil ukendt sammensætning indeholdende lansoprazol og fremgangsmåde til fremstilling deraf
ZA979937B (en) * 1996-11-06 1999-05-18 Sharmatek Inc Delayed delivery system for acid-sensitive drugs
GB9710800D0 (en) * 1997-05-23 1997-07-23 Cipla Limited Pharmaceutical composition and method of preparing it
SE9704870D0 (sv) * 1997-12-22 1997-12-22 Astra Ab New pharmaceutical formulation I
SE9704869D0 (sv) * 1997-12-22 1997-12-22 Astra Ab New pharmaceutical formulaton II

Also Published As

Publication number Publication date
ES2189232T3 (es) 2003-07-01
NO330144B1 (no) 2011-02-21
EP1051174B1 (de) 2003-02-05
WO1999038511A1 (fr) 1999-08-05
IS2866B (is) 2014-01-15
PL342044A1 (en) 2001-05-21
DK1051174T4 (da) 2012-10-01
KR100510366B1 (ko) 2005-08-24
KR20010040502A (ko) 2001-05-15
CZ20002709A3 (cs) 2000-12-13
EP1051174B2 (de) 2012-07-04
CA2319015C (fr) 2008-08-05
EE200000466A (et) 2002-04-15
SK285666B6 (sk) 2007-05-03
TR200002214T2 (tr) 2000-12-21
AU9074898A (en) 1999-08-16
SI1051174T2 (sl) 2013-01-31
DE69811278D1 (de) 2003-03-13
HK1032354A1 (en) 2001-07-20
EE05620B1 (et) 2013-02-15
RS50245B (sr) 2009-07-15
BG104634A (bg) 2001-02-28
IL137536A0 (en) 2001-07-24
CA2319015A1 (fr) 1999-08-05
BG65087B1 (bg) 2007-02-28
DE69811278T3 (de) 2012-11-29
JP4286452B2 (ja) 2009-07-01
NO20004654L (no) 2000-09-18
BR9814924A (pt) 2000-10-17
CN1284877A (zh) 2001-02-21
SI1051174T1 (en) 2003-06-30
JP2002501895A (ja) 2002-01-22
FR2774288B1 (fr) 2001-09-07
NZ505998A (en) 2003-11-28
SK11412000A3 (sk) 2001-04-09
CN1114405C (zh) 2003-07-16
US6551621B1 (en) 2003-04-22
EA200000797A1 (ru) 2001-02-26
AU755882B2 (en) 2003-01-02
ES2189232T5 (es) 2012-11-07
CZ299192B6 (cs) 2008-05-14
BR9814924B1 (pt) 2010-07-13
PL200043B1 (pl) 2008-11-28
HUP0100347A2 (hu) 2001-10-28
HU229956B1 (hu) 2015-03-02
UA61988C2 (uk) 2003-12-15
YU48400A (sh) 2003-02-28
NO20004654D0 (no) 2000-09-18
FR2774288A1 (fr) 1999-08-06
DK1051174T3 (da) 2003-05-26
EP1051174A1 (de) 2000-11-15
ATE232100T1 (de) 2003-02-15
EA002879B1 (ru) 2002-10-31
GEP20032941B (en) 2003-04-25
HUP0100347A3 (en) 2002-12-28
IS5577A (is) 2000-07-25
PT1051174E (pt) 2003-06-30

Similar Documents

Publication Publication Date Title
DE69811278D1 (de) Gegen magensaft geschützte omeprazol-mikrogranülen, herstellungsverfahren und pharmazeutische zubereitungen
NO995313D0 (no) Mikroartikler nyttige som ultrasoniske kontrastmidler og til levering av legemidler i blodbanen
ID26340A (id) Kapsul ganda dengan penggunaan bahan-bahan aktif dalam berbagai macam pengobatan
DE69918310D1 (de) Tablette mit verzögerter freigabe enthaltend einen blutzuckersenkenden wirkstoff und einen antihyperglyzemischen wirkstoff
DE60228281D1 (de) Darreichungsformen mit kern und äusserer hülle
TR199500832A2 (tr) Benzimidazol türevleri ve bunlarin medikal terapide kullanimi ve bunlari iceren farmasötik formülasyonlar.
EE05506B1 (et) Ravimi manustamise vahend eriti progestiinide ja”strogeenide manustamiseks
DE69813602D1 (de) Venlafaxinhaltiges arzneimittel mit verlängerter wirkstoffabgabe
DE59804823D1 (de) Arzneimittelformulierung mit kontrollierter wirkstofffreisetzung
DE69919490D1 (de) Puder mit fettlöslichem wirkstoff
DE60037816D1 (de) Pharmazeutische formulierung enthaltend megalatran und dessen pro-pharmaka
DE60004815D1 (de) Gegen magensaft geschützte omeprazol-mikrogranülen, herstellungsverfahren und pharmazeutische zubereitungen
ATE290854T1 (de) Carbamazepinformulierung mit verzögerter freigabe
DE69941825D1 (de) Arzneistoffhaltiger kaugummi, dessen herstellungsverfahren und so erhaltene tablette
PT1221845E (pt) Combinacoes de substancias activas com caracteristicas insecticidas e acaricidas
HUP0104238A3 (en) Benzoxazole derivatives and drugs containing the same as the active ingredient and their use
DE69914472D1 (de) Levosimendanhaltige oral anzuwendende arzneimittel mit gesteuerter wirkstoffverabreichung
AU2001262699A1 (en) Biologically active agents and drugs
HUP0301119A3 (en) Biologically active agent and drug
DE69513632D1 (de) Mikrogranulate enthaltend 5-nitroimidazolderivate
EP0995758A4 (de) Physiologisch aktive polyoxypeptine und deoxypolyoxypeptine sowie diese enthaltende krebsmittel
EE9900562A (et) Ravimimanustusvahendid ja meetodid viirus- ning mikroobsete infektsioonide ja kurnatusesündroomi raviks
FI981129A0 (fi) Diagnostinen menetelmä, reagenssipakkaus, lääke ja terapeuttinen käsittely

Legal Events

Date Code Title Description
8363 Opposition against the patent