ES2145077T3 - Vacuna contra la enfermedad de lyme. - Google Patents
Vacuna contra la enfermedad de lyme.Info
- Publication number
- ES2145077T3 ES2145077T3 ES94112144T ES94112144T ES2145077T3 ES 2145077 T3 ES2145077 T3 ES 2145077T3 ES 94112144 T ES94112144 T ES 94112144T ES 94112144 T ES94112144 T ES 94112144T ES 2145077 T3 ES2145077 T3 ES 2145077T3
- Authority
- ES
- Spain
- Prior art keywords
- burgdorferi
- agreement
- ecacc
- antigeno
- obtaining
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 229960005486 vaccine Drugs 0.000 title abstract 3
- 208000016604 Lyme disease Diseases 0.000 title abstract 2
- 241000589969 Borreliella burgdorferi Species 0.000 abstract 5
- 239000000427 antigen Substances 0.000 abstract 3
- 102000036639 antigens Human genes 0.000 abstract 3
- 108091007433 antigens Proteins 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 3
- 244000052769 pathogen Species 0.000 abstract 2
- 230000001717 pathogenic effect Effects 0.000 abstract 2
- 101001086191 Borrelia burgdorferi Outer surface protein A Proteins 0.000 abstract 1
- 206010062746 Carditis Diseases 0.000 abstract 1
- -1 GANISM Species 0.000 abstract 1
- 241001465754 Metazoa Species 0.000 abstract 1
- 239000008186 active pharmaceutical agent Substances 0.000 abstract 1
- 206010003246 arthritis Diseases 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 208000006454 hepatitis Diseases 0.000 abstract 1
- 231100000283 hepatitis Toxicity 0.000 abstract 1
- 230000008105 immune reaction Effects 0.000 abstract 1
- 238000002955 isolation Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/20—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Spirochaetales (O), e.g. Treponema, Leptospira
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
- C07K16/1203—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria
- C07K16/1207—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria from Spirochaetales (O), e.g. Treponema, Leptospira
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Virology (AREA)
- Microbiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicinal Preparation (AREA)
- Saccharide Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
LA INVENCION SE REFIERE A UNA VACUNA PASIVA CONTRA LA ENFERMEDAD DE LYME, QUE CONTIENE UNO O MULTIPLES ANTICUERPOS MONOCLONALES ESPECIFICOS DEL B. BURGDORFERI PARA EL 31 KD ANTIGENO (OSPA) Y/O EL 34 KD ANTIGENO (OSPB) Y EN ANIMALES DE INVESTIGACION INMUNODEFICIENTES, QUE SON INFECTADOS CON EL ORGANISMO B. BURGDORFERI PATOGENO CON CAPACIDAD DE VIDA, PARA EVITAR LA FORMACION DE ARTRITIS, PANCARDITIS Y HEPATITIS. LA INVENCION SE REFIERE ADEMAS A UN PROCEDIMIENTO PARA LA OBTENCION DE LAS VACUNAS DE ACUERDO CON LA INVENCION, COMO HIBRIDOMAZELLINIEN ECACC 89 09 1302, ECACC 90050405, ECACC 90050406 Y ECACC 90050407, QUE SEGREGAN ANTICUERPOS DE ACUERDO CON LA INVENCION Y EL TRONCO ZS7 (DSM 5527) DEL B. BURGDORFERI PATOGENO. EVENTUALMENTE EL OBJETO DE LA INVENCION ES UN ANTIGENO A PARTIR DEL B. BURGDORFERI, QUE POSEE REACCION INMUNE CON UN ANTICUERPO DE ACUERDO CON LA INVENCION, UN PROCESO PARA LA OBTENCION DE LOS ANTIGENOS DE ACUERDO CON LA INVENCION, ASI COMO VACUNAS ACTIVAS CONTRA LA ENFERMEDAD DE LYME, CONTENIENDO ANTIGENOS DE ACUERDO CON LA INVENCION COMO COMPONENTE ESENCIAL. LA INVENCION SE REFIERE FINALMENTE A UN PROCESO PARA EL AISLAMIENTO Y RECULTIVO DEL ORGANISMO B. BURGDORFERI PATOGENO A PARTIR DE ANIMALES DE INVESTIGACION INMUNODEFICIENTES.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE3931236 | 1989-09-19 | ||
DE4015911A DE4015911A1 (de) | 1989-09-19 | 1990-05-17 | Impfstoff gegen die lyme-krankheit |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2145077T3 true ES2145077T3 (es) | 2000-07-01 |
Family
ID=25885304
Family Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES90117943T Expired - Lifetime ES2082812T3 (es) | 1989-09-19 | 1990-09-18 | Vacuna contra la enfermedad de lyme. |
ES94112144T Expired - Lifetime ES2145077T3 (es) | 1989-09-19 | 1990-09-18 | Vacuna contra la enfermedad de lyme. |
ES94112143T Expired - Lifetime ES2129551T3 (es) | 1989-09-19 | 1990-09-18 | Vacuna contra la enfermedad de lyme. |
ES94112145T Expired - Lifetime ES2141182T3 (es) | 1989-09-19 | 1990-09-18 | Vacuna contra la enfermedad de lyme. |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES90117943T Expired - Lifetime ES2082812T3 (es) | 1989-09-19 | 1990-09-18 | Vacuna contra la enfermedad de lyme. |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES94112143T Expired - Lifetime ES2129551T3 (es) | 1989-09-19 | 1990-09-18 | Vacuna contra la enfermedad de lyme. |
ES94112145T Expired - Lifetime ES2141182T3 (es) | 1989-09-19 | 1990-09-18 | Vacuna contra la enfermedad de lyme. |
Country Status (24)
Country | Link |
---|---|
US (6) | US5178859A (es) |
EP (5) | EP0633313B1 (es) |
JP (3) | JP3205932B2 (es) |
KR (2) | KR100205462B1 (es) |
AT (4) | ATE131732T1 (es) |
AU (1) | AU651560B2 (es) |
CA (1) | CA2025597C (es) |
CZ (2) | CZ284538B6 (es) |
DE (5) | DE4015911A1 (es) |
DK (4) | DK0633028T3 (es) |
ES (4) | ES2082812T3 (es) |
FI (1) | FI102248B (es) |
GR (3) | GR3018995T3 (es) |
HK (2) | HK1002405A1 (es) |
HR (1) | HRP940545B1 (es) |
HU (2) | HU212716B (es) |
IE (1) | IE903377A1 (es) |
NO (2) | NO311767B1 (es) |
NZ (1) | NZ235260A (es) |
PL (2) | PL169804B1 (es) |
PT (1) | PT95349B (es) |
SI (1) | SI9011773B (es) |
SK (3) | SK456090A3 (es) |
YU (2) | YU48250B (es) |
Families Citing this family (45)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK590288D0 (da) | 1988-10-24 | 1988-10-24 | Symbicom Ab | Kemiske forbindelser |
WO1993008306A1 (en) * | 1991-10-22 | 1993-04-29 | Symbicom Aktiebolag | Improvement in borrelia burgdorferi diagnosis and prophylaxis |
US5777095A (en) * | 1988-10-24 | 1998-07-07 | Symbicom Aktiebolag | Osp A and B Sequence of Borrelia burgdonferi strains ACA1 and IP90 |
US6143872A (en) * | 1988-10-24 | 2000-11-07 | Symbicom Aktiebolag | Borrelia burdorferi Osp A and B proteins and immunogenic peptides |
US7094391B1 (en) * | 1988-10-24 | 2006-08-22 | The University Of Texas System | Compositions and methods for administering Borrelia burgdorferi antigens |
DE4015911A1 (de) * | 1989-09-19 | 1991-03-28 | Max Planck Gesellschaft | Impfstoff gegen die lyme-krankheit |
US5582829A (en) * | 1990-04-05 | 1996-12-10 | Rx Technologies, Inc. | Sonicated borrelia burgdorferi vaccine |
CA2084413A1 (en) | 1990-06-15 | 1991-12-16 | Richard A. Flavell | Compositions and methods for the prevention and diagnosis of lyme disease |
DK0465204T3 (da) * | 1990-07-06 | 2000-10-09 | American Home Prod | Vaccine mod Lyme sygdom |
CA2057536C (en) * | 1990-12-21 | 1999-10-26 | John J. Dunn | Cloning and expression of borrelia lipoproteins |
US6221363B1 (en) * | 1991-07-11 | 2001-04-24 | Baxter Aktiengesellschaft | Vaccine for the prevention of lyme disease |
US6872550B1 (en) | 1991-07-11 | 2005-03-29 | Baxter Vaccine Ag | Immunogenic formulation of OspC antigen vaccines for the prevention and treatment of lyme disease and recombinant methods for the preparation of such antigens |
EP0874051A3 (en) * | 1991-08-15 | 1998-11-04 | SMITHKLINE BEECHAM BIOLOGICALS s.a. | OSP a protein of borrelia burgdorferi subgroups, encoding genes and vaccines. |
US6676942B1 (en) * | 1991-08-15 | 2004-01-13 | Smithkline Beecham Biologicals (S.A.) | Osp a proteins of Borrelia burgdorferi subgroups, encoding genes and vaccines |
JPH06511154A (ja) * | 1991-10-18 | 1994-12-15 | コノート ラボラトリーズ インコーポレイテッド | 組換えBorreliaタンパクの製造法 |
US6303129B1 (en) * | 1992-07-28 | 2001-10-16 | Rx Technologies | Production of borrelia burgdorferi vaccine, product produced thereby and method of use |
US6716591B1 (en) | 1993-07-30 | 2004-04-06 | Yale University | B. burgdorferi polypeptides |
US5656451A (en) * | 1993-07-30 | 1997-08-12 | Yale University | OspE, OspF, and S1 polypeptides in borrelia burgdorferi |
US7008625B2 (en) | 1993-11-01 | 2006-03-07 | Research Foundation Of The State University Of New York | Recombinant constructs of Borrelia burgdorferi |
US5558993A (en) * | 1994-06-17 | 1996-09-24 | The Regents Of The University Of California | Cloned Borrelia burgdorferi virulence protein |
GB9511909D0 (en) * | 1995-06-12 | 1995-08-09 | Microbiological Res Authority | Vaccine |
EP0894143B2 (en) | 1996-02-21 | 2012-04-18 | Board Of Regents, The University Of Texas System | Vmp-like sequences of pathogenic borrelia |
DE19632862B4 (de) | 1996-08-14 | 2006-08-03 | Mikrogen Molekularbiologische Entwicklungs-Gmbh | Immunologisch aktive Proteine von Borrelia burgdorferi, dafür kodierende Nukleinsäuren sowie deren Verwendung in Testkits und als Impfstoffe |
US6458555B1 (en) * | 1996-08-21 | 2002-10-01 | Gerd Bach | Cytologic method of examining mucous membranes |
US6060082A (en) * | 1997-04-18 | 2000-05-09 | Massachusetts Institute Of Technology | Polymerized liposomes targeted to M cells and useful for oral or mucosal drug delivery |
DE19740735A1 (de) * | 1997-09-16 | 1999-03-18 | Max Planck Gesellschaft | Arzneimittel zur Therapie einer manifesten Lyme-Borreliose |
US6306623B1 (en) | 1998-02-24 | 2001-10-23 | The University Of California | Leptospiral major outer membrane protein LipL32 |
ATE386805T1 (de) | 1998-07-31 | 2008-03-15 | Gundersen Lutheran Medical Fou | Verwendungen eines borreliaziden epitops des aussermembranproteins c von borrelia burgdorferi (ospc) als impstoff |
WO2000056298A2 (en) * | 1999-03-19 | 2000-09-28 | Luitpold Pharmaceuticals, Inc. | Treatment of lyme disease with polysulfated glycosaminoglycan formulations |
WO2000078345A1 (en) * | 1999-06-21 | 2000-12-28 | Milkhaus Laboratory, Inc. | Method for treatment of lyme disease |
WO2002016421A2 (en) | 2000-08-18 | 2002-02-28 | Research Foundation Of The State University Of New York | Altered ospa of borrelia burgdorferi |
US7847084B2 (en) | 2002-12-20 | 2010-12-07 | Board Of Regents, The University Of Texas System | VMP-like sequences of pathogenic Borrelia species and strains |
NZ576564A (en) | 2006-11-03 | 2012-03-30 | Schering Plough Ltd | Canine lyme disease vaccine |
WO2008116468A2 (en) | 2007-03-26 | 2008-10-02 | Dako Denmark A/S | Mhc peptide complexes and uses thereof in infectious diseases |
EP2167537A2 (en) | 2007-07-03 | 2010-03-31 | Dako Denmark A/S | Compiled methods for analysing and sorting samples |
US10611818B2 (en) | 2007-09-27 | 2020-04-07 | Agilent Technologies, Inc. | MHC multimers in tuberculosis diagnostics, vaccine and therapeutics |
US10968269B1 (en) | 2008-02-28 | 2021-04-06 | Agilent Technologies, Inc. | MHC multimers in borrelia diagnostics and disease |
WO2010009735A2 (en) | 2008-07-23 | 2010-01-28 | Dako Denmark A/S | Combinatorial analysis and repair |
GB0817244D0 (en) | 2008-09-20 | 2008-10-29 | Univ Cardiff | Use of a protein kinase inhibitor to detect immune cells, such as T cells |
US11992518B2 (en) | 2008-10-02 | 2024-05-28 | Agilent Technologies, Inc. | Molecular vaccines for infectious disease |
US10369204B2 (en) | 2008-10-02 | 2019-08-06 | Dako Denmark A/S | Molecular vaccines for infectious disease |
AU2010322085B2 (en) * | 2009-11-17 | 2016-09-15 | Zoetis Services Llc | Peptides and methods for the detection of Lyme disease antibodies |
US8758772B2 (en) | 2011-11-04 | 2014-06-24 | Abaxis, Inc. | Peptides and methods for the detection of lyme disease antibodies |
PL223175B1 (pl) | 2012-10-22 | 2016-10-31 | Inst Chemii Bioorganicznej Polskiej Akademii Nauk | Szczepionka przeciw boreliozie, konstrukt genetyczny, rekombinowane białko, sposób otrzymywania konstruktu genetycznego, sposób otrzymywania szczepionki, sposób otrzymywania rekombinowanych białek, zastosowanie rekombinowanych białek do wytwarzania szczepionki przeciwko boreliozie |
US9610336B1 (en) * | 2014-07-16 | 2017-04-04 | Amiram Katz | Immunotherapy for lyme disease |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK590288D0 (da) * | 1988-10-24 | 1988-10-24 | Symbicom Ab | Kemiske forbindelser |
US4772464A (en) | 1985-08-01 | 1988-09-20 | Miles Laboratories, Inc. | Protective antibodies to serotypic determinants of flagellar antigens |
US4888276A (en) * | 1986-06-26 | 1989-12-19 | Minnesota Mining And Manufacturing Company | Method and composition for the diagnosis of Lyme disease |
US4721617A (en) | 1986-08-14 | 1988-01-26 | Regents Of The University Of Minnesota | Vaccine against lyme disease |
US5034515A (en) * | 1987-09-22 | 1991-07-23 | Wisconsin Alumni Research Foundation | Staphylococcal fibronectin receptor, monoclonal antibodies thereto and methods of use |
DE4015911A1 (de) * | 1989-09-19 | 1991-03-28 | Max Planck Gesellschaft | Impfstoff gegen die lyme-krankheit |
ES2092560T5 (es) * | 1989-12-22 | 2004-09-16 | Mikrogen Molekularbiologische Entwicklungs-Gmbh | Proteinas inmunologicamente activas de borrelia burgdorferi, estuches de ensayo relacionados y vacuna. |
CA2084413A1 (en) * | 1990-06-15 | 1991-12-16 | Richard A. Flavell | Compositions and methods for the prevention and diagnosis of lyme disease |
DK0465204T3 (da) * | 1990-07-06 | 2000-10-09 | American Home Prod | Vaccine mod Lyme sygdom |
CA2057536C (en) * | 1990-12-21 | 1999-10-26 | John J. Dunn | Cloning and expression of borrelia lipoproteins |
EP0874051A3 (en) * | 1991-08-15 | 1998-11-04 | SMITHKLINE BEECHAM BIOLOGICALS s.a. | OSP a protein of borrelia burgdorferi subgroups, encoding genes and vaccines. |
ATE174378T1 (de) * | 1991-08-27 | 1998-12-15 | Novo Nordisk As | Waschmittelzusammensetzungen |
JPH06511154A (ja) * | 1991-10-18 | 1994-12-15 | コノート ラボラトリーズ インコーポレイテッド | 組換えBorreliaタンパクの製造法 |
JPH07502646A (ja) * | 1991-10-21 | 1995-03-23 | メディミューン,インコーポレーテッド | リポタンパク質の分泌シグナルをコード化するdnaを含む細菌発現ベクター |
-
1990
- 1990-05-17 DE DE4015911A patent/DE4015911A1/de not_active Withdrawn
- 1990-09-07 HU HU905816A patent/HU212716B/hu not_active IP Right Cessation
- 1990-09-11 NZ NZ235260A patent/NZ235260A/xx unknown
- 1990-09-12 AU AU62444/90A patent/AU651560B2/en not_active Ceased
- 1990-09-18 DE DE59010888T patent/DE59010888D1/de not_active Expired - Fee Related
- 1990-09-18 PL PL90286918A patent/PL169804B1/pl not_active IP Right Cessation
- 1990-09-18 EP EP94112144A patent/EP0633313B1/de not_active Expired - Lifetime
- 1990-09-18 DE DE59010863T patent/DE59010863D1/de not_active Expired - Fee Related
- 1990-09-18 DE DE59009978T patent/DE59009978D1/de not_active Expired - Fee Related
- 1990-09-18 EP EP94112145A patent/EP0633028B1/de not_active Expired - Lifetime
- 1990-09-18 AT AT90117943T patent/ATE131732T1/de not_active IP Right Cessation
- 1990-09-18 DK DK94112145T patent/DK0633028T3/da active
- 1990-09-18 EP EP98105444A patent/EP0861664A3/de not_active Withdrawn
- 1990-09-18 EP EP94112143A patent/EP0643974B1/de not_active Expired - Lifetime
- 1990-09-18 DK DK90117943.2T patent/DK0418827T3/da active
- 1990-09-18 DK DK94112143T patent/DK0643974T3/da active
- 1990-09-18 ES ES90117943T patent/ES2082812T3/es not_active Expired - Lifetime
- 1990-09-18 IE IE337790A patent/IE903377A1/en not_active IP Right Cessation
- 1990-09-18 FI FI904597A patent/FI102248B/fi not_active IP Right Cessation
- 1990-09-18 PL PL90307358A patent/PL170229B1/pl not_active IP Right Cessation
- 1990-09-18 AT AT94112143T patent/ATE175576T1/de not_active IP Right Cessation
- 1990-09-18 DK DK94112144T patent/DK0633313T3/da active
- 1990-09-18 ES ES94112144T patent/ES2145077T3/es not_active Expired - Lifetime
- 1990-09-18 NO NO19904062A patent/NO311767B1/no unknown
- 1990-09-18 YU YU177390A patent/YU48250B/sh unknown
- 1990-09-18 AT AT94112145T patent/ATE186646T1/de not_active IP Right Cessation
- 1990-09-18 DE DE59010903T patent/DE59010903D1/de not_active Expired - Fee Related
- 1990-09-18 CA CA002025597A patent/CA2025597C/en not_active Expired - Fee Related
- 1990-09-18 EP EP90117943A patent/EP0418827B1/de not_active Expired - Lifetime
- 1990-09-18 ES ES94112143T patent/ES2129551T3/es not_active Expired - Lifetime
- 1990-09-18 ES ES94112145T patent/ES2141182T3/es not_active Expired - Lifetime
- 1990-09-18 AT AT94112144T patent/ATE191499T1/de not_active IP Right Cessation
- 1990-09-18 SI SI9011773A patent/SI9011773B/sl not_active IP Right Cessation
- 1990-09-19 JP JP24765090A patent/JP3205932B2/ja not_active Expired - Fee Related
- 1990-09-19 SK SK4560-90A patent/SK456090A3/sk unknown
- 1990-09-19 PT PT95349A patent/PT95349B/pt active IP Right Grant
- 1990-09-19 CZ CS904560A patent/CZ284538B6/cs not_active IP Right Cessation
- 1990-09-19 SK SK1511-98A patent/SK283089B6/sk unknown
- 1990-09-19 KR KR1019900014814A patent/KR100205462B1/ko not_active IP Right Cessation
- 1990-09-19 US US07/585,310 patent/US5178859A/en not_active Expired - Lifetime
- 1990-09-19 CZ CZ95970A patent/CZ284616B6/cs not_active IP Right Cessation
- 1990-09-19 SK SK1510-98A patent/SK283088B6/sk unknown
-
1993
- 1993-05-27 US US08/068,063 patent/US5434077A/en not_active Expired - Fee Related
-
1994
- 1994-09-15 HR HR940545A patent/HRP940545B1/xx not_active IP Right Cessation
-
1995
- 1995-03-20 US US08/406,623 patent/US5780030A/en not_active Expired - Fee Related
- 1995-03-20 US US08/407,350 patent/US5686267A/en not_active Expired - Lifetime
- 1995-04-24 HU HU95P/P00108P patent/HU211228A9/hu unknown
-
1996
- 1996-02-14 GR GR960400397T patent/GR3018995T3/el unknown
-
1997
- 1997-03-12 YU YU9097A patent/YU49370B/sh unknown
-
1998
- 1998-02-13 HK HK98101147A patent/HK1002405A1/xx not_active IP Right Cessation
- 1998-02-23 US US09/027,843 patent/US5856447A/en not_active Expired - Fee Related
- 1998-08-29 KR KR1019980035375A patent/KR100202128B1/ko not_active IP Right Cessation
- 1998-12-23 HK HK98114958A patent/HK1013620A1/xx not_active IP Right Cessation
-
1999
- 1999-10-07 US US09/413,858 patent/US6613331B1/en not_active Expired - Fee Related
- 1999-11-30 GR GR990403104T patent/GR3032010T3/el unknown
-
2000
- 2000-06-14 GR GR20000401362T patent/GR3033675T3/el not_active IP Right Cessation
- 2000-07-26 JP JP2000225341A patent/JP3328644B2/ja not_active Expired - Fee Related
- 2000-12-11 JP JP2000376159A patent/JP3418171B2/ja not_active Expired - Fee Related
-
2001
- 2001-09-24 NO NO20014624A patent/NO315905B1/no unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES2145077T3 (es) | Vacuna contra la enfermedad de lyme. | |
Alderete et al. | Identification and properties of Trichomonas vaginalis proteins involved in cytadherence | |
Burgdorfer et al. | Rhipicephalus sanguineus: vector of a new spotted fever group rickettsia in the United States | |
ES2065303T5 (es) | Procedimiento de diagnosis y vacuna especifica. | |
ECSP055551A (es) | Composiciones de vacunas que contienen arreglos de antígeno amiloide beta 1-6 | |
MX9203605A (es) | Proteina receptora de ctla4 codificada por secuencia de amino acido. | |
Bockenstedt et al. | What ticks do under your skin: two-photon intravital imaging of Ixodes scapularis feeding in the presence of the lyme disease spirochete | |
Esser et al. | Trypanosoma rhodesiense blood forms express all antigen specificities relevant to protection against metacyclic (insect form) challenge. | |
DE69132417T2 (de) | Impfstoff gegen die Lyme-Krankheit | |
AU2017272265B2 (en) | Enhancing immunity to tuberculosis | |
ES2126145T3 (es) | Redireccionamiento de anticuerpos. | |
ATE508139T1 (de) | Synthetische peptid-hiv-vakzine: das cbd-epitop als effizientes immunogen zur induktion hiv- neutralisierender antikörper | |
DE69030099T2 (de) | Verfahren zur herstellung von impfstoffen oder toxoiden | |
DE69031426T2 (de) | Impfstoff zur immunisierung von katzen gegen toxoplasmen ohne verbreitung der oozysten | |
DE69333730D1 (de) | Impfstoff, der acemannan als adjuvans enthält | |
ATE151994T1 (de) | Aufspüren und behandeln von infektionen durch verwendung von immunokonjukaten | |
US20170008954A1 (en) | Monoclonal Antibodies that Modulate Immunity to MTB and Enhance Immune Clearance | |
Wilson | Immunological aspects of bovine trypanosomiasis: III. Patterns in the development of immunity | |
Gardiner et al. | Further studies of cyclical transmission and antigenic variation of the ILDar 1 serodeme of Trypanosoma vivax | |
ES2090331T3 (es) | Ctaa 28a32, antigeno reconocido por mca 28a32. | |
ES2056780T1 (es) | Un procedimiento para el aislamiento de virus de hav. | |
ATE138269T1 (de) | Zweiphasensystem zur herstellung und präsentation von fremdantigenen in hybriden lebendimpfstoffen | |
Fuenzalida et al. | Production of hyperimmune antirabies serum in horses | |
Saphra et al. | A New Salmonella Type: S. Virginia. | |
EA200500480A1 (ru) | Иммунизация против аутологичного грелина |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
Ref document number: 633313 Country of ref document: ES |