DE69030099T2 - Verfahren zur herstellung von impfstoffen oder toxoiden - Google Patents
Verfahren zur herstellung von impfstoffen oder toxoidenInfo
- Publication number
- DE69030099T2 DE69030099T2 DE69030099T DE69030099T DE69030099T2 DE 69030099 T2 DE69030099 T2 DE 69030099T2 DE 69030099 T DE69030099 T DE 69030099T DE 69030099 T DE69030099 T DE 69030099T DE 69030099 T2 DE69030099 T2 DE 69030099T2
- Authority
- DE
- Germany
- Prior art keywords
- toxoid
- colonized
- pathogenic
- vaccine
- producing vaccine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 229960005486 vaccine Drugs 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- 230000001717 pathogenic effect Effects 0.000 abstract 4
- 239000000427 antigen Substances 0.000 abstract 2
- 102000036639 antigens Human genes 0.000 abstract 2
- 108091007433 antigens Proteins 0.000 abstract 2
- 244000005700 microbiome Species 0.000 abstract 2
- 108020004511 Recombinant DNA Proteins 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000028993 immune response Effects 0.000 abstract 1
- 230000003053 immunization Effects 0.000 abstract 1
- 238000002649 immunization Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 244000052769 pathogen Species 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
- C12N15/746—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for lactic acid bacteria (Streptococcus; Lactococcus; Lactobacillus; Pediococcus; Enterococcus; Leuconostoc; Propionibacterium; Bifidobacterium; Sporolactobacillus)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/036—Fusion polypeptide containing a localisation/targetting motif targeting to the medium outside of the cell, e.g. type III secretion
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/16011—Herpesviridae
- C12N2710/16611—Simplexvirus, e.g. human herpesvirus 1, 2
- C12N2710/16622—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/225—Lactobacillus
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Virology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Tropical Medicine & Parasitology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/430,491 US5149532A (en) | 1989-11-01 | 1989-11-01 | Method of vaccine or toxoid preparation and immunization by colonization with recombinant microorganisms |
PCT/US1990/004988 WO1991006654A1 (en) | 1989-11-01 | 1990-08-30 | A method of vaccine or toxoid preparation and immunization by colonization with recombinant microorganisms |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69030099D1 DE69030099D1 (de) | 1997-04-10 |
DE69030099T2 true DE69030099T2 (de) | 1997-07-31 |
Family
ID=23707776
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69030099T Expired - Fee Related DE69030099T2 (de) | 1989-11-01 | 1990-08-30 | Verfahren zur herstellung von impfstoffen oder toxoiden |
Country Status (8)
Country | Link |
---|---|
US (1) | US5149532A (de) |
EP (1) | EP0498804B1 (de) |
JP (1) | JPH05501401A (de) |
AT (1) | ATE149569T1 (de) |
CA (1) | CA2072657A1 (de) |
DE (1) | DE69030099T2 (de) |
ES (1) | ES2100893T3 (de) |
WO (1) | WO1991006654A1 (de) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6737521B1 (en) * | 1990-05-11 | 2004-05-18 | The Rockefeller University | Delivery and expression of a hybrid surface protein on the surface of gram positive bacteria |
GB2261372A (en) * | 1991-11-15 | 1993-05-19 | Gregor Reid | Lactobacillus and skim milk compositions for prevention of urogenital infection |
DK0652758T3 (da) * | 1992-06-18 | 2000-05-08 | Harvard College | Diferitoxin-vacciner |
US6455673B1 (en) | 1994-06-08 | 2002-09-24 | President And Fellows Of Harvard College | Multi-mutant diphtheria toxin vaccines |
AU774535B2 (en) * | 1995-10-20 | 2004-07-01 | Actogenix Nv | Delivery of biologically active polypeptides |
GB9521568D0 (en) * | 1995-10-20 | 1995-12-20 | Lynxvale Ltd | Delivery of biologically active polypeptides |
US7780961B2 (en) * | 2001-05-03 | 2010-08-24 | Actogenix N.V. | Self-containing Lactococcus strain |
DE60319822T2 (de) * | 2002-06-19 | 2009-06-04 | Actogenix Nv | Verfahren und mittel zur erhöhung der darmabsorption |
CA2506031A1 (en) * | 2002-11-15 | 2004-06-03 | Vib Vzw | Self-containing lactobacillus strain comprising a thya mutation and therapeutic applications thereof |
RU2420569C2 (ru) | 2005-11-29 | 2011-06-10 | Актогеникс Нв | Индукция толерантности к антигенам через слизистую |
EP2774621B1 (de) | 2007-01-25 | 2018-01-24 | Intrexon Actobiotics NV | Behandlung von Immunerkrankungen durch mukosale Abgabe von Antigenen |
PT2850431T (pt) | 2012-05-16 | 2018-07-23 | Immune Design Corp | Vacinas para hsv-2 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1338705C (en) * | 1981-10-22 | 1996-11-12 | Roy Curtiss Iii | Vaccines obtained from antigenic gene products of recombinant genes |
US4888170A (en) * | 1981-10-22 | 1989-12-19 | Research Corporation | Vaccines obtained from antigenic gene products of recombinant genes |
PT77014B (en) * | 1982-07-20 | 1986-01-24 | Molecular Genetics Inc | Production of herpes simplex viral proteins |
EP0175699A4 (de) * | 1984-02-01 | 1988-06-13 | Enterovax Res Pty Ltd | Bakterielle stämme. |
NL8503316A (nl) * | 1985-11-29 | 1987-06-16 | Stichting Nl I Zuivelonderzoek | Werkwijze voor het bereiden van proteinen met behulp van gastheer-organismen, in het bijzonder melkzuurbacterien, welke recombinant dna-plasmiden met een hoge replicon-aktiviteit en een hoge promotor-aktiviteit voor het betreffende proteine-coderende gen bevatten, de van dergelijke recombinant dna-plasmiden voorziene gastheerorganismen, de recombinant dna-plasmiden zelve, de replicon-aktiviteit en promotor-aktiviteit coderende dna-fragmenten, alsmede de verkregen proteinen. |
EP0319690A1 (de) * | 1987-11-24 | 1989-06-14 | Nisshin Flour Milling Co., Ltd. | Verfahren zum Einbringen von Fremd-DNA in bestimmten Bakterien |
-
1989
- 1989-11-01 US US07/430,491 patent/US5149532A/en not_active Expired - Fee Related
-
1990
- 1990-08-30 DE DE69030099T patent/DE69030099T2/de not_active Expired - Fee Related
- 1990-08-30 AT AT90914003T patent/ATE149569T1/de not_active IP Right Cessation
- 1990-08-30 CA CA002072657A patent/CA2072657A1/en not_active Abandoned
- 1990-08-30 EP EP90914003A patent/EP0498804B1/de not_active Expired - Lifetime
- 1990-08-30 JP JP2513027A patent/JPH05501401A/ja active Pending
- 1990-08-30 WO PCT/US1990/004988 patent/WO1991006654A1/en active IP Right Grant
- 1990-08-30 ES ES90914003T patent/ES2100893T3/es not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
ES2100893T3 (es) | 1997-07-01 |
WO1991006654A1 (en) | 1991-05-16 |
EP0498804B1 (de) | 1997-03-05 |
DE69030099D1 (de) | 1997-04-10 |
CA2072657A1 (en) | 1991-05-02 |
US5149532A (en) | 1992-09-22 |
ATE149569T1 (de) | 1997-03-15 |
JPH05501401A (ja) | 1993-03-18 |
EP0498804A1 (de) | 1992-08-19 |
EP0498804A4 (en) | 1992-12-09 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |