ATE109004T1 - Toleranzinduktion gegenüber einem fremdantigen. - Google Patents

Toleranzinduktion gegenüber einem fremdantigen.

Info

Publication number
ATE109004T1
ATE109004T1 AT89907436T AT89907436T ATE109004T1 AT E109004 T1 ATE109004 T1 AT E109004T1 AT 89907436 T AT89907436 T AT 89907436T AT 89907436 T AT89907436 T AT 89907436T AT E109004 T1 ATE109004 T1 AT E109004T1
Authority
AT
Austria
Prior art keywords
antigen
foreign antigen
tolerance induction
mammal
receptor
Prior art date
Application number
AT89907436T
Other languages
English (en)
Inventor
Terry B Strom
Vicki E Kelley
Original Assignee
Beth Israel Hospital
Brigham & Womens Hospital
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beth Israel Hospital, Brigham & Womens Hospital filed Critical Beth Israel Hospital
Application granted granted Critical
Publication of ATE109004T1 publication Critical patent/ATE109004T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/642—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the peptide or protein in the drug conjugate being a cytokine, e.g. IL2, chemokine, growth factors or interferons being the inactive part of the conjugate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Electrical Discharge Machining, Electrochemical Machining, And Combined Machining (AREA)
  • Fittings On The Vehicle Exterior For Carrying Loads, And Devices For Holding Or Mounting Articles (AREA)
  • Peptides Or Proteins (AREA)
  • Manufacturing Of Steel Electrode Plates (AREA)
AT89907436T 1988-05-19 1989-05-18 Toleranzinduktion gegenüber einem fremdantigen. ATE109004T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US19603688A 1988-05-19 1988-05-19

Publications (1)

Publication Number Publication Date
ATE109004T1 true ATE109004T1 (de) 1994-08-15

Family

ID=22723875

Family Applications (1)

Application Number Title Priority Date Filing Date
AT89907436T ATE109004T1 (de) 1988-05-19 1989-05-18 Toleranzinduktion gegenüber einem fremdantigen.

Country Status (6)

Country Link
EP (1) EP0414816B1 (de)
JP (1) JPH03504248A (de)
AT (1) ATE109004T1 (de)
CA (1) CA1340494C (de)
DE (1) DE68917138T2 (de)
WO (1) WO1989011287A1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5152980A (en) * 1988-05-19 1992-10-06 The Beth Israel Hospital Association Induction of tolerance to a foreign antigen IL-2 receptor-binding substances
EP0537229A1 (de) * 1990-07-05 1993-04-21 Akzo Nobel N.V. Gegen rezeptoren gerichtete toxin-konjugate
AU1643692A (en) * 1991-03-07 1992-10-06 Seragen, Inc. Use of cell surface receptor targeted molecules for the treatment of viral diseases
PL217296B1 (pl) 2002-11-15 2014-07-31 Genmab As Wyizolowane ludzkie przeciwciało monoklonalne, wytwarzająca je hybrydoma, kodujący to przeciwciało wektor ekspresyjny i zawierająca je kompozycja farmaceutyczna, immunokoniugat, bispecyficzna lub multispecyficzna cząsteczka obejmująca kwasy nukleinowe kodujące ciężki i lekki łańcuch transfektoma, ich zastosowania, zwłaszcza w medycynie, obejmująca te kwasy ex vivo eukariotyczna lub prokariotyczna komórka gospodarza oraz nie będące człowiekiem zwierzę transgeniczne lub roślina, sposób in vitro hamowania wzrostu i/lub proliferacji komórek wyrażających CD25 lub eliminowania komórek wyrażających CD25, sposób wykrywania w próbce obecności antygenu CD25 lub komórki wyrażającej CD25, zestaw diagnostyczny do wykrywania w próbce obecności antygenu CD25 lub komórki wyrażającej CD25
KR102430891B1 (ko) * 2016-03-10 2022-08-09 더 존스 홉킨스 유니버시티 응집체-비함유 단량체성 디프테리아 독소 융합 단백질의 제조 방법 및 치료적 용도
US11965009B2 (en) 2016-03-10 2024-04-23 The Johns Hopkins University Methods of producing aggregate-free monomeric diphtheria toxin fusion proteins and therapeutic uses
US11203626B2 (en) 2016-03-10 2021-12-21 The Johns Hopkins University Methods of producing aggregate-free monomeric diphtheria toxin fusion proteins and therapeutic uses

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0108146B1 (de) * 1982-05-12 1987-01-28 The President And Fellows Of Harvard College Hybridproteinekodierende fusionierte Gene, sie enthaltende Klonierungsvektoren und deren Verwendung
US4545985A (en) * 1984-01-26 1985-10-08 The United States Of America As Represented By The Secretary, Dept. Of Health And Human Services Pseudomonas exotoxin conjugate immunotoxins
US4681760A (en) * 1985-04-17 1987-07-21 The Board Of Trustees Of The Leland Stanford Junior University Method of conferring immunotolerance to a specific antigen
GB8608068D0 (en) * 1986-04-02 1986-05-08 Cobbold S P Monoclonal antibodies

Also Published As

Publication number Publication date
JPH03504248A (ja) 1991-09-19
EP0414816A1 (de) 1991-03-06
EP0414816B1 (de) 1994-07-27
DE68917138T2 (de) 1995-02-23
WO1989011287A1 (en) 1989-11-30
CA1340494C (en) 1999-04-13
EP0414816A4 (en) 1991-11-13
DE68917138D1 (de) 1994-09-01

Similar Documents

Publication Publication Date Title
ZA91559B (en) Vaccines against cancer and infectious diseases
EP0109942A3 (en) Immunogenic protein or peptide complex, method of producing said complex and the use thereof as an immune stimulant and as a vaccine
DE3679708D1 (de) Verfahren zur verleihung von immuntoleranz gegen ein spezifisches antigen.
FI873141A (fi) Daeggdjurs interleukin-4.
DK543488A (da) Midler til stimulering af et pattedyrs immunreaktion over for gnrh samt et modificeret gnrh og en vaccine til inhibering af et pattedyrs reproduktionsevne
FI852683A0 (fi) Immunisk motverkan foer tumoerer och virus.
AU1013601A (en) Method of inducing and/or enhancing an immune response to tumor antigens
FI854257L (fi) Orala vacciner.
FR2522967B1 (fr) Conjugues d'haptenes et de muramyl-peptides, doues d'activite immunogene et compositions les contenant
NZ189756A (en) Muramyl peptides antigens covalently bonded to muramyl-peptides medicaments and vaccines
RU93004915A (ru) Липосомы, осуществляющие тимус-зависимую помощь "слабым" антигенам, используемым для приготовления вакцины
IT1198289B (it) Antigene di flavvirus
ATE109004T1 (de) Toleranzinduktion gegenüber einem fremdantigen.
AU1308288A (en) Method to stimulate the immune response to specific antigens
FI932759A0 (fi) Anvaendningen av IL-4 foer oekning av pao vacciners immunogener verkande immunreaktioner
GB2020665A (en) Acyl-N-acetylmuramylpeptide- antigen conjugate
KR890701743A (ko) B형 간염 표면 항원 백신
EP0254845A3 (de) Immun-Stimulation mit Chondroitin-sulfat
PT636030E (pt) Vacina de bacterina-toxoide de pasteurella haemolytica tipo a-1
ATE162724T1 (de) Impfstoff gegen schweinedysenterie mit vermindertem gehalt an proteinuntereinheit
PT87001A (pt) Processo para a preparacao de uma vacina contra a disenteria suina e fins analogos
ES2011679A6 (es) Procedimiento para la preparacion de polipeptidos sinteticos secuenc iales inmunologicamente activos.
DE68926294D1 (de) Antigen gegen diabetes
FR2608926B1 (fr) Antigene de babesia divergens, procede pour le produire et vaccin le contenant
IT1254147B (it) Metodo di rivelazione di marcatori tumorali.

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee