DE68917138D1 - Toleranzinduktion gegenüber einem fremdantigen. - Google Patents
Toleranzinduktion gegenüber einem fremdantigen.Info
- Publication number
- DE68917138D1 DE68917138D1 DE68917138T DE68917138T DE68917138D1 DE 68917138 D1 DE68917138 D1 DE 68917138D1 DE 68917138 T DE68917138 T DE 68917138T DE 68917138 T DE68917138 T DE 68917138T DE 68917138 D1 DE68917138 D1 DE 68917138D1
- Authority
- DE
- Germany
- Prior art keywords
- antigen
- foreignant
- tolerance induction
- mammal
- receptor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/642—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the peptide or protein in the drug conjugate being a cytokine, e.g. IL2, chemokine, growth factors or interferons being the inactive part of the conjugate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Electrical Discharge Machining, Electrochemical Machining, And Combined Machining (AREA)
- Fittings On The Vehicle Exterior For Carrying Loads, And Devices For Holding Or Mounting Articles (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Manufacturing Of Steel Electrode Plates (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US19603688A | 1988-05-19 | 1988-05-19 | |
| PCT/US1989/002166 WO1989011287A1 (en) | 1988-05-19 | 1989-05-18 | Induction of tolerance to a foreign antigen |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE68917138D1 true DE68917138D1 (de) | 1994-09-01 |
| DE68917138T2 DE68917138T2 (de) | 1995-02-23 |
Family
ID=22723875
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE68917138T Expired - Fee Related DE68917138T2 (de) | 1988-05-19 | 1989-05-18 | Toleranzinduktion gegenüber einem fremdantigen. |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP0414816B1 (de) |
| JP (1) | JPH03504248A (de) |
| AT (1) | ATE109004T1 (de) |
| CA (1) | CA1340494C (de) |
| DE (1) | DE68917138T2 (de) |
| WO (1) | WO1989011287A1 (de) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5152980A (en) * | 1988-05-19 | 1992-10-06 | The Beth Israel Hospital Association | Induction of tolerance to a foreign antigen IL-2 receptor-binding substances |
| AU657910B2 (en) * | 1990-07-05 | 1995-03-30 | Akzo N.V. | Receptor directed-toxin conjugates |
| WO1992015318A1 (en) * | 1991-03-07 | 1992-09-17 | Seragen, Inc. | Use of cell surface receptor targeted molecules for the treatment of viral diseases |
| WO2004045512A2 (en) | 2002-11-15 | 2004-06-03 | Genmab A/S | Human monoclonal antibodies against cd25 |
| US11965009B2 (en) | 2016-03-10 | 2024-04-23 | The Johns Hopkins University | Methods of producing aggregate-free monomeric diphtheria toxin fusion proteins and therapeutic uses |
| US11203626B2 (en) | 2016-03-10 | 2021-12-21 | The Johns Hopkins University | Methods of producing aggregate-free monomeric diphtheria toxin fusion proteins and therapeutic uses |
| US10988512B2 (en) * | 2016-03-10 | 2021-04-27 | The Johns Hopkins University | Methods of producing aggregate-free monomeric diphtheria toxin fusion proteins and therapeutic uses |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU573529B2 (en) * | 1982-05-12 | 1988-06-16 | President And Fellows Of Harvard College | Hybrid proteins |
| US4545985A (en) * | 1984-01-26 | 1985-10-08 | The United States Of America As Represented By The Secretary, Dept. Of Health And Human Services | Pseudomonas exotoxin conjugate immunotoxins |
| US4681760A (en) * | 1985-04-17 | 1987-07-21 | The Board Of Trustees Of The Leland Stanford Junior University | Method of conferring immunotolerance to a specific antigen |
| GB8608068D0 (en) * | 1986-04-02 | 1986-05-08 | Cobbold S P | Monoclonal antibodies |
-
1989
- 1989-05-18 EP EP89907436A patent/EP0414816B1/de not_active Expired - Lifetime
- 1989-05-18 AT AT89907436T patent/ATE109004T1/de not_active IP Right Cessation
- 1989-05-18 CA CA000600100A patent/CA1340494C/en not_active Expired - Fee Related
- 1989-05-18 JP JP1506819A patent/JPH03504248A/ja active Pending
- 1989-05-18 WO PCT/US1989/002166 patent/WO1989011287A1/en active IP Right Grant
- 1989-05-18 DE DE68917138T patent/DE68917138T2/de not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| ATE109004T1 (de) | 1994-08-15 |
| WO1989011287A1 (en) | 1989-11-30 |
| JPH03504248A (ja) | 1991-09-19 |
| EP0414816B1 (de) | 1994-07-27 |
| EP0414816A4 (en) | 1991-11-13 |
| CA1340494C (en) | 1999-04-13 |
| DE68917138T2 (de) | 1995-02-23 |
| EP0414816A1 (de) | 1991-03-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |