RU93004915A - Липосомы, осуществляющие тимус-зависимую помощь "слабым" антигенам, используемым для приготовления вакцины - Google Patents
Липосомы, осуществляющие тимус-зависимую помощь "слабым" антигенам, используемым для приготовления вакциныInfo
- Publication number
- RU93004915A RU93004915A RU93004915/14A RU93004915A RU93004915A RU 93004915 A RU93004915 A RU 93004915A RU 93004915/14 A RU93004915/14 A RU 93004915/14A RU 93004915 A RU93004915 A RU 93004915A RU 93004915 A RU93004915 A RU 93004915A
- Authority
- RU
- Russia
- Prior art keywords
- liposomes
- antigenes
- thymus
- weak
- implementing
- Prior art date
Links
- 239000002502 liposome Substances 0.000 title claims 4
- 229960005486 vaccines Drugs 0.000 title 1
- 239000000427 antigen Substances 0.000 claims 3
- 102000038129 antigens Human genes 0.000 claims 3
- 108091007172 antigens Proteins 0.000 claims 3
- 150000002632 lipids Chemical class 0.000 claims 2
- 230000002209 hydrophobic Effects 0.000 claims 1
- 230000028993 immune response Effects 0.000 claims 1
- 230000003993 interaction Effects 0.000 claims 1
- 239000000463 material Substances 0.000 claims 1
Claims (1)
- Иммунный ответ на целевой антиген может быть усилен путем введения антигена в липосому вместе с дополнительным компонентом, содержащим по крайней мере один сайт узнавания Т - лимфоцита - хелпера. Липосомы могут включать в себя липидные материалы широкого ряда. Антиген и компонент, содержащий сайт узнавания Т - лимфоцита - хелпера, могут быть ассоциированы с липосомой посредством гидрофобных взаимодействий или ковалентного связывания с липидом.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US55896090A | 1990-07-27 | 1990-07-27 | |
US558,960 | 1990-07-27 | ||
US558960 | 1990-07-27 | ||
PCT/US1991/005231 WO1992002243A1 (en) | 1990-07-27 | 1991-07-24 | Liposomes that provide thymic dependent help to weak vaccine antigens |
Publications (2)
Publication Number | Publication Date |
---|---|
RU93004915A true RU93004915A (ru) | 1996-02-20 |
RU2107493C1 RU2107493C1 (ru) | 1998-03-27 |
Family
ID=24231699
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU93004915A RU2107493C1 (ru) | 1990-07-27 | 1991-07-24 | Липосомы, осуществляющие тимус-зависимую помощь "слабым" антигенам, используемым для приготовления вакцины |
Country Status (22)
Country | Link |
---|---|
US (1) | US5464630A (ru) |
EP (1) | EP0542923B1 (ru) |
JP (1) | JP3518866B2 (ru) |
KR (1) | KR100213851B1 (ru) |
CN (1) | CN1032236C (ru) |
AT (1) | ATE157537T1 (ru) |
AU (1) | AU650299B2 (ru) |
CA (1) | CA2088163C (ru) |
DE (1) | DE69127545T2 (ru) |
DK (1) | DK0542923T3 (ru) |
ES (1) | ES2106088T3 (ru) |
FI (1) | FI107515B (ru) |
GR (1) | GR3025377T3 (ru) |
HK (1) | HK1008304A1 (ru) |
IE (1) | IE912535A1 (ru) |
IL (1) | IL98935A (ru) |
NO (1) | NO311167B1 (ru) |
NZ (1) | NZ239072A (ru) |
PT (1) | PT98470B (ru) |
RU (1) | RU2107493C1 (ru) |
WO (1) | WO1992002243A1 (ru) |
ZA (1) | ZA915755B (ru) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5879685A (en) * | 1991-05-08 | 1999-03-09 | Schweiz, Serum- & Impfinstitut Bern | Immunostimulating and immunopotentiating reconstituted influenza virosomes and vaccines containing them |
US6004534A (en) * | 1993-07-23 | 1999-12-21 | Massachusetts Institute Of Technology | Targeted polymerized liposomes for improved drug delivery |
WO1996007102A1 (en) * | 1994-09-01 | 1996-03-07 | Wisconsin Alumni Research Foundation | Therapeutic remodeling in aids |
US6060082A (en) * | 1997-04-18 | 2000-05-09 | Massachusetts Institute Of Technology | Polymerized liposomes targeted to M cells and useful for oral or mucosal drug delivery |
AUPO732997A0 (en) * | 1997-06-12 | 1997-07-03 | Csl Limited | Ganglioside immunostimulating complexes and uses thereof |
US5993852A (en) * | 1997-08-29 | 1999-11-30 | Pharmaderm Laboratories Ltd. | Biphasic lipid vesicle composition for transdermal administration of an immunogen |
US6027731A (en) * | 1998-11-17 | 2000-02-22 | Wisconsin Alumni Research Foundation | Pertussis toxin induced lymphocytosis |
JP4685350B2 (ja) * | 2001-07-26 | 2011-05-18 | オタゴ イノベイション リミティド | 抗原性組成物 |
JP2009510032A (ja) * | 2005-09-30 | 2009-03-12 | リポクセン テクノロジーズ リミテッド | 多糖抗原及びタンパク質アジュバントを含む多価リポソームワクチン組成物 |
RU2480479C1 (ru) * | 2011-11-01 | 2013-04-27 | Елена Викторовна Свирщевская | Гетерологичный пептидный мини-антиген в составе полимерной частицы для создания противоаллергенной вакцины |
DK2800762T3 (en) | 2012-01-03 | 2018-04-16 | Us Health | NATIVE AND AGONISTIC CTL EPITOPES OF THE MUC1 TUMOR ANTIGEN |
EP3412304A3 (en) | 2013-10-23 | 2019-03-20 | The United States of America, as represented by The Secretary, Department of Health and Human Services | Hla-a24 agonist epitopes of muc1-c oncoprotein and compositions and methods of use |
EP3331554B1 (en) | 2015-08-03 | 2022-05-11 | The U.S.A. as represented by the Secretary, Department of Health and Human Services | Brachyury deletion mutants, non-yeast vectors encoding brachyury deletion mutants, and their use |
AU2017355564B2 (en) | 2016-11-07 | 2022-04-14 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Development of agonist epitopes of the human papillomavirus |
WO2020102404A1 (en) | 2018-11-14 | 2020-05-22 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Tp5, a peptide inhibitor of aberrant and hyperactive cdk5/p25 as treatment for cancer |
EP4093432A1 (en) | 2020-01-21 | 2022-11-30 | The United States of America, as represented by the Secretary, Department of Health and Human Services | Human immunogenic epitopes of hemo and hhla2 human endogenous retroviruses (hervs) |
WO2021150713A2 (en) | 2020-01-21 | 2021-07-29 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Human immunogenic epitopes of h, k, and e human endogenous retroviruses (hervs) |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2009343C3 (de) * | 1970-02-27 | 1980-10-23 | Max-Planck-Gesellschaft Zur Foerderung Der Wissenschaften E.V., 3400 Goettingen | Verwendung von Lysolecithinen als immunologische Adjuvantien |
GB1502774A (en) * | 1974-06-25 | 1978-03-01 | Nat Res Dev | Immunological preparations |
US4196191A (en) * | 1975-09-29 | 1980-04-01 | Burroughs Wellcome Co. | Biological preparations |
US4235871A (en) * | 1978-02-24 | 1980-11-25 | Papahadjopoulos Demetrios P | Method of encapsulating biologically active materials in lipid vesicles |
GB2026340B (en) * | 1978-07-03 | 1982-12-22 | Ash P | Stabilising microvesicles |
US4199565A (en) * | 1979-03-26 | 1980-04-22 | Merck & Co., Inc. | Liposome particle containing viral or bacterial antigenic subunit |
HU184141B (en) * | 1979-12-27 | 1984-07-30 | Human Oltoanyagtermelo | Adjuvant particles compositions containing said particles and biologically active substances adsorbed thereon and a process for the preparation thereof |
US4673574A (en) * | 1981-08-31 | 1987-06-16 | Anderson Porter W | Immunogenic conjugates |
US4902506A (en) * | 1983-07-05 | 1990-02-20 | The University Of Rochester | Immunogenic conjugates |
US4761283A (en) * | 1983-07-05 | 1988-08-02 | The University Of Rochester | Immunogenic conjugates |
US4565696A (en) * | 1983-08-03 | 1986-01-21 | The Regents Of The University Of California | Production of immunogens by antigen conjugation to liposomes |
US4708933A (en) * | 1984-06-12 | 1987-11-24 | Leaf Huang | Immunoliposome assay-methods and products |
JPH0832637B2 (ja) * | 1985-02-14 | 1996-03-29 | アクゾ・エヌ・ヴエー | 合成免疫原 |
US4797285A (en) * | 1985-12-06 | 1989-01-10 | Yissum Research And Development Company Of The Hebrew University Of Jerusalem | Lipsome/anthraquinone drug composition and method |
US4882145A (en) * | 1986-12-09 | 1989-11-21 | Scripps Clinic And Research Foundation | T cell epitopes of the hepatitis B virus nucleocapsid protein |
EP0306912A3 (en) * | 1987-09-08 | 1989-07-05 | Albany Medical College | Immunogenic composites capable of selectively inducing antibody production and pharmaceutical compositions employing the same. |
-
1991
- 1991-07-18 IE IE253591A patent/IE912535A1/en not_active IP Right Cessation
- 1991-07-22 NZ NZ239072A patent/NZ239072A/en not_active IP Right Cessation
- 1991-07-23 IL IL9893591A patent/IL98935A/en not_active IP Right Cessation
- 1991-07-23 ZA ZA915755A patent/ZA915755B/xx unknown
- 1991-07-24 RU RU93004915A patent/RU2107493C1/ru not_active IP Right Cessation
- 1991-07-24 EP EP91918697A patent/EP0542923B1/en not_active Expired - Lifetime
- 1991-07-24 CA CA002088163A patent/CA2088163C/en not_active Expired - Fee Related
- 1991-07-24 JP JP51779191A patent/JP3518866B2/ja not_active Expired - Fee Related
- 1991-07-24 KR KR1019930700231A patent/KR100213851B1/ko not_active IP Right Cessation
- 1991-07-24 ES ES91918697T patent/ES2106088T3/es not_active Expired - Lifetime
- 1991-07-24 WO PCT/US1991/005231 patent/WO1992002243A1/en active IP Right Grant
- 1991-07-24 AT AT91918697T patent/ATE157537T1/de not_active IP Right Cessation
- 1991-07-24 DK DK91918697.3T patent/DK0542923T3/da active
- 1991-07-24 DE DE69127545T patent/DE69127545T2/de not_active Expired - Fee Related
- 1991-07-24 AU AU87597/91A patent/AU650299B2/en not_active Ceased
- 1991-07-26 PT PT98470A patent/PT98470B/pt not_active IP Right Cessation
- 1991-07-27 CN CN91105793A patent/CN1032236C/zh not_active Expired - Fee Related
-
1993
- 1993-01-21 NO NO19930202A patent/NO311167B1/no unknown
- 1993-01-26 FI FI930319A patent/FI107515B/fi active
-
1995
- 1995-01-30 US US08/380,213 patent/US5464630A/en not_active Expired - Lifetime
-
1997
- 1997-11-13 GR GR970403020T patent/GR3025377T3/el unknown
-
1998
- 1998-07-20 HK HK98109269A patent/HK1008304A1/xx not_active IP Right Cessation
Similar Documents
Publication | Publication Date | Title |
---|---|---|
RU93004915A (ru) | Липосомы, осуществляющие тимус-зависимую помощь "слабым" антигенам, используемым для приготовления вакцины | |
CA2088163A1 (en) | Liposomes that provide thymic dependent help to weak vaccine antigens | |
IT8822145A0 (it) | Vaccini contenenti antigeni tumorali e coadiuvanti e relativo procedimento di preparazione | |
CA2143823A1 (en) | Retro-, inverso - and retro-inverso synthetic peptide analogues | |
EP0284587A3 (en) | Synthetic peptide antigens for the detection of hiv-1 infection | |
FR2557458B1 (fr) | Nouveaux anticorps capables de reconnaitre specifiquement des groupements hapteniques, leur preparation et leur application, et nouveaux antigenes permettant de les preparer | |
DE3872754D1 (de) | Nachweis von antikoerpern humaner immundefizienz-viren. | |
NZ189756A (en) | Muramyl peptides antigens covalently bonded to muramyl-peptides medicaments and vaccines | |
IL62913A (en) | Isolation of glycoproteic antigens of a virus and the preparation of a vaccine from such antigens | |
KR890700683A (ko) | 인체 면역 결핍 바이러스에 대한 항체 검색 방법 | |
ATE2048T1 (de) | Isolierung von hepatitis be-antigen. | |
ATE109004T1 (de) | Toleranzinduktion gegenüber einem fremdantigen. | |
RU96119399A (ru) | Иммуномодулирующее лекарственное средство | |
ITRM910385A0 (it) | Vaccini utilizzanti eritrociti come veicoli di antigeni. | |
NO882865D0 (no) | Fremgangsmaate for fremstilling av et emulsjon-sprengstoff. | |
WO1990015132A3 (en) | Cloned treponema hyodysenteriae endoflagellar antigen | |
IT8205149A0 (it) | Procedimento per la preparazione di bevande calde mediante l'uso preferibilmente di sostanze solubili o liofilizzate. | |
IT8919110A0 (it) | Peptidi sintetici e loro uso come carriers universali per la preparazione di coniugati immunogenici adatti per lo sviluppo di vaccini sintetici. | |
IT8205149A1 (it) | Procedimento per la preparazione di bevande calde mediante l'uso preferibilmente di sostanze solubili o liofilizzate. | |
KR860008779A (ko) | 항체 형성 화합물의 제조방법 | |
BR7902674A (pt) | Colhedeira de cafe com sistema de succao e vibracao atraves de grampos que abrem e fecham | |
HK57497A (en) | Synthetic antigens for the detection of antibodies to hepatitis C virus | |
BR8902127A (pt) | Sistema pre-emulsificador utilizado no preparo de emulsoes combustiveis e processo de pre-emulsificacao utilizando referido sistema | |
IT8922409A0 (it) | Peptidi sintetici e loro uso come carriers universali per la preparazione di coniugati immunogenici adatti per lo sviluppo di vaccini sintetici | |
IT8247648A0 (it) | Composizione copolimerica antigengi vite e procedimento di preparazione |