NO311167B1 - Fremgangsmåte for fremstilling av en liposomal immunogenb¶rer for antigener - Google Patents
Fremgangsmåte for fremstilling av en liposomal immunogenb¶rer for antigener Download PDFInfo
- Publication number
- NO311167B1 NO311167B1 NO19930202A NO930202A NO311167B1 NO 311167 B1 NO311167 B1 NO 311167B1 NO 19930202 A NO19930202 A NO 19930202A NO 930202 A NO930202 A NO 930202A NO 311167 B1 NO311167 B1 NO 311167B1
- Authority
- NO
- Norway
- Prior art keywords
- dnp
- antigen
- helper
- producing
- liposomes
- Prior art date
Links
- 239000000427 antigen Substances 0.000 title claims abstract description 75
- 102000036639 antigens Human genes 0.000 title claims abstract description 75
- 108091007433 antigens Proteins 0.000 title claims abstract description 75
- 230000002163 immunogen Effects 0.000 title claims description 12
- 238000000034 method Methods 0.000 title claims description 12
- 239000002502 liposome Substances 0.000 claims abstract description 70
- 150000002632 lipids Chemical class 0.000 claims abstract description 22
- 230000002209 hydrophobic effect Effects 0.000 claims abstract description 9
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- 108090000765 processed proteins & peptides Proteins 0.000 claims description 31
- 101800000324 Immunoglobulin A1 protease translocator Proteins 0.000 claims description 23
- 238000004519 manufacturing process Methods 0.000 claims description 18
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 13
- 210000002443 helper t lymphocyte Anatomy 0.000 claims description 9
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- WTJKGGKOPKCXLL-RRHRGVEJSA-N phosphatidylcholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCC=CCCCCCCCC WTJKGGKOPKCXLL-RRHRGVEJSA-N 0.000 claims description 6
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- JZNWSCPGTDBMEW-UHFFFAOYSA-N Glycerophosphorylethanolamin Natural products NCCOP(O)(=O)OCC(O)CO JZNWSCPGTDBMEW-UHFFFAOYSA-N 0.000 claims description 3
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- JSPNNZKWADNWHI-PNANGNLXSA-N (2r)-2-hydroxy-n-[(2s,3r,4e,8e)-3-hydroxy-9-methyl-1-[(2r,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoctadeca-4,8-dien-2-yl]heptadecanamide Chemical compound CCCCCCCCCCCCCCC[C@@H](O)C(=O)N[C@H]([C@H](O)\C=C\CC\C=C(/C)CCCCCCCCC)CO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O JSPNNZKWADNWHI-PNANGNLXSA-N 0.000 claims 1
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- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 4
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- LOTKRQAVGJMPNV-UHFFFAOYSA-N 1-fluoro-2,4-dinitrobenzene Chemical compound [O-][N+](=O)C1=CC=C(F)C([N+]([O-])=O)=C1 LOTKRQAVGJMPNV-UHFFFAOYSA-N 0.000 description 1
- XZKIHKMTEMTJQX-UHFFFAOYSA-N 4-Nitrophenyl Phosphate Chemical compound OP(O)(=O)OC1=CC=C([N+]([O-])=O)C=C1 XZKIHKMTEMTJQX-UHFFFAOYSA-N 0.000 description 1
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- 108091003079 Bovine Serum Albumin Proteins 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 1
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- ZBCBWPMODOFKDW-UHFFFAOYSA-N diethanolamine Chemical compound OCCNCCO ZBCBWPMODOFKDW-UHFFFAOYSA-N 0.000 description 1
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- HEGSGKPQLMEBJL-RKQHYHRCSA-N octyl beta-D-glucopyranoside Chemical compound CCCCCCCCO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O HEGSGKPQLMEBJL-RKQHYHRCSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/829—Liposomes, e.g. encapsulation
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dispersion Chemistry (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US55896090A | 1990-07-27 | 1990-07-27 | |
| PCT/US1991/005231 WO1992002243A1 (en) | 1990-07-27 | 1991-07-24 | Liposomes that provide thymic dependent help to weak vaccine antigens |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO930202L NO930202L (no) | 1993-01-21 |
| NO930202D0 NO930202D0 (no) | 1993-01-21 |
| NO311167B1 true NO311167B1 (no) | 2001-10-22 |
Family
ID=24231699
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO19930202A NO311167B1 (no) | 1990-07-27 | 1993-01-21 | Fremgangsmåte for fremstilling av en liposomal immunogenb¶rer for antigener |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US5464630A (ru) |
| EP (1) | EP0542923B1 (ru) |
| JP (1) | JP3518866B2 (ru) |
| KR (1) | KR100213851B1 (ru) |
| CN (1) | CN1032236C (ru) |
| AT (1) | ATE157537T1 (ru) |
| AU (1) | AU650299B2 (ru) |
| CA (1) | CA2088163C (ru) |
| DE (1) | DE69127545T2 (ru) |
| DK (1) | DK0542923T3 (ru) |
| ES (1) | ES2106088T3 (ru) |
| FI (1) | FI107515B (ru) |
| GR (1) | GR3025377T3 (ru) |
| HK (1) | HK1008304A1 (ru) |
| IE (1) | IE912535A1 (ru) |
| IL (1) | IL98935A (ru) |
| NO (1) | NO311167B1 (ru) |
| NZ (1) | NZ239072A (ru) |
| PT (1) | PT98470B (ru) |
| RU (1) | RU2107493C1 (ru) |
| WO (1) | WO1992002243A1 (ru) |
| ZA (1) | ZA915755B (ru) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5879685A (en) * | 1991-05-08 | 1999-03-09 | Schweiz, Serum- & Impfinstitut Bern | Immunostimulating and immunopotentiating reconstituted influenza virosomes and vaccines containing them |
| US6004534A (en) * | 1993-07-23 | 1999-12-21 | Massachusetts Institute Of Technology | Targeted polymerized liposomes for improved drug delivery |
| WO1996007102A1 (en) * | 1994-09-01 | 1996-03-07 | Wisconsin Alumni Research Foundation | Therapeutic remodeling in aids |
| US6060082A (en) * | 1997-04-18 | 2000-05-09 | Massachusetts Institute Of Technology | Polymerized liposomes targeted to M cells and useful for oral or mucosal drug delivery |
| AUPO732997A0 (en) * | 1997-06-12 | 1997-07-03 | Csl Limited | Ganglioside immunostimulating complexes and uses thereof |
| US5993852A (en) * | 1997-08-29 | 1999-11-30 | Pharmaderm Laboratories Ltd. | Biphasic lipid vesicle composition for transdermal administration of an immunogen |
| US6027731A (en) * | 1998-11-17 | 2000-02-22 | Wisconsin Alumni Research Foundation | Pertussis toxin induced lymphocytosis |
| JP4685350B2 (ja) * | 2001-07-26 | 2011-05-18 | オタゴ イノベイション リミティド | 抗原性組成物 |
| JP2009510032A (ja) * | 2005-09-30 | 2009-03-12 | リポクセン テクノロジーズ リミテッド | 多糖抗原及びタンパク質アジュバントを含む多価リポソームワクチン組成物 |
| RU2480479C1 (ru) * | 2011-11-01 | 2013-04-27 | Елена Викторовна Свирщевская | Гетерологичный пептидный мини-антиген в составе полимерной частицы для создания противоаллергенной вакцины |
| DK2800762T3 (en) | 2012-01-03 | 2018-04-16 | Us Health | NATIVE AND AGONISTIC CTL EPITOPES OF THE MUC1 TUMOR ANTIGEN |
| EP3412304A3 (en) | 2013-10-23 | 2019-03-20 | The United States of America, as represented by The Secretary, Department of Health and Human Services | Hla-a24 agonist epitopes of muc1-c oncoprotein and compositions and methods of use |
| EP3331554B1 (en) | 2015-08-03 | 2022-05-11 | The U.S.A. as represented by the Secretary, Department of Health and Human Services | Brachyury deletion mutants, non-yeast vectors encoding brachyury deletion mutants, and their use |
| AU2017355564B2 (en) | 2016-11-07 | 2022-04-14 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Development of agonist epitopes of the human papillomavirus |
| WO2020102404A1 (en) | 2018-11-14 | 2020-05-22 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Tp5, a peptide inhibitor of aberrant and hyperactive cdk5/p25 as treatment for cancer |
| EP4093432A1 (en) | 2020-01-21 | 2022-11-30 | The United States of America, as represented by the Secretary, Department of Health and Human Services | Human immunogenic epitopes of hemo and hhla2 human endogenous retroviruses (hervs) |
| WO2021150713A2 (en) | 2020-01-21 | 2021-07-29 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Human immunogenic epitopes of h, k, and e human endogenous retroviruses (hervs) |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2009343C3 (de) * | 1970-02-27 | 1980-10-23 | Max-Planck-Gesellschaft Zur Foerderung Der Wissenschaften E.V., 3400 Goettingen | Verwendung von Lysolecithinen als immunologische Adjuvantien |
| GB1502774A (en) * | 1974-06-25 | 1978-03-01 | Nat Res Dev | Immunological preparations |
| US4196191A (en) * | 1975-09-29 | 1980-04-01 | Burroughs Wellcome Co. | Biological preparations |
| US4235871A (en) * | 1978-02-24 | 1980-11-25 | Papahadjopoulos Demetrios P | Method of encapsulating biologically active materials in lipid vesicles |
| GB2026340B (en) * | 1978-07-03 | 1982-12-22 | Ash P | Stabilising microvesicles |
| US4199565A (en) * | 1979-03-26 | 1980-04-22 | Merck & Co., Inc. | Liposome particle containing viral or bacterial antigenic subunit |
| HU184141B (en) * | 1979-12-27 | 1984-07-30 | Human Oltoanyagtermelo | Adjuvant particles compositions containing said particles and biologically active substances adsorbed thereon and a process for the preparation thereof |
| US4673574A (en) * | 1981-08-31 | 1987-06-16 | Anderson Porter W | Immunogenic conjugates |
| US4902506A (en) * | 1983-07-05 | 1990-02-20 | The University Of Rochester | Immunogenic conjugates |
| US4761283A (en) * | 1983-07-05 | 1988-08-02 | The University Of Rochester | Immunogenic conjugates |
| US4565696A (en) * | 1983-08-03 | 1986-01-21 | The Regents Of The University Of California | Production of immunogens by antigen conjugation to liposomes |
| US4708933A (en) * | 1984-06-12 | 1987-11-24 | Leaf Huang | Immunoliposome assay-methods and products |
| JPH0832637B2 (ja) * | 1985-02-14 | 1996-03-29 | アクゾ・エヌ・ヴエー | 合成免疫原 |
| US4797285A (en) * | 1985-12-06 | 1989-01-10 | Yissum Research And Development Company Of The Hebrew University Of Jerusalem | Lipsome/anthraquinone drug composition and method |
| US4882145A (en) * | 1986-12-09 | 1989-11-21 | Scripps Clinic And Research Foundation | T cell epitopes of the hepatitis B virus nucleocapsid protein |
| EP0306912A3 (en) * | 1987-09-08 | 1989-07-05 | Albany Medical College | Immunogenic composites capable of selectively inducing antibody production and pharmaceutical compositions employing the same. |
-
1991
- 1991-07-18 IE IE253591A patent/IE912535A1/en not_active IP Right Cessation
- 1991-07-22 NZ NZ239072A patent/NZ239072A/en not_active IP Right Cessation
- 1991-07-23 IL IL9893591A patent/IL98935A/en not_active IP Right Cessation
- 1991-07-23 ZA ZA915755A patent/ZA915755B/xx unknown
- 1991-07-24 RU RU93004915A patent/RU2107493C1/ru not_active IP Right Cessation
- 1991-07-24 EP EP91918697A patent/EP0542923B1/en not_active Expired - Lifetime
- 1991-07-24 CA CA002088163A patent/CA2088163C/en not_active Expired - Fee Related
- 1991-07-24 JP JP51779191A patent/JP3518866B2/ja not_active Expired - Fee Related
- 1991-07-24 KR KR1019930700231A patent/KR100213851B1/ko not_active IP Right Cessation
- 1991-07-24 ES ES91918697T patent/ES2106088T3/es not_active Expired - Lifetime
- 1991-07-24 WO PCT/US1991/005231 patent/WO1992002243A1/en active IP Right Grant
- 1991-07-24 AT AT91918697T patent/ATE157537T1/de not_active IP Right Cessation
- 1991-07-24 DK DK91918697.3T patent/DK0542923T3/da active
- 1991-07-24 DE DE69127545T patent/DE69127545T2/de not_active Expired - Fee Related
- 1991-07-24 AU AU87597/91A patent/AU650299B2/en not_active Ceased
- 1991-07-26 PT PT98470A patent/PT98470B/pt not_active IP Right Cessation
- 1991-07-27 CN CN91105793A patent/CN1032236C/zh not_active Expired - Fee Related
-
1993
- 1993-01-21 NO NO19930202A patent/NO311167B1/no unknown
- 1993-01-26 FI FI930319A patent/FI107515B/fi active
-
1995
- 1995-01-30 US US08/380,213 patent/US5464630A/en not_active Expired - Lifetime
-
1997
- 1997-11-13 GR GR970403020T patent/GR3025377T3/el unknown
-
1998
- 1998-07-20 HK HK98109269A patent/HK1008304A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| CN1059279A (zh) | 1992-03-11 |
| WO1992002243A1 (en) | 1992-02-20 |
| JPH06502630A (ja) | 1994-03-24 |
| PT98470A (pt) | 1992-06-30 |
| HK1008304A1 (en) | 1999-05-07 |
| FI107515B (fi) | 2001-08-31 |
| CN1032236C (zh) | 1996-07-10 |
| RU2107493C1 (ru) | 1998-03-27 |
| AU650299B2 (en) | 1994-06-16 |
| KR100213851B1 (ko) | 1999-08-02 |
| CA2088163C (en) | 2003-06-17 |
| DK0542923T3 (da) | 1997-10-13 |
| NO930202L (no) | 1993-01-21 |
| GR3025377T3 (en) | 1998-02-27 |
| NZ239072A (en) | 1997-06-24 |
| ZA915755B (en) | 1993-02-24 |
| EP0542923B1 (en) | 1997-09-03 |
| IL98935A (en) | 1994-01-24 |
| CA2088163A1 (en) | 1992-01-28 |
| ES2106088T3 (es) | 1997-11-01 |
| FI930319A0 (fi) | 1993-01-26 |
| DE69127545D1 (de) | 1997-10-09 |
| US5464630A (en) | 1995-11-07 |
| EP0542923A4 (ru) | 1994-04-13 |
| JP3518866B2 (ja) | 2004-04-12 |
| NO930202D0 (no) | 1993-01-21 |
| DE69127545T2 (de) | 1998-01-08 |
| IE912535A1 (en) | 1992-01-29 |
| EP0542923A1 (en) | 1993-05-26 |
| FI930319A (fi) | 1993-01-26 |
| IL98935A0 (en) | 1992-07-15 |
| ATE157537T1 (de) | 1997-09-15 |
| PT98470B (pt) | 1998-02-27 |
| AU8759791A (en) | 1992-03-02 |
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