SI9011773B - Vaccine against lyme disease, process for obtaining it, monoclonal antibody, antigene, recombinant dna, recombinant vector and process for obtaining this antigene - Google Patents

Vaccine against lyme disease, process for obtaining it, monoclonal antibody, antigene, recombinant dna, recombinant vector and process for obtaining this antigene Download PDF

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Publication number
SI9011773B
SI9011773B SI9011773A SI9011773A SI9011773B SI 9011773 B SI9011773 B SI 9011773B SI 9011773 A SI9011773 A SI 9011773A SI 9011773 A SI9011773 A SI 9011773A SI 9011773 B SI9011773 B SI 9011773B
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Slovenia
Prior art keywords
antigen
burgdorferi
obtaining
antigene
lyme disease
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SI9011773A
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English (en)
Other versions
SI9011773A (sl
Inventor
M Markus Simon
E Ulrich Schaible
Klaus Eichmann
Michael Kramer
Wallich Reinhard
Original Assignee
Max Planck Gesellschaft
Deutsches Krebsforsch
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25885304&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SI9011773(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Max Planck Gesellschaft, Deutsches Krebsforsch filed Critical Max Planck Gesellschaft
Publication of SI9011773A publication Critical patent/SI9011773A/sl
Publication of SI9011773B publication Critical patent/SI9011773B/sl

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/20—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Spirochaetales (O), e.g. Treponema, Leptospira
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1203—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria
    • C07K16/1207—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria from Spirochaetales (O), e.g. Treponema, Leptospira
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Claims (6)

1 PATENTNI ZAHTEVKI 1. Postopek za pridobivanje cepiva proti lajmski bolezni, označen s tem, da imuniziramo poskusne živali, prednostno miši, z 31 kD antigenom (OspA) ali/in s 34 kD antigenom (OspB) B.burgdorferi ZS7 (DSM 5527) in/ali B31 (ATCC 35210) in iz imunizirane poskusne živali pridobimo na običajen način protektivna monoklonska protitelesa proti OspA ali/in OspB.
2. Patogeni B.burgdorferi soj ZS7, DSM5527.
3. Antigen, označen s tem, da imunsko reagira s protitelesom proti 31 kD antigenu (OspA) B.burgdorferi in vsebuje naslednjo aminokislinsko sekvenco ali imunogeni epitop iz te sekvence: M K K Y L L G I G L I L A L I A C K Q N V s s L D E K N s V s V D L P G E M N V L v s K E K N X D G K Y D L I A T V D K L E L K G T S D K N N G S G v L E G V K A D K S K V K L T I S D D L G Q T T L E V F K E D G K T L V S K K V T S K D K 5 S T E E K F N E K G E V S E K I I T R A D G T R L E Y T E I K S D G s G K A K ir V L K S Y V L E G T L T A E K T T L V V K E G T V T L S K s I S K S G E v S V £ L K D T D S S A A T K K T A A W H S G T S T L T I T V M S K K X K D L V F T K Ξ n T I T V Q Q Y D s N G T X L E G S A V E I T K L D E r K N A L K A , κ.νν>· 2
4. Antigen po zahtevku 3, označen s tem, da se nahaja zanj kodirajoča sekvenca DNA na vektorju, prednostno prokariontskem vektorju, kije primeren za izražanje proteina.
5. Antigen po zahtevku 3 ali 4, označen s tem, da je antigen β-galaktozidazni fuzijski protein ali nefuzijski protein.
6. Rekombinantna DNA, označena s tem, da kodira za antigen po enem od zahtevkov 3, 4 ali 5 ter vsebuje (1) v nadaljevanju prikazano sekvenco nukleinske kisline ali (2) sekvenco, ki ji ustreza v okviru degeneracije genetske kode: atgaaaaaacaLttac.tgggaataggtctaat.accagccttaat.agcatgtaagcaaaa.t ςζ tagcagccttgacgagaaaaacagcgtctcagtagatT:tgcctggc.gaaatgaacgi.:: cz. tgxaagcaaagaaaaaaacaaagacggcaagtacg«tc::aactgcaacagT.agacaag cztgagctt.aaaggaaczt.cE.gai.aAaaacaa:.ggawCt.ggagT.act'gaaggcgcaaaa gcrgacaaaagx.aaagx&aaattaacaattcctgacgat.ccaggxcaaaccacacctgaa g^ttccaaagaagatggcaaaacaccagxaccaaaaaaacx.aacccccaaagacaagwca ccaacagaagaaaaaLtcaatgaaaaaggxgaagtatctgaaaaaat.aacaacaagagca gacggaaccagacttgaatacacagaaattasaagcgatggatct.ggaaaagct.aaagag gr.tttaaaaagccatg^c.ct rgaaggaact^taactgctgaaaaaacaacattggzggtt. aaagaaggaact.gT.tacctcaagcaaaaa*attteaaaatctggggaagccccagTtgaa cctaac.gacactgacagtagtgctgccactaaaaaaactgcagcttggaactcaggcact. ccaaccccaacaaL^accg^aaacagrcaaaaaaactaaagaccccgtgcccacaaaagaa aacacaacc.acagr.acaacaaracgactcaaatggcaccaaactagaggggtcagcagct
gaaactacaaaacctgacgaaaccaaaaacgctccaaaataa
SI9011773A 1989-09-19 1990-09-18 Vaccine against lyme disease, process for obtaining it, monoclonal antibody, antigene, recombinant dna, recombinant vector and process for obtaining this antigene SI9011773B (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE3931236 1989-09-19
DE4015911A DE4015911A1 (de) 1989-09-19 1990-05-17 Impfstoff gegen die lyme-krankheit
YU177390A YU48250B (sh) 1989-09-19 1990-09-18 Postupak za pripremanje aktivne vakcine protiv lajmske bolesti

Publications (2)

Publication Number Publication Date
SI9011773A SI9011773A (sl) 1998-04-30
SI9011773B true SI9011773B (en) 2001-12-31

Family

ID=25885304

Family Applications (1)

Application Number Title Priority Date Filing Date
SI9011773A SI9011773B (en) 1989-09-19 1990-09-18 Vaccine against lyme disease, process for obtaining it, monoclonal antibody, antigene, recombinant dna, recombinant vector and process for obtaining this antigene

Country Status (24)

Country Link
US (6) US5178859A (sl)
EP (5) EP0633313B1 (sl)
JP (3) JP3205932B2 (sl)
KR (2) KR100205462B1 (sl)
AT (4) ATE186646T1 (sl)
AU (1) AU651560B2 (sl)
CA (1) CA2025597C (sl)
CZ (2) CZ284538B6 (sl)
DE (5) DE4015911A1 (sl)
DK (4) DK0418827T3 (sl)
ES (4) ES2082812T3 (sl)
FI (1) FI102248B (sl)
GR (3) GR3018995T3 (sl)
HK (2) HK1002405A1 (sl)
HR (1) HRP940545B1 (sl)
HU (2) HU212716B (sl)
IE (1) IE903377A1 (sl)
NO (2) NO311767B1 (sl)
NZ (1) NZ235260A (sl)
PL (2) PL170229B1 (sl)
PT (1) PT95349B (sl)
SI (1) SI9011773B (sl)
SK (3) SK280285B6 (sl)
YU (2) YU48250B (sl)

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DK590288D0 (da) 1988-10-24 1988-10-24 Symbicom Ab Kemiske forbindelser
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US6143872A (en) * 1988-10-24 2000-11-07 Symbicom Aktiebolag Borrelia burdorferi Osp A and B proteins and immunogenic peptides
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DE4015911A1 (de) * 1989-09-19 1991-03-28 Max Planck Gesellschaft Impfstoff gegen die lyme-krankheit
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WO1992000055A1 (en) * 1990-06-15 1992-01-09 Yale University Compositions and methods for the prevention and diagnosis of lyme disease
EP1016416A3 (en) * 1990-07-06 2002-10-23 Wyeth Vaccine against lyme disease and a challenge model for evaluating vaccine efficacy
CA2057536C (en) * 1990-12-21 1999-10-26 John J. Dunn Cloning and expression of borrelia lipoproteins
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US6872550B1 (en) 1991-07-11 2005-03-29 Baxter Vaccine Ag Immunogenic formulation of OspC antigen vaccines for the prevention and treatment of lyme disease and recombinant methods for the preparation of such antigens
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US6676942B1 (en) 1991-08-15 2004-01-13 Smithkline Beecham Biologicals (S.A.) Osp a proteins of Borrelia burgdorferi subgroups, encoding genes and vaccines
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AU2903892A (en) * 1991-10-22 1993-05-21 Symbicom Aktiebolag Improvement in (borrelia burgdorferi) diagnosis and prophylaxis
US6303129B1 (en) * 1992-07-28 2001-10-16 Rx Technologies Production of borrelia burgdorferi vaccine, product produced thereby and method of use
US5656451A (en) * 1993-07-30 1997-08-12 Yale University OspE, OspF, and S1 polypeptides in borrelia burgdorferi
US6716591B1 (en) 1993-07-30 2004-04-06 Yale University B. burgdorferi polypeptides
US7008625B2 (en) 1993-11-01 2006-03-07 Research Foundation Of The State University Of New York Recombinant constructs of Borrelia burgdorferi
US5558993A (en) * 1994-06-17 1996-09-24 The Regents Of The University Of California Cloned Borrelia burgdorferi virulence protein
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DE69733944T3 (de) * 1996-02-21 2012-07-26 The Board Of Regents, The University Of Texas System Vmp-ähnliche sequenzen von pathogener borrelia
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DE19740735A1 (de) * 1997-09-16 1999-03-18 Max Planck Gesellschaft Arzneimittel zur Therapie einer manifesten Lyme-Borreliose
US6306623B1 (en) * 1998-02-24 2001-10-23 The University Of California Leptospiral major outer membrane protein LipL32
DE69938183T2 (de) 1998-07-31 2009-02-19 Gundersen Lutheran Medical Foundation, Inc., La Crosse Verwendungen eines borreliaziden epitops des aussermembranproteins c von borrelia burgdorferi (ospc) als impstoff
WO2000056298A2 (en) * 1999-03-19 2000-09-28 Luitpold Pharmaceuticals, Inc. Treatment of lyme disease with polysulfated glycosaminoglycan formulations
US6592875B1 (en) 1999-06-21 2003-07-15 Milkhaus Laboratory, Inc. Method for treatment of lyme disease
ES2298249T3 (es) 2000-08-18 2008-05-16 Research Foundation Of State University Of New York Ospa modificada de borrelia burgdorferi.
US7847084B2 (en) 2002-12-20 2010-12-07 Board Of Regents, The University Of Texas System VMP-like sequences of pathogenic Borrelia species and strains
MX2009004866A (es) 2006-11-03 2009-05-19 Schering Plough Ltd Vacuna para enfermedad de lyme canina.
WO2008116468A2 (en) 2007-03-26 2008-10-02 Dako Denmark A/S Mhc peptide complexes and uses thereof in infectious diseases
EP2167537A2 (en) 2007-07-03 2010-03-31 Dako Denmark A/S Compiled methods for analysing and sorting samples
US10611818B2 (en) 2007-09-27 2020-04-07 Agilent Technologies, Inc. MHC multimers in tuberculosis diagnostics, vaccine and therapeutics
DK2254592T3 (da) 2008-02-28 2019-09-09 Dako Denmark As MHC-multimerer til Borrelia-diagnostik og sygdom
US10722562B2 (en) 2008-07-23 2020-07-28 Immudex Aps Combinatorial analysis and repair
GB0817244D0 (en) 2008-09-20 2008-10-29 Univ Cardiff Use of a protein kinase inhibitor to detect immune cells, such as T cells
US11992518B2 (en) 2008-10-02 2024-05-28 Agilent Technologies, Inc. Molecular vaccines for infectious disease
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US8758772B2 (en) 2011-11-04 2014-06-24 Abaxis, Inc. Peptides and methods for the detection of lyme disease antibodies
PL223175B1 (pl) 2012-10-22 2016-10-31 Inst Chemii Bioorganicznej Polskiej Akademii Nauk Szczepionka przeciw boreliozie, konstrukt genetyczny, rekombinowane białko, sposób otrzymywania konstruktu genetycznego, sposób otrzymywania szczepionki, sposób otrzymywania rekombinowanych białek, zastosowanie rekombinowanych białek do wytwarzania szczepionki przeciwko boreliozie
US9610336B1 (en) * 2014-07-16 2017-04-04 Amiram Katz Immunotherapy for lyme disease

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US4772464A (en) 1985-08-01 1988-09-20 Miles Laboratories, Inc. Protective antibodies to serotypic determinants of flagellar antigens
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US4721617A (en) 1986-08-14 1988-01-26 Regents Of The University Of Minnesota Vaccine against lyme disease
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DE4015911A1 (de) * 1989-09-19 1991-03-28 Max Planck Gesellschaft Impfstoff gegen die lyme-krankheit
ATE140461T1 (de) * 1989-12-22 1996-08-15 Mikrogen Molekularbiol Entw Immunologisch aktive proteine von borrelia burgdorferi, zusammenhängende testkits und impfstoff
WO1992000055A1 (en) * 1990-06-15 1992-01-09 Yale University Compositions and methods for the prevention and diagnosis of lyme disease
EP1016416A3 (en) * 1990-07-06 2002-10-23 Wyeth Vaccine against lyme disease and a challenge model for evaluating vaccine efficacy
CA2057536C (en) * 1990-12-21 1999-10-26 John J. Dunn Cloning and expression of borrelia lipoproteins
EP0877085A1 (en) * 1991-08-15 1998-11-11 SMITHKLINE BEECHAM BIOLOGICALS s.a. OspA protein of borrelia burgdorferi subgroups, encoding genes and vaccines
DE69227844T2 (de) * 1991-08-27 1999-08-05 Novo Nordisk As Waschmittelzusammensetzungen
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GR3032010T3 (en) 2000-03-31
DE59010863D1 (de) 1999-02-25
HK1013620A1 (en) 1999-09-03
EP0861664A2 (de) 1998-09-02
JPH03209400A (ja) 1991-09-12
ES2082812T3 (es) 1996-04-01
EP0643974B1 (de) 1999-01-13
JP3418171B2 (ja) 2003-06-16
NO904062L (no) 1991-03-20
SK456090A3 (en) 1999-11-08
EP0633028A1 (de) 1995-01-11
KR910005889A (ko) 1991-04-27
CA2025597C (en) 2004-02-03
US5434077A (en) 1995-07-18
FI904597A0 (fi) 1990-09-18
KR100202128B1 (en) 1999-06-15
NO904062D0 (no) 1990-09-18
HK1002405A1 (en) 1998-08-21
DE4015911A1 (de) 1991-03-28
CZ456090A3 (cs) 1998-08-12
HU211228A9 (en) 1995-11-28
DE59010888D1 (de) 1999-12-23
CA2025597A1 (en) 1991-03-20
PT95349B (pt) 1997-06-30
DK0633028T3 (da) 2000-04-10
EP0418827A1 (de) 1991-03-27
PL170229B1 (pl) 1996-11-29
EP0861664A3 (de) 1999-02-24
HU905816D0 (en) 1991-03-28
JP2001069969A (ja) 2001-03-21
CZ97095A3 (en) 1995-09-13
AU6244490A (en) 1991-03-28
DE59009978D1 (de) 1996-02-01
DE59010903D1 (de) 2000-05-11
GR3033675T3 (en) 2000-10-31
FI102248B1 (fi) 1998-11-13
ES2129551T3 (es) 1999-06-16
US5856447A (en) 1999-01-05
NO20014624D0 (no) 2001-09-24
SK280285B6 (sk) 1999-11-08
DK0643974T3 (da) 1999-09-06
EP0633313B1 (de) 2000-04-05
AU651560B2 (en) 1994-07-28
DK0633313T3 (da) 2000-07-24
ATE131732T1 (de) 1996-01-15
SK151098A3 (en) 1999-04-13
YU49370B (sh) 2005-09-19
YU48250B (sh) 1997-09-30
HUT59613A (en) 1992-06-29
YU177390A (sh) 1993-05-28
US5178859A (en) 1993-01-12
GR3018995T3 (en) 1996-05-31
HRP940545B1 (en) 2000-06-30
ATE186646T1 (de) 1999-12-15
CZ284538B6 (cs) 1998-12-16
ATE191499T1 (de) 2000-04-15
HU212716B (en) 1996-10-28
CZ284616B6 (cs) 1999-01-13
US5780030A (en) 1998-07-14
SK283089B6 (sk) 2003-02-04
JP2001204467A (ja) 2001-07-31
FI102248B (fi) 1998-11-13
US6613331B1 (en) 2003-09-02
SK283088B6 (sk) 2003-02-04
IE990173A1 (en) 2000-11-01
SI9011773A (sl) 1998-04-30
NZ235260A (en) 1993-04-28
PL169804B1 (pl) 1996-09-30
EP0418827B1 (de) 1995-12-20
US5686267A (en) 1997-11-11
ATE175576T1 (de) 1999-01-15
SK151198A3 (en) 1999-04-13
NO311767B1 (no) 2002-01-21
EP0633313A1 (de) 1995-01-11
ES2145077T3 (es) 2000-07-01
IE903377A1 (en) 1991-04-10
YU9097A (sh) 1999-06-15
KR100205462B1 (ko) 1999-07-01
JP3328644B2 (ja) 2002-09-30
EP0633028B1 (de) 1999-11-17
HRP940545A2 (en) 1997-04-30
NO20014624L (no) 1991-03-20
PT95349A (pt) 1991-05-22
DK0418827T3 (da) 1996-05-06
JP3205932B2 (ja) 2001-09-04
EP0643974A1 (de) 1995-03-22
ES2141182T3 (es) 2000-03-16
NO315905B1 (no) 2003-11-10

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