ES2095942T3 - Derivados de bencenoacetamida inhibidores del vih. - Google Patents
Derivados de bencenoacetamida inhibidores del vih.Info
- Publication number
- ES2095942T3 ES2095942T3 ES91912334T ES91912334T ES2095942T3 ES 2095942 T3 ES2095942 T3 ES 2095942T3 ES 91912334 T ES91912334 T ES 91912334T ES 91912334 T ES91912334 T ES 91912334T ES 2095942 T3 ES2095942 T3 ES 2095942T3
- Authority
- ES
- Spain
- Prior art keywords
- hydrogen
- represent
- alkyl
- halo
- independently
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000003112 inhibitor Substances 0.000 title 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical group [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 6
- 239000001257 hydrogen Substances 0.000 abstract 6
- 229910052739 hydrogen Inorganic materials 0.000 abstract 6
- 150000001875 compounds Chemical class 0.000 abstract 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- -1 CARBOXYL Chemical class 0.000 abstract 1
- UGFAIRIUMAVXCW-UHFFFAOYSA-N Carbon monoxide Chemical class [O+]#[C-] UGFAIRIUMAVXCW-UHFFFAOYSA-N 0.000 abstract 1
- JCXJVPUVTGWSNB-UHFFFAOYSA-N Nitrogen dioxide Chemical class O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003254 radicals Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 239000011593 sulfur Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C327/00—Thiocarboxylic acids
- C07C327/38—Amides of thiocarboxylic acids
- C07C327/40—Amides of thiocarboxylic acids having carbon atoms of thiocarboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C327/44—Amides of thiocarboxylic acids having carbon atoms of thiocarboxamide groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of an unsaturated carbon skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/45—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by at least one doubly—bound oxygen atom, not being part of a —CHO group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
- C07C205/57—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/20—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
- C07C237/30—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to hydrogen atoms or to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
- C07C237/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
- C07C251/32—Oximes
- C07C251/34—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
- C07C251/48—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with the carbon atom of at least one of the oxyimino groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
- C07C251/72—Hydrazones
- C07C251/86—Hydrazones having doubly-bound carbon atoms of hydrazone groups bound to carbon atoms of six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
- C07C255/32—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
- C07C255/42—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being further bound to other hetero atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C255/57—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and carboxyl groups, other than cyano groups, bound to the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/004—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reaction with organometalhalides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
- C07C49/80—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen
- C07C49/813—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen polycyclic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Virology (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Communicable Diseases (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP90201857 | 1990-07-10 | ||
| EP91200646 | 1991-03-22 | ||
| PCT/EP1991/001254 WO1992000952A1 (en) | 1990-07-10 | 1991-07-04 | Hiv-inhibiting benzeneacetamide derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2095942T3 true ES2095942T3 (es) | 1997-03-01 |
Family
ID=26125946
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES91912334T Expired - Lifetime ES2095942T3 (es) | 1990-07-10 | 1991-07-04 | Derivados de bencenoacetamida inhibidores del vih. |
Country Status (42)
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69217992T2 (de) * | 1991-12-30 | 1997-06-12 | Janssen Pharmaceutica Nv | Alpha-substituierte benzenmethanamin-derivate |
| US6177435B1 (en) | 1992-05-13 | 2001-01-23 | Glaxo Wellcome Inc. | Therapeutic combinations |
| DK0577945T3 (da) * | 1992-07-06 | 1996-09-02 | American Cyanamid Co | Herbicidmellemproduktet o-nitrophenyl-cyclopropyl-keton og fremgangsmåde til fremstilling deraf |
| CA2155829A1 (en) * | 1993-02-22 | 1994-09-01 | Koenraad Josef Lodewijk Marcel Andries | Method of reversing resistance of hiv-1 strains to zidovudine |
| US5767310A (en) * | 1993-03-19 | 1998-06-16 | Merck & Co., Inc. | Phenoxyphenylacetic acid derivatives |
| US5686478A (en) * | 1993-07-20 | 1997-11-11 | Merck & Co. Inc. | Endothelin antagonists |
| IL112739A0 (en) * | 1994-02-23 | 1995-05-26 | Wellcome Found | Ayrlthiobenzonitrile compounds, their preparation and pharmaceutical compositions containing them |
| GB9403408D0 (en) * | 1994-02-23 | 1994-04-13 | Wellcome Found | Therapeutic benzonitriles |
| GB9403449D0 (en) * | 1994-02-23 | 1994-04-13 | Wellcome Found | Therapeutic benzonitriles |
| US5559135A (en) * | 1994-09-14 | 1996-09-24 | Merck & Co., Inc. | Endothelin antagonists bearing pyridyl amides |
| US5538991A (en) * | 1994-09-14 | 1996-07-23 | Merck & Co., Inc. | Endothelin antagonists bearing 5-membered heterocyclic amides |
| EP0872233A1 (en) * | 1997-04-14 | 1998-10-21 | Janssen Pharmaceutica N.V. | Antiretroviral compositions with improved bioavailability |
| AU739511B2 (en) * | 1997-08-22 | 2001-10-11 | F. Hoffmann-La Roche Ag | N-aroylphenylalanine derivatives |
| EP1087941B9 (en) * | 1998-06-19 | 2007-11-07 | THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, Department of Health and Human Services | Thiolesters and uses thereof |
| TR200200763T2 (tr) | 1999-09-24 | 2003-09-22 | Janssen Pharmaceutica N.V. | Antiviral bileşimler |
| DE60136187D1 (de) | 2000-08-11 | 2008-11-27 | Japan Tobacco Inc | Calciumrezeptor-antagonisten |
| BRPI0510059B8 (pt) * | 2004-04-23 | 2021-05-25 | Hoffmann La Roche | inibidores da transcriptase reversa não-nucleosídica e seus usos |
| US7625949B2 (en) | 2004-04-23 | 2009-12-01 | Roche Palo Alto Llc | Methods for treating retroviral infections |
| JP2009539873A (ja) * | 2006-06-08 | 2009-11-19 | ブリストル−マイヤーズ スクイブ カンパニー | 抗凝固剤として有用な第ＶＩＩａ因子インヒビターとしての２−アミノカルボニルフェニルアミノ−２−フェニルアセトアミド類 |
| RU2449985C2 (ru) * | 2010-03-31 | 2012-05-10 | Федеральное государственное унитарное предприятие "Российский научный центр "Прикладная химия" | Способ получения n,n-диметилацетамида |
| CN102675212B (zh) * | 2012-05-09 | 2014-11-05 | 昆明理工大学 | N-取代苯基-2-((1h-苯并咪唑-2-基)巯基)乙酰胺类衍生物及其用途 |
| CN104000807B (zh) * | 2014-05-28 | 2016-05-18 | 中山大学 | 苯基-酰胺类化合物在制备抗hiv-1病毒药物中的应用 |
| CN105367437B (zh) * | 2015-10-12 | 2017-08-01 | 湖北文理学院 | 一种2‑芳氨基乙酰胺类化合物的制备方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1423430A (en) * | 1973-03-29 | 1976-02-04 | Wyeth John & Brother Ltd | Thioamides |
| US4246429A (en) * | 1978-06-23 | 1981-01-20 | Janssen Pharmaceutica, N.V. | Novel α-amino-phenylacetic acid derivatives |
| CH637828A5 (en) * | 1978-11-15 | 1983-08-31 | Koehler Franz Dr Chemie Kg | Cytostatics |
| DE69217992T2 (de) * | 1991-12-30 | 1997-06-12 | Janssen Pharmaceutica Nv | Alpha-substituierte benzenmethanamin-derivate |
-
1991
- 1991-06-25 IE IE220891A patent/IE75693B1/en not_active IP Right Cessation
- 1991-06-26 AP APAP/P/1991/000288A patent/AP311A/en active
- 1991-06-27 NZ NZ238763A patent/NZ238763A/xx unknown
- 1991-07-02 MY MYPI91001206A patent/MY108580A/en unknown
- 1991-07-02 PH PH42728A patent/PH30977A/en unknown
- 1991-07-04 PL PL91297608A patent/PL167076B1/pl unknown
- 1991-07-04 AU AU82120/91A patent/AU643056B2/en not_active Ceased
- 1991-07-04 AT AT91912334T patent/ATE144765T1/de not_active IP Right Cessation
- 1991-07-04 SG SG1996002190A patent/SG48829A1/en unknown
- 1991-07-04 KR KR1019930700032A patent/KR0183446B1/ko not_active Expired - Fee Related
- 1991-07-04 WO PCT/EP1991/001254 patent/WO1992000952A1/en not_active Ceased
- 1991-07-04 DE DE69122963T patent/DE69122963T2/de not_active Expired - Fee Related
- 1991-07-04 ES ES91912334T patent/ES2095942T3/es not_active Expired - Lifetime
- 1991-07-04 JP JP3511631A patent/JPH0819068B2/ja not_active Expired - Fee Related
- 1991-07-04 EP EP91912334A patent/EP0538301B1/en not_active Expired - Lifetime
- 1991-07-04 DK DK91912334.9T patent/DK0538301T3/da active
- 1991-07-04 RU RU9192016592A patent/RU2087465C1/ru active
- 1991-07-04 RO RO93-00015A patent/RO112855B1/ro unknown
- 1991-07-04 HU HU9332A patent/HUT64013A/hu unknown
- 1991-07-04 CA CA002084508A patent/CA2084508A1/en not_active Abandoned
- 1991-07-05 MX MX9100100A patent/MX9100100A/es not_active IP Right Cessation
- 1991-07-08 SK SK2102-91A patent/SK279639B6/sk unknown
- 1991-07-08 CZ CS912102A patent/CZ279901B6/cs not_active IP Right Cessation
- 1991-07-08 MA MA22481A patent/MA22208A1/fr unknown
- 1991-07-08 SI SI9111204A patent/SI9111204A/sl unknown
- 1991-07-08 YU YU120491A patent/YU120491A/sh unknown
- 1991-07-08 IL IL9875691A patent/IL98756A/en active IP Right Grant
- 1991-07-08 IL IL11192491A patent/IL111924A/en not_active IP Right Cessation
- 1991-07-09 PT PT98259A patent/PT98259B/pt not_active IP Right Cessation
- 1991-07-09 DZ DZ910091A patent/DZ1514A1/fr active
- 1991-07-09 ZA ZA915334A patent/ZA915334B/xx unknown
- 1991-07-10 CN CN91105305A patent/CN1028990C/zh not_active Expired - Fee Related
- 1991-07-10 TN TNTNSN91056A patent/TNSN91056A1/fr unknown
- 1991-08-09 TW TW080106282A patent/TW204337B/zh active
-
1992
- 1992-11-27 LV LVP-92-231A patent/LV10086B/en unknown
-
1993
- 1993-01-06 BG BG97265A patent/BG61809B1/bg unknown
- 1993-01-07 NO NO930047A patent/NO303777B1/no not_active IP Right Cessation
- 1993-01-08 FI FI930070A patent/FI930070A7/fi unknown
- 1993-01-08 OA OA60329A patent/OA09770A/fr unknown
- 1993-03-23 HR HR930485A patent/HRP930485A2/xx not_active Application Discontinuation
- 1993-08-10 LT LTIP848A patent/LT3602B/lt not_active IP Right Cessation
-
1994
- 1994-10-25 CN CN94117208A patent/CN1033142C/zh not_active Expired - Fee Related
- 1994-12-07 IL IL11192494A patent/IL111924A0/xx unknown
-
1995
- 1995-03-27 US US08/411,039 patent/US5556886A/en not_active Expired - Fee Related
- 1995-03-27 US US08/411,118 patent/US5684049A/en not_active Expired - Fee Related
- 1995-06-29 HU HU95P/P00536P patent/HU211873A9/hu unknown
-
1996
- 1996-11-28 GR GR960403220T patent/GR3021829T3/el unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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